Linyong Zhi, Guimei Zhang, Zhen Li, Fang Chen, Qiwei Qin, Youhua Huang, Xiaohong Huang, Jun Wang
{"title":"Polystyrene nanoplastics significantly facilitate largemouth bass ranavirus infection of host cells.","authors":"Linyong Zhi, Guimei Zhang, Zhen Li, Fang Chen, Qiwei Qin, Youhua Huang, Xiaohong Huang, Jun Wang","doi":"10.1016/j.jhazmat.2024.135597","DOIUrl":"10.1016/j.jhazmat.2024.135597","url":null,"abstract":"<p><p>Novel pollutants nanoplastics (NPs) are widely distributed in aquatic environments and may pose a health threat to aquatic organisms. Notably, the contribution of NPs to the occurrence of viral diseases in aquatic animals remains largely uncertain. In this study, the effects of polystyrene nanoplastics (PS-NPs) on Largemouth bass ranavirus (LMBV)-infected MsF cells were investigated. MsF cells took up PS-NPs in a time- and dose-dependent manner and significantly affect cell viability at an exposure concentration of 500 μg/mL. Western blot and qPCR assays indicated that exposure to PS-NPs accelerated LMBV replication in MsF cells. PS-NPs act synergistically with LMBV to disrupt the cellular antioxidant system, as evidenced by increased ROS production and decreased mRNA levels of antioxidant-associated genes. Furthermore, PS-NPs was found to exacerbate LMBV-induced inflammatory responses, as demonstrated by disturbed expression of inflammation-related factors. In addition, our results suggest that PS-NPs reduce IFN production by inhibiting the expression of molecules related to the cGAS-STING signaling pathway, thereby promoting viral replication. Collectively, our findings suggest the potential threat of NPs to infectious diseases caused by freshwater fish viruses and provide new insights for fish disease prevention and control.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cadmium stress alleviates lipid accumulation caused by chiral penthiopyrad through regulating endoplasmic reticulum stress and mitochondrial dysfunction in zebrafish liver.","authors":"Xinquan Wang, Weixuan Di, Zhiwei Wang, Peipei Qi, Zhenzhen Liu, Huiyu Zhao, Wei Ding, Shanshan Di","doi":"10.1016/j.jhazmat.2024.135560","DOIUrl":"10.1016/j.jhazmat.2024.135560","url":null,"abstract":"<p><p>The coexistence of cadmium (Cd) can potentiate (synergism) or reduce (antagonism) the pesticide effects on organisms, which may change with chiral pesticide enantiomers. Previous studies have reported the toxic effects of chiral penthiopyrad on lipid metabolism in zebrafish (Danio rerio) liver. The Cd effects and toxic mechanism on lipid accumulation were investigated from the perspective of endoplasmic reticulum (ER) stress and mitochondrial dysfunction. The coexistence of Cd increased the concentrations of penthiopyrad and its metabolites in zebrafish. Penthiopyrad exposure exhibited significant effects on lipid metabolism and mitochondrial function-related indicators, which were verified by lipid droplets and mitochondrial damage in subcellular structures. Moreover, penthiopyrad activated the genes of ER unfolded protein reaction (UPR) and Ca<sup>2+</sup> permeable channels, and S-penthiopyrad exhibited more serious effects on ER stress with ER hyperplasia than R-penthiopyrad. As a mitochondrial uncoupler, the coexistence of Cd could decrease lipid accumulation by alleviating ER stress and mitochondrial dysfunction, and these effects were the most significant for R-penthiopyrad. There were antagonistic effects between Cd and penthiopyrad, which could reduce the damage caused by penthiopyrad in zebrafish, thus increasing the bioaccumulation of penthiopyrad in zebrafish. These findings highlighted the importance and necessity of evaluating the ecological risks of metal-chiral pesticide mixtures.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Challenging established norms: The unanticipated role of alcohols in UV/PDS radical quenching.","authors":"Boqiang Li, Baiyang Chen, Zongsu Wei","doi":"10.1016/j.jhazmat.2024.135502","DOIUrl":"10.1016/j.jhazmat.2024.135502","url":null,"abstract":"<p><p>UV/peroxydisulfate (UV/PDS) process is known to be highly efficient for degrading micropollutants from water by generating sulfate (SO<sub>4</sub><sup>•-</sup>) and hydroxyl radicals (HO<sup>•</sup>). Reliable analyses of short-lived SO<sub>4</sub><sup>•-</sup> and HO<sup>•</sup> are therefore critical for understanding reaction mechanisms and optimizing operating conditions. Currently, alcohols are commonly used as quenchers to distinguish radicals based on the assumption that they