Metabolism open最新文献

{"title":"Glycemic control and its association with sleep quality and duration among type 2 diabetic patients","authors":"Yadelew Yimer Shibabaw ,&nbsp;Tadesse Asmamaw Dejenie ,&nbsp;Kibur Hunie Tesfa","doi":"10.1016/j.metop.2023.100246","DOIUrl":"10.1016/j.metop.2023.100246","url":null,"abstract":"<div><h3>Background</h3><p>Poor glycemic control is the current most important tragedy in type 2 diabetic patients. Sleep has a major modulatory effect on endocrine and metabolic function. Sleep disturbance is associated with increased circulating cortisol levels, sympathetic activity, and epinephrine secretion. These physiological conditions are directly or indirectly associated with glucose metabolism in our body cells. In Ethiopia, sleep pattern association with glycemic control level is not studied yet.</p></div><div><h3>Objectives</h3><p>To assess glycemic control and its association with sleep quality, sleep duration and napping among patients with type 2 diabetes mellitus in Felege Hiwot Comprehensive Referral and Specialized Hospital Northwest Ethiopia.</p></div><div><h3>Method</h3><p>An institutional-based cross-sectional study was conducted among 407 type 2 diabetes mellitus patients from July 1, 2020, to April 28, 2021, using a systematic random sampling technique. We drew 5 mL of blood from each patient before breakfast to determine their fasting blood sugar level. The Pittsburg Sleep Quality Index was used to assess patients' sleep quality, and the presence or absence of Obstructive Sleep Apnea was determined using the STOP-BANG questionnaire. Data were analysed using STATA version 14.1.variables with a P-value of &lt;0.05 were considered statistically significant.</p></div><div><h3>Results</h3><p>Glycemic control was found to be poor in 54.05% of the study participants. Female sex, poor sleep quality, and short and long sleep durations were all significantly associated with impaired glycemic control. Being female increased the odds of poor glycemic control by 2.7 times (AOR = 2.7, 95% CI: 1.23, 6.15) compared to males. T2DM patients who had poor sleep quality had 3.3 times (AOR = 3.3, 95% CI (1.16, 9.37) higher odds of poor glycemic control compared to patients who had good sleep quality. The odds of having poor glycemic control among T2DM patients who were at low risk of OSA and intermediate risk of OSA were decreased by 96% (AOR = 0.03, 95% CI: 0.01, 0.12) and 86% (AOR = 0.14, 95% CI: 0.05, 0.43) compared to T2DM patients who were at high risk of OSA, respectively. T2DM patients who had short sleep duration (&lt;6 hours) were 8.3 times (AOR = 8.3, 95% CI: 2.66–25.85) higher chances of poor glycemic control compared to patients who had average sleep duration. T2DM patients who had long sleep duration (&gt;8 hours) increased the odds of poor glycemic control by 2.6 times (AOR = 2.6, 95% CI (1.12–6.04) compared to those who had average sleep duration. The chances of having poor glycemic control among T2DM patients who did not take the balanced diet recommended by their physician were increased by 3.8 times (AOR = 3.8 95% CI: 1.05–13.77).</p></div><div><h3>Conclusion</h3><p>The prevalence of poor glycemic control in T2DM patients was high. Poor sleep quality, both short and long sleep duration, and an intermediate or low risk of obstr","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100246"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4c/06/main.PMC10238567.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9956090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global prevalence of sexual dysfunction among diabetic patients from 2008 to 2022: Systematic review and meta-analysis","authors":"Natnael Atnafu Gebeyehu ,&nbsp;Molalegn Melese Gesese ,&nbsp;Kirubel Dagnaw Tegegne ,&nbsp;Yenalem Solomon Kebede ,&nbsp;Gizachew Ambaw Kassie ,&nbsp;Misganaw Asmamaw Mengstie ,&nbsp;Melkamu Aderajaw Zemene ,&nbsp;Berihun Bantie ,&nbsp;Sefineh Fenta Feleke ,&nbsp;Tadesse Asmamaw Dejenie ,&nbsp;Endeshaw Chekol Abebe ,&nbsp;Denekew Tenaw Anley ,&nbsp;Anteneh Mengist Dessie ,&nbsp;Wubet Alebachew Bayih ,&nbsp;Getachew Asmare Adela","doi":"10.1016/j.metop.2023.100247","DOIUrl":"10.1016/j.metop.2023.100247","url":null,"abstract":"<div><h3>Background</h3><p>Both men and women can have a wide range of physical, emotional, and sexual issues as a result of diabetes. One of them is sexual dysfunction, which has an effect on marital relationships as well as the effectiveness of therapy and can develop into a serious social and psychological condition. As a result, the purpose of this study was to identify the global prevalence of sexual dysfunction among diabetic patients.