Metabolism open最新文献

{"title":"The determinants of fasting and post-load non-esterified fatty acids in older adults: The cardiovascular health study","authors":"Yakubu Bene-Alhasan ,&nbsp;David S. Siscovick ,&nbsp;Joachim H. Ix ,&nbsp;Jorge R. Kizer ,&nbsp;Russell Tracy ,&nbsp;Luc Djoussé ,&nbsp;Kenneth J. Mukamal","doi":"10.1016/j.metop.2023.100261","DOIUrl":"https://doi.org/10.1016/j.metop.2023.100261","url":null,"abstract":"<div><h3>Aim</h3><p>Non-esterified fatty acids (NEFA) are potential targets for prevention of key cardiometabolic diseases of aging, but their population-level correlates remain uncertain. We sought to identify modifiable factors associated with fasting and post-load NEFA levels in older adults.</p></div><div><h3>Methods</h3><p>We used linear regression to determine the cross-sectional associations of demographic, anthropometric, and lifestyle characteristics and medication use with serum fasting and post-load NEFA concentrations amongst community-dwelling older adults enrolled in the Cardiovascular Health Study (n = 1924).</p></div><div><h3>Results</h3><p>Fasting NEFA levels generally demonstrated a broader set of determinants, while post-load NEFA were more consistently associated with metabolic factors. Waist circumference and weight were associated with higher fasting and post-load NEFA. Cigarette smoking and caffeine intake were associated with lower levels of both species, and moderate alcohol intake was associated with higher fasting levels whereas greater consumption was associated with lower post-load levels. Unique factors associated with higher fasting NEFA included female sex, higher age, loop and thiazide diuretic use and calcium intake, while factors associated with lower fasting levels included higher educational attainment, beta-blocker use, and protein intake. Hours spent sleeping during the daytime were associated with higher post-load NEFA, while DASH score was associated with lower levels.</p></div><div><h3>Conclusion</h3><p>Fasting and post-load NEFA have both common and unique modifiable risk factors, including sociodemographics, anthropometric, medications, and diet. Post-load NEFA were particularly sensitive to metabolic factors, while a broader range of determinants were associated with fasting levels. These factors warrant study as targets for lowering levels of NEFA in older adults.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"20 ","pages":"Article 100261"},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936823000336/pdfft?md5=767698879f156b12350e540ac6329960&pid=1-s2.0-S2589936823000336-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92044499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of mango consumption on vascular health and immune function","authors":"Robert J. Castro,&nbsp;Kazandra Pedroza,&nbsp;Mee Young Hong","doi":"10.1016/j.metop.2023.100260","DOIUrl":"https://doi.org/10.1016/j.metop.2023.100260","url":null,"abstract":"<div><h3>Objectives</h3><p>Heart disease, caused by atherosclerosis, is the leading cause of death. Maintaining vascular integrity is crucial to reducing atherosclerosis risk. Mangos are rich in fiber, vitamins, minerals, and phytochemicals that may offer cardioprotective and immune-boosting benefits. However, their effects on the vasculature and immune system in adults with overweight and obesity remain unclear. The objective of this study was to investigate the effects of mango consumption on vascular health and immune function in adults with overweight and obesity.</p></div><div><h3>Methods</h3><p>In a 12-week, crossover study, 27 overweight and obese participants consumed either 100 kcals of mangos daily or isocaloric low-fat cookies daily. Fasting blood samples were collected at baseline, week 4, and week 12 and analyzed for vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), P-selectin, E-selectin, sCD4, sCD8, sCD3E, and sCD45, tumor necrosis factor-alpha (TNF-α), catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD).</p></div><div><h3>Results</h3><p>Mango consumption significantly decreased VCAM-1 between baseline and week 4 (P = 0.046) and week 12 (P = 0.004). CAT increased between baseline and week 12 (P = 0.035) with mango consumption. GPx increased at week 12 compared to baseline and week 4 (P &lt; 0.05). At week 12, SOD was higher after mango consumption compared to low-fat cookie consumption (P = 0.046). There were no significant differences in ICAM-1, P-selectin, E-selectin, sCD4, sCD8, sCD3E, sCD45 or TNF-α concentrations (P &gt; 0.05 for all non-significant results).