Metabolism open最新文献

{"title":"Effects of fructose added to an oral glucose tolerance test on plasma glucose excursions in healthy adults","authors":"Amée M. Buziau ,&nbsp;Jean L.J.M. Scheijen ,&nbsp;Coen D.A. Stehouwer ,&nbsp;Casper G. Schalkwijk ,&nbsp;Martijn C.G.J. Brouwers","doi":"10.1016/j.metop.2023.100245","DOIUrl":"10.1016/j.metop.2023.100245","url":null,"abstract":"<div><h3>Background and objective</h3><p>Previous experimental studies have shown that fructose interacts with glucose metabolism by increasing hepatic glucose uptake. However, human studies investigating the effects of small (‘catalytic’) amounts of fructose, added to an oral glucose load, on plasma glucose levels remain inconclusive. The aim of this study, therefore, was to repeat and extend these previous studies by examining the plasma glucose response during a 75 g oral glucose tolerance test (OGTT) with the addition of different doses of fructose.</p></div><div><h3>Methods</h3><p>Healthy adults (n = 13) received an OGTT without addition of fructose and OGTTs with addition of different doses of fructose (1, 2, 5, 7.5 and 15 g) in a random order, on six separate occasions. Plasma glucose levels were measured every 15 min for 120 min during the study<strong>.</strong></p></div><div><h3>Findings</h3><p>The plasma glucose incremental area under the curve (iAUC) of the OGTT without addition of fructose was not significantly different from any OGTT with fructose (p ≥ 0.2 for all fructose doses). Similar results were observed when these data were clustered with data from a similar, previous study (pooled mean difference: 10.6; 95%CI: 45.0; 23.8 for plasma glucose iAUC of the OGTT without addition of fructose versus an OGTT with 5 g fructose; fixed-effect meta-analysis, n = 38). Of interest, serum fructose increased from 4.8 μmol/L (interquartile range: 4.1–5.9) at baseline to 5.3 μmol/L (interquartile range: 4.8–7.5) at T = 60 min during an OGTT <em>without</em> addition of fructose (p = 0.002).</p></div><div><h3>Conclusion</h3><p>Low doses of fructose added to an OGTT do not affect plasma glucose levels in healthy adults. The role of endogenous fructose production, as a potential explanation of these null-findings, deserves further investigation.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100245"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9550483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between personality traits and glycemic control after inpatient diabetes education","authors":"Taisuke Uchida ,&nbsp;Hiroaki Ueno ,&nbsp;Ayaka Konagata ,&nbsp;Takayuki Nakamura ,&nbsp;Norifumi Taniguchi ,&nbsp;Hiroki Nabekura ,&nbsp;Fumiko Kogo ,&nbsp;Yuma Nagatomo ,&nbsp;Yuri Tanaka ,&nbsp;Koichiro Shimizu ,&nbsp;Tomomi Shiiya ,&nbsp;Hideki Yamaguchi ,&nbsp;Kazuya Shimoda","doi":"10.1016/j.metop.2023.100244","DOIUrl":"10.1016/j.metop.2023.100244","url":null,"abstract":"<div><h3>Aims</h3><p>The longitudinal effect of personality traits on glycemic control is unclear. This prospective observational study explored the relationship between personality traits and glycemic control in patients with uncontrolled diabetes after inpatient diabetes education.</p></div><div><h3>Methods</h3><p>Patients with diabetes mellitus (HbA1c ≥ 7.5%, measured by high-performance liquid chromatography) who received inpatient diabetes education were scored on the Big Five personality traits: neuroticism, extraversion, openness, agreeableness, and conscientiousness. Multiple linear analysis was used to determine whether any personality traits were independently associated with HbA1c on admission and HbA1c change from admission to 1, 3, and 6 months after discharge.</p></div><div><h3>Results</h3><p>One hundred seventeen participants (mean age 60.4 ± 14.5 years; 59.0% male) were enrolled. HbA1c values on admission and 1, 3, and 6 months after discharge were 10.2 ± 2.1%, 8.3 ± 1.4%, 7.6 ± 1.4%, and 7.7 ± 1.5%, respectively. Multiple linear analysis showed that no personality traits were associated with HbA1c on admission. Neuroticism was negatively associated with the HbA1c change from admission to 3 months (β = −0.192, <em>P</em> = 0.025) and 6 months after discharge (β = −0.164, <em>P</em> = 0.043).