Journal of hazardous materials最新文献_第10页

Effects of cortisone in zebrafish (Danio rerio): Insights into gut microbiota interactions and molecular mechanisms underlying DNA damage and apoptosis. 可的松对斑马鱼（Danio rerio）的影响：洞察肠道微生物群相互作用以及 DNA 损伤和细胞凋亡的分子机制。

Journal of hazardous materials Pub Date : 2024-10-05 Epub Date: 2024-08-20 DOI: 10.1016/j.jhazmat.2024.135576

Jiefeng Tan, Lihua Yang, Meixin Ye, Yuxin Geng, Yanfang Guo, Hong Zou, Liping Hou

{"title":"Effects of cortisone in zebrafish (Danio rerio): Insights into gut microbiota interactions and molecular mechanisms underlying DNA damage and apoptosis.","authors":"Jiefeng Tan, Lihua Yang, Meixin Ye, Yuxin Geng, Yanfang Guo, Hong Zou, Liping Hou","doi":"10.1016/j.jhazmat.2024.135576","DOIUrl":"10.1016/j.jhazmat.2024.135576","url":null,"abstract":"Cortisone can enter aquatic ecosystems and pose a risk to organisms therein. However, few studies have explored the effects of cortisone on the gut microbiota of aquatic organisms. Here, we exposed zebrafish (Danio rerio) to cortisone at environmentally relevant concentrations (5.0, 50.0, or 500.0 ng L-1) for 60 days to explore its toxicological effects and their association with gut microbiota changes. The terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling assay revealed that exposure to 50 ng L-1 cortisone significantly increased the intestinal cell apoptosis rate, 8-hydroxydeoxyguanosine contents, and caspase-3 and caspase-8 activities. Moreover, the transcriptome analysis results demonstrated a notable downregulation in the expression of most differentially expressed genes associated with apoptosis pathways, as well as changes in DNA replication, oxidative stress, and drug metabolism pathways; these results indicated the occurrence of cortisone-induced stress response in zebrafish. Molecular docking analysis revealed that cortisone can bind to caspase-3 through hydrogen bonds and hydrophobic interactions but that no such interactions occur between cortisone and caspase-8. Thus, cortisone may induce oxidative DNA damage and apoptosis by activating caspase-3. Finally, the 16S rRNA sequencing results demonstrated that cortisone significantly affected microbial community structures and functions in the intestinal ecosystem. These changes may indicate gut microbiota response to cortisone-induced intestinal damage and inflammation. In conclusion, the current results clarify the mechanisms underlying intestinal response to cortisone exposure and provide a basis for evaluating the health risks of cortisone in animals.","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"478 ","pages":"135576"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence for sustainably reducing secondary pollutants in a typical industrial city in China: Co-benefit from controlling sources with high reduction potential beyond industrial process. 中国典型工业城市可持续减少二次污染物的证据：控制工业过程之外的高减排潜力源的共同效益。

Journal of hazardous materials Pub Date : 2024-10-05 Epub Date: 2024-08-21 DOI: 10.1016/j.jhazmat.2024.135556

Yueyuan Niu, Yulong Yan, Jiaqi Dong, Ke Yue, Xiaolin Duan, Dongmei Hu, Junjie Li, Lin Peng

{"title":"Evidence for sustainably reducing secondary pollutants in a typical industrial city in China: Co-benefit from controlling sources with high reduction potential beyond industrial process.","authors":"Yueyuan Niu, Yulong Yan, Jiaqi Dong, Ke Yue, Xiaolin Duan, Dongmei Hu, Junjie Li, Lin Peng","doi":"10.1016/j.jhazmat.2024.135556","DOIUrl":"10.1016/j.jhazmat.2024.135556","url":null,"abstract":"Under China's strict industrial control measures, the reduction of secondary pollutants (O3 and secondary organic aerosols [SOA]) and precursors (volatile organic compounds [VOCs] and NOx) caused by industrial processes has encountered bottlenecks. In this study, the net O3 formation rate (Net [O3]) in summer and the self-reaction rate between peroxy radicals (Self-Rnxs) in winter are used to characterize the formation potentials of O3 and SOA, respectively. Assuming that the precursor reduction ratio based on emission inventories is approximately equal to that based on observed concentrations, this study combines emission inventory and observation-based model (OBM) methods to indicate the potential source of secondary pollutants reduction. The findings show that strict control measures implemented by local governments, particularly those targeting industrial processes and fossil fuel combustion, are effective in reducing VOCs and NOx emissions during summer, and the two sources result in 3.8 % and 5.3 % decrease in the Net (O3), respectively. Similarly, control measures focusing on industrial processes help to significantly reduce VOCs emissions during winter, resulting in an 8.0 % decrease in Self-Rnxs. However, current measures for industrial processes are stringent and have little potential for further reduction. Therefore, additional sources with higher reduction potentials beyond industrial processes should be subject to stringent controls in industrial cities. Given the limited emission reduction potential associated with industrial processes, this study provides perspectives for sustained reduction of secondary pollutants in industrial cities.","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"478 ","pages":"135556"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating automated machine learning and metabolic reprogramming for the identification of microplastic in soil: A case study on soybean. 整合自动机器学习和代谢重编程，识别土壤中的微塑料：大豆案例研究。