</p></div><div><h3>Conclusions</h3><p>This study suggests that 100 kcals of mangos may benefit the integrity of the vasculature by reducing VCAM-1 and increasing SOD, CAT, and GPx levels. Mangos can be an alternative snack for improving atherosclerosis and oxidative stress risk factors.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"20 ","pages":"Article 100260"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50173529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of fresh vs dried mango consumption on satiety and postprandial glucose in healthy adults","authors":"Candice Stamper,&nbsp;Sama Safadi,&nbsp;Andrew Gehr,&nbsp;Pia Asuncion,&nbsp;Mee Young Hong","doi":"10.1016/j.metop.2023.100253","DOIUrl":"10.1016/j.metop.2023.100253","url":null,"abstract":"<div><p>Mango is a widely favored fruit that offers high nutritional value. Mango has been studied to examine its influence on postprandial glucose, but few studies have used fresh mango compared to dried mango to measure blood glucose and satiety after consumption. Therefore, the objective of the present study was to investigate the effects of fresh versus dried mango consumption on satiety and postprandial glucose. A crossover design was implemented where 34 healthy adults (29 females and 5 males; 25.0 ± 6.0 years; BMI 23.8 ± 4.3 kg/m²) consumed either 100 kcal of fresh mango, dried mango, or white bread on three separate occasions. Following consumption, satiety was assessed every 15 min for 90 min and blood glucose was assessed every 30 min for 90 min. Consumption of fresh mango results showed a significant increase in satiety (tendency of greater fullness (P = 0.073) and less desire to eat (P &lt; 0.05)) in participants. Fresh mango exhibited a more efficient decrease in postprandial glucose levels (P &lt; 0.05) compared to dried mango or white bread, and fresh mango promoted a greater stability in blood glucose. Dried mango consumption also significantly lowered postprandial glucose compared to white bread (P &lt; 0.05). These results suggest that fresh mango consumption may be beneficial in improving satiety responses and postprandial glucose control when compared to its dried alternative or white bread. The results of the study may help guide individuals who are overweight or obese and/or have type 2 diabetes by altering their food choices that ultimately could improve their health.</p><p>ClinicalTrials.gov Identifier: NCT03956602.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"19 ","pages":"Article 100253"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e2/1b/main.PMC10374964.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10267328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of circulating lipid profiles, D-dimer and fibrinogen levels between hypertensive patients with and without stroke","authors":"Endeshaw Chekol Abebe ,&nbsp;Misganaw Asmamaw Mengstie ,&nbsp;Mohammed Abdu Seid ,&nbsp;Natnael Atnafu Gebeyehu ,&nbsp;Getachew Asmare Adella ,&nbsp;Gizachew Ambaw Kassie ,&nbsp;Molalegn Mesele Gesese ,&nbsp;Kirubel Dagnaw Tegegne ,&nbsp;Denekew Tenaw Anley ,&nbsp;Sefineh Fenta Feleke ,&nbsp;Melkamu Aderajew Zemene ,&nbsp;Anteneh Mengist Dessie ,&nbsp;Natnael Amare Tesfa ,&nbsp;Natnael Moges ,&nbsp;Ermias Sisay Chanie ,&nbsp;Yenealem Solomon Kebede ,&nbsp;Berihun Bantie ,&nbsp;Tadesse Asmamaw Dejenie","doi":"10.1016/j.metop.2023.100252","DOIUrl":"10.1016/j.metop.2023.100252","url":null,"abstract":"<div><h3>Background</h3><p>Stroke is one of the leading causes of global mortality and disability, particularly in hypertensive patients. This study aimed to compare lipid profile, fibrinogen, and D-dimer levels between hypertensive patient with and without stroke.</p></div><div><h3>Methods</h3><p>This was a facility-based cross-sectional study conducted from November 2022 to January 2023 among 115 hypertensive patients (70 patients without stroke and 45 with stroke) who had follow-up at Yikatit 12 Hospital Medical College, Ethiopia. All data analyses were done using SPSS version 25.0 and comparisons of variables between groups were made using the Chi-square test, independent sample <em>t</em>-test, and Mann-Whitney <em>U</em> test. Multiple logistic regression analysis was done to identify predictors of stroke among hypertensive patients. A p-value &lt;0.05 was assumed to be statistically significant for all statistical tests.</p></div><div><h3>Results</h3><p>Significantly elevated levels of TC, LDL-C, D-DI, and fibrinogen were observed in the stroke group than in the non-stroke group (p-value&lt;0.05). The mean values of TC, D-DI, and fibrinogen were significantly higher in patients with ischemic stroke compared to those with hemorrhagic stroke. Duration of hypertension (AOR: 1.21; CI: 1.10, 2.09), TC (AOR:1.07; CI: 1.01, 1.22), D-DI (AOR: 1.15; CI: 1.05, 1.69) and fibrinogen (AOR:1.19; CI: 1.10, 2.89) were identified to be independent predictors of stroke in hypertensive patients.