Metabolism open最新文献

{"title":"Adropin: A crucial regulator of cardiovascular health and metabolic balance","authors":"S. Rooban ,&nbsp;K.A. Arul Senghor ,&nbsp;V.M. Vinodhini ,&nbsp;J.S. Kumar","doi":"10.1016/j.metop.2024.100299","DOIUrl":"https://doi.org/10.1016/j.metop.2024.100299","url":null,"abstract":"<div><p>Adropin, a peptide discovered in 2008, has gained recognition as a key regulator of cardiovascular health and metabolic balance. Initially identified for its roles in energy balance, lipid metabolism, and glucose regulation, adropin has also been found to improve cardiovascular health by enhancing endothelial function, modulating lipid profiles, and reducing oxidative stress. These protective mechanisms suggest that adropin may be able to help prevent conditions such as atherosclerosis, hypertension, and other cardiovascular diseases. Research has established connections between adropin and cardiovascular risk factors, such as obesity, insulin resistance, and dyslipidemia, positioning it as a valuable biomarker for evaluating cardiovascular disease risk. New studies highlight adropin's diagnostic and prognostic significance, showing that higher levels are linked to better cardiovascular outcomes, while lower levels are associated with a higher risk of cardiovascular diseases. This review aims to summarize current knowledge on adropin, emphasizing its significance as a promising focus in the intersection of cardiovascular health and metabolic health. By summarizing the latest research findings, this review aims to offer insights into the potential applications of adropin in both clinical practice and research, leading to a deeper understanding of its role in maintaining cardiovascular and metabolic health.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100299"},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000318/pdfft?md5=3a7014005f5cc0966d12437e6b0a19f2&pid=1-s2.0-S2589936824000318-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescribing patterns of statins and associated factors among type 2 diabetes mellitus patients in Africa: A systematic review and meta-analysis","authors":"Worku Chekol Tassew ,&nbsp;Yeshiwas Ayale Ferede ,&nbsp;Agerie Mengistie Zeleke","doi":"10.1016/j.metop.2024.100297","DOIUrl":"https://doi.org/10.1016/j.metop.2024.100297","url":null,"abstract":"<div><h3>Background</h3><p>In sub-Saharan African nations, there's a documented shortfall in the utilization of statins, despite established clinical guidelines advocating their use for reducing cardiovascular risks and overall mortality among Type 2 diabetes patients aged 40–75 years old. Most clinical guidelines recommend prescribing statins to individuals with type 2 diabetes to reduce the chances of cardiovascular disease. There is currently a lack of extensive research on statin utilization specifically for primary prevention of cardiovascular disease in Africa. Thus, this study aimed to assess the prescription patterns of statins for preventing cardiovascular disease in type 2 diabetes patients.</p></div><div><h3>Methods</h3><p>The findings of the review were presented following the guidelines outlined in the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA-2020) checklist. We conducted searches on electronic databases including PubMed, EMBASE, Cochrane Library, Science Direct, African Journal Online, and Google Scholar. This systematic review and meta-analysis included articles that met specific inclusion criteria: observational studies such as cross-sectional, cohort, and case-control studies focusing on determinants, risk factors, or correlates associated with statin prescription within Africa. Only published articles up to June 2, 2024, published in English, and conducted in either community or healthcare facility settings were considered. Data import was initially conducted using Microsoft Excel, and statistical analysis was performed using STATA software. Cochran's Q test was employed to assess whether there was a significant variance in prevalence among the studies. Additionally, the I² statistic was utilized to quantify the extent of heterogeneity. A funnel plot, a visual tool, was utilized to evaluate publication bias.</p></div><div><h3>Results</h3><p>The search strategy resulted in 7695 published original articles. The full texts of the 89 papers were assessed for eligibility and quality. Moreover, some articles were rejected due to inaccuracies in the outcome variable. Ultimately, only ten studies focusing on the prevalence of statin prescription were examined. The research suggests that the pooled prevalence of statin prescription among Type 2 diabetic individuals in Africa is found to be 48.82% (95% CI: 35.41–63.24). Age greater than 65 years (AOR = 3.56, 95% CI: 1.70–7.45; I² = 54.7%), comorbidity (AOR = 1.13, 95% CI: 0.27–4.63, I² = 96.4%), dyslipidemia (AOR = 3.15, 95% CI: 1.54–6.44, I² = 61.7%), DM duration greater than ten years (AOR = 1.36, 95% CI: 0.81–2.28, I² = 77.3%), and government insurance (AOR = 8.85, 95% CI: 2.72–28.76, I² = 81.5%) were factors associated with statin prescription among type 2 diabetic patients.