Metabolism open最新文献

{"title":"Coffee pulp improves glucose and lipid metabolism disorder in high-fat diet-induced diabetic mice","authors":"Shuaishuai Zhu ,&nbsp;Chenying Wang ,&nbsp;Zhuo-Xian Meng","doi":"10.1016/j.metop.2024.100303","DOIUrl":"10.1016/j.metop.2024.100303","url":null,"abstract":"<div><h3>Background</h3><p>Coffee berry extracts are anti-lipogenic and lipolytic. This study aims to investigate the effect and mechanism of coffee pulp on high-fat diet (HFD)-induced glucose and lipid metabolism disorder in mice.</p></div><div><h3>Methods</h3><p>The type 2 diabetes (T2D) mouse model was established by feeding the C57BL/6 J mice with HFD. Mice were administered with coffee pulp diluted in drinking water before or after the establishment of the T2D mouse model. After treatment, the body weight and fasting blood glucose (FBG) of mice were monitored; the intraperitoneal glucose tolerance test (IPGTT) of mice was performed; plasma insulin was determined by ELISA; serum total cholesterol (TC), triglyceride (TG) and liver TG were determined by biochemical analysis; hematoxylin-eosin (H&amp;E) staining was used to evaluate organ histomorphology. Gene expression of key genes in de novo lipogenesis (DNL) in the liver was examined by quantitative reverse transcription PCR (RT-qPCR).</p></div><div><h3>Results</h3><p>Mice that consumed coffee pulp after modeling showed reduced FBG and liver TG, improved IPGTT, and alleviated fatty liver. Consuming coffee pulp before modeling prevented HFD-induced blood glucose and plasma TG increases. Mice consuming coffee pulp also had lower body fat and liver TG compared to the model group. qPCR results showed that the expression of transcription factors (Srebp1, PPARγ) and genes (Fasn, CideA, Plin3, Plin4, Plin5) related to DNL and lipid droplets (LD) formation in the liver of mice consuming coffee pulp were significantly lower than those of the control group.</p></div><div><h3>Conclusions</h3><p>Our study demonstrated that coffee pulp can attenuate HFD-induced disorders of glucose and lipid metabolism, and this effect may be related to the key pathways of lipid synthesis DNL and LD formation pathways in the liver.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100303"},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000355/pdfft?md5=88538692c3cf7f4a23b2f59581b86211&pid=1-s2.0-S2589936824000355-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental detection of hereditary bisalbuminemia in a patient with positive DAT coombs: A case-based review","authors":"Elena Avgoustou ,&nbsp;Dimitris Kounatidis ,&nbsp;Natalia G. Vallianou ,&nbsp;Irene Karampela ,&nbsp;Theodora Stratigou ,&nbsp;Maria Dalamaga","doi":"10.1016/j.metop.2024.100307","DOIUrl":"10.1016/j.metop.2024.100307","url":null,"abstract":"<div><p>Bisalbuminemia is a rare, typically benign condition marked by the presence of a bifid albumin band on serum protein electrophoresis. It can either be inherited due to a point mutation or acquired in association with various medical conditions, most commonly diabetes mellitus. Bisalbuminuria, the presence of bifid albumin in urine, may or may not accompany bisalbuminemia. Both conditions are often discovered incidentally during screening for monoclonal gammopathy. Bisalbuminemia and related variants provide insights into albumin's genetic diversity and functional roles, influencing clinical diagnostics and research in human genetics. Understanding these variants aids in distinguishing benign conditions from potential disease states, guiding appropriate clinical management. In this case-based review, we present a case of hereditary bisalbuminemia identified unexpectedly during an investigation of a positive Direct Antiglobulin Test Coombs in an adult female patient. This review aims to highlight the key features of bisalbuminemia, a rare condition that should be recognized by clinicians.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100307"},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000392/pdfft?md5=e24796c078da6c2030430d6420b5530b&pid=1-s2.0-S2589936824000392-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low muscle mass is associated with low insulin sensitivity, impaired pancreatic β cell function, and high glucose excursion in nondiabetic nonobese Japanese women","authors":"Satomi Minato-Inokawa ,&nbsp;Ayaka Tsuboi-Kaji ,&nbsp;Mari Honda ,&nbsp;Mika Takeuchi ,&nbsp;Kaori Kitaoka ,&nbsp;Miki Kurata ,&nbsp;Bin Wu ,&nbsp;Tsutomu Kazumi ,&nbsp;Keisuke Fukuo","doi":"10.1016/j.metop.2024.100306","DOIUrl":"10.1016/j.metop.2024.100306","url":null,"abstract":"<div><h3>Aim</h3><p>We tested whether skeletal muscle mass is associated with insulin sensitivity, pancreatic β-cell function, and postglucose glycemia.