Journal of hazardous materials Pub Date : 2024-10-05 Epub Date: 2024-08-22 DOI: 10.1016/j.jhazmat.2024.135555

Zhimin Liu, Weijun Wang, Yibo Geng, Yuting Zhang, Xuan Gao, Junfeng Xu, Xiaolu Liu

{"title":"Integrating automated machine learning and metabolic reprogramming for the identification of microplastic in soil: A case study on soybean.","authors":"Zhimin Liu, Weijun Wang, Yibo Geng, Yuting Zhang, Xuan Gao, Junfeng Xu, Xiaolu Liu","doi":"10.1016/j.jhazmat.2024.135555","DOIUrl":"10.1016/j.jhazmat.2024.135555","url":null,"abstract":"The accumulation of polyethylene microplastic (PE-MPs) in soil can significantly impact plant quality and yield, as well as affect human health and food chain cycles. Therefore, developing rapid and effective detection methods is crucial. In this study, traditional machine learning (ML) and H2O automated machine learning (H2O AutoML) were utilized to offer a powerful framework for detecting PE-MPs (0.1 %, 1 %, and 2 % by dry soil weight) and the co-contamination of PE-MPs and fomesafen (a common herbicide) in soil. The development of the framework was based on the results of the metabolic reprogramming of soybean plants. Our study stated that traditional ML exhibits lower accuracy due to the challenges associated with optimizing complex parameters. H2O AutoML can accurately distinguish between clean soil and contaminated soil. Notably, H2O AutoML can detect PE-MPs as low as 0.1 % (with 100 % accuracy) and co-contamination of PE-MPs and fomesafen (with 90 % accuracy) in soil. The VIP and SHAP analyses of the H2O AutoML showed that PE-MPs and the co-contamination of PE-MPs and fomesafen significantly interfered with the antioxidant system and energy regulation of soybean. We hope this study can provide a reliable scientific basis for sustainable development of the environment.","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"478 ","pages":"135555"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient density functional theory directed identification of siderophores with increased selectivity towards indium and germanium. 以密度泛函理论为指导，高效识别对铟和锗具有更高选择性的苷元。

Journal of hazardous materials Pub Date : 2024-10-05 Epub Date: 2024-08-19 DOI: 10.1016/j.jhazmat.2024.135523

Christian Hintersatz, Satoru Tsushima, Tobias Kaufer, Jerome Kretzschmar, Angela Thewes, Katrin Pollmann, Rohan Jain

{"title":"Efficient density functional theory directed identification of siderophores with increased selectivity towards indium and germanium.","authors":"Christian Hintersatz, Satoru Tsushima, Tobias Kaufer, Jerome Kretzschmar, Angela Thewes, Katrin Pollmann, Rohan Jain","doi":"10.1016/j.jhazmat.2024.135523","DOIUrl":"10.1016/j.jhazmat.2024.135523","url":null,"abstract":"Siderophores are promising ligands for application in novel recycling and bioremediation technologies, as they can selectively complex a variety of metals. However, with over 250 known siderophores, the selection of suiting complexants in the wet lab is impractical. Thus, this study established a density functional theory (DFT) based approach to efficiently identify siderophores with increased selectivity towards target metals on the example of germanium and indium. Considering 239 structures, chemically similar siderophores were clustered, and their complexation reactions modeled utilizing DFT. The calculations revealed siderophores with, compared to the reference siderophore desferrioxamine B (DFOB), up to 128 % or 48 % higher selectivity for indium or germanium, respectively. Experimental validation of the method was conducted with fimsbactin A and agrobactin, demonstrating up to 40 % more selective indium binding and at least sevenfold better germanium binding than DFOB, respectively. The results generated in this study open the door for the utilization of siderophores in eco-friendly technologies for the recovery of many different critical metals from various industry waters and leachates or bioremediation approaches. This endeavor is greatly facilitated by applying the herein-created database of geometry-optimized siderophore structures as de novo modeling of the molecules can be omitted.","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"478 ","pages":"135523"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel visible-light activated photocatalytic ultrafiltration membrane for simultaneous separation and degradation of emerging contaminants. 用于同时分离和降解新兴污染物的新型可见光激活光催化超滤膜。