</p></div><div><h3>Conclusions</h3><p>Neuroticism was associated with good long-term glycemic control after inpatient diabetes education.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100244"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9742928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative assessment of hepatoprotective properties of Artesunate and flavonoids from Artemisia annua on acetaminophen and carbon tetrachloride-induced cytotoxicity in primary mice hepatocytes","authors":"Marie Ange Djeungoue Petga ,&nbsp;Arnaud Fondjo Kouam ,&nbsp;Rosine Désirée Chougouo Kengne ,&nbsp;Boris Rosnay Galani Tietcheu ,&nbsp;Josué Simo Louokdom ,&nbsp;Claude Bérenger Ngantchouko Ngalemo ,&nbsp;Pascal Dieudonné Chuisseu Djamen ,&nbsp;Paul Fewou Moundipa","doi":"10.1016/j.metop.2023.100241","DOIUrl":"https://doi.org/10.1016/j.metop.2023.100241","url":null,"abstract":"<div><h3>Background</h3><p>Artesunate (ART) is a semi-synthetized molecule from Artemisinin, an active compound isolated from the medicinal plant <em>Artemisia annua</em>, widely used for the treatment of malaria. Previous studies reported that ART may exert a dual effect on the liver. Accordingly, this study investigated the potential protective action of ART against Acetaminophen (APAP) and Carbon tetrachloride (CCl₄)-induced hepatotoxicity in primary mice hepatocytes, in comparison to that of flavonoid extracted from <em>A. annua</em> (FAA). In addition, the antioxidant properties of FAA were also assessed.</p></div><div><h3>Methods</h3><p>The antioxidant activities of FAA and Ascorbic acid (ASC) (0.01–100 μg/mL) were assessed through inhibition of lipid peroxidation, reduction of ferric and phosphomolydenum, and hydroxyl and DPPH radicals scavenging assays. The hepatoprotective effects of FAA and ART (0.1–100 μg/mL) were evaluated against APAP (11 mM) or CCl4 (4 mM) induced oxidative damage in primary mouse hepatocytes. Biochemical parameters associated with hepatotoxicity assessed include cell viability, cell membrane integrity, cellular glutathione, and antioxidant enzyme activities.</p></div><div><h3>Results</h3><p>The obtained finding revealed FAA displayed a remarkable antioxidant activities as evidenced by the low IC₅₀/EC₅₀ values (3.85–19.32 μg/mL), comparable to that of ASC (3.26–18.04 μg/mL). When tested at 10 μg/mL, both FAA and ART significantly (p˂0.05) preserved cell viability, inhibited alanine aminotransferase leakage and lipid membrane peroxidation, and restored superoxide dismutase and catalase activities and glutathione content induced by APAP or CCl₄ in a similar way as Silymarin. However, ART showed a significant (p˂0.05) cytotoxic effect on hepatocytes at 100 and 1000 μg/mL and did not confer obvious protection at 100 μg/mL.</p></div><div><h3>Conclusion</h3><p>Overall, our data demonstrated that ART harms mice hepatocytes at high concentration while conferring relative protection against APAP and CCl₄-hepatotoxicity at low concentration. In contrast, FAA effectively protects liver cells without cytotoxicity effect, event at 100 μg/mL. Accordingly, ART should be given to the patient only under a medical prescription.