</p></div><div><h3>Conclusion</h3><p>The circulating levels of TC, LDL-C, D-DI and fibrinogen in hypertensive patients with stroke were significantly higher than in those without stroke. But only TC, D-DI, and fibrinogen were found to be predictors of stroke in hypertensives. Considerably higher TC, D-DI, and fibrinogen levels were also seen in patients with ischemic stroke than in those with hemorrhagic stroke. This confirms the key roles of dyslipidemia (hypercholesterolemia) and aberrant hemostatic activation to stroke development, notably ischemic stroke.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"19 ","pages":"Article 100252"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/aa/76/main.PMC10407734.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9963562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal changes in pancreatic volume and pancreatic fat with weight gain in Japanese without diabetes: An analysis using health check-up data","authors":"Maria Sunouchi ,&nbsp;Jun Inaishi ,&nbsp;Ryoko Shimizu-Hirota ,&nbsp;Yoshifumi Saisho ,&nbsp;Kaori Hayashi ,&nbsp;Hiromasa Takaishi ,&nbsp;Hiroshi Itoh","doi":"10.1016/j.metop.2023.100250","DOIUrl":"10.1016/j.metop.2023.100250","url":null,"abstract":"<div><h3>Aims/introduction</h3><p>There have been few reports about the longitudinal changes in pancreas volume (PV) or pancreatic steatosis (PS) in response to obesity. In this longitudinal analysis using health check-up data, we explored changes in PV, PS and glucose metabolic indices that occurred after weight gain in Japanese without diabetes.</p></div><div><h3>Materials/methods</h3><p>Clinical data on 37 Japanese subjects with a ≥1 kg/m² increase in body mass index between two health check-ups and without diabetes were collected. PV, pancreas attenuation (PA) and splenic attenuation (SA) were evaluated using computed tomography (CT) images. The pancreas area was outlined by hand in multiple images with slice thickness of 2 mm, and the PV was computed by summing these areas. PS was defined as the difference between SA and PA (SA-PA). Medical records were collected, including findings on immunoreactive insulin (IRI), homeostasis model assessment of insulin resistance (HOMA-R) and beta cell function (HOMA-β). Paired <em>t</em>-test and Spearman's correlation coefficient were used in the analyses.</p></div><div><h3>Results</h3><p>The median follow-up period was 21.1 months and the mean BMI was increased from 25.5 ± 3.3 kg/m² to 27.0 ± 3.3 kg/m². PV (53.5 ± 15.9 cm³ vs. 56.2 ± 16.4 cm³) and SA-PA (8.7 ± 9.1 HU vs. 13.6 ± 10.9 HU) increased significantly after weight gain (both, P &lt; 0.001). There were significant increases of IRI and HOMA-R with the weight gain (both, P &lt; 0.05), whereas HOMA-β exhibited only a nonsignificant trend of increase (55.4％ (41.5-65.5) vs. 56.8％ (46.2-83.7), P = 0.07).</p></div><div><h3>Conclusions</h3><p>Both PV and PS were increased longitudinally with weight gain in Japanese without diabetes.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"19 ","pages":"Article 100250"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/41/3c/main.PMC10314282.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9745542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of fructose added to an oral glucose tolerance test on plasma glucose excursions in healthy adults","authors":"Amée M. Buziau ,&nbsp;Jean L.J.M. Scheijen ,&nbsp;Coen D.A. Stehouwer ,&nbsp;Casper G. Schalkwijk ,&nbsp;Martijn C.G.J. Brouwers","doi":"10.1016/j.metop.2023.100245","DOIUrl":"10.1016/j.metop.2023.100245","url":null,"abstract":"<div><h3>Background and objective</h3><p>Previous experimental studies have shown that fructose interacts with glucose metabolism by increasing hepatic glucose uptake. However, human studies investigating the effects of small (‘catalytic’) amounts of fructose, added to an oral glucose load, on plasma glucose levels remain inconclusive. The aim of this study, therefore, was to repeat and extend these previous studies by examining the plasma glucose response during a 75 g oral glucose tolerance test (OGTT) with the addition of different doses of fructose.</p></div><div><h3>Methods</h3><p>Healthy adults (n = 13) received an OGTT without addition of fructose and OGTTs with addition of different doses of fructose (1, 2, 5, 7.5 and 15 g) in a random order, on six separate occasions. Plasma glucose levels were measured every 15 min for 120 min during the study<strong>.