exclusively react with target radicals without other influences. However, this study for the first time reveals a series of unexpected effects that challenge this conventional wisdom because: 1) adding alcohols altered the decomposition rates of PDS by replacing the reactions between SO<sub>4</sub><sup>•-</sup> and HO<sup>•</sup> with PDS by the reactions between secondary reactive species and PDS; and 2) SO<sub>4</sub><sup>•-</sup> preferably reacted with alcohols to generate nonnegligible level of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) under oxygen-rich conditions, which subsequently led to indirect formation of HO<sup>•</sup>. Additionally, the formation of H<sub>2</sub>O<sub>2</sub> was substantially impacted by the types of alcohols, dosages, dissolved oxygen, and solution pH. Using probe tests as tools, we found that the actual SO<sub>4</sub><sup>•-</sup> levels after dosing alcohols were only slightly different from assumed/expected levels, whereas the actually HO<sup>•</sup> levels were 43.7, 3364.9, and 12.5 times higher than assumed/expected conditions for samples dosed with methanol, iso-propanol, and tert-butanol, respectively. These unanticipated effects thus suggest that cautions are needed when using alcohols to qualitative and quantitative determine HO<sup>•</sup> and SO<sub>4</sub><sup>•-</sup> in UV/PDS process.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bei Ma, Bobing Lu, Hanyu Tang, Hui Wang, Zhaoyong Bian
{"title":"Square-wave pulsed potential driven electrocatalytic degradation of 4-chlorophenol using Fe-Ni/rGO/PPy@NF three dimensional electrode.","authors":"Bei Ma, Bobing Lu, Hanyu Tang, Hui Wang, Zhaoyong Bian","doi":"10.1016/j.jhazmat.2024.136054","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136054","url":null,"abstract":"<p><p>To develop an energy-efficient system for the removal of chlorinated organic pollutants, Fe-Ni/reduced graphite oxide/polymerized polypyrrole@nickel foam was constructed as a catalytic cathode for pulsed electrocatalytic degradation, where cathode-catalyzed production of hydrogen radicals (H*) and hydroxyl radical (·OH) generated at the anode led to dechlorination of 4-chlorophenol (4-CP), and dechlorination products were mineralized and degraded under the action of·OH. When energy was continuously supplied to the reaction system in the constant potential mode, the 4-CP concentration near the electrode was insufficient, limiting the reaction rate. Conversely, in the square-wave pulsed potential mode, mass transfer limitations were mitigated, significantly enhancing reaction efficiency and reducing energy consumption. At -1.2 V (vs. Ag/AgCl), the 4-CP removal efficiency reached 93.79 % in the pulsed potential mode, surpassing the constant potential mode's performance of 81.40 %. The synergistic periodic oscillation of the potential, direct electron transfer, and catalytic generation of active free radicals in the pulsed potential mode reduced intermediate concentrations and increased 4-CP mineralization, while the degradation pathway remained unchanged. This research presents a method for the efficient treatment of chlorinated organic pollutants in water using pulsed electrocatalytic degradation.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Copper-nickel-MOF/nickel foam catalysts grown in situ for efficient electrochemical nitrate reduction to ammonia.","authors":"Chenxia Yang, Ying Tang, Qian Yang, Bo Wang, Xianghao Liu, Yuxiang Li, Weixia Yang, Kunxuan Zhao, Gang Wang, Zongyuan Wang, Feng Yu","doi":"10.1016/j.jhazmat.2024.136036","DOIUrl":"10.1016/j.jhazmat.2024.136036","url":null,"abstract":"<p><p>Reducing nitrate (NO<sub>3</sub><sup>-</sup>) in an aqueous solution to ammonia under ambient conditions can provide a green and sustainable NH<sub>3</sub>-synthesis technology and mitigate global energy and pollution issues. In this work, a CuNi<sub>0.75</sub>-1,3,5-benzenetricarboxylic acid/nickel foam (CuNi<sub>0.75</sub>-MOF/NF) catalyst grown in situ was prepared via a one-pot method as an efficient cathode material for electrocatalytic nitrate reduction reaction (NO<sub>3</sub>RR). The CuNi<sub>0.75</sub>-MOF/NF catalyst exhibited excellent electrocatalytic NO<sub>3</sub>RR performance at -1.0 V versus a reversible hydrogen electrode, achieving an outstanding faradaic efficiency of 95.88 % and an NH<sub>3</sub> yield of 51.78 mg h<sup>-1</sup> cm<sup>-2</sup>. The <sup>15</sup>N isotope labeling experiments confirmed that the sole source of N in the electrocatalytic