Journal of cancer research and therapeutics最新文献_第2页

Dosimetric evaluation of the tangential and supraclavicular breast radiotherapy fields junction in mono and dual isocentric techniques with practical measurement and comparison versus TomoDirect technique. 单、双等心技术对切向和锁骨上乳房放疗场交界处的剂量学评价与实用测量和与TomoDirect技术的比较。

IF 1.3

Journal of cancer research and therapeutics Pub Date : 2026-01-01 Epub Date: 2026-03-30 DOI: 10.4103/jcrt.jcrt_1814_25

Hossein Mirzaie, Nooshin Banaee, Hassan Ali Nedaie, Negar Samaei

{"title":"Dosimetric evaluation of the tangential and supraclavicular breast radiotherapy fields junction in mono and dual isocentric techniques with practical measurement and comparison versus TomoDirect technique.","authors":"Hossein Mirzaie, Nooshin Banaee, Hassan Ali Nedaie, Negar Samaei","doi":"10.4103/jcrt.jcrt_1814_25","DOIUrl":"10.4103/jcrt.jcrt_1814_25","url":null,"abstract":"Purpose: Accurate dose distribution at the junction of tangential and supraclavicular fields in breast radiotherapy is affected by various dosimetric uncertainties. This study evaluates the accuracy of the Monaco treatment planning system (TPS) and compares the dose distributions of monoisocentric (MI), dual-isocentric (DIHS, DIFS), and TomoDirect techniques to determine the most effective approach for dose accuracy and homogeneity.Materials and methods: An anthropomorphic phantom was used for experimental dose verification. Dose distributions of 3DCRT techniques (MI, dual-isocentric half-field (DIHS), and dual-isocentric full-field (DIFS) techniques) were calculated in Monaco TPS. Gamma index analysis was performed on dose profiles obtained at depths of 0.5, 1, 2, and 3 cm to evaluate the agreement between calculated and measured doses using EBT3 films. Additionally, TomoDirect 3DCRT (TD-3DCRT) and IMRT (TD-IMRT) techniques were compared with 3DCRT techniques.Results: The Monaco TPS with the XVMC algorithm demonstrated superior accuracy in the buildup region compared to the CCC algorithm, achieving gamma agreement above 90% at deeper depths. Among techniques, TD-IMRT provided the most homogeneous dose distribution at the junction of breast and supraclavicular PTVs. The MI technique resulted in lower dose variations than DIHS, DIFS, and TD-3DCRT and minimized dose escalation in the superficial layers of the supraclavicular region.Conclusion: The Monaco TPS with the XVMC algorithm ensures greater accuracy than the CCC algorithm. TD-IMRT offers optimal dose homogeneity at the field junction, while the MI technique achieves superior tumor dose coverage with reduced surface dose in the supraclavicular region, making it a preferable choice.","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"22 1","pages":"144-154"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epstein-Barr virus latent membrane protein-1 expression in nasopharyngeal carcinoma with clinical correlation. A study in North East India. eb病毒潜伏膜蛋白-1在鼻咽癌组织中的表达及临床意义印度东北部的一项研究。

IF 1.3

Journal of cancer research and therapeutics Pub Date : 2026-01-01 Epub Date: 2026-03-30 DOI: 10.4103/jcrt.jcrt_2091_25

Nito Yepthomi, Mejungsangla Longkumer, Khrutsozo Kikhi, Shirley Leivon, Clement Momin, Senjumroni S Kikon