</p></div><div><h3>Methods</h3><p>Appendicular skeletal muscle mass (ASM) (relative to body size, %ASM) by DXA, surrogate measures of insulin sensitivity, insulin secretion and the disposition index (insulin sensitivity adjusted insulin secretion: a product of the insulinogenic index and Matsuda insulin sensitivity index) inferred from serum insulin kinetics during a 75 g oral glucose tolerance test (OGTT) were evaluated in 168 young and 65 middle-aged women, whose BMI averaged &lt;23.0 kg/m² and HbA1c ≦ 5.5 %.</p></div><div><h3>Results</h3><p>In two groups of women, %ASM was associated negatively with homeostasis model assessment insulin resistance (HOMA-IR) and 2-h insulin (both p &lt; 0.01 or less). In middle-aged women not in young women, %ASM was associated inversely with the Matsuda index (p &lt; 0.001). In middle-aged women only, it also showed a positive association with the disposition index (p = 0.02) and inverse associations with 1-h and 2-h glucose (both p &lt; 0.01) and area under the glucose concentration curve during OGTT (p = 0.006). On multivariate linear regression analyses, 2-h insulin emerged as a determinant of %ASM independently of HOMA-IR in young women (standardized β: 0.287, p &lt; 0.001, R² = 0.077). In middle-aged women, the Matsuda index emerged as a determinant of %ASM (standardized β: 0.476, p &lt; 0.001) independently of HOMA-IR, log ODI and AUCg and explained 21.3 % of %ASM variability. Post-glucose glycemia and AUCg were higher and log ODI was lower in middle-aged women with low compared with high %ASM.</p></div><div><h3>Conclusion</h3><p>Low skeletal muscle mass (relative to body size) was associated with low insulin sensitivity in young and middle-aged Japanese women who were neither obese nor diabetic. Middle-aged women with low muscle mass had low disposition index, an early marker of inadequate pancreatic β-cell compensation, and hence high glucose excursion. Low skeletal muscle mass may be associated with the development of type 2 diabetes at a much lower BMI in Japanese people.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100306"},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000380/pdfft?md5=ffdc0afef1e7d6169159eca5d76375bf&pid=1-s2.0-S2589936824000380-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141962467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraneoplastic hypoglycemia: An overview for optimal clinical guidance","authors":"Nikolaos Nektarios Karamanolis ,&nbsp;Dimitris Kounatidis ,&nbsp;Natalia G. Vallianou ,&nbsp;Konstantinos Alexandropoulos ,&nbsp;Eleni Kovlakidi ,&nbsp;Pinelopi Kaparou ,&nbsp;Irene Karampela ,&nbsp;Theodora Stratigou ,&nbsp;Maria Dalamaga","doi":"10.1016/j.metop.2024.100305","DOIUrl":"10.1016/j.metop.2024.100305","url":null,"abstract":"<div><p>Paraneoplastic hypoglycemia, also known as non-islet cell tumor hypoglycemia (NICTH), is a rare but critical condition occurring in patients with different types of malignancy. This condition is commonly linked to tumors producing insulin-like growth (IGF) factors, particularly IGF-2 and its precursors, which disrupt glucose homeostasis and lead to excessive glucose consumption. The diagnosis typically involves documenting symptomatic hypoglycemia and ruling out other potential causes. Essential diagnostic tools include imaging studies and laboratory tests, specifically measuring IGF-2 levels and the IGF-2:IGF-1 ratio. Treatment strategies for NICTH are multifaceted and may include surgical resection of the tumor if feasible, pharmacological interventions such as corticosteroids to suppress IGF-2 production, or supportive measures to manage acute hypoglycemic episodes. Novel therapeutic approaches targeting IGF-2, such as monoclonal antibodies or siRNA, are also being explored and hold promise for future treatment options. This review aims to enhance understanding of paraneoplastic hypoglycemia, focusing on its pathogenesis and diagnosis, to guide optimal medical treatment.