Carbohydrate Research最新文献_第10页

Synthesis and evaluation of improved green nanofilm using biomass Eichhornia crassipes nanocellulose and Littorina littorea nanochitin reinforced with PVA/sodium alginate 生物质石竹纳米纤维素和聚乙烯醇/海藻酸钠增强Littorina littorea纳米甲壳素改性绿色纳米膜的合成与评价

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-06-25 DOI: 10.1016/j.carres.2025.109590

Vidhyadevi Udayakumar, Brinda Lakshmi Anguraj

{"title":"Synthesis and evaluation of improved green nanofilm using biomass Eichhornia crassipes nanocellulose and Littorina littorea nanochitin reinforced with PVA/sodium alginate","authors":"Vidhyadevi Udayakumar, Brinda Lakshmi Anguraj","doi":"10.1016/j.carres.2025.109590","DOIUrl":"10.1016/j.carres.2025.109590","url":null,"abstract":"<div><div>Modifications of surface-active carriers/films are being explored to optimize their advancement in multiscale applications across the biorefinery, biotechnology, and food industries. This study aims to investigate the fabrication of a modified green nanofilm via a new combination of waste biomass water hyacinth (WH)-derived nanocellulose (NC) and periwinkle shell (PWS)-derived nanochitin (NCh). Using a top-down approach, NC and NCh were synthesized from the biomass above via a cost-effective DES-assisted microwave and ultrasonication ternary pretreatment method and characterized via SEM, TEM, DLS, FTIR, XRD, and TGA. The analysis confirmed the successful synthesis of nanofibrous Type I cellulose (232.5 nm) and nano whisker γ-type chitin (80 nm). Both NC/NCh materials exhibit excellent thermal stability at temperatures up to 500 °C. Next, the synthesized NC/NCh were combined at various concentrations (1 %, 3 %, and 5 wt%) as a composite for film preparation. An ultrasonicated emulsion mixture (3 wt% PVA and 3 wt% sodium alginate) was selectively introduced as a reinforcement filling agent to the composite mixture and successfully fabricated as a film by solution casting. Surface cross-linking was highly improved by binary chemical treatment (tannic acid--glutaraldehyde) and microwave irradiation at 300 W for 60 s. Finally, the best results were obtained for the green nanocomposite film with a composite of 5 wt% NC and 3 wt% NCh in terms of film integrity, moderate hydrophilicity, high wet stability (≥16 %), significant mechanical properties (tensile strength (16.38 MPa) and elongation break (12.21 %)). Thus, the fibrous polymer film exhibited enhanced uniform surface roughness with sustained mechanical stability and strong structural bonding.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"555 ","pages":"Article 109590"},"PeriodicalIF":2.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of C-4 indolyl 2-keto/2,3-unsaturated glycopyranosides C-4吲哚基2-酮/2,3不饱和甘黄苷的合成

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-06-25 DOI: 10.1016/j.carres.2025.109587

Chaitra Narayan Hegde , Anil Shetty , M.G. Greeshma , Chepuri V. Ramana

引用次数: 0

Biological effects of chitosan oligosaccharides on the skin and their clinical applicability 壳聚糖对皮肤的生物学效应及其临床应用

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-06-23 DOI: 10.1016/j.carres.2025.109588

Sung Hoon Lee , Jung Woo Kim , Jin Won Hyun , Hyeon Ju Kim , Sang-Pil Yoon

引用次数: 0

Impact of enzymatic hydrolysis and drying on cellulose nanocrystal properties 酶解和干燥对纤维素纳米晶体性质的影响

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-06-21 DOI: 10.1016/j.carres.2025.109589

Kelly Cristina Coelho de Carvalho Benini, Sergio Luis Yupanqui-Mendoza, Valdeir Arantes