Journal of hazardous materials Pub Date : 2024-10-05 Epub Date: 2024-08-24 DOI: 10.1016/j.jhazmat.2024.135634

Ran Li, Zhidong Wei, Peng Li, Yangbo Qiu, Chengyi Wang, Chao Wang, Long-Fei Ren, Jiahui Shao, Yiliang He

{"title":"Novel visible-light activated photocatalytic ultrafiltration membrane for simultaneous separation and degradation of emerging contaminants.","authors":"Ran Li, Zhidong Wei, Peng Li, Yangbo Qiu, Chengyi Wang, Chao Wang, Long-Fei Ren, Jiahui Shao, Yiliang He","doi":"10.1016/j.jhazmat.2024.135634","DOIUrl":"10.1016/j.jhazmat.2024.135634","url":null,"abstract":"Emerging contaminants (ECs) in secondary effluent of wastewater treatment plants (WWTPs) have received increasing attention due to their adverse effects on aquatic ecosystems and human health. Herein, visible-light responsive photocatalyst TM (TiO2 @NH2-MIL-101(Fe)) and resultant photocatalytic ultrafiltration (PUF, PVDF/TM) membrane were prepared to remove 32 typical compounds of antibiotics, 296 compounds of antibiotic resistance genes (ARGs), and their corresponding bacterial hosts. The construction of heterojunction photocatalyst promoted the electron transfer from NH2-MIL-101(Fe) to TiO2 and the formation of N-TiO2, enhancing visible-light (λ ≥ 420 nm) photocatalytic activity. With highly-hydrophilic surface and delicately-regulated pore structure, the initial water permeance of optimal PUF membrane significantly increased to 3912.2 L/m2/h at 1.0 bar. Meanwhile, membrane retention (via adsorption, electrostatic interaction, and steric hindrance) was improved due to the narrowed pore size, highly-negative surface charge and abundant functional groups. Additionally, hydroxyl radical (•OH) was the dominant active reactive oxygen species (ROS) for ECs degradation, and the narrowed pore structure could serve as microreactors to increase ROS concentration and reduce migration distance. Consequently, the removal efficiencies of antibiotics, bacteria and ARGs were 86.5 %, 91.4 % and 91.8 %, respectively. Overall, this novel visible-light-activated PUF membrane expands membrane application, and has great potential in ECs treatment.","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"478 ","pages":"135634"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rainwater-borne H₂O₂ accelerates roxarsone degradation and reduces bioavailability of arsenic in paddy rice soils. 雨水中的 H2O2 可加速洛克沙砷的降解，降低砷在水稻田土壤中的生物利用率。

Journal of hazardous materials Pub Date : 2024-10-05 Epub Date: 2024-08-23 DOI: 10.1016/j.jhazmat.2024.135633

Kaiqing Fan, Liji Chen, Huashou Li, Jun Wei Lim, Chuxia Lin, Junhao Qin, Rongliang Qiu

{"title":"Rainwater-borne H2O2 accelerates roxarsone degradation and reduces bioavailability of arsenic in paddy rice soils.","authors":"Kaiqing Fan, Liji Chen, Huashou Li, Jun Wei Lim, Chuxia Lin, Junhao Qin, Rongliang Qiu","doi":"10.1016/j.jhazmat.2024.135633","DOIUrl":"10.1016/j.jhazmat.2024.135633","url":null,"abstract":"Contamination of rice by arsenic represents a significant human health risk. Roxarsone -bearing poultry manure is a major pollution source of arsenic to paddy soils. A mesocosm experiment plus a laboratory experiment was conducted to reveal the role of rainwater-borne H2O2 in the degradation of roxarsone in paddy rice soils. While roxarsone could be degraded via chemical oxidation by Fenton reaction-derived hydroxyl radical, microbially mediated decomposition was the major mechanism. The input of H2O2 into the paddy soils created a higher redox potential, which favored certain roxarsone-degrading and As(III)-oxidizing bacterial strains and disfavored certain As(V)-reducing bacterial strains. This was likely to be responsible for the enhanced roxarsone degradation and transformation of As(III) to As(V). Fenton-like reaction also tended to enhance the formation of Fe plaque on the root surface, which acted as a filter to retain As. The dominance of As(V) in porewater, combined with the filtering effect of Fe plaque significantly reduced the uptake of inorganic As by the rice plants and consequently its accumulation in the rice grains. The findings have implications for developing management strategies to minimize the negative impacts from the application of roxarsone-containing manure for fertilization of paddy rice soils.","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"478 ","pages":"135633"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A PM_2.5 pollution-level adaptive air filtration system based on elastic filters for reducing energy consumption. 基于弹性过滤器的 PM2.5 污染级自适应空气过滤系统，可降低能耗。