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100305"},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000379/pdfft?md5=57f2dc8e33423f37f581a98f626fd3cb&pid=1-s2.0-S2589936824000379-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucometric parameter changes in patients with type 2 diabetes during ramadan fasting: A prospective comparative real-world study","authors":"Ayman Al Hayek,&nbsp;Wael M. Al Zahrani,&nbsp;Mohamed Abdulaziz Al Dawish","doi":"10.1016/j.metop.2024.100304","DOIUrl":"10.1016/j.metop.2024.100304","url":null,"abstract":"<div><h3>Background</h3><p>This study assessed glucometric changes in Type 2 diabetes mellitus (T2DM) patients before, during, and after Ramadan fasting using an intermittently scanned continuous glucose monitoring system (isCGMS).</p></div><div><h3>Methods</h3><p>This prospective comparative study included T2DM patients aged 30–70 years who were receiving nonintensive insulin in Riyadh, Saudi Arabia. In addition to the baseline characteristics, glycated hemoglobin (HbA1c) and ambulatory glucose profile (AGP)-derived metric data were collected at three specific points: pre-, during-, and post-Ramadan. Self-care activities during Ramadan were evaluated using the Diabetes Self-Management Questionnaire (DSMQ).</p></div><div><h3>Results</h3><p>Overall, a total of 93 T2DM patients were enrolled in the study. Their mean age ±SD age was 47.9 ± 7.5 years, and 51.6 % of them were males. Compared with pre- and post-Ramadan, there was a significant decrease in HbA1c (p &lt; 0.001 for both periods), average glucose level (p = 0.001 and p = 0.026, respectively), glucose variability (p = 0.043 and p = 0.005, respectively), and % time above the range of 181–250 mg/dL (p &lt; 0.001 for both periods), as well as a significant increase in % time in target (70–180 mg/dL) during Ramadan (p &lt; 0.001 for both periods). However, the % time below 54 mg/dL was slightly greater during Ramadan than both pre- and post-Ramadan (p &lt; 0.001 and p = 0.002, respectively). Furthermore, 32.3 % reported inadequate self-care behaviors during Ramadan.</p></div><div><h3>Conclusions</h3><p>Ramadan fasting could improve glucose levels in T2DM patients who were not on intensive insulin, with a relatively low incidence of hypoglycemia.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100304"},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000367/pdfft?md5=48fb339890bd8c4747a0b69a18fac6da&pid=1-s2.0-S2589936824000367-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnic differences in vitamin D status, bone and body composition in South Asian indian and caucasian men","authors":"A. Altasan ,&nbsp;A. Aljahdali ,&nbsp;R. Ramadoss ,&nbsp;M.M. Cheung ,&nbsp;R.D. Dall ,&nbsp;M. Bruneau Jr ,&nbsp;J.A. Nasser ,&nbsp;J. Kindler ,&nbsp;A. Ramakrishnan ,&nbsp;D. Sukumar","doi":"10.1016/j.metop.2024.100302","DOIUrl":"10.1016/j.metop.2024.100302","url":null,"abstract":"<div><h3>Background</h3><p>High prevalence of metabolic abnormalities and poor bone health in ethnic minorties may stem from differences in body composition and alterations in endocrine milieu. South Asian Indians (SAIs) are at greater risk for metabolic syndrome (MetS) and poor bone health than Caucasians. Often these differences are reported later in life and/or in a resident immigrant population compared to a Caucasian population. In this study, we determined whether vitamin D status, bone, body composition differed in young SAIs and Caucasians. Notably we compared differences amongst recent SAI immigrants and Caucasians.</p></div><div><h3>Methods</h3><p>We examined differences in bone density, body composition, serum 25-hydroxy vitamin D (s25(OH)D), parathyroid hormone (sPTH), vitamin D binding protein (sDBP), osteocalcin (sOC), and dietary intakes in young healthy SAI and Caucasian men.</p></div><div><h3>Results</h3><p>Sixty men (N = 30 SAIs and N = 30 Caucasians) with a mean age of 27.8 ± 7.4 years completed the study. Compared to the Caucasians, SAIs had statistically significantly lower s25(OH)D and higher sPTH (<em>p</em> &lt; 0.05). We also found that s25(OH)D was negatively associated with sPTH only among the SAIs (r = - 0.389, <em>p</em> = 0.037). Also, lean mass% (LM%) and fat-free mass% (FFM%) were lower in SAIs (<em>p</em> &lt; 0.05) compared to caucasians. s25(OH)D correlated with nearly all body composition parameters, while sPTH correlated negatively with LM% and FFM%, and positively with FM% (all <em>p</em> &lt; 0.05) in the Caucasian group. Bone mineral density at most sites were also significantly lower (p &lt; 0.05) in the SAI's compared to caucasians.</p></div><div><h3>Conclusion</h3><p>Young SAIs have a poor vitamin D status and less favorable bone and body composition parameters compared to Caucasians. These findings highlight the possible complex interplay between skeletal and metabolic health in different ethnicities which may be evident early on in life. Interventions to improve bone and metabolic health should therefore target younger ethnic minorities.