NO<sub>3</sub>RR was the NO<sub>3</sub><sup>-</sup> in the electrolyte. The reaction pathway for the electrocatalytic NO<sub>3</sub>RR was derived by in situ Fourier transform infrared spectroscopy and in situ differential electrochemical mass spectrometry. Density functional theory calculations revealed that the Ni element in the CuNi<sub>0.75</sub>-MOF/NF catalyst had excellent O-H activation ability and strong *H adsorption capacity. These *H species were transferred from the Ni sites to the *NO adsorption intermediates located on the Cu sites, providing a continuous supply of *H to Cu, thereby promoting the formation of *NOH intermediates and enhancing the hydrogenation process of the electrocatalytic NO<sub>3</sub>RR.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Melamine enhancing Cu-Fenton reaction for degradation of anthracyclines.","authors":"Yixuan Zhao, Jiahui Zhao, Shuqin Liu, Dunqing Wang, Jian Liu, Fei Zhang, Xiangshu Chen","doi":"10.1016/j.jhazmat.2024.136035","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136035","url":null,"abstract":"<p><p>Melamine (MA) enhanced Cu-Fenton process was developed for the degradation of anthracyclines. Taking daunorubicin (DNR) degradation as an example, we found that the initial first-order apparent constant of Cu<sup>2+</sup>/MA/H<sub>2</sub>O<sub>2</sub> system with a molar ratio of 1:8 for Cu<sup>2+</sup>:MA was 5.2 times higher than that of conventional Cu<sup>2+</sup>/H<sub>2</sub>O<sub>2</sub> system. The in-situ reductive coordination between Cu<sup>2+</sup> and MA facilitated the generation and stabilization of Cu<sup>+</sup> species, thereby accelerating the rate-limiting step of Cu<sup>2+</sup>/Cu<sup>+</sup> conversion and maintaining high levels of Cu<sup>+</sup> during the degradation process. Moreover, pre-synthesized Cu<sup>+</sup>-MA complexes (e.g., CM-250) further enhanced the efficiency of the Cu-Fenton reaction by increasing both the Cu<sup>+</sup> proportion and MA chelation. The apparent activation energy for DNR degradation in CM-250 mediated Fenton reaction (15.9 kJ mol<sup>-1</sup>) was lower than that in systems involving Cu<sup>2+</sup>/MA (41.2 kJ mol<sup>-1</sup>) and Cu<sup>2+</sup> (65.6 kJ mol<sup>-1</sup>). Enhanced generation of various reactive oxygen species (·OH,·O<sub>2</sub><sup>-</sup>, and <sup>1</sup>O<sub>2</sub>) was confirmed, with <sup>1</sup>O<sub>2</sub> playing a dominant role, significantly improving both degradation rate and mineralization degree for DNR. MA-enhanced Cu-Fenton process also offers a convenient alternative to effectively remove other anthracyclines and organic micropollutants, holding great promise for advancing advanced oxidation processes as well as practical large-scale degradation applications targeting multiple pollutants.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuhang He, Zhicheng Jiang, Ming Zeng, Shenbin Cao, Xiaohui Yu, Nan Wu
{"title":"Deciphering retention effect of extracellular polymeric substances to typical heavy metals and their interaction with key inner enzymes of Candidatus Kuenenia.","authors":"Yuhang He, Zhicheng Jiang, Ming Zeng, Shenbin Cao, Xiaohui Yu, Nan Wu","doi":"10.1016/j.jhazmat.2024.135367","DOIUrl":"10.1016/j.jhazmat.2024.135367","url":null,"abstract":"<p><p>This study employed spectroscopy, metagenomics, and molecular simulation to investigate the inhibitory effects of Cd(II) and Cu(II) on the anammox system, examining both intracellular and extracellular effects. At concentrations of 5 mg/L, Cd(II) and Cu(II) significantly reduced nitrogen removal efficiency by 41.46 % and 62.03 %, respectively. Additionally, elevated metal concentrations were correlated with decreased extracellular polymeric substances (EPS), thereby reducing their capacity to absorb heavy metals, particularly Cu(II), which decreased from 76.47 % to 14.67 %. Spectral analysis revealed alterations in the secondary structures of EPS induced by Cd(II) and Cu(II), decreasing the ratio of extracellular protein α-helix to (β-sheet + random coil), which resulted in looser extracellular protein configurations. The results of the metagenomics study showed that the abundance of Candidatus Kuenenia and its genes encoding nitrogen removal-related enzymes was reduced. The abundance of hzs-γ was reduced by 35.09 % at a concentration of 5 mg/L Cu(II). Conversely, genes associated with metal efflux enzymes, like czcR, increased by 54.86 % at 2 mg/L Cd(II). Molecular docking revealed robust bindings of Cd(II) to HZS-α (-342.299 ± 218.165 kJ/mol) and Cu(II) to HZS-γ (-880.934 ± 55.526 kJ/mol). This study elucidated the inhibitory mechanisms of Cd(II) and Cu(II) on the anammox system, providing insights into the resistance of anammox bacteria to heavy metals.