</p></div><div><h3>Conclusions</h3><p>In general, the extent of statin prescriptions for individuals with type 2 di","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100297"},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S258993682400029X/pdfft?md5=2d2dfa7844f60362bf3c33e03fa5e59e&pid=1-s2.0-S258993682400029X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141438978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"25-hydroxyvitamin D and parathyroid hormone in new onset sepsis: A prospective study in critically ill patients","authors":"Irene Karampela ,&nbsp;Theodora Stratigou ,&nbsp;Georgios Antonakos ,&nbsp;Dimitris Kounatidis ,&nbsp;Natalia G. Vallianou ,&nbsp;Dimitrios Tsilingiris ,&nbsp;Maria Dalamaga","doi":"10.1016/j.metop.2024.100296","DOIUrl":"https://doi.org/10.1016/j.metop.2024.100296","url":null,"abstract":"<div><p>Hypovitaminosis D is highly prevalent in critically ill patients, and it has been suggested to be a risk factor for infections, sepsis and higher mortality. We sought to investigate whether serum 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) in critically ill patients with new onset sepsis are associated with severity and outcome. We prospectively included 50 consecutive critically ill adult cases with new onset sepsis and 50 healthy controls matched for age and sex. PTH and 25(OH)D were determined in serum via electrochemiluminescence immunoassays at inclusion in the study in all cases and controls, and one week after sepsis onset in cases. Patients had reduced 25(OH)D compared to controls at sepsis onset (7.9 ± 3 vs 24.6 ± 6.7 ng/mL, p &lt; 0.001), whilst PTH was similar (median (range): 34.5 (5.7–218.5) vs 44.2 (14.2–98.1) pg/mL, p = 0.35). In patients, 25(OH)D upon enrollment and one week after did not differ significantly (7.9 ± 3 vs 7 ± 4.3 ng/mL, p = 0.19). All patients presented with hypovitaminosis D (25(OH)D &lt; 20 ng/mL), while 40 patients (80 %) had vitamin D deficiency (25(OH)D &lt; 12 ng/mL) at sepsis onset, including all ten (20 %) nonsurvivors, who died within 28 days from sepsis onset. Patients with sepsis (N = 28) and septic shock (N = 22) as well as survivors (N = 40) and nonsurvivors (N = 10) had similar 25(OH)D at enrollment (p &gt; 0.05). 25(OH)D was positively correlated with ionized calcium (r = 0.46, p &lt; 0.001) and negatively with PTH (p &lt; 0.05), while inflammatory biomarkers or the severity scores exhibited no correlation with 25(OH)D. Patients with septic shock and nonsurvivors had lower PTH than patients with sepsis and survivors respectively (42.2 ± 42.9 vs 73.4 ± 61.9 pg/mL, p = 0.04, and 18.3 ± 10.7 vs 69.9 ± 58.8 pg/mL, p = 0.001, respectively). C-reactive protein was negatively associated with PTH (r = −0.44, p = 0.001). In conclusion, vitamin D deficiency was present in 80 % of critically ill patients at sepsis onset, while nonsurvivors exhibited lower PTH than survivors. Additional, larger and multicenter studies are warranted to elucidate the contribution of vitamin D and PTH to the pathogenesis of sepsis and its outcomes.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100296"},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000288/pdfft?md5=e03d054fea77cabb55eec21157726239&pid=1-s2.0-S2589936824000288-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141333020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of associations between alcohol consumption and metabolic syndrome according to three definitions: The Swedish INTERGENE study","authors":"Alina Skultecka ,&nbsp;Fredrik Nyberg ,&nbsp;Lauren Lissner ,&nbsp;Maria Rosvall ,&nbsp;Dag S. Thelle ,&nbsp;Anna-Carin Olin ,&nbsp;Kjell Torén ,&nbsp;Lena Björck ,&nbsp;Annika Rosengren ,&nbsp;Kirsten Mehlig","doi":"10.1016/j.metop.2024.100292","DOIUrl":"10.1016/j.metop.2024.100292","url":null,"abstract":"<div><h3>Background</h3><p>While prevalence estimates differ by definition of metabolic syndrome (MetS), it is less clear how different definitions affect associations with alcohol consumption.</p></div><div><h3>Methods</h3><p>We included 3051 adults aged 25–77 from the baseline examination of the Swedish INTERGENE cohort (2001–2004). Using multiple logistic regression, we investigated cross-sectional associations between ethanol intake and MetS defined according to the Adult Treatment Panel III (ATP III), the International Diabetes Federation (IDF), and the Joint Interim Statement (JIS). Alcohol exposure categories comprised abstinence, and low, medium, and high consumption defined via sex-specific tertiles of ethanol intake among current consumers. Covariates included sociodemographics, health, and lifestyle factors.