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100241"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50199352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferroptosis in diabetic nephropathy: Mechanisms and therapeutic implications","authors":"Misganaw Asmamaw Mengstie ,&nbsp;Mohammed Abdu Seid ,&nbsp;Natnael Atnafu Gebeyehu ,&nbsp;Getachew Asmare Adella ,&nbsp;Gizchew Ambaw Kassie ,&nbsp;Wubet Alebachew Bayih ,&nbsp;Molalegn Mesele Gesese ,&nbsp;Denekew Tenaw Anley ,&nbsp;Sefineh Fenta Feleke ,&nbsp;Melkamu Aderajew Zemene ,&nbsp;Anteneh Mengist Dessie ,&nbsp;Yenealem Solomon ,&nbsp;Berihun Bantie ,&nbsp;Tadesse Asmamaw Dejenie ,&nbsp;Assefa Agegnehu Teshome ,&nbsp;Endeshaw Chekol Abebe","doi":"10.1016/j.metop.2023.100243","DOIUrl":"10.1016/j.metop.2023.100243","url":null,"abstract":"<div><p>Diabetic Nephropathy (DN), the most common complication in diabetes mellitus, has been affecting the lives of people diabetic for a long time. Numerous studies have demonstrated the unbreakable connection between ferroptosis and kidney cell damage. Ferroptosis is a type of iron-dependent, non-apoptotic, regulated cell death, characterized by the buildup of intracellular lipid peroxides to lethal levels. Although the role of programmed cell deaths like apoptosis, autophagy, and necroptosis in the pathogenesis of DN has been demonstrated, the implication of ferroptosis in DN was least interrogated. Hence, the main aim of this review was to discuss the current understanding of ferroptosis focusing on its potential mechanisms, its involvement in DN, and emerging therapeutic opportunities.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100243"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/53/main.PMC10130620.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9386553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energetic homeostasis achieved through biophoton energy and accompanying medication treatment resulted in sustained levels of Thyroiditis-Hashimoto's, iron, vitamin D & vitamin B12","authors":"Mariola A. Smotrys ,&nbsp;James Z. Liu ,&nbsp;Suzanne Street ,&nbsp;Seth Robinson","doi":"10.1016/j.metop.2023.100248","DOIUrl":"10.1016/j.metop.2023.100248","url":null,"abstract":"<div><p>We present the case of a 37-year-old premenopausal woman, who presented with fatigue, weakness, pallor, and myalgias. She was on treatment for Hashimoto's Thyroiditis, iron deficiency anemia, deficiency of vitamin D and B12. Further diagnostic workup revealed her anemia was attributed to a long history of menorrhagia, deficiency of vitamin D and B12 which was attributed to Celiac disease. Her overall health improved with daily medication and by being around the biophoton generators, a device-generated biophoton field. Supplemental exposure to biophoton energy stabilized her blood component levels and improved the functional and energetic conditions of all her organs and systems.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100248"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c1/12/main.PMC10251148.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9617593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SENP2 knockdown in human adipocytes reduces glucose metabolism and lipid accumulation, while increases lipid oxidation","authors":"Solveig A. Krapf ,&nbsp;Jenny Lund ,&nbsp;Hege G. Bakke ,&nbsp;Tuula A. Nyman ,&nbsp;Stefano Bartesaghi ,&nbsp;Xiao-Rong Peng ,&nbsp;Arild C. Rustan ,&nbsp;G. Hege Thoresen ,&nbsp;Eili T. Kase","doi":"10.1016/j.metop.2023.100234","DOIUrl":"10.1016/j.metop.2023.100234","url":null,"abstract":"<div><p>Adipose tissue is one of the main regulative sites for energy metabolism. Excess lipid storage and expansion of white adipose tissue (WAT) is the primary contributor to obesity, a strong predisposing factor for development of insulin resistance. Sentrin-specific protease (SENP) 2 has been shown to play a role in metabolism in murine fat and skeletal muscle cells, and we have previously demonstrated its role in energy metabolism of human skeletal muscle cells. In the present work, we have investigated the impact of SENP2 on fatty acid and glucose metabolism in primary human fat cells by using cultured primary human adipocytes to knock down the SENP2 gene. Glucose uptake and oxidation, as well as accumulation and distribution of oleic acid into complex lipids were decreased, while oleic acid oxidation was increased in SENP2-knockdown cells compared to control adipocytes. Furthermore, lipogenesis was reduced by SENP2-knockdown in adipocytes. Although TAG accumulation relative to total uptake was unchanged, there was increased mRNA expression of metabolically relevant genes such as <em>UCP1</em> and <em>PPARGC1A</em> and mRNA and proteomic data revealed increased levels of mRNA and proteins related to mitochondrial function by SENP2-knockdown. In conclusion, SENP2 is an important regulator of energy metabolism in primary human adipocytes and its knockdown reduce glucose metabolism and lipid accumulation, while increasing lipid oxidation in human adipocytes.