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Screening diluents to optimize cesium contaminant separation using t-BAMBP extractant.","authors":"Kaizhong Li, Li Wang, Lei Zhang","doi":"10.1016/j.jhazmat.2024.135410","DOIUrl":"10.1016/j.jhazmat.2024.135410","url":null,"abstract":"<p><p>The widespread use of nuclear energy has raised concerns about nuclear safety and radioactive waste management, particularly due to the release of radioactive cesium. This study investigates the use of t-BAMBP (4-tert-butyl-2-(α-methylbenzyl) phenol) for the extraction and separation of cesium from simulate high concentration cesium containing wastewater, focusing on the selection of suitable diluents to enhance the efficiency of the process. We performed a systematic study using density functional theory (DFT) calculations to evaluate the intrinsic properties and interactions of various common diluents with t-BAMBP. The diluents studied include aromatic hydrocarbons (benzene, toluene, xylene), alkanes (cyclohexane, hexane, heptane), and alcohols (hexanol, octanol). Our computational results revealed that cyclohexane is the most suitable diluent due to its moderate solvation-free energy, high nonpolarity, and optimal balance between solubility and reactivity. Experimental validation confirmed the computational findings. The cyclohexane-diluted t-BAMBP system achieved the highest cesium extraction efficiency of over 94 %, with a separation factor (β<sub>Cs/K</sub>) of 767.67. Cyclohexane demonstrated the lowest toxicity and cost among the diluents evaluated, making it a safer and more economical choice for practical applications. The results of this study provide a comprehensive theoretical and experimental basis for the selection of diluents in the t-BAMBP extraction system, offering insights for the sustainable utilization of cesium resources and effective management of radioactive waste.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhenchao Zhou, Erping Cui, Abbas Ali Abid, Lin Zhu, Jianming Xu, Hong Chen
{"title":"Evaluating the impact of biochar amendment on antibiotic resistance genes and microbiome dynamics in soil, rhizosphere, and endosphere at field scale.","authors":"Zhenchao Zhou, Erping Cui, Abbas Ali Abid, Lin Zhu, Jianming Xu, Hong Chen","doi":"10.1016/j.jhazmat.2024.135440","DOIUrl":"10.1016/j.jhazmat.2024.135440","url":null,"abstract":"<p><p>Biochar amendment is a promising strategy for mitigating antibiotic resistance genes (ARGs) in soil and plants, but its effects on ARGs at field scale are not fully understood. Here, field trials were executed utilizing two plant varieties, Brassica juncea and Lolium multiflorum, with four types of biochar to investigate changes in ARGs and microbiome in soil, rhizosphere, root endophytes, and leaf endophytes. Results showed that biochar altered ARG distribution in soil and plant, and restrained their transmission from soil and rhizosphere to endophytes. A reduction of 1.2-2.2 orders of magnitude in the quantity of ARGs was observed in root and leaf endophytes following biochar addition, while no significant changes were observed in soil and rhizosphere samples. Procrustes and network analyses revealed significant correlations between microbial communities and mobile genetic elements with ARGs (P < 0.05). Besides, redundancy and variation partitioning analysis indicated that bacterial communities may play a dominant role in shaping the ARGs profile, contributing to 43 % of the variation observed in ARGs. These field results suggest that biochar amendment alone may not fully alleviate ARGs in soil, but it has a significant beneficial impact on food safety and human health by effectively reducing ARGs in plant endophytes.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141904015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liangliang Zhang, Ruoqing Ma, Lv Yang, Xiang Zhang, Hong He
{"title":"Corrigendum to \"Impact of environmental pollution on ant (Camponotus japonicus) development and labial gland disease\" [J. Hazard. Mater. 477 (2024) 135360].","authors":"Liangliang Zhang, Ruoqing Ma, Lv Yang, Xiang Zhang, Hong He","doi":"10.1016/j.jhazmat.2024.135448","DOIUrl":"10.1016/j.jhazmat.2024.135448","url":null,"abstract":"","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}