{"title":"Epstein-Barr virus latent membrane protein-1 expression in nasopharyngeal carcinoma with clinical correlation. A study in North East India.","authors":"Nito Yepthomi, Mejungsangla Longkumer, Khrutsozo Kikhi, Shirley Leivon, Clement Momin, Senjumroni S Kikon","doi":"10.4103/jcrt.jcrt_2091_25","DOIUrl":"10.4103/jcrt.jcrt_2091_25","url":null,"abstract":"Background: Nasopharyngeal carcinoma (NPC) is a malignant mucosal epithelial neoplasm covering the nasopharynx with varied geographical distribution. A number of etiological factors have been associated with the development of NPC, and infection with Epstein-Barr virus (EBV) being a long-recognized contributor. The study aims to correlate the status of EBV infection in relation to NPC within the region.Methods: A retrospective cross-sectional study on histologically confirmed, archived tissues from January 2020 to December 2024 was conducted. Immunohistochemistry expression of latent membrane protein-1 (LMP-1) was used to detect EBV infection in the tissues.Results: A total of 112 cases were enrolled in this study. The mean age was 46.13 years with a male-to-female ratio of 2.6:1. The highest number of EBV-positive cases occurred in the 36-45 year age group. About 24.1% of the 112 samples tested positive for LMP-1, all of which were non-keratinizing carcinoma. Non-keratinizing carcinoma was the most common histopathological subtype (n = 109; 97.3%). Keratinizing had three cases, representing the remaining 2.7%. No cases of basaloid variant were recorded. The majority of LMP-1 positive cases were locally advanced.Conclusion: A significant proportion of NPC, particularly non-keratinizing histological subtype, positive for LMP-1 by immunohistochemistry were locally advanced. This method may serve as a practical approach for detecting EBV infection in tissue biopsies, particularly in resource-limited settings.","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"22 1","pages":"53-57"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study exploring the roles of desmoplastic reaction, tumor budding, tumor infiltrating lymphocytes, and depth of invasion as potential predictive parameters for extranodal extension in oral squamous cell carcinoma. 探讨结缔组织增生反应、肿瘤出芽、肿瘤浸润淋巴细胞和浸润深度作为口腔鳞状细胞癌结外扩散的潜在预测参数的作用。

IF 1.3

Journal of cancer research and therapeutics Pub Date : 2026-01-01 Epub Date: 2026-03-30 DOI: 10.4103/jcrt.jcrt_986_25

Trupti R Jansari, Jay Jansari, Vishwa Gevariya, Amit Chauhan, Shikha Shah

{"title":"A study exploring the roles of desmoplastic reaction, tumor budding, tumor infiltrating lymphocytes, and depth of invasion as potential predictive parameters for extranodal extension in oral squamous cell carcinoma.","authors":"Trupti R Jansari, Jay Jansari, Vishwa Gevariya, Amit Chauhan, Shikha Shah","doi":"10.4103/jcrt.jcrt_986_25","DOIUrl":"10.4103/jcrt.jcrt_986_25","url":null,"abstract":"Background: Head and neck squamous cell carcinomas constitute the eighth most common malignancy worldwide. Desmoplastic reaction (DR), tumor budding (TB), tumor-infiltrating lymphocytes (TILs), and depth of invasion (DOI) are some of the histological predictors of extranodal extension (ENE) and poor prognosis. In this study, we aimed to investigate their association in oral squamous cell carcinoma (OSCC).Materials and methods: This retrospective analytical study included 329 specimens of OSCC from our hospital. All data were collected from the histopathological records (e.g. age, gender, diagnosis, lymph node metastasis, ENE, DR, TB, TILs, and DOI). The datasets were analyzed using the Chi-square test and GraphPad InStat 3 software.Results: The majority of cases were seen in the age group of ≥60 years (221/329, 67.17%). Out of 35 ENE-positive patients, 31 (88.6%) had progressive OSCC. We found a significant association between immature DR (DR-I), high TB (TB-H), and low TILs with pathological DOI (pDOI) >10 mm (P value: <0.0001, 0.001, and < 0.001, respectively). There was a significant association between DR, TB, and TILs at the primary site with that of the ENE sites (P value: 0.02, 0.002, and 0.001, respectively). TB-H and pDOI >10 mm were the independent variables for the prediction of ENE (95% confidence interval [CI] = 1.07-4.95, P value: 0.003 and 95% CI = 1.11-1.52, P value: 0.0008, respectively). TB-H and pDOI >10 mm showed the highest sensitivity (85.1% and 97.1%, respectively) and DR-I exhibited the highest specificity (83.8%) for the presence of ENE.Conclusion: Detecting ENE not only predicts outcomes but also influences the treatment strategies and quality of life.","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"22 1","pages":"104-108"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal cell carcinoma with hemangioblastoma-like features: A rare entity and a dignostic challenge. 肾细胞癌伴血管母细胞瘤样特征：一种罕见的实体和诊断挑战。

IF 1.3

Journal of cancer research and therapeutics Pub Date : 2026-01-01 Epub Date: 2026-03-30 DOI: 10.4103/jcrt.jcrt_2228_22

