Journal of hazardous materials最新文献

{"title":"Colloid-facilitated release of PFAS from polluted-soil monoliths.","authors":"Elisabeth Fries, Denis Courtier-Murias, Pierre Labadie, Béatrice Béchet, Pierre-Emmanuel Peyneau, Chloé Caurel, Quentin Dubois, Patrick Pardon, Hélène Budzinski, Eric Michel","doi":"10.1016/j.jhazmat.2026.142279","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.142279","url":null,"abstract":"<p><p>Firefighting Aqueous Film Forming Foams contain per- and polyfluoroalkyl substances (PFAS). Because PFAS are persistent, firefighting training sites constitute a source of soil and groundwater contamination. Colloidal soil particles are known to facilitate the mobility of contaminants that have a strong affinity for soils. Indeed, colloid-facilitated transport of PFAS has been brought up repeatedly to discuss experimental observations regarding PFAS mobility. Still, it has only been observed experimentally for two PFAS molecules, using model experimental situations: repacked soil columns spiked with PFAS. We investigated for the first time the determinants and extent of colloid-facilitated transport of PFAS from AFFF-impacted undisturbed-soil monoliths during simulated rainfalls. These experiments showed that: (i) colloids contributed to the mobility-up to 70% of their concentration in leachates-of 12 PFAS having a perfluorinated carbon chain length n_c ≥ 6, out of the 20 PFAS present in leachates; (ii) PFAS content in colloids was up to 25 times higher than in bulk soil, this enrichment stemmed from the adsorption on colloids of PFAS present in the soil solution; (iii) colloid-facilitated transport was exacerbated during transient flow regimes, which was probably related to the adsorption of PFAS and colloids to the moving air-water-interfaces. In addition, diffusion was the mechanism limiting the mobility of eight other PFAS with n_c ≤ 7 and hydrodynamic conditions, linked to the soil structure, strongly affected the mobility of PFAS. The importance of colloidal particles as a carrier phase of PFAS calls for a renewed conceptual model of PFAS fate in soils.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"511 ","pages":"142279"},"PeriodicalIF":11.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one induces obesogenic effects by targeting fatty acid synthase.","authors":"Jing Li, Chenyan Hu, Maaz Ahmad, Lianguo Chen","doi":"10.1016/j.jhazmat.2026.142299","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.142299","url":null,"abstract":"<p><p>The widespread use of biocides to control biofouling has led to significant marine pollution. Among these, 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) has emerged as a prominent antifouling contaminant known to disrupt lipid metabolism in marine organisms. However, the chronic effects and underlying mechanisms of DCOIT-induced lipid dysregulation remain unclear. In this study, marine medaka embryos were exposed to environmentally relevant concentrations of DCOIT (0, 1, 3, and 10 μg/L) throughout their entire life cycle. Disturbances in lipid metabolism were systematically characterized by integrating histopathological, biochemical, transcriptional, proteomic, and lipidomic analyses. DCOIT exposure significantly increased whole-body fat content, induced fatty liver pathology, and promoted adipocyte hypertrophy, with more severe effects in males (10.6-fold enlargement of adipocyte size). Consistently, exposed livers accumulated excessive triglycerides (TG) and fatty acids in a sex-dependent manner. Lipidomic profiling further revealed that TG accumulation was significantly elevated only in male adipose, explaining the pronounced adipocyte hypertrophy. DCOIT also remodeled TG composition, characterized by increased palmitic acid (C16:0), the principal product of fatty acid synthase (FAS). Multifaceted approaches confirmed a strong binding affinity between DCOIT and FAS, establishing FAS as a key molecular target of DCOIT-induced lipid toxicity. This study provides the first evidence that DCOIT functions as a potent obesogen, significantly impairing the health and viability of marine teleosts.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"511 ","pages":"142299"},"PeriodicalIF":11.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the effect of intermittent feeding strategy on the performances of modular moving bed constructed wetland: Nitrogen removal and antimicrobial resistance dissemination.","authors":"Lei Zhou, Jiawei Xie, Liming Zhang, Xueqing Sui, Weicong Wang, Jianshi Huang, Shuangqi Wu, Naxin Cui, Shengbing He, Shuiping Cheng","doi":"10.1016/j.jhazmat.2026.142288","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.142288","url":null,"abstract":"<p><p>Constructed wetlands (CWs) are widely applied for advanced treatment of wastewater treatment plant effluents, and their pollutant removal performance are closely related to the internal oxygen conditions. This study investigated the effect of intermittent feeding strategy (an oxygen regulation strategy) on nitrogen removal performance under antibiotic stress and the fate of antibiotic resistance genes (ARGs) in a newly designed modular moving bed constructed wetland (MMB-CW). The results showed that the intermittent feeding strategy significantly increased ammonium removal by 17.0% (p < 0.05) and maintaining a stable nitrate removal efficiency of 96.4%. The improved performance was primarily attributed to the enrichment