</p></div><div><h3>Methods</h3><p>Science Direct, Scopus, Google Scholar, and PubMed were all searched for information. Data were extracted using Microsoft Excel (v. 14), STATA statistical software, and STATA. Publication bias was investigated by a forest plot, rank test, and Egger's regression test. To detect heterogeneity, I² was calculated and an overall estimated analysis was performed. Subgroup analysis was done by study region and sample size. The pooled odds ratio was also computed.</p></div><div><h3>Results</h3><p>The study was able to include 15 of the 654 publications that were evaluated since they met the criteria. 67,040 people participated in the survey in all. The pooled global prevalence of sexual dysfunction among diabetic patients was 61.4% (95% CI: 51.80, 70.99), I2 = 71.6%. The frequency of sexual dysfunction was highest in the European region (66.05%). For males, the prevalence of sexual dysfunction was 65.91%, while for females, it was 58.81%. Patients with type 2 diabetes mellitus were more likely (71.03%) to experience sexual dysfunction.</p></div><div><h3>Conclusion</h3><p>Finally, sexual dysfunction was fairly common all across the world. There were variations in the prevalence of sexual dysfunction depending on the sex, type of diabetes, and location of the study participant. Our findings imply that screening and appropriate treatment are required for diabetes persons exhibiting sexual dysfunction.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100247"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/f7/main.PMC10267599.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10028778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between testosterone-estradiol ratio and some anthropometric and metabolic parameters among Nigerian men","authors":"Holiness Stephen Adedeji Olasore ,&nbsp;Tolulope Adejoke Oyedeji ,&nbsp;Matthew Olamide Olawale ,&nbsp;Omobolanle Ibukun Ogundele ,&nbsp;Joseph Ogo-Oluwa Faleti","doi":"10.1016/j.metop.2023.100249","DOIUrl":"10.1016/j.metop.2023.100249","url":null,"abstract":"<div><h3>Background</h3><p>Alterations in sex hormone levels are implicated in the regulation of metabolic processes in men. In recent years, the prevalence of metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes, has risen in Nigeria. In men, these disorders may be associated with the ratio of serum testosterone to estradiol levels. Therefore, we investigated the relationship between the testosterone-estradiol (T/E2) ratio, anthropometry, and metabolic parameters in Nigerian men.</p></div><div><h3>Method</h3><p>Eighty-five adult men were recruited for this study. Participants’ data such as age, weight, height, BMI, and waist circumference were collected. Plasma total testosterone and estradiol levels, as well as metabolic parameters such as fasting blood sugar, creatinine, urea, HDL cholesterol, total cholesterol, and triglycerides levels, were determined. The data were analyzed using SPSS version 25 software.</p></div><div><h3>Results</h3><p>Anthropometric parameters such as weight, height, BMI, and waist circumference showed a negative correlation with plasma T/E2 (r = −0.265, −0.288, −0.106, −0.204; p = 0.007, 0.004, 0.167, 0.061 respectively). However, the T/E2 ratio showed a positive correlation with the metabolic parameters such as fasting blood sugar, HDL cholesterol levels, plasma creatinine, and urea (r = 0.219, 0.096, 0.992, 0.152; p = 0.022, 0.192, &lt;0.001, 0.082 respectively), while there were negative correlations with total cholesterol and triglycerides levels (r = −0.200, −0.083; p = 0.034, 0.226 respectively).</p></div><div><h3>Conclusion</h3><p>These findings show that there are significant correlations between the T/E2 ratio and weight, height, fasting blood sugar, creatinine, and urea, while there are no significant correlations between T/E2 ratio and BMI, waist circumference, HDL-cholesterol, and triglycerides.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100249"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9736456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive significance of glomerular insulin receptor substrate-1 in patients with diabetic kidney disease","authors":"Akira Mima,&nbsp;Ami Murakami,&nbsp;Rina Lee,&nbsp;Shinji Lee","doi":"10.1016/j.metop.2023.100240","DOIUrl":"10.1016/j.metop.2023.100240","url":null,"abstract":"<div><h3>Background</h3><p>In rodents, glomerular expression of insulin receptor substrate 1 (IRS1) is decreased in diabetic kidney disease (DKD) and reduced associated functioning is involved in the development and progression of DKD. This study aimed to evaluate the significance of glomerular IRS1 expression in DKD patients, and investigated whether glomerular IRS1 expression can reflect renal pathology and predict renal outcomes.