{"title":"Impact of enzymatic hydrolysis and drying on cellulose nanocrystal properties","authors":"Kelly Cristina Coelho de Carvalho Benini, Sergio Luis Yupanqui-Mendoza, Valdeir Arantes","doi":"10.1016/j.carres.2025.109589","DOIUrl":"10.1016/j.carres.2025.109589","url":null,"abstract":"<div><div>Cellulose nanocrystals (CNCs) are highly crystalline, rod-like nanoparticles derived from cellulose, with significant potential for various applications. Their properties—size, crystallinity, thermal stability, and surface chemistry—depend on production methods and processing conditions. While CNCs are typically used as aqueous colloidal dispersions or gel-like forms, certain applications, such as reinforcement for polymer nanocomposites, require CNCs in a dried powder form. However, drying often induces agglomeration, negatively impacting CNC performance. In this study, CNCs were successfully produced via enzymatic hydrolysis using a commercial cellulase blend. Particle size, chemical composition, and X-ray diffraction (XRD) analyses identified optimal production conditions: 5 U/g enzyme loading and 72 h hydrolysis, achieving a maximum yield of 75.7 % even at larger scale. Atomic force microscopy (AFM) confirmed the individual nanoparticle morphology, while XRD and thermogravimetric analysis (TGA) demonstrated preserved crystallinity and thermal stability. The CNCs obtained under these optimized conditions were then subjected to various drying methods. Spray drying (CNC-SD) proved the most effective, yielding uniform, thermally stable particles with higher crystallinity and reduced agglomeration compared to freeze-dried (CNC-FD) and oven-dried (CNC-OD) samples. CNC-SD also exhibited lower moisture loss, enhancing its suitability for nanocomposites. These findings demonstrate the importance of optimizing CNC production and drying techniques to obtain high-performance CNCs. Combining enzymatic hydrolysis and efficient drying strategies provides a robust framework for integrating CNCs into advanced composite materials and expanding their industrial applications in sustainable technologies.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"555 ","pages":"Article 109589"},"PeriodicalIF":2.4,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new route for the preparation of iduronate-2-sulfate glycosides: A new substrate for iduronate-2-sulfatase for screening and diagnosis of Mucopolysaccharidosis-II 制备2-硫酸伊杜醛酸苷的新途径：用于筛选和诊断粘多糖病的2-硫酸伊杜醛酸酶的新底物

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-06-20 DOI: 10.1016/j.carres.2025.109585

Gurpreet Singh , Sanghyun Lim , Joseph Wakpal , Hamid Khaledi , Michael H. Gelb

引用次数: 0

Synthesis of the endogenous non-reducing end heparan sulfate disaccharide for newborn screening and diagnosis of Mucopolysaccharidosis type IIIA 内源性不还原性端硫酸肝素双糖的合成对新生儿IIIA型粘多糖病的筛查和诊断

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-06-19 DOI: 10.1016/j.carres.2025.109584

Sachin Popat Gholap , Zackary Herbst , Rajan K. Paranji , Michael H. Gelb

引用次数: 0

Unveiling the structure of Delftia acidovorans Lipopolysaccharide: insights into O-antigen and lipid A 揭示Delftia酸多聚糖脂多糖的结构：对o抗原和脂质A的见解

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-06-18 DOI: 10.1016/j.carres.2025.109586

Anna Notaro , Luisa Sturiale , Angelo Palmigiano , Domenico Garozzo , Immacolata Speciale

{"title":"Unveiling the structure of Delftia acidovorans Lipopolysaccharide: insights into O-antigen and lipid A","authors":"Anna Notaro , Luisa Sturiale , Angelo Palmigiano , Domenico Garozzo , Immacolata Speciale","doi":"10.1016/j.carres.2025.109586","DOIUrl":"10.1016/j.carres.2025.109586","url":null,"abstract":"<div><div><em>Delftia acidovorans</em> is a Gram-negative bacterium traditionally considered as an environmental organism, although it has recently been identified as an opportunistic pathogen in immunocompromised patients. Furthermore, this bacterium was also recognized as part of the crypt-specific core microbiota in healthy mice. Despite its detection in various contexts, the chemical structure of its lipopolysaccharide (LPS) remains uncharacterized.</div><div>Here, the structure of O-antigen and lipid A from <em>Delftia acidovorans</em> were characterized by combining chemical approaches with spectroscopic and spectrometric studies. In detail, the O-antigen is found to consist of a novel glycan sequence composed of 3)-α-<span>l</span>-rhamnose-(1→4)-α-<span>d</span>-glucose-(1→ disaccharide in the linear backbone, where glucose is in turn branched at the O-2 position with a β-<span>d</span>-<em>N</em>-acetyl-glucosamine, that is non-stoichiometrically acetylated at position O-6. Whereas lipid A is predominantly represented by a hexa-acylated species with a symmetric distribution of acyl chains.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"555 ","pages":"Article 109586"},"PeriodicalIF":2.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the link between structural properties of polysaccharides and anti-inflammatory activity: A review 揭示多糖结构特性与抗炎活性之间的联系：综述