of the aerobic denitrifier Thauera and genes napAB, which restructured nitrogen metabolic pathways and alleviated the antibiotic inhibition. However, compared with continuous feeding, intermittent feeding drove a significant absolute increase of 1324.6 TPM in total ARG abundance (p < 0.05). The increased abundance of mobile genetic elements (MGEs) and their positive correlation with that of ARGs indicated enhanced horizontal gene transfer (HGT) driven by MGEs. Intermittent feeding further increased the abundance of genes encoding key functional profiles involved in antioxidative system, SOS repair, membrane permeability, adenosine triphosphate synthesis, extracellular polymeric substance secretion, and signal transduction. These changes in cellular behavior together with the increased abundance of genes related to the competence pseudopilus of bacteria, collectively formed the physiological basis driving HGT of ARGs through bacterial transformation. This study systematically revealed the dual-edged effect of intermittent feeding strategy on the MMB-CW, providing critical performance- and ecological risk-based insights for oxygen regulation strategies in CWs.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"511 ","pages":"142288"},"PeriodicalIF":11.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon metabolic homogenization is linked to microbial competition and antimicrobial resistance in soils under forest-to-cropland conversion.","authors":"Shaoyang Zhang, Tianlun Zhang, Shuai Du, Zhugen Yang, Shengen Liu, Guiyao Zhou, Manuel Delgado-Baquerizo, Dong Zhu","doi":"10.1016/j.jhazmat.2026.142281","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.142281","url":null,"abstract":"<p><p>Global agricultural expansion by converting natural forests into croplands often leads to soil functional homogenization and antimicrobial resistance enhancement, threatening ecosystem services. However, the associations between microbial carbon metabolic homogenization and antimicrobial resistance remain largely unknown. Here, we collected 240 paired forest and cropland soil samples from the most intensively farmed Yangtze River Basin in China, and constructed a novel framework based on microbial functional traits to decipher the role of carbon metabolic homogenization on antimicrobial resistance via microbial competition for metabolites. Using genome-scale metabolic models, we found that carbon metabolic homogenization was associated with a shift in microbial interactions from cooperation toward competition, with a 45.6% increase in competitive interactions that coincided with a 35.6% higher antimicrobial resistance gene (ARG) diversity. This shift was accompanied by smaller genome sizes and higher 16S rRNA copy numbers, indicating fast-growing, resource-acquisitive microbial strategies. Metabolic transfer analyses further revealed less cooperation relationships among microbial communities in cropland soils than in forest soils, indicating an intensified battle for communal metabolites and an attenuated exchange for complementary metabolites. Together, these findings provide a new framework to understand the association between carbon metabolic homogenization and soil antimicrobial resistance risks from the perspective of microbial traits and interactions under land use change.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"511 ","pages":"142281"},"PeriodicalIF":11.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic hydrothermal treatment of sewage sludge and phosphorus tailings via iron-polyphenol coating: Mechanistic insights into enhanced dewatering and detoxification.","authors":"Renjie Chen, Bin Dong, Zuxin Xu","doi":"10.1016/j.jhazmat.2026.142295","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.142295","url":null,"abstract":"<p><p>Sewage sludge (SS) and Phosphorus tailings (PT) are two typical bulk solid wastes characterized by a dual nature as both potential resources and environmental burdens. However, a critical bottleneck remains in developing synergistic conversion pathways that can transform these wastes into high-value products while ensuring the elimination of their toxicity. This study developed an innovative hydrothermal-based strategy for the synergistic management of SS and PT through the construction of a tannic acid (TA)-Fe(Ⅲ) coating on PT (PT-TA-Fe(Ⅲ)), coupled with Fe(Ⅱ) addition. The established hydrothermal treatment (HT)/PT-TA-Fe(Ⅲ)/Fe(Ⅱ) system reduced the optimal hydrothermal temperature for sludge deep dewatering from 180 °C to 140 °C, suppressing the formation of refractory compounds. Moreover, the system achieved exceptional antibiotic removal efficiencies, exceeding 99% for tetracyclines and reaching 86.0-87.4% for fluoroquinolones. Mechanism studies revealed that Fe(Ⅱ) could activate dissolved oxygen to initial generate hydroxyl radical (·OH) during HT. Critically, the polyphenol-iron coordination framework in PT-TA-Fe(Ⅲ) facilitated efficient electron transfer via the generation of semiquinone radicals (SQ^•-), accelerating the Fe(Ⅲ)/Fe(Ⅱ) redox cycle and thereby significantly increasing ·OH production. The ·OH subsequently hydrolyzed and mineralized high-molecular-weight (HMW) proteins, which improved the surface hydrophobicity of sludge flocs and ultimately achieved sludge deep dewatering. Furthermore, during HT process, the dolomite within PT can effectively immobilize heavy metals (e.g., Cu, Zn, Pb, Cd) by transforming them into stable residual fractions via carbonate precipitation and ion substitution, thereby reducing the potential ecological risk of sludge and PT. Overall, this work provides a new strategy for sludge deep dewatering and detoxification, ultimately improves the potential of sludge and PT as a high-value soil amendment.