</p></div><div><h3>Methods</h3><p>This study included 10 patients who underwent renal biopsy and were diagnosed with DKD or minor glomerular abnormality (MGA). IRS1-positive cells were determined based on renal biopsy and immunostaining, and the associations of the number of these cells with baseline and prognostic parameters were analyzed.</p></div><div><h3>Results</h3><p>IRS1-positive cells were significantly decreased in DKD than in MGA. IRS1 positivity tended to be negatively correlated with global glomerulosclerosis and tubulointerstitial fibrosis. The rate of change in estimated glomerular filtration rate before and 12 months after renal biopsy was positively correlated to the number of IRS1-positive cells. Furthermore, a tendency towards negative correlation was observed between the number of glomerular IRS1-positive cells and the proteinuria.</p></div><div><h3>Conclusions</h3><p>This study shows the glomerular IRS1-positive cell count was significantly decreased in DKD, and that the degree IRS1 positivity was partially correlated with renal pathology and function.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100240"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070893/pdf/main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9264101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aldehyde dehydrogenase 2 polymorphism is an important gene for insulin resistance in Japanese patients with type 2 diabetes","authors":"Tsuyoshi Okura ,&nbsp;Risa Nakamura ,&nbsp;Mari Anno ,&nbsp;Yuichi Ito ,&nbsp;Sonoko Kitao ,&nbsp;Satomi Endo ,&nbsp;Natsuka Taneda ,&nbsp;Kazuhisa Matsumoto ,&nbsp;Kyoko Shoji ,&nbsp;Hiroko Okura ,&nbsp;Kazuhiko Matsuzawa ,&nbsp;Shoichiro Izawa ,&nbsp;Etsuko Ueta ,&nbsp;Masahiko Kato ,&nbsp;Takeshi Imamura ,&nbsp;Shin-ichi Taniguchi ,&nbsp;Kazuhiro Yamamoto","doi":"10.1016/j.metop.2023.100242","DOIUrl":"10.1016/j.metop.2023.100242","url":null,"abstract":"<div><h3>Background</h3><p>Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme involved in alcohol metabolism. ALDH2 polymorphism has been reported as a risk factor for type 2 diabetes mellitus (T2DM) and is associated with liver insulin resistance due to alcohol consumption in non-diabetic individuals. Herein, we investigated the association between ALDH2 polymorphisms and insulin resistance in patients with T2DM.</p></div><div><h3>Methods</h3><p>We performed a meal tolerance test and the hyperinsulinemic-euglycemic clamp on 71 Japanese participants: 34 patients with T2DM, and 37 non-diabetic participants. We analyzed the ALDH2 polymorphism (ALDH2 rs67); GG type was defined as the T2DM high-risk group, compared with the low-risk AG and AA groups.</p></div><div><h3>Results</h3><p>Glucose levels were similar in the high- and low-risk T2DM groups. The high-risk group for T2DM showed a significantly higher BMI (p &lt; 0.005), insulin resistance in HOMA-IR (p &lt; 0.05), and Insulin sensitivity index (p &lt; 0.05); however, there were no significant differences in insulin resistance in the clamp test (p = 0.10). Alcohol consumption did not differ significantly between groups (p = 0.66). Non-diabetic participants also showed higher HOMA-IR insulin resistance in the high-risk group (p &lt; 0.05), but insulin resistance levels in the glucose clamp tests (p = 0.56) and insulin secretion were not significant.</p></div><div><h3>Conclusion</h3><p>The results suggest that ALDH2 is an important gene associated with insulin resistance and obesity in Japanese patients with type 2 diabetes.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100242"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4c/fb/main.PMC10130494.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9386554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tapinanthus dodoneifolius leaf inhibits the activity of carbohydrate digesting enzymes and improves the insulin resistance induced in rats by dexamethasone","authors":"David Miaffo ,&nbsp;Fidèle Ntchapda ,&nbsp;Sylviane Laure Poualeu Kamani ,&nbsp;Angèle Kopodjing Bello ,&nbsp;Talba Abba Mahamad ,&nbsp;Barthelemy Maidadi ,&nbsp;Kilenma Kolefer","doi":"10.1016/j.metop.2023.100238","DOIUrl":"https://doi.org/10.1016/j.metop.2023.100238","url":null,"abstract":"<div><h3>Background</h3><p><em>Tapinanthus dodoneifolius</em> is a plant used in traditional African medicine to treat diabetes mellitus. This study aimed to evaluate the preventive antidiabetic potential of the aqueous extract of <em>T. dodoneifolius</em> leaves (AETD) in insulin resistant rats.