</p></div><div><h3>Results</h3><p>MetS prevalence estimates varied between 13.9 % (ATP III) and 25.3 % (JIS), with higher prevalence in men than women. Adjusted for age and sex, medium-high alcohol consumption was associated with lower odds of MetS compared to low consumption, while no difference was observed for abstainers. Only the most specific (and thus severe) definition of MetS (ATP III) showed decreasing odds for ethanol intake when adjusted for all covariates.</p></div><div><h3>Conclusion</h3><p>Our study shows that alcohol-related associations differ by definition of MetS. The finding that individuals with the most stringently defined MetS may benefit from alcohol consumption calls for further well-controlled studies.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"23 ","pages":"Article 100292"},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000240/pdfft?md5=5ae0a8d899fa1433ff6f3e96c1a28a63&pid=1-s2.0-S2589936824000240-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141392578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogen sulfide derived from apoptotic cells supports immune homeostasis","authors":"Ying Xu,&nbsp;Suzhen Chen,&nbsp;Junli Liu","doi":"10.1016/j.metop.2024.100276","DOIUrl":"10.1016/j.metop.2024.100276","url":null,"abstract":"","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"22 ","pages":"Article 100276"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000082/pdfft?md5=d03603572055875b624c059bd677d9a4&pid=1-s2.0-S2589936824000082-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140469767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet induced thermogenesis, older and newer data with emphasis on obesity and diabetes mellitus - A narrative review","authors":"Evangelia Tzeravini,&nbsp;Tentolouris Anastasios,&nbsp;Kokkinos Alexander,&nbsp;Tentolouris Nikolaos,&nbsp;Katsilambros Nikolaos","doi":"10.1016/j.metop.2024.100291","DOIUrl":"https://doi.org/10.1016/j.metop.2024.100291","url":null,"abstract":"<div><p>Obesity is a major public health problem with a prevalence increasing at an alarming rate worldwide. There is an urgent need for efficient approaches to weight management. Diet induced thermogenesis (DIT) is the process by which the body increases its energy expenditure in response to a meal. It is estimated to account for approximately 10 % of total energy expenditure and is considered a potentially modifiable component of energy expenditure. The palatability of food, meal's composition in macronutrients, the circadian rhythm and sleep, as well as individual's characteristics such as age, the presence of obesity or diabetes mellitus, and the proportion of physical activity are the main factors that affect DIT. However, studies examining DIT are mostly characterized by small sample size and the methodology varies considerably between studies. It seems that even today there is a lot of contradiction between the relative studies. Inspite of that, future research might lead to the modification of DIT in order to achieve some weight loss in obese people.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"22 ","pages":"Article 100291"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000239/pdfft?md5=8cefeda294d6573004b1fd2da1c9a27e&pid=1-s2.0-S2589936824000239-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141291955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beta cell-derived nanovesicle MicroRNAs promote insulin resistance","authors":"Ning Wang,&nbsp;Suzhen Chen,&nbsp;Junli Liu","doi":"10.1016/j.metop.2023.100266","DOIUrl":"10.1016/j.metop.2023.100266","url":null,"abstract":"","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"22 ","pages":"Article 100266"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936823000385/pdfft?md5=05551e8ca4bc520f14d15180e0f6bf66&pid=1-s2.0-S2589936823000385-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139015418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical metabolomics: Useful insights, perspectives and challenges","authors":"Maria Dalamaga","doi":"10.1016/j.metop.2024.100290","DOIUrl":"https://doi.org/10.1016/j.metop.2024.100290","url":null,"abstract":"<div><p>Metabolomics, a cutting-edge omics technique, is a rapidly advancing field in biomedical research, concentrating on the elucidation of pathogenetic mechanisms and the discovery of novel metabolite signatures predictive of disease risk, aiding in earlier disease detection, prognosis and prediction of treatment response. The capacity of this omics approach to simultaneously quantify thousands of metabolites, i.e. small molecules less than 1500 Da in samples, positions it as a promising tool for research and clinical applications in personalized medicine. Clinical metabolomics studies have proven valuable in understanding cardiometabolic disorders, potentially uncovering diagnostic biomarkers predictive of disease risk. Liquid chromatography-mass spectrometry is the predominant analytical method used in metabolomics, particularly untargeted. Metabolomics combined with extensive genomic data, proteomics, clinical chemistry data, imaging, health records, and other pertinent health-related data may yield significant advances beneficial for both public health initiatives, clinical applications and precision medicine, particularly in rare disorders and multimorbidity. This special issue has gathered original research articles in topics related to clinical metabolomics as well as research articles, reviews, perspectives and highlights in the broader field of translational and clinical metabolic research. Additional research is necessary to identify which metabolites consistently enhance clinical risk prediction across various populations and are causally linked to disease progression.