</strong></p></div><div><h3>Findings</h3><p>The plasma glucose incremental area under the curve (iAUC) of the OGTT without addition of fructose was not significantly different from any OGTT with fructose (p ≥ 0.2 for all fructose doses). Similar results were observed when these data were clustered with data from a similar, previous study (pooled mean difference: 10.6; 95%CI: 45.0; 23.8 for plasma glucose iAUC of the OGTT without addition of fructose versus an OGTT with 5 g fructose; fixed-effect meta-analysis, n = 38). Of interest, serum fructose increased from 4.8 μmol/L (interquartile range: 4.1–5.9) at baseline to 5.3 μmol/L (interquartile range: 4.8–7.5) at T = 60 min during an OGTT <em>without</em> addition of fructose (p = 0.002).</p></div><div><h3>Conclusion</h3><p>Low doses of fructose added to an OGTT do not affect plasma glucose levels in healthy adults. The role of endogenous fructose production, as a potential explanation of these null-findings, deserves further investigation.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100245"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9550483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between personality traits and glycemic control after inpatient diabetes education","authors":"Taisuke Uchida ,&nbsp;Hiroaki Ueno ,&nbsp;Ayaka Konagata ,&nbsp;Takayuki Nakamura ,&nbsp;Norifumi Taniguchi ,&nbsp;Hiroki Nabekura ,&nbsp;Fumiko Kogo ,&nbsp;Yuma Nagatomo ,&nbsp;Yuri Tanaka ,&nbsp;Koichiro Shimizu ,&nbsp;Tomomi Shiiya ,&nbsp;Hideki Yamaguchi ,&nbsp;Kazuya Shimoda","doi":"10.1016/j.metop.2023.100244","DOIUrl":"10.1016/j.metop.2023.100244","url":null,"abstract":"<div><h3>Aims</h3><p>The longitudinal effect of personality traits on glycemic control is unclear. This prospective observational study explored the relationship between personality traits and glycemic control in patients with uncontrolled diabetes after inpatient diabetes education.</p></div><div><h3>Methods</h3><p>Patients with diabetes mellitus (HbA1c ≥ 7.5%, measured by high-performance liquid chromatography) who received inpatient diabetes education were scored on the Big Five personality traits: neuroticism, extraversion, openness, agreeableness, and conscientiousness. Multiple linear analysis was used to determine whether any personality traits were independently associated with HbA1c on admission and HbA1c change from admission to 1, 3, and 6 months after discharge.</p></div><div><h3>Results</h3><p>One hundred seventeen participants (mean age 60.4 ± 14.5 years; 59.0% male) were enrolled. HbA1c values on admission and 1, 3, and 6 months after discharge were 10.2 ± 2.1%, 8.3 ± 1.4%, 7.6 ± 1.4%, and 7.7 ± 1.5%, respectively. Multiple linear analysis showed that no personality traits were associated with HbA1c on admission. Neuroticism was negatively associated with the HbA1c change from admission to 3 months (β = −0.192, <em>P</em> = 0.025) and 6 months after discharge (β = −0.164, <em>P</em> = 0.043).</p></div><div><h3>Conclusions</h3><p>Neuroticism was associated with good long-term glycemic control after inpatient diabetes education.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100244"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9742928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative assessment of hepatoprotective properties of Artesunate and flavonoids from Artemisia annua on acetaminophen and carbon tetrachloride-induced cytotoxicity in primary mice hepatocytes","authors":"Marie Ange Djeungoue Petga ,&nbsp;Arnaud Fondjo Kouam ,&nbsp;Rosine Désirée Chougouo Kengne ,&nbsp;Boris Rosnay Galani Tietcheu ,&nbsp;Josué Simo Louokdom ,&nbsp;Claude Bérenger Ngantchouko Ngalemo ,&nbsp;Pascal Dieudonné Chuisseu Djamen ,&nbsp;Paul Fewou Moundipa","doi":"10.1016/j.metop.2023.100241","DOIUrl":"https://doi.org/10.1016/j.metop.2023.100241","url":null,"abstract":"<div><h3>Background</h3><p>Artesunate (ART) is a semi-synthetized molecule from Artemisinin, an active compound isolated from the medicinal plant <em>Artemisia annua</em>, widely used for the treatment of malaria. Previous studies reported that ART may exert a dual effect on the liver. Accordingly, this study investigated the potential protective action of ART against Acetaminophen (APAP) and Carbon tetrachloride (CCl₄)-induced hepatotoxicity in primary mice hepatocytes, in comparison to that of flavonoid extracted from <em>A. annua</em> (FAA). In addition, the antioxidant properties of FAA were also assessed.