</p></div><div><h3>Methods</h3><p>A quantitative phytochemical study of AETD was carried out to determine the contents of total phenols, tannins, flavonoids, and saponins. AETD was tested <em>in vitro</em> on the activity of α-amylase and α-glucosidase enzymes. Insulin resistance was induced for 10 days by daily subcutaneous injection of dexamethasone (1 mg/kg). One hour before, the rats were divided into 5 groups and treated as follows: group 1 received distilled water (10 mL/kg); group 2 received metformin (40 mg/kg), and groups 3, 4, and 5 were treated with AETD (125, 250, and 500 mg/kg). Body weight, blood sugar, food and water consumption, serum insulin level, lipid profile, and oxidative status were assessed. One-way analysis of variance followed by Turkey's post-test and two-way analysis followed by Bonferroni's post-test were used to analyze univariate and bivariate parameters, respectively.</p></div><div><h3>Results</h3><p>Results showed that the phenol content of AETD (54.13 ± 0.14 mg GAE/g extract) was higher than that of flavonoids (16.73 ± 0.06 mg GAE/g extract), tannins (12.08 ± 0.07 mg GAE/g extract), and saponins (IC₅₀ = 13.56 ± 0.03 mg DE/g extract). AETD showed a higher inhibitory potential on α-glucosidase activity (IC₅₀ = 191.51 ± 5.63 μg/mL) than on α-amylase activity (IC₅₀ = 1774.90 ± 10.32 μg/mL). AETD (250 and/or 500 mg/kg) prevented drastic loss of body weight and reduced food and water consumption in insulin resistant rats. The levels of blood glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and malondialdehyde were also reduced while high-density lipoprotein cholesterol level, reduced glutathion level, and catalase and superoxide dismutase activity increased after administration of AETD (250 and 500 mg/kg) in insulin resistant rats.</p></div><div><h3>Conclusion</h3><p>AETD has significant antihyperglycemic, antidyslipidemic, and antioxidant potential, thus it can be used for the management of type 2 diabetes mellitus and its complications.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100238"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50199351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of incretin-based therapeutic agents including tirzepatide on renal outcomes in patients with type 2 diabetes: A systemic review and meta-analysis","authors":"Akira Mima,&nbsp;Hidemasa Gotoda,&nbsp;Rina Lee,&nbsp;Ami Murakami,&nbsp;Ryosuke Akai,&nbsp;Shinji Lee","doi":"10.1016/j.metop.2023.100236","DOIUrl":"10.1016/j.metop.2023.100236","url":null,"abstract":"<div><h3>Background</h3><p>This meta-analysis was conducted to investigate the effects of incretin-based therapeutic agents, including the latest agent tirzepatide, on renal outcomes in patients with type 2 diabetes.</p></div><div><h3>Methods</h3><p>MEDLINE (via PubMed) and Cochrane databases were searched for studies involving incretin-based therapeutic agents up to July 2022. Randomized and controlled trials comparing incretin-based therapeutic agents with placebo or other antidiabetic agents, and reporting renal outcomes were selected. The inclusion criteria were items related to the effects on albuminuria and the kidney-specific composite outcomes. A network meta-analysis was conducted to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs).</p></div><div><h3>Results</h3><p>Twelve trials consisting of 75,346 participants were included in this meta-analysis. Glucagon-like peptide-1 (GLP-1) receptor agonists reduced the risk of the kidney-specific composite outcome by 21% (HR 0.79, 95% CI 0.75–0.85), and worsening albuminuria by 24% (HR 0.76, 95% CI 0.71–0.82). In particular, the dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonist tirzepatide remarkably reduced the risk of the kidney-specific composite outcome by 45% (HR 0.55, 95% CI 0.40–0.77), and worsening albuminuria by 62% (HR 0.38, 95% CI 0.24–0.61).</p></div><div><h3>Conclusions</h3><p>Among incretin-based therapeutic agents, tirzepatide was associated with a significantly reduced risk of diabetic kidney disease.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"17 ","pages":"Article 100236"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a7/ec/main.PMC10009293.