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100234"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066554/pdf/main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9240892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential metabolic host response to pathogens associated with community-acquired pneumonia","authors":"Ilona den Hartog ,&nbsp;Naama Karu ,&nbsp;Laura B. Zwep ,&nbsp;G. Paul Voorn ,&nbsp;Ewoudt M.W. van de Garde ,&nbsp;Thomas Hankemeier ,&nbsp;J.G. Coen van Hasselt","doi":"10.1016/j.metop.2023.100239","DOIUrl":"10.1016/j.metop.2023.100239","url":null,"abstract":"<div><h3>Background</h3><p>Metabolic changes induced by the host immune response to pathogens found in patients with community-acquired pneumonia (CAP) may provide insight into its pathogenesis. In this study, we characterized differences in the host metabolic response to common CAP-associated pathogens.</p></div><div><h3>Method</h3><p>Targeted metabolomic profiling was performed on serum samples obtained from hospitalized CAP patients (n = 119) at admission. We quantified 347 unique metabolites across multiple biochemical classes, including amines, acylcarnitines, and signaling lipids. We evaluated if unique associations between metabolite levels and specific CAP-associated pathogens could be identified.</p></div><div><h3>Results</h3><p>Several acylcarnitines were found to be elevated in <em>C. burnetii</em> and herpes simplex virus and lowered in <em>M. pneumoniae</em> as compared to other pathogens. Phenylalanine and kynurenine were found elevated in <em>L. pneumophila</em> as compared to other pathogens. S-methylcysteine was elevated in patients with <em>M. pneumoniae</em>, and these patients also showed lowered cortisol levels in comparison to almost all other pathogens. For the herpes simplex virus, we observed a unique elevation of eicosanoids and several amines. Many lysophosphatidylcholines showed an altered profile in <em>C. burnetii</em> versus S<em>. pneumoniae, L. pneumophila,</em> and respiratory syncytial virus. Finally, phosphatidylcholines were negatively affected by the influenza virus in comparison to <em>S. pneumoniae</em>.</p></div><div><h3>Conclusions</h3><p>In this exploratory analysis, metabolites from different biochemical classes were found to be altered in serum samples from patients with different CAP-associated pathogens, which may be used for hypothesis generation in studies on differences in pathogen host response and pathogenesis of CAP.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100239"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070890/pdf/main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9264100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycemic control and its association with sleep quality and duration among type 2 diabetic patients","authors":"Yadelew Yimer Shibabaw ,&nbsp;Tadesse Asmamaw Dejenie ,&nbsp;Kibur Hunie Tesfa","doi":"10.1016/j.metop.2023.100246","DOIUrl":"10.1016/j.metop.2023.100246","url":null,"abstract":"<div><h3>Background</h3><p>Poor glycemic control is the current most important tragedy in type 2 diabetic patients. Sleep has a major modulatory effect on endocrine and metabolic function. Sleep disturbance is associated with increased circulating cortisol levels, sympathetic activity, and epinephrine secretion. These physiological conditions are directly or indirectly associated with glucose metabolism in our body cells. In Ethiopia, sleep pattern association with glycemic control level is not studied yet.