</p></div><div><h3>Methods</h3><p>The antioxidant activities of FAA and Ascorbic acid (ASC) (0.01–100 μg/mL) were assessed through inhibition of lipid peroxidation, reduction of ferric and phosphomolydenum, and hydroxyl and DPPH radicals scavenging assays. The hepatoprotective effects of FAA and ART (0.1–100 μg/mL) were evaluated against APAP (11 mM) or CCl4 (4 mM) induced oxidative damage in primary mouse hepatocytes. Biochemical parameters associated with hepatotoxicity assessed include cell viability, cell membrane integrity, cellular glutathione, and antioxidant enzyme activities.</p></div><div><h3>Results</h3><p>The obtained finding revealed FAA displayed a remarkable antioxidant activities as evidenced by the low IC₅₀/EC₅₀ values (3.85–19.32 μg/mL), comparable to that of ASC (3.26–18.04 μg/mL). When tested at 10 μg/mL, both FAA and ART significantly (p˂0.05) preserved cell viability, inhibited alanine aminotransferase leakage and lipid membrane peroxidation, and restored superoxide dismutase and catalase activities and glutathione content induced by APAP or CCl₄ in a similar way as Silymarin. However, ART showed a significant (p˂0.05) cytotoxic effect on hepatocytes at 100 and 1000 μg/mL and did not confer obvious protection at 100 μg/mL.</p></div><div><h3>Conclusion</h3><p>Overall, our data demonstrated that ART harms mice hepatocytes at high concentration while conferring relative protection against APAP and CCl₄-hepatotoxicity at low concentration. In contrast, FAA effectively protects liver cells without cytotoxicity effect, event at 100 μg/mL. Accordingly, ART should be given to the patient only under a medical prescription.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100241"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50199352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferroptosis in diabetic nephropathy: Mechanisms and therapeutic implications","authors":"Misganaw Asmamaw Mengstie ,&nbsp;Mohammed Abdu Seid ,&nbsp;Natnael Atnafu Gebeyehu ,&nbsp;Getachew Asmare Adella ,&nbsp;Gizchew Ambaw Kassie ,&nbsp;Wubet Alebachew Bayih ,&nbsp;Molalegn Mesele Gesese ,&nbsp;Denekew Tenaw Anley ,&nbsp;Sefineh Fenta Feleke ,&nbsp;Melkamu Aderajew Zemene ,&nbsp;Anteneh Mengist Dessie ,&nbsp;Yenealem Solomon ,&nbsp;Berihun Bantie ,&nbsp;Tadesse Asmamaw Dejenie ,&nbsp;Assefa Agegnehu Teshome ,&nbsp;Endeshaw Chekol Abebe","doi":"10.1016/j.metop.2023.100243","DOIUrl":"10.1016/j.metop.2023.100243","url":null,"abstract":"<div><p>Diabetic Nephropathy (DN), the most common complication in diabetes mellitus, has been affecting the lives of people diabetic for a long time. Numerous studies have demonstrated the unbreakable connection between ferroptosis and kidney cell damage. Ferroptosis is a type of iron-dependent, non-apoptotic, regulated cell death, characterized by the buildup of intracellular lipid peroxides to lethal levels. Although the role of programmed cell deaths like apoptosis, autophagy, and necroptosis in the pathogenesis of DN has been demonstrated, the implication of ferroptosis in DN was least interrogated. Hence, the main aim of this review was to discuss the current understanding of ferroptosis focusing on its potential mechanisms, its involvement in DN, and emerging therapeutic opportunities.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100243"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/53/main.PMC10130620.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9386553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energetic homeostasis achieved through biophoton energy and accompanying medication treatment resulted in sustained levels of Thyroiditis-Hashimoto's, iron, vitamin D & vitamin B12","authors":"Mariola A. Smotrys ,&nbsp;James Z. Liu ,&nbsp;Suzanne Street ,&nbsp;Seth Robinson","doi":"10.1016/j.metop.2023.100248","DOIUrl":"10.1016/j.metop.2023.100248","url":null,"abstract":"<div><p>We present the case of a 37-year-old premenopausal woman, who presented with fatigue, weakness, pallor, and myalgias. She was on treatment for Hashimoto's Thyroiditis, iron deficiency anemia, deficiency of vitamin D and B12. Further diagnostic workup revealed her anemia was attributed to a long history of menorrhagia, deficiency of vitamin D and B12 which was attributed to Celiac disease. Her overall health improved with daily medication and by being around the biophoton generators, a device-generated biophoton field. Supplemental exposure to biophoton energy stabilized her blood component levels and improved the functional and energetic conditions of all her organs and systems.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100248"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c1/12/main.PMC10251148.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9617593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}