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"511 ","pages":"142295"},"PeriodicalIF":11.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poplar catkin contamination in vehicle air conditioning systems: Effects on filter performance, microbial survival, and mitigation approaches.","authors":"Feng Dai, Ruiqing Shen, Weidong He, Xiaotong Zhou, Jingxian Liu","doi":"10.1016/j.jhazmat.2026.142292","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.142292","url":null,"abstract":"<p><p>During the spring-to-summer transition, the poplar catkins pose a substantial challenge to cabin air filters, fundamentally distinct from conventional particulate matter pollutants such as dust. Once drawn into the air conditioning system, poplar catkins readily entangle in filter media, forming a dense layer that considerably increases pressure drop and promotes microbial survival. However, this dual challenge of accelerated clogging and microbial risk remains largely unexplored. In this study, microscopy and scanning electron microscopy (SEM) were employed to characterize used cabin air filters during the peak poplar catkin season. Field sampling and quantitative analysis were conducted to determine poplar catkin concentrations, as well as dust levels under different traffic conditions. A wind tunnel bench-scale test platform was established to systematically evaluate the dynamic pressure drop and particulate matter filtration efficiency of cabin air filters under three conditions: poplar catkin contamination alone, dust contamination alone, and combined contamination. The results indicate that poplar catkins and pollen not only physically clog cabin air filters but also transform them into potential microbial reservoirs, enhancing the survival rates of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) by over 40% by providing nutrients and a humid microenvironment. This study proposes and evaluates a practical method for effectively slowing the rate of pressure drop increase in air conditioning systems by installing pre-filter materials at the air intake, and reducing bacterial survival and persistence by minimizing poplar catkin accumulation on cabin air filters.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"511 ","pages":"142292"},"PeriodicalIF":11.3,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temperature robustness of sulfur and hydrogen autotrophic reduction systems for antimonate detoxification: Experiment and machine learning-driven evaluation.","authors":"Qiaochong He, Yangli Mao, Jin Xie, Yiduo Wang, Dongli Guo, Shikan Zheng, Dongjin Wan","doi":"10.1016/j.jhazmat.2026.142286","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.142286","url":null,"abstract":"<p><p>This study, for the first time, revealed the temperature robustness of elemental sulfur (S⁰) (SAR) and hydrogen (H₂) (HAR), and a combination of S⁰ and H₂ autotrophic reduction (SHAR) systems for Sb(V) removal from water. SHAR system demonstrated superior temperature stability, with only a 4.4-fold decline in the maximum specific removal rate (q_max) for Sb(V) from 30°C to 10°C compared to 9.1-fold for SAR and 5.0-fold for HAR. Furthermore, SHAR systems showed a 70% lower sulfate generation rate than SAR systems, and the generation rate decreased by around half when the temperature decreased from 30°C to 10°C for both systems. In addition, the sulfide generation rate in the SHAR was only 0.14 times that in the SAR system at 30°C, and low temperatures significantly inhibited sulfide production in both systems. Arrhenius and thermodynamic analyses showed that the energy barrier in the SHAR system was reduced by 51.2% due to the synergy of S⁰ and H₂ compared to the SAR system, and that spontaneous Sb(V) removal occurred at 20°C-30°C but was non-spontaneous at 10°C. Machine learning revealed that categorical boosting (CatBoost) achieved high accuracy in predicting Sb removal and byproduct generation, and Shapley additive explanations (SHAP) analysis confirmed that the SHAR system exhibited superior temperature robustness compared to SAR and HAR systems. SHAR system enriched a relatively independent genus, Cloacibacterium, and the temperature-tolerant Sb(V)-reducing genera Ralstonia and Defluviimonas, enabling them to withstand temperature changes, further stabilizing expression of key functional genes.