Sabrine Derqaoui, Siham Mesmoudi, Kaoutar Znati, Zakia Bernoussi

引用次数: 0

CROSS at the crossroads-what lies next for chemoradiation in esophageal cancers. 十字路口的十字路口——食管癌放化疗的下一步是什么？

IF 1.3

Journal of cancer research and therapeutics Pub Date : 2026-01-01 Epub Date: 2026-03-30 DOI: 10.4103/jcrt.jcrt_381_25

Soorej B Kaliyath, Punyasha Mohanty

引用次数: 0

Identifying high-risk groups for recurrence in endometrial cancer: The role of ESMO-ESGO-ESTRO risk classification. 确定子宫内膜癌复发的高危人群：ESMO-ESGO-ESTRO风险分类的作用

IF 1.3

Journal of cancer research and therapeutics Pub Date : 2026-01-01 Epub Date: 2026-03-30 DOI: 10.4103/jcrt.jcrt_1917_24

Ömer F Elçiçek, Özge Yalici, Kubilay Karaboyun, Mehmet B Şentürk, Sevil Karabağ, Eyyüp Çavdar, Yıldız G Bilen, İlker Karaduman, Okan Avci, Erdogan S Seber

{"title":"Identifying high-risk groups for recurrence in endometrial cancer: The role of ESMO-ESGO-ESTRO risk classification.","authors":"Ömer F Elçiçek, Özge Yalici, Kubilay Karaboyun, Mehmet B Şentürk, Sevil Karabağ, Eyyüp Çavdar, Yıldız G Bilen, İlker Karaduman, Okan Avci, Erdogan S Seber","doi":"10.4103/jcrt.jcrt_1917_24","DOIUrl":"10.4103/jcrt.jcrt_1917_24","url":null,"abstract":"Objective: This study aimed to identify prognostic factors associated with recurrence in patients with stages I-III endometrial cancer who underwent surgical treatment.Methods: The data of all patients who were followed in our clinic 2010-2024 after surgery for endometrial cancer were analyzed retrospectively. Patients were classified into four groups-low, intermediate, high-intermediate, and high risk-according to the 2016 ESMO-ESGO-ESTRO consensus risk classification system.Results: A total of 200 patients were included in the study. The median follow-up duration for the cohort was 39 months (range: 7-180), and recurrence was observed in 26 patients (13%). The endometrioid subtype was present in 175 patients (87.5%). According to the ESMO-ESGO-ESTRO risk classification, 79 patients (39.5%) were in the low-risk group, while 49 patients (24.5%) were classified as high risk. Age over 65 years (P < 0.001), a high ECOG performance score (P < 0.001), non-endometrioid histology (P < 0.001), ≥50% myometrial invasion (P = 0.002), presence of lymphovascular space invasion (P < 0.001), high tumor grade (P < 0.001), abnormal p53 status (P = 0.002), increased tumor diameter (P < 0.001), and high ESMO-ESGO-ESTRO risk category (P < 0.001) were significantly associated with recurrence. In multivariate analysis, high ECOG performance score (P = 0.002) and high ESMO-ESGO-ESTRO risk group (P = 0.011) were identified as independent predictive factors.Conclusion: ECOG performance status is an accessible, low-cost clinical parameter that can be effectively integrated with the ESMO-ESGO-ESTRO risk classification to guide treatment decisions and identify high-risk patients for closer follow-up. In settings where molecular classification is not feasible, the 2016 risk stratification remains a reliable tool for therapeutic planning.","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"22 1","pages":"77-83"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the effects of intrathecal hyperbaric bupivacaine, levobupivacaine, and ropivacaine during interventional brachytherapy: A double-blind, randomized crossover study. 介入近距离放射治疗中鞘内高压布比卡因、左旋布比卡因和罗哌卡因的效果比较：一项双盲、随机交叉研究。

IF 1.3

Journal of cancer research and therapeutics Pub Date : 2026-01-01 Epub Date: 2026-03-30 DOI: 10.4103/jcrt.jcrt_2101_25

Prateek Maurya, Surjyendu Ghosh, Nishkarsh Gupta, Raghav Gupta, Rakesh Garg, Sachidanand J Bharati, Vinod Kumar, Brajesh K Ratre, Saurabh Vig, Prashant Sirohiya, Karun Kamboj, Seema Mishra, Sushma Bhatnagar