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-06-17 DOI: 10.1016/j.carres.2025.109583

Yuanhao Qiu , Aoying Zhang , Xiuning Lian , Tongtong Zheng , Xin Xue , Zhihui Luo , Huashan Gao , Xinhua Zheng

{"title":"Unraveling the link between structural properties of polysaccharides and anti-inflammatory activity: A review","authors":"Yuanhao Qiu , Aoying Zhang , Xiuning Lian , Tongtong Zheng , Xin Xue , Zhihui Luo , Huashan Gao , Xinhua Zheng","doi":"10.1016/j.carres.2025.109583","DOIUrl":"10.1016/j.carres.2025.109583","url":null,"abstract":"<div><div>Polysaccharides, are natural biological macromolecules, exhibiting anti-inflammatory effects to treat inflammatory pathologies via targeting body's defense system. Polysaccharides exhibit anti-inflammatory properties by influencing the host immunity either via direct interaction with immune cells or by altering intestinal microbiota composition. Meanwhile, molecular weight, monosaccharides composition, glycosidic bonds linkages, and branching features of polysaccharides have pivotal role in determining their anti-inflammatory properties. Recent studies on natural polysaccharides with anti-inflammatory effects highlighted diverse molecular mechanisms and targeted organs where these effects were observed. Moreover, structural characterization of these bioactive polysaccharides has also been discussed, emphasizing their role in modulating inflammation pathways. This article summarizes the research progress on the relationship between polysaccharides' structural properties and anti-inflammatory activity in recent years. The review aimed to deepen the understanding of structural features of polysaccharides with anti-inflammatory properties, offering valuable insights for the development and application of polysaccharide based anti-inflammatory drugs.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"555 ","pages":"Article 109583"},"PeriodicalIF":2.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

1,3-Butadiyne as a rigid linker and five-membered heterocycles generated from 1,3-butadiyne as flexible linkers: Synthesis of dinucleosides as inhibitors of Ribonuclease A 作为刚性连接体的1,3-丁二炔和由1,3-丁二炔生成的五元杂环作为柔性连接体：核糖核酸酶a抑制剂二核苷的合成

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-06-16 DOI: 10.1016/j.carres.2025.109578

Pampa Mondal, Swagata Dasgupta, Tanmaya Pathak

{"title":"1,3-Butadiyne as a rigid linker and five-membered heterocycles generated from 1,3-butadiyne as flexible linkers: Synthesis of dinucleosides as inhibitors of Ribonuclease A","authors":"Pampa Mondal, Swagata Dasgupta, Tanmaya Pathak","doi":"10.1016/j.carres.2025.109578","DOIUrl":"10.1016/j.carres.2025.109578","url":null,"abstract":"<div><div>The active site homology among the ribonuclease family of enzymes suggests that designing Ribonuclease A (RNase A) inhibitors could be a useful approach for developing potential inhibitors of ribonucleases. Thus, a new class of dinucleosides with rigid 1,3-butadiyne is designed and synthesized as inhibitors of Ribonuclease A (RNase A). The functional group was selected for its ability to undergo transformation into five membered heterocycles to generate a set of flexible linkers connecting the same set of nucleosides. Preliminary assays, including agarose and precipitation assays, indicated promising inhibitory activity for dimers connected by 1,3-butadiyne, thiophene, and 1,2-isoxazole linkers. Kinetic studies identified that the rigid 1,3-butadiyne linked bisuridine <strong>11</strong> displayed the highest potency, with an inhibition constant of 29.17 ± 0.8 μM. Docking studies provided insights into binding interactions and highlighted the utility of a rod-like rigid linker as opposed to the flexible linkers in accessing different enzyme subsites. These findings have significant implications for designing new chemical entities as novel therapeutic agents targeting RNase A and related enzymes, because of their involvement in diverse biological processes and diseases.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"555 ","pages":"Article 109578"},"PeriodicalIF":2.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemistry and applications of glycosides from Syzygium genus: A mini review 丁香属植物化学及苷类化合物的应用综述

IF 2.4 3区化学

Carbohydrate Research Pub Date : 2025-06-14 DOI: 10.1016/j.carres.2025.109582

Charu Gupta , Richa Srivastava , Geetanjali , Ram Singh

引用次数: 0