Journal of hazardous materials Pub Date : 2024-10-05 Epub Date: 2024-08-15 DOI: 10.1016/j.jhazmat.2024.135546

Zhuolun Niu, Qiguang He, Chun Chen

{"title":"A PM2.5 pollution-level adaptive air filtration system based on elastic filters for reducing energy consumption.","authors":"Zhuolun Niu, Qiguang He, Chun Chen","doi":"10.1016/j.jhazmat.2024.135546","DOIUrl":"10.1016/j.jhazmat.2024.135546","url":null,"abstract":"Exacerbated by human activities and natural events, air pollution poses severe health risks, requiring effective control measures to ensure healthy living environments. Traditional filtration systems that employ high-efficiency particulate air (HEPA) filters are capable of effectively removing particulate matter (PM) in indoor environments. However, these systems often work without considering the fluctuations in air pollution levels, leading to high energy consumption. This study proposed a novel PM2.5 pollution-level adaptive air filtration system that combined elastic thermoplastic polyurethane (TPU) filters and an Internet of Things (IoT) system. The developed system can effectively adjust its filtration performance (i.e., pressure drop and PM2.5 filtration efficiency) in response to real-time air quality conditions by mechanically altering the structures of TPU filters. Furthermore, while operating in varied pollution conditions, the proposed system demonstrated remarkable reductions in pressure drop without notably compromising the pollution control capability. Finally, the energy consumption of the pollution-level adaptive air filtration system was estimated when applied in mechanical ventilation systems in different cities (Hong Kong, Beijing, and Xi'an) with various pollution conditions. The results revealed that, compared to a traditional fixed system, the annual energy consumption could be reduced by up to ∼26.4 % in Hong Kong.","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"478 ","pages":"135546"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transfer of heavy metals along the food chain: A review on the pest control performance of insect natural enemies under heavy metal stress. 重金属沿食物链的转移：重金属胁迫下昆虫天敌的害虫控制性能综述。

Journal of hazardous materials Pub Date : 2024-10-05 Epub Date: 2024-08-22 DOI: 10.1016/j.jhazmat.2024.135587

Zhe Zhang, Hongfei Wu, Aoying Zhang, Mingtao Tan, Shanchun Yan, Dun Jiang

{"title":"Transfer of heavy metals along the food chain: A review on the pest control performance of insect natural enemies under heavy metal stress.","authors":"Zhe Zhang, Hongfei Wu, Aoying Zhang, Mingtao Tan, Shanchun Yan, Dun Jiang","doi":"10.1016/j.jhazmat.2024.135587","DOIUrl":"10.1016/j.jhazmat.2024.135587","url":null,"abstract":"Heavy metal contamination represents a critical global environmental concern. The movement of heavy metals through the food chain inevitably subjects insect natural enemies to heavy metal stress, leading to various adverse effects. This review assesses the risks posed by heavy metal exposure to insect natural enemies, evaluates how such exposure impacts their pest control efficacy, and investigates the mechanisms affecting their fitness. Heavy metals transfer and accumulate from soil to plants, then to herbivorous insects, and ultimately to their natural enemies, impeding growth, development, and reproduction of insect natural enemies. Typically, diminished growth and reproduction directly compromise the pest control efficacy of these natural enemies. Nonetheless, within tolerable limits, increased feeding may occur as these natural enemies strive to meet the energy demands for detoxification, potentially enhancing their pest control capabilities. The production of reactive oxygen species and oxidative damage caused by heavy metals in insect natural enemies, combined with disrupted energy metabolism in host insects, are key factors contributing to the reduced fitness of insect natural enemies. In summary, heavy metal pollution emerges as a significant abiotic factor adversely impacting the pest control performance of these beneficial insects.","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"478 ","pages":"135587"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biotransformation of 6:2/4:2 fluorotelomer alcohols by Dietzia aurantiaca J3: Enzymes and proteomics. Dietzia aurantiaca J3 对 6:2/4:2 氟代醇的生物转化：酶和蛋白质组学。

Journal of hazardous materials Pub Date : 2024-10-05 Epub Date: 2024-08-13 DOI: 10.1016/j.jhazmat.2024.135510

