Carbohydrate Research最新文献

Residue-specific protein-glycan conjugation strategies for the development of pharmaceutically promising glycoconjugate vaccines: A recent update

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-04-01 DOI: 10.1016/j.carres.2025.109476

Rajib Sarkar , Ayan Bandyopadhyay , Goutam Brahmachari

引用次数: 0

Total synthesis of conjugation ready repeating unit of Acinetobacter baumannii strain K141 capsular polysaccharide via a [2 + 2] convergent approach

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-04-01 DOI: 10.1016/j.carres.2025.109478

Sunil K. Yadav, Somnath Yadav

引用次数: 0

Biological properties and application of chitosan and low molecular weight chitosan in food industry: A review

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-03-28 DOI: 10.1016/j.carres.2025.109475

Jacqueline Onumah , Newlove A. Afoakwah , Peter Osei Boamah , Emmanuel Duah Osei , Anthony Amotoe-Bondzie

引用次数: 0

A short synthesis of carbohydrate derived N-benzyl aminocyclopentitols through N-O bond cleavage of the corresponding isoxazolidine derivatives: Evaluation of their anticancer properties using in vitro and in silico studies

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-03-28 DOI: 10.1016/j.carres.2025.109465

Tapas Halder , Rituparna Ghosh , Alaka Sahoo , Shasank Sekhar Swain , Ratul Hore , Sourav Ghosh , Prosenjit Saha , Joykrishna Maity

{"title":"A short synthesis of carbohydrate derived N-benzyl aminocyclopentitols through N-O bond cleavage of the corresponding isoxazolidine derivatives: Evaluation of their anticancer properties using in vitro and in silico studies","authors":"Tapas Halder , Rituparna Ghosh , Alaka Sahoo , Shasank Sekhar Swain , Ratul Hore , Sourav Ghosh , Prosenjit Saha , Joykrishna Maity","doi":"10.1016/j.carres.2025.109465","DOIUrl":"10.1016/j.carres.2025.109465","url":null,"abstract":"<div><div>A short synthesis of a potent glycosidase inhibitor N-benzyl-β-D-gluco aminocyclopentitol along with its 2-deoxy, and orthogonally protected 2-O-benzyl, 1,2,3-tri-O-benzyl and 1,2,3-tri-O-acetyl analogues through carbohydrate derived cyclopentane-fused isoxazolidine derivatives has been described herein. The key steps involve NaI mediated vinylation of D-glucose derived 5,6-di-O-mesylated compounds in sealed tube to produce 5,6-dideoxy-l,2-O-isopropylidene-α-D-xylo-hexo-5-enofuranos derivatives in very good yields. Subsequent acetonide deprotection and stereoselective intramolecular nitrone cycloaddition (INC) reaction involving C-4-vinyl functionalities and the latent aldehyde moiety at C-1 yielded various cyclopentano-isoxazolidines. The N-O bond cleavage of the isoxazolidine rings produced the targeted aminocyclopentitols. In vitro anticancer activities of the isoxazolidines and N-benzyl aminocyclopentitols were performed and found only 1,2,3-tri-O-benzyl analogue (20c) of N-benzyl-β-D-gluco aminocyclopentitols emerged as potent anticancer agent with IC50 value 54.90 μM. Furthermore, the molecular docking study confirmed that 20c, compared with the other derivatives, scores higher binding affinity for all the targeted receptors, HSP90, PLK1, and TOP2A.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"552 ","pages":"Article 109465"},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure of O-polysaccharide from the Azospirillum himalayense ptl-3T lipopolysaccharide

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-03-28 DOI: 10.1016/j.carres.2025.109471

Evelina L. Zdorovenko , Elena N. Sigida , Andrey S. Dmitrenok , Svetlana A. Konnova , Yulia P. Fedonenko

引用次数: 0

Organocatalyzed O-glycosylation of glycosyl trichloroacetimidates donors: l-prolinethioamide as brønsted acid catalyst

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-03-28 DOI: 10.1016/j.carres.2025.109470

Ashwani Tiwari , Ariza Khanam , Pintu Kumar Mandal

引用次数: 0

Effects of molecular weights on the bioactivity of hyaluronic acid: A review

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-03-28 DOI: 10.1016/j.carres.2025.109472

Xiaoyun Wang , Xiaojun Liu , Chao Li , Jiangtao Li , Meng Qiu , Yongliang Wang , Wenwei Han

引用次数: 0

Biopolymeric starch-based matrix: A sustainable platform for slow release fertilizers

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-03-28 DOI: 10.1016/j.carres.2025.109474

Mani Prabha , Puneet Tiwari , Pankaj Kumar Yadav , Vandana Singh , Devendra Narayan Tripathi , Tulika Malviya