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"512 ","pages":"142286"},"PeriodicalIF":11.3,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ibuprofen/graphene oxide co-exposure in Chlorella vulgaris: Distinct targets and a dose- and time-dependent shift from synergy to antagonism.","authors":"Xin Hu, Qichen Yuan, Liang Tang, Jing Fu","doi":"10.1016/j.jhazmat.2026.142264","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.142264","url":null,"abstract":"<p><p>As the use of pharmaceuticals and nanomaterials continues to rise, their concurrent presence in aquatic ecosystems has become increasingly likely, challenging primary producers with complex exposure conditions. Yet, the molecular mechanisms governing their joint impacts are still unclear. This study presents a multi-scale investigation of the time- and concentration-dependent interactions between ibuprofen (IBU) and graphene oxide (GO) in the green alga Chlorella vulgaris. Environmentally relevant concentrations (ERCs) and sublethal concentrations were used, with physiological screening integrated with transcriptomic and metabolomic analyses to assess the effects of IBU, GO, and their mixture (MIX) on algal growth, energy metabolism, and cellular vitality under both acute and chronic conditions. Multi-omics and physiological data revealed concentration-dependent disruptions of MIX in cellular energy metabolism, redox homeostasis, photosynthesis, and cofactor biosynthesis. IBU chiefly disturbed cellular energy pathways and redox homeostasis, consistent with mitochondrial dysfunction, while GO primarily impaired photosynthesis and caused pronounced oxidative stress. Under ERCs and acute conditions, exposure produced largely additive effects with instances of IBU-driven synergism. But the net interaction between IBU and GO shifted toward antagonism, with GO inducing more pronounced oxidative stress and exacerbated mitochondrial damage under sublethal and chronic conditions. By elucidating the time- and concentration- dependent mechanistic interplay between pharmaceuticals and nanomaterials, this work advances understanding of complex co-exposure effects in algae and highlights the importance of chronic, multi-endpoint omics approaches in ecological risk assessment.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"511 ","pages":"142264"},"PeriodicalIF":11.3,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PE microplastics and sulfadiazine drive cross-domain microbial restructuring and antibiotic resistance gene dynamics in biofilms.","authors":"Shenglong Ma, Baowei Zhao, Hui Liu, Yin Zhang, Xin Zhang, Xiaoping Gao","doi":"10.1016/j.jhazmat.2026.142269","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.142269","url":null,"abstract":"<p><p>Microplastic-associated biofilms are increasingly recognized as hotspots for microbial colonization and the accumulation of antibiotic resistance genes (ARGs) in environmental systems. However, most studies have focused primarily on bacterial communities, while how fungal and archaeal communities respond to combined microplastic and antibiotic exposure, and how these responses influence ARG dynamics, remain poorly understood. In this study, biofilms were exposed to polyethylene (PE) microplastics (MPs) of varying sizes and concentrations, with or without the sulfonamide sulfadiazine (SD). Bacterial, fungal, and archaeal communities were jointly characterized, along with sulfonamide resistance genes (SRGs; sul1-sul4) and the class 1 integron integrase gene (intI1). Both PE MPs and SD significantly altered microbial community composition, with domain-specific responses observed based on α- and β-diversity analyses. Distinct shifts were observed across bacterial, fungal, and archaeal communities. Partial redundancy analysis identified SD exposure and microbial community structure as major contributors to ARG variation. Co-occurrence network analysis further revealed domain-specific associations between microbial taxa and ARGs, with sul1-sul3 mainly linked to bacterial taxa, while sul4 showed associations with fungal communities, likely reflecting co-occurrence patterns rather than direct gene carriage. Overall, these results demonstrate that PE MPs reshape multi-domain microbial restructuring and indirectly influence ARG distribution through changes in community structure. Our findings underscore the importance of considering bacteria, fungi, and archaea when evaluating antibiotic resistance risks in microplastic-contaminated environments.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"511 ","pages":"142269"},"PeriodicalIF":11.3,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotics in agroecosystems: Environmental fate, bioavailability, plant uptake, and associated health risks.","authors":"Fanding Zhai, Jiabao Wu, Caixia Chen, Zhaoheng Jiang, Feiran Chen, Zhenggao Xiao, Zhenyu Wang","doi":"10.1016/j.jhazmat.2026.142259","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.142259","url":null,"abstract":"<p><p>Agricultural soils serve as primary sinks for antibiotics, posing severe threats to environmental health and food safety. This review synthesizes the key mechanisms driving antibiotic bioavailability, soil-plant translocation and plant uptake. Our meta-analysis demonstrates that antibiotic exposure induced a substantial oxidative burst in plants, increasing reactive oxygen species by 139.1%. Consequently, this stress reduced chlorophyll and carotenoid contents by 27%-34%, and significantly decreased shoot and root biomass by 26.6% and 45.3%, respectively. Furthermore, antibiotic bioaccumulation in crops facilitated cross-trophic transfer along the food chain. Regarding human health risks, we highlight a critically underestimated threat: the gastrointestinal reactivation of plant-derived masked metabolites, which substantially amplifies actual dietary exposure. These integrated insights provide a robust scientific foundation for refining current risk assessments and developing targeted mitigation strategies for antibiotic pollution in agroecosystems.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"511 ","pages":"142259"},"PeriodicalIF":11.3,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}