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100302"},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000343/pdfft?md5=6ca34f43071ed2e851a836006d22915e&pid=1-s2.0-S2589936824000343-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141853698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of vitamin D on risk of falls and fractures – The contribution of recent mega-trials","authors":"Bess Dawson-Hughes","doi":"10.1016/j.metop.2024.100300","DOIUrl":"10.1016/j.metop.2024.100300","url":null,"abstract":"<div><p>Three recently-completed, large clinical trials in the U.S, New Zealand, and Australia, referred to herein as the ‘mega-trials’, were conducted to determine the impact of supplemental vitamin D on a variety of outcomes including falls and fractures. The trials were similar in design and collectively included over 50,000 generally vitamin D replete, older men and women. The mega-trials established that vitamin D supplementation with the equivalent of 2000 to 3300 IU/d of vitamin D₃ had no favorable effect on risk of falls or fractures. This review focuses on specific design elements of the trials and how they likely influenced these trial findings. While these trials were in progress, evidence emerged that circulating 25-hydroxyvitamin D levels have a U-shaped association with risk of falling, raising concern about a potential untoward effect of high dose supplementation. There is compelling evidence that in older, vitamin D- and calcium-insufficient nursing home residents, the combination of vitamin D and calcium in modest replacement doses dramatically reduces the risk of hip and other fractures. Community-dwelling older adults in many populous countries around the globe have widespread vitamin D and calcium insufficiency. It is time to follow the evidence trail and determine the effect of vitamin D and calcium replacement on their risk of falls and fractures.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100300"},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S258993682400032X/pdfft?md5=465b81989f58807aa537e3f5f2347064&pid=1-s2.0-S258993682400032X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between APOE genotypes and metabolic syndrome in a middle aged and elderly Urban South Indian population","authors":"Shilna Azhuvalappil ,&nbsp;Raghav Prasad ,&nbsp;Pravin Sahadevan ,&nbsp;Priya Chatterjee ,&nbsp;Hitesh Pradhan ,&nbsp;Pooja Rai ,&nbsp;Anant Gupta ,&nbsp;Reddy Peera Kommaddi ,&nbsp;Thomas G. Issac ,&nbsp;Jonas S. Sundarakumar","doi":"10.1016/j.metop.2024.100301","DOIUrl":"10.1016/j.metop.2024.100301","url":null,"abstract":"<div><h3>Background</h3><p>This study examines the association between apolipoprotein E (APOE) genotypes and metabolic syndrome (MetS) in an older urban population in South India, as part of the Tata Longitudinal Study on Aging.</p></div><div><h3>Methods</h3><p>A total of 618 participants aged 45 and above were analyzed cross-sectionally for the association between APOE carrier status and MetS (based on both NCEP ATP III and Consensus criteria).</p></div><div><h3>Results</h3><p>Despite the high prevalence of MetS observed in this cohort (51.62 % by NCEP-ATP III and 61.33 % by Consensus criteria), multivariable logistic regression revealed no significant association between APOE genotypes and MetS under both criteria. However, specific associations were noted in age and sex-stratified analyses; notably, E2 carriers under 60 showed 0.42-fold decreased odds (95%CI:0.20,0.89, p-value-0.023) for an increased waist circumference, and E4 carriers above 60 were at 1.85 times increased odds (95 % CI:1.04,3.28, p-value&lt;0.05) for decreased HDL.</p></div><div><h3>Conclusion</h3><p>These findings suggest that while APOE genotypes influence certain metabolic parameters, their impact on MetS may be limited in this urban setting, possibly overshadowed by environmental factors and lifestyle influences, which was highlighted by the differences seen in its sister rural cohort.