{"title":"Biopolymeric starch-based matrix: A sustainable platform for slow release fertilizers","authors":"Mani Prabha , Puneet Tiwari , Pankaj Kumar Yadav , Vandana Singh , Devendra Narayan Tripathi , Tulika Malviya","doi":"10.1016/j.carres.2025.109474","DOIUrl":"10.1016/j.carres.2025.109474","url":null,"abstract":"<div><div>Starch, a renewable and biodegradable biopolymer, offers immense potential as a base material for developing slow-release fertilizers. This study focuses on utilizing starch-based materials to encapsulate nutrients that enable slow and regulated release in response to environmental conditions. Various methods like chemical reduction, crosslinking, sol-gel, mixing and blending, etc. with other polymers were explored for modification of starch. These alterations may help to increase the mechanical strength and also enhance the water resistance along with the release dynamics of the fertilizer matrix. The potential use of starch-based fertilizers in maximizing crop yield as well as plant growth and lowering nutrient losses was also explored. This article offers a comprehensive overview of the most recent findings on starch, including its modification in addition to its applications in slow-release fertilizers. It also highlights their ability to boost productivity, enhance nutrient management, and support sustainable farming practices.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"552 ","pages":"Article 109474"},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Edible films based on sulfated polysaccharides from the seaweed Gracilaria birdiae: Physicochemical, optical and mechanical properties

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-03-28 DOI: 10.1016/j.carres.2025.109473

Cláudia Brandão Vieira , Juliana Rabelo Sousa , Diego Alves Do Vale , Cybele Pinheiro Guimarães , Karolina Costa de Sousa , Adriano Lincoln Albuquerque Mattos , André Luís Coelho Silva , Men de Sá Moreira Souza Filho , Bartolomeu Warlene Silva Souza

{"title":"Edible films based on sulfated polysaccharides from the seaweed Gracilaria birdiae: Physicochemical, optical and mechanical properties","authors":"Cláudia Brandão Vieira , Juliana Rabelo Sousa , Diego Alves Do Vale , Cybele Pinheiro Guimarães , Karolina Costa de Sousa , Adriano Lincoln Albuquerque Mattos , André Luís Coelho Silva , Men de Sá Moreira Souza Filho , Bartolomeu Warlene Silva Souza","doi":"10.1016/j.carres.2025.109473","DOIUrl":"10.1016/j.carres.2025.109473","url":null,"abstract":"<div><div>Sulfated polysaccharide (SP) was successfully extracted from rhodophyta Gracilaria birdiae cultivated in northeast Brazil. For the first time, edible SP films from G. birdiae were formulated by the casting method using an experimental design 32, in which the variables were SP concentration and glycerol concentration. A polysaccharide extraction yield of 26.4 % was obtained through hot aqueous extraction and purification by dialysis. The chemical composition indicated the quality of the SP due to the high total carbohydrate (85.1 %) and sulfate (8.1 %) contents and the absence of proteins. Structural characterization showed the presence, besides the sulfate group, of the methylated monosaccharide residues, namely 3,6-α-l-anhydrogalactose-2-O-methyl and β-d-galactose-6-O-methyl with methylation degree of 0.257. In addition, the polysaccharide chain was mainly composed of 3,6-α-l-anhydrogalactose → β-d-galactose, α-l-galactose-6-sulfate → β-d-galactose, β-d-galactose → 3,6-α-l-anhydrogalactose, and β-d-galactose → α-l-galactose-6-sulfato. SP was also considered thermostable, showing a thermal degradation pattern similar to that of galactans. Through experimental design, it was observed that the film formulation with 2 % SP and 0.2 % glycerol presented the best mechanical, physico-chemical and optical properties for application in food packaging.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"552 ","pages":"Article 109473"},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of 1,6-anhydro-functionalized carbohydrate-fused spiro-chromanones via intramolecular domino/spirocyclization

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-03-28 DOI: 10.1016/j.carres.2025.109466

Nicole Jankowski , Christopher Hager , Holly Arcure , Jessie Lopez , Any M. Barrios Gomez , Zbigniew J. Witczak , Roman Bielski , Donald E. Mencer

{"title":"Construction of 1,6-anhydro-functionalized carbohydrate-fused spiro-chromanones via intramolecular domino/spirocyclization","authors":"Nicole Jankowski , Christopher Hager , Holly Arcure , Jessie Lopez , Any M. Barrios Gomez , Zbigniew J. Witczak , Roman Bielski , Donald E. Mencer","doi":"10.1016/j.carres.2025.109466","DOIUrl":"10.1016/j.carres.2025.109466","url":null,"abstract":"<div><div>The synthetic protocol for the first synthesis of carbohydrate-fused spiro-chromanones via intramolecular domino reaction between o-hydroxyacetophenones and dihydrolevoglucosenone (DHL) is described. The reactions proceed via the formation of an acetophenone (APh) enamine intermediate when performed in the presence of pyrrolidine in ethanol. The formation of a new carbon-carbon bond between nucleophilic carbon of the enamine of APh and C-2 of DHL is followed by cyclization, producing a new six-membered ring, as the result of an intramolecular domino process. Several substituted o-hydroxyacetophenones were reacted. The structure of products was determined using 1H and 13C NMR, GC-MS and X-ray crystallography. The yields are good to excellent (62–92 %), and the products are crystalline and easy to isolate. So far, the synthesized compounds were tested only for their antifungal properties. The results were disappointing.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"552 ","pages":"Article 109466"},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0