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"22 ","pages":"Article 100290"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000227/pdfft?md5=f169ac7a3c9590bd18a34a9df53866b8&pid=1-s2.0-S2589936824000227-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141323717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrion quality control for longevity promotion","authors":"Yao Zhang,&nbsp;Suzhen Chen,&nbsp;Junli Liu","doi":"10.1016/j.metop.2023.100259","DOIUrl":"10.1016/j.metop.2023.100259","url":null,"abstract":"","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"22 ","pages":"Article 100259"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936823000312/pdfft?md5=024c1dd48687932985fa582211659b40&pid=1-s2.0-S2589936823000312-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136009282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eye care service utilization and associated factors among diabetic patients in Africa: A Systematic Review and Meta-Analysis","authors":"Worku Chekol Tassew ,&nbsp;Agerie Mengistie Zeleke ,&nbsp;Yeshiwas Ayal Ferede","doi":"10.1016/j.metop.2024.100293","DOIUrl":"https://doi.org/10.1016/j.metop.2024.100293","url":null,"abstract":"<div><h3>Introduction</h3><p>'Vision 2020, the Right to Sight', jointly coordinated by the World Health Organization's program for the prevention of blindness and deafness and the international agency for the prevention of blindness, was launched in 1999, however, the initiative faces many challenges to hitting its target. One of the challenges for this is, the absence of comprehensive data regarding eye care service utilization among diabetes mellitus patients in Africa. Therefore, this study was aimed at assessing the prevalence of eye care service utilization and associated factors among adult diabetes mellitus patients in Africa.</p></div><div><h3>Methods</h3><p>This systematic review and meta-analysis was conducted as per the international preferred reporting items for systematic review and meta-analysis protocols (PRISMA) guidelines. Published articles were searched using reputable databases (PubMed, Cochrane Library) and Web searches (Science Direct, African Journals Online, and Google Scholar). Quality appraisal was assessed based on the Joanna Briggs Institute's (JBI) critical appraisal checklist. The extracted data was exported to STATA version 11 (STATA Corp., LLC) for further analysis. Heterogeneity between the results of primary studies was assessed using Cochran's Q chi-square test and quantified with the I² statistics. Publication bias was assessed by visual inspection of the funnel plot and Egger's regression tests.</p></div><div><h3>Results</h3><p>The database search found 26,966 articles. The pooled prevalence of eye care service utilization among diabetic patients in Africa is found to be 40.92 % (95 % CI: 27.14–54.70, P &lt; 0.001). Good knowledge (POR = 3.57, 95 % CI: 2.67–4.76), good attitude (POR = 5.68, 95 % CI: 4.20–7.68), age greater than 65 years old (POR = 7.11, 95 % CI: 3.86–13.10), urban residence (POR = 5.03, 95 % CI: 2.12–11.96), and disease duration greater than 6 years (POR = 3.81, 95 % CI: 2.25–6.45) were factors associated with eye care service utilization.</p></div><div><h3>Conclusion</h3><p>This meta-analysis revealed that a high proportion of people with diabetes failed to use eye care services. Older age, good knowledge, urban residence and longer duration of illness were found to be the contributing factors for the utilization of eye care services in diabetes mellitus patients. Therefore, by considering the negative impact of low eye care service utilization, it is important to improve the habit of regular screening of the eye into routine assessment of diabetes mellitus follow up targeting patients with older age and longer duration of illness to reduce the magnitude of the problem.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"22 ","pages":"Article 100293"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589936824000252/pdfft?md5=432519b1e9cad9ee3b2f44818a572f7d&pid=1-s2.0-S2589936824000252-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141291954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}