{"title":"Comparison of the effects of intrathecal hyperbaric bupivacaine, levobupivacaine, and ropivacaine during interventional brachytherapy: A double-blind, randomized crossover study.","authors":"Prateek Maurya, Surjyendu Ghosh, Nishkarsh Gupta, Raghav Gupta, Rakesh Garg, Sachidanand J Bharati, Vinod Kumar, Brajesh K Ratre, Saurabh Vig, Prashant Sirohiya, Karun Kamboj, Seema Mishra, Sushma Bhatnagar","doi":"10.4103/jcrt.jcrt_2101_25","DOIUrl":"10.4103/jcrt.jcrt_2101_25","url":null,"abstract":"Background: The choice of intrathecal local anesthetic influences discharge readiness and brachytherapy success. Evidence comparing hyperbaric bupivacaine, levobupivacaine, and ropivacaine is limited.Methods: In this double-blind, randomized crossover study, 40 women undergoing three brachytherapy sessions received, in random order, intrathecal hyperbaric ropivacaine 0.5%, levobupivacaine 0.5%, or bupivacaine 0.75%, with ≥1 week between sessions. Sensory and motor block onset/duration, hemodynamic variables, and complications were monitored. Data were analyzed using two-way analysis of variance (ANOVA) and Chi-square tests.Results: Ropivacaine produced the fastest sensory block (2.68 ± 0.20 min) versus levobupivacaine (2.72 ± 0.18 min) and bupivacaine (2.84 ± 0.22 min); the difference between ropivacaine and bupivacaine was -0.16 min (95% confidence interval (CI) -0.25 to -0.07). Sensory block lasted 57.2 ± 8.6, 58.5 ± 9.3, and 61.3 ± 7.7 min, respectively; ropivacaine shortened duration by 4.1 min versus bupivacaine (95%CI -7.7 to -0.5). Motor block onset was fastest with levobupivacaine (4.99 ± 0.50 min), followed by bupivacaine (5.41 ± 0.35 min) and ropivacaine (5.70 ± 0.25 min). Motor block lasted 60 ± 8.8, 62 ± 8.3, and 66 ± 5.0 min, respectively. Hypotension within 10 min occurred in 17.5%, 40%, and 85% with levobupivacaine, ropivacaine, and bupivacaine; tachycardia occurred in 15%, 35%, and 80%.Conclusions: All three agents provided effective spinal anesthesia for brachytherapy. Ropivacaine offered the shortest sensory/motor blocks; levobupivacaine afforded the most stable cardiovascular profile. Bupivacaine produced longer blocks but higher hypotension/tachycardia rates.","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"22 1","pages":"90-96"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimation of set-up errors and planning target volume margin in craniospinal irradiation: A prospective study. 一项前瞻性研究：颅脊柱照射中设置误差和计划靶体积裕度的估计。

IF 1.3

Journal of cancer research and therapeutics Pub Date : 2026-01-01 Epub Date: 2026-03-30 DOI: 10.4103/jcrt.jcrt_199_25

Sureka Dhayalan, Renu Madan, Arun S Oinam, Shikha Goyal, Narendra Kumar, Parsee Tomar, Divya Khosla, Rakesh Kapoor, Manpreet Singh, Ashma Avasthy, Sushant K Sahoo, Chandershekhar Gendle, Ashish Aggarwal, M Karthigeyan