Shefali Bhardwaj, Matthew Lee, Denis O'Carroll, James McDonald, Keith Osborne, Stuart Khan, Russell Pickford, Nicholas Coleman, Casey O'Farrell, Sarah Richards, Michael J Manefield

{"title":"Biotransformation of 6:2/4:2 fluorotelomer alcohols by Dietzia aurantiaca J3: Enzymes and proteomics.","authors":"Shefali Bhardwaj, Matthew Lee, Denis O'Carroll, James McDonald, Keith Osborne, Stuart Khan, Russell Pickford, Nicholas Coleman, Casey O'Farrell, Sarah Richards, Michael J Manefield","doi":"10.1016/j.jhazmat.2024.135510","DOIUrl":"10.1016/j.jhazmat.2024.135510","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFAS) are recalcitrant synthetic organohalides known to negatively impact human health. Short-chain fluorotelomer alcohols are considered the precursor of various perfluorocarboxylic acids (PFCAs) in the environment. Their ongoing production and widespread detection motivate investigations of their biological transformation. Dietzia aurantiaca strain J3 was isolated from PFAS-contaminated landfill leachate using 6:2 fluorotelomer sulphonate (6:2 FTS) as a sulphur source. Resting cell experiments were used to test if strain J3 could transform fluorotelomer alcohols (6:2 and 4:2 FTOH). Strain J3 transformed fluorotelomer alcohols into PFCAs, polyfluorocarboxylic acids and transient intermediates. Over 6 days, 80 % and 58 % of 6:2 FTOH (0.1 mM) and 4:2 FTOH (0.12 mM) were degraded with 6.4 % and 14 % fluoride recovery respectively. Fluorotelomer unsaturated carboxylic acid (6:2 FTUCA) was the most abundant metabolite, accounting for 21 to 30 mol% of 6:2 FTOH (0.015 mM) applied on day zero. Glutathione (GSH) conjugates of 6:2/4:2 FTOH and 5:3 FTCA adducts were also structurally identified. Proteomics studies conducted to identify enzymes in the biotransformation pathway have revealed the role of various enzymes involved in β oxidation. This is the first report of 6:2/4:2 FTOH glutathione conjugates and 5:3 FTCA adducts in prokaryotes, and the first study to explore the biotransformation of 4:2 FTOH by pure bacterial strain.","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"478 ","pages":"135510"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polystyrene nanoplastics significantly facilitate largemouth bass ranavirus infection of host cells. 聚苯乙烯纳米塑料大大促进了大口鲈鱼匐茎病毒对宿主细胞的感染。

Journal of hazardous materials Pub Date : 2024-10-05 Epub Date: 2024-08-23 DOI: 10.1016/j.jhazmat.2024.135597

Linyong Zhi, Guimei Zhang, Zhen Li, Fang Chen, Qiwei Qin, Youhua Huang, Xiaohong Huang, Jun Wang

{"title":"Polystyrene nanoplastics significantly facilitate largemouth bass ranavirus infection of host cells.","authors":"Linyong Zhi, Guimei Zhang, Zhen Li, Fang Chen, Qiwei Qin, Youhua Huang, Xiaohong Huang, Jun Wang","doi":"10.1016/j.jhazmat.2024.135597","DOIUrl":"10.1016/j.jhazmat.2024.135597","url":null,"abstract":"Novel pollutants nanoplastics (NPs) are widely distributed in aquatic environments and may pose a health threat to aquatic organisms. Notably, the contribution of NPs to the occurrence of viral diseases in aquatic animals remains largely uncertain. In this study, the effects of polystyrene nanoplastics (PS-NPs) on Largemouth bass ranavirus (LMBV)-infected MsF cells were investigated. MsF cells took up PS-NPs in a time- and dose-dependent manner and significantly affect cell viability at an exposure concentration of 500 μg/mL. Western blot and qPCR assays indicated that exposure to PS-NPs accelerated LMBV replication in MsF cells. PS-NPs act synergistically with LMBV to disrupt the cellular antioxidant system, as evidenced by increased ROS production and decreased mRNA levels of antioxidant-associated genes. Furthermore, PS-NPs was found to exacerbate LMBV-induced inflammatory responses, as demonstrated by disturbed expression of inflammation-related factors. In addition, our results suggest that PS-NPs reduce IFN production by inhibiting the expression of molecules related to the cGAS-STING signaling pathway, thereby promoting viral replication. Collectively, our findings suggest the potential threat of NPs to infectious diseases caused by freshwater fish viruses and provide new insights for fish disease prevention and control.","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":"478 ","pages":"135597"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0