</p></div><div><h3>Objectives</h3><p>To assess glycemic control and its association with sleep quality, sleep duration and napping among patients with type 2 diabetes mellitus in Felege Hiwot Comprehensive Referral and Specialized Hospital Northwest Ethiopia.</p></div><div><h3>Method</h3><p>An institutional-based cross-sectional study was conducted among 407 type 2 diabetes mellitus patients from July 1, 2020, to April 28, 2021, using a systematic random sampling technique. We drew 5 mL of blood from each patient before breakfast to determine their fasting blood sugar level. The Pittsburg Sleep Quality Index was used to assess patients' sleep quality, and the presence or absence of Obstructive Sleep Apnea was determined using the STOP-BANG questionnaire. Data were analysed using STATA version 14.1.variables with a P-value of &lt;0.05 were considered statistically significant.</p></div><div><h3>Results</h3><p>Glycemic control was found to be poor in 54.05% of the study participants. Female sex, poor sleep quality, and short and long sleep durations were all significantly associated with impaired glycemic control. Being female increased the odds of poor glycemic control by 2.7 times (AOR = 2.7, 95% CI: 1.23, 6.15) compared to males. T2DM patients who had poor sleep quality had 3.3 times (AOR = 3.3, 95% CI (1.16, 9.37) higher odds of poor glycemic control compared to patients who had good sleep quality. The odds of having poor glycemic control among T2DM patients who were at low risk of OSA and intermediate risk of OSA were decreased by 96% (AOR = 0.03, 95% CI: 0.01, 0.12) and 86% (AOR = 0.14, 95% CI: 0.05, 0.43) compared to T2DM patients who were at high risk of OSA, respectively. T2DM patients who had short sleep duration (&lt;6 hours) were 8.3 times (AOR = 8.3, 95% CI: 2.66–25.85) higher chances of poor glycemic control compared to patients who had average sleep duration. T2DM patients who had long sleep duration (&gt;8 hours) increased the odds of poor glycemic control by 2.6 times (AOR = 2.6, 95% CI (1.12–6.04) compared to those who had average sleep duration. The chances of having poor glycemic control among T2DM patients who did not take the balanced diet recommended by their physician were increased by 3.8 times (AOR = 3.8 95% CI: 1.05–13.77).</p></div><div><h3>Conclusion</h3><p>The prevalence of poor glycemic control in T2DM patients was high. Poor sleep quality, both short and long sleep duration, and an intermediate or low risk of obstr","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100246"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4c/06/main.PMC10238567.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9956090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global prevalence of sexual dysfunction among diabetic patients from 2008 to 2022: Systematic review and meta-analysis","authors":"Natnael Atnafu Gebeyehu ,&nbsp;Molalegn Melese Gesese ,&nbsp;Kirubel Dagnaw Tegegne ,&nbsp;Yenalem Solomon Kebede ,&nbsp;Gizachew Ambaw Kassie ,&nbsp;Misganaw Asmamaw Mengstie ,&nbsp;Melkamu Aderajaw Zemene ,&nbsp;Berihun Bantie ,&nbsp;Sefineh Fenta Feleke ,&nbsp;Tadesse Asmamaw Dejenie ,&nbsp;Endeshaw Chekol Abebe ,&nbsp;Denekew Tenaw Anley ,&nbsp;Anteneh Mengist Dessie ,&nbsp;Wubet Alebachew Bayih ,&nbsp;Getachew Asmare Adela","doi":"10.1016/j.metop.2023.100247","DOIUrl":"10.1016/j.metop.2023.100247","url":null,"abstract":"<div><h3>Background</h3><p>Both men and women can have a wide range of physical, emotional, and sexual issues as a result of diabetes. One of them is sexual dysfunction, which has an effect on marital relationships as well as the effectiveness of therapy and can develop into a serious social and psychological condition. As a result, the purpose of this study was to identify the global prevalence of sexual dysfunction among diabetic patients.