{"title":"Estimation of set-up errors and planning target volume margin in craniospinal irradiation: A prospective study.","authors":"Sureka Dhayalan, Renu Madan, Arun S Oinam, Shikha Goyal, Narendra Kumar, Parsee Tomar, Divya Khosla, Rakesh Kapoor, Manpreet Singh, Ashma Avasthy, Sushant K Sahoo, Chandershekhar Gendle, Ashish Aggarwal, M Karthigeyan","doi":"10.4103/jcrt.jcrt_199_25","DOIUrl":"10.4103/jcrt.jcrt_199_25","url":null,"abstract":"Background: Cranio-spinal irradiation (CSI) planning is complex due to large target volume and numerous organs at risk (OARs). In the index study, we assessed set-up errors and daily shifts during CSI using cone-beam computed tomography (CBCT) on a conventional linear accelerator. The aim of the study is to calculate the planning target volume (PTV) margin for CSI.Materials and methods: CSI was planned by the volumetric modulated arc technique (VMAT). CBCT was taken daily for the first 3 days and twice weekly thereafter at the level of sella, T1, and L3 vertebrae. The CBCT images were coregistered with planning CT images to check daily shifts and to calculate systematic (Σ) and random errors (σ). PTV margins were calculated using Van Herk's (2.5Σ +0.7σ) formula.Results: A total of 20 medulloblastoma patients were analyzed. In the absence of daily imaging, the required PTV margins along lateral, longitudinal, and vertical directions were 7.8, 7.3, and 7.4 mm (8 mm isotropic margin); 10.1, 11.5, and 8.7 mm (12 mm isotropic margin); and 14.7, 12.4, and 10.6 mm (15 mm isotropic margin) for brain, upper spine, and lower spine, respectively.Conclusion: As the set-up inaccuracies increase towards lower spine, a uniform PTV margin risks missing the target or overexposing OARs to radiation, necessitating the need for the differential PTV margin. We calculated the isotropic PTV margin of 8 mm, 12 mm, and 15 mm in the brain, upper spine, and lower spine, respectively, in the absence of daily imaging. The margins can be further reduced using daily image guidance such as CBCT to minimize radiation exposure to surrounding normal tissue.","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"22 1","pages":"58-64"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Total neoadjuvant therapy with short-course radiotherapy: Clarifying response rates and long-term control. 全新辅助治疗与短期放疗：明确有效率和长期控制。

IF 1.3

Journal of cancer research and therapeutics Pub Date : 2026-01-01 Epub Date: 2026-03-30 DOI: 10.4103/jcrt.jcrt_3_26

Rashad Ismayilov

引用次数: 0

Patterns and outcomes of radiotherapy in octogenarian and nonagenarian patients: Experience from a Tertiary Care Center in North India. 八十多岁和九十多岁患者放射治疗的模式和结果：来自印度北部三级保健中心的经验。

IF 1.3

Journal of cancer research and therapeutics Pub Date : 2026-01-01 Epub Date: 2026-03-30 DOI: 10.4103/jcrt.jcrt_1022_25

Vandana Thakur, Pratibha Prashar, Hardik Sharma, Poorva Vias, Anupam Thakur, Ankita Pandey

{"title":"Patterns and outcomes of radiotherapy in octogenarian and nonagenarian patients: Experience from a Tertiary Care Center in North India.","authors":"Vandana Thakur, Pratibha Prashar, Hardik Sharma, Poorva Vias, Anupam Thakur, Ankita Pandey","doi":"10.4103/jcrt.jcrt_1022_25","DOIUrl":"10.4103/jcrt.jcrt_1022_25","url":null,"abstract":"Background: The elderly population (≥80 years) represents a growing demographic in oncology, yet remains underrepresented in clinical trials. With advancements in radiotherapy (RT) techniques, its role in managing cancer in octogenarians and nonagenarians warrants evaluation.Objective: To assess treatment patterns, outcomes, and prognostic factors in elderly cancer patients receiving RT at our institute.Methods: This retrospective study included 102 patients aged ≥80 years who underwent RT between 2022 and 2024. Data on demographics, tumor characteristics, RT intent and techniques, and outcomes were collected. Overall survival (OS) and progression-free survival (PFS) were analyzed using Kaplan-Meier methods and Cox regression.Results: Median patient age was 82 years; 70.6% were male. Head and neck cancers (36.3%) were most prevalent. Curative intent RT was delivered in 40% of patients, with hypofractionated regimens used predominantly in palliative settings. The two-year OS and PFS were 52% and 47%, respectively. On univariate analysis, Karnofsky performance status (KPS > 70%), treatment intent, and RT dose >30 Gy were significantly associated with better OS and PFS (P < 0.05). However, multivariate analysis identified only KPS >70% as an independent predictor for both OS (hazard ratio [HR] =0.408, P = 0.04) and PFS (HR = 0.360, P = 0.01).Conclusion: RT is a feasible and effective treatment modality in cancer patients aged ≥ 80 years, particularly in those with good performance status. These findings advocate for individualized treatment decisions based on functional status rather than chronological age and emphasize the need for more age-inclusive clinical research.","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"22 1","pages":"46-52"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0