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9122555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium butyrate aggravates glucose dysregulation and dyslipidemia in high fat-fed Wistar rats","authors":"Adewumi Oluwafemi Oyabambi ,&nbsp;Kehinde Samuel Olaniyi","doi":"10.1016/j.metop.2022.100226","DOIUrl":"10.1016/j.metop.2022.100226","url":null,"abstract":"<div><p>Sodium butyrate (NaB), a short chain fatty acid (SCFA) has been shown to improve metabolic, glucose and lipid signaling. High fat diet elicits increased risk of cardiometabolic disease due to dysmetabolism, altered endothelial function and elevated oxidant activities. This study aims at evaluating the effect of NaB on high fat diet-fed female Wistar rats, and the possible role of vascular endothelial growth factor (VEGF). Twenty female Wistar rats with mean weight of 120 ± 5 g were divided randomly after one week of acclimatization into four groups: Control diet (CTR), High fat diet (HFD), NaB (200 mg/kg), and HFD + NaB. After six weeks of the experimental procedure, blood samples were collected by cardiac puncture. Data were analyzed and expressed in mean ± SEM and p-values &lt;0.05 were accepted as significant. Data showed that HFD increased lactate dehydrogenase (LD) and free fatty acid (FFA), but not triglyceride (TG) and total cholesterol (TC). It also led to insulin resistance (elevated fasting blood glucose, insulin and homeostasis model assessment for insulin resistance). These effects of HFD were accompanied by increased lipid peroxidation (malondialdehyde and 4-hydroxynonenal). Sodium butyrate significantly decreased circulating nitric oxide (NO) and LD while increasing FFA, TG, insulin resistance, aggravated lipid peroxidation and increased VEGF in HFD rats (P &lt; 0.05). We speculated therefore, that NaB aggravated glucose dysregulation and dyslipidemia, which is accompanied by increased VEGF.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"17 ","pages":"Article 100226"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b2/3c/main.PMC9807820.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10481972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do diabetes phenotypes in US women differ by race/ethnicity? A population-based cluster analysis","authors":"Daesung Choi,&nbsp;Rebecca Jones-Antwi,&nbsp;Mohammed K. Ali,&nbsp;Shivani A. Patel","doi":"10.1016/j.metop.2022.100225","DOIUrl":"10.1016/j.metop.2022.100225","url":null,"abstract":"<div><h3>Objective</h3><p>US women exhibit racial disparities in the lifetime risk of diabetes and related outcomes. Identifying heterogeneity in clinical presentation may assist with reducing racial disparities in diabetes outcomes. We identified clinical phenotypes of diabetes and examined their racial and ethnic distribution in US women.</p></div><div><h3>Research design and methods</h3><p>We conducted cluster analysis based on five factors in US women with diagnosed diabetes assessed in the National Health and Nutrition Examination Surveys 1999–2018 (n = 825). Multinomial logistic regression analysis was performed to identify racial and ethnic differences in the distribution of phenotypes.</p></div><div><h3>Results</h3><p>We identified four distinct clinical phenotypes. Two phenotypes, mild age-related and severe insulin-deficient diabetes, each included approximately a third of women. Mild insulin-resistant and severe insulin-resistant diabetes phenotypes accounted for 19.9% and 13.7%, respectively. The distribution of clusters did not differ by race and ethnicity.</p></div><div><h3>Conclusions</h3><p>The prevalence of four clinically distinct diabetes phenotypes identified in US women did not differ by race and ethnicity.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"17 ","pages":"Article 100225"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/74/3d/main.PMC9816965.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9860297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives in vaccines, immune response, therapeutic interventions and COVID-19","authors":"Irene Karampela","doi":"10.1016/j.metop.2022.100223","DOIUrl":"10.1016/j.metop.2022.100223","url":null,"abstract":"","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"17 ","pages":"Article 100223"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d8/c9/main.PMC9758070.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10517201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}