</p></div><div><h3>Methods</h3><p>Science Direct, Scopus, Google Scholar, and PubMed were all searched for information. Data were extracted using Microsoft Excel (v. 14), STATA statistical software, and STATA. Publication bias was investigated by a forest plot, rank test, and Egger's regression test. To detect heterogeneity, I² was calculated and an overall estimated analysis was performed. Subgroup analysis was done by study region and sample size. The pooled odds ratio was also computed.</p></div><div><h3>Results</h3><p>The study was able to include 15 of the 654 publications that were evaluated since they met the criteria. 67,040 people participated in the survey in all. The pooled global prevalence of sexual dysfunction among diabetic patients was 61.4% (95% CI: 51.80, 70.99), I2 = 71.6%. The frequency of sexual dysfunction was highest in the European region (66.05%). For males, the prevalence of sexual dysfunction was 65.91%, while for females, it was 58.81%. Patients with type 2 diabetes mellitus were more likely (71.03%) to experience sexual dysfunction.</p></div><div><h3>Conclusion</h3><p>Finally, sexual dysfunction was fairly common all across the world. There were variations in the prevalence of sexual dysfunction depending on the sex, type of diabetes, and location of the study participant. Our findings imply that screening and appropriate treatment are required for diabetes persons exhibiting sexual dysfunction.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100247"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/f7/main.PMC10267599.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10028778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between testosterone-estradiol ratio and some anthropometric and metabolic parameters among Nigerian men","authors":"Holiness Stephen Adedeji Olasore ,&nbsp;Tolulope Adejoke Oyedeji ,&nbsp;Matthew Olamide Olawale ,&nbsp;Omobolanle Ibukun Ogundele ,&nbsp;Joseph Ogo-Oluwa Faleti","doi":"10.1016/j.metop.2023.100249","DOIUrl":"10.1016/j.metop.2023.100249","url":null,"abstract":"<div><h3>Background</h3><p>Alterations in sex hormone levels are implicated in the regulation of metabolic processes in men. In recent years, the prevalence of metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes, has risen in Nigeria. In men, these disorders may be associated with the ratio of serum testosterone to estradiol levels. Therefore, we investigated the relationship between the testosterone-estradiol (T/E2) ratio, anthropometry, and metabolic parameters in Nigerian men.</p></div><div><h3>Method</h3><p>Eighty-five adult men were recruited for this study. Participants’ data such as age, weight, height, BMI, and waist circumference were collected. Plasma total testosterone and estradiol levels, as well as metabolic parameters such as fasting blood sugar, creatinine, urea, HDL cholesterol, total cholesterol, and triglycerides levels, were determined. The data were analyzed using SPSS version 25 software.</p></div><div><h3>Results</h3><p>Anthropometric parameters such as weight, height, BMI, and waist circumference showed a negative correlation with plasma T/E2 (r = −0.265, −0.288, −0.106, −0.204; p = 0.007, 0.004, 0.167, 0.061 respectively). However, the T/E2 ratio showed a positive correlation with the metabolic parameters such as fasting blood sugar, HDL cholesterol levels, plasma creatinine, and urea (r = 0.219, 0.096, 0.992, 0.152; p = 0.022, 0.192, &lt;0.001, 0.082 respectively), while there were negative correlations with total cholesterol and triglycerides levels (r = −0.200, −0.083; p = 0.034, 0.226 respectively).</p></div><div><h3>Conclusion</h3><p>These findings show that there are significant correlations between the T/E2 ratio and weight, height, fasting blood sugar, creatinine, and urea, while there are no significant correlations between T/E2 ratio and BMI, waist circumference, HDL-cholesterol, and triglycerides.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100249"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9736456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}