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100301"},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000331/pdfft?md5=4b4091c837908c2d495bb021de4051a4&pid=1-s2.0-S2589936824000331-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141706129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal variation and Vitamin-D status in ostensibly healthy Indian population: An experience from a tertiary care institute","authors":"Karli Sreenivasulu ,&nbsp;Mithu Banerjee ,&nbsp;Sojit Tomo ,&nbsp;Kamalkant Shukla ,&nbsp;Maithili Karpaga Selvi ,&nbsp;Mahendra Kumar Garg ,&nbsp;Sumit Banerjee ,&nbsp;Praveen Sharma ,&nbsp;Ravindra Shukla","doi":"10.1016/j.metop.2024.100298","DOIUrl":"https://doi.org/10.1016/j.metop.2024.100298","url":null,"abstract":"<div><h3>Background</h3><p>25-hydroxy vitamin-D (25(OH)D) deficiency is prevalent worldwide including India. Earlier some cross-sectional studies have discussed 25(OH)D deficiency and its prevalence. The correlation of 25(OH)D with seasonal variation has been reported rarely in India. To determine the 25(OH)D levels and seasonal changes of 25(OH)D status at a tertiary care hospital in North-western India.</p></div><div><h3>Materials and methods</h3><p>25(OH)D assessments performed in laboratories between 2018 and 2020 was acquired using hospital records. A total of 11,428 assays of serum 25(OH)D were analyzed in the study. Subjects were divided into three groups based on the International Endocrine Society's recommendation for serum 25(OH)D level. The 25(OH)D deficiency &lt;20 ng/ml, insufficiency 20–29 ng/mL and sufficiency ≥30 ng/mL was defined. The months have been separated into the following seasons to analyze seasonal trends: Summer/monsoon (April–September), and winter/spring (October–March).</p></div><div><h3>Results</h3><p>The median 25(OH)D was 17.2 ng/mL. We observed the prevalence of 60 %, 24.1 % &amp; 15.9 % of 25(OH)D deficiency, 25(OH)D insufficiency, and sufficiency respectively in the total number of individuals tested. 56 % male and 63 % females were 25(OH)D deficient. Notably, the lowest median 25(OH)D value was found in the 21–30 age group (14.8 ng/mL). A significant difference in 25(OH)D levels between the summer (18.7 ng/mL) and winter (15.8 ng/mL) seasons has been noticed.</p></div><div><h3>Discussion</h3><p>Current study revealing that 25(OH)D deficiency is common in all age groups and genders, according to our findings. Surprisingly, the lowest levels were reported in young adults. Seasonal variation has an impact on 25(OH)D status, however in all seasons 25(OH)D levels are lower than reference intervals. These findings suggest that the criteria for determining the state of 25(OH)D insufficiency and deficiency in the Indian population should be reconsidered.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100298"},"PeriodicalIF":0.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000306/pdfft?md5=cf05258561852e455be66a27b50015ba&pid=1-s2.0-S2589936824000306-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adropin: A crucial regulator of cardiovascular health and metabolic balance","authors":"S. Rooban ,&nbsp;K.A. Arul Senghor ,&nbsp;V.M. Vinodhini ,&nbsp;J.S. Kumar","doi":"10.1016/j.metop.2024.100299","DOIUrl":"https://doi.org/10.1016/j.metop.2024.100299","url":null,"abstract":"<div><p>Adropin, a peptide discovered in 2008, has gained recognition as a key regulator of cardiovascular health and metabolic balance. Initially identified for its roles in energy balance, lipid metabolism, and glucose regulation, adropin has also been found to improve cardiovascular health by enhancing endothelial function, modulating lipid profiles, and reducing oxidative stress. These protective mechanisms suggest that adropin may be able to help prevent conditions such as atherosclerosis, hypertension, and other cardiovascular diseases. Research has established connections between adropin and cardiovascular risk factors, such as obesity, insulin resistance, and dyslipidemia, positioning it as a valuable biomarker for evaluating cardiovascular disease risk. New studies highlight adropin's diagnostic and prognostic significance, showing that higher levels are linked to better cardiovascular outcomes, while lower levels are associated with a higher risk of cardiovascular diseases. This review aims to summarize current knowledge on adropin, emphasizing its significance as a promising focus in the intersection of cardiovascular health and metabolic health. By summarizing the latest research findings, this review aims to offer insights into the potential applications of adropin in both clinical practice and research, leading to a deeper understanding of its role in maintaining cardiovascular and metabolic health.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100299"},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000318/pdfft?md5=3a7014005f5cc0966d12437e6b0a19f2&pid=1-s2.0-S2589936824000318-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}