Journal of cancer research and therapeutics最新文献

{"title":"Predicting the incidence of hematologic toxicity in concurrent chemoradiotherapy for cervical cancer using pelvic MRI imaging.","authors":"Xue Ke, Chunbao Zang, Ailing Wu, Yunqin Liu","doi":"10.4103/jcrt.jcrt_205_24","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_205_24","url":null,"abstract":"<p><strong>Background and objectives: </strong>Cervical cancer is one of the most common malignancies in women. Concurrent chemoradiotherapy (CRT) is the standard treatment approach for this disease; however, it can result in severe hematologic toxicity (HT), affecting the treatment outcomes and prognosis. This study aimed to use pelvic magnetic resonance imaging (MRI) to delineate the red bone marrow and analyze its relationship with HT. The objective was to limit the red bone marrow dose and reduce the incidence of HT in CRT for cervical cancer, thereby improving the treatment efficacy and survival rates.</p><p><strong>Methods: </strong>Detailed hematological assessments were performed on 34 patients undergoing CRT for cervical cancer. The dose-volume parameters of active bone marrow regions (BMact) and whole bone marrows (BMtot) were analyzed using pelvic MRI. Univariate and multivariate logistic regression analyses were conducted to investigate the correlations between these parameters and HT.</p><p><strong>Results: </strong>Decreases in white blood cells, neutrophils, platelets, and hemoglobin were observed after CRT. Univariate analysis revealed significant correlations between HT occurrence and the dose-volume parameters of BMact and BMtot. Notably, BMact V15, BMtot V10, and BMtot V15 were significantly associated with grade 2 or higher HT incidence.</p><p><strong>Conclusion: </strong>These findings suggest that limiting the dose to red bone marrow may reduce the incidence of HT in CRT for cervical cancer. BMact V15 and BMtot V15 levels may be associated with HT risk. Reducing the occurrence of HT contributes to the completion of the treatment regimen, thereby improving the treatment efficacy and survival rates.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 2","pages":"354-361"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transarterial chemoembolization combined with percutaneous ethanol injection for the treatment of hepatocellular carcinoma at high-risk areas.","authors":"Wencong Feng, Yapan Guo, Shitao Lu, Yu Yin, Tongqin Xue, Zhi Li","doi":"10.4103/jcrt.jcrt_2226_24","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_2226_24","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the efficacy and safety of the combination of transarterial chemoembolization (TACE) with percutaneous ethanol injection (PEI) in the treatment of hepatocellular carcinoma (HCC) at high-risk areas.</p><p><strong>Materials and methods: </strong>Data from cases involving TACE combined with PEI for HCC treatment in high-risk regions were analyzed from January 2016 to December 2023 at three medical centers. High-risk areas were defined as those less than 10 mm from the diaphragm, gallbladder, gastrointestinal tract, or secondary branches of the portal vein or bile duct. The guidance modalities for PEI were computed tomograph (CT) and cone beam computed tomograph (CBCT). Each lesion received only one session of TACE combined with PEI. Treatment efficacy was assessed by complete ablation rate of target lesions at the 2-month follow-up. Factors affecting the efficacy were determined by binary logistic regression analysis. The difference in efficacy between CT-guided and CBCT-guided PEI was analyzed by Chi-square test.</p><p><strong>Results: </strong>About 62 patients with 67 target lesions were included in the analysis. The overall complete ablation rate lesion-based was 80.6% (54/67). Lesion diameter was significantly associated with the probability of achieving complete ablation (OR = 6.89, 95% CI: 1.57-30.234, P = 0.011). There was no significant difference in the complete ablation rates between CT- and CBCT-guided approaches (83.3% vs. 80%, P = 0.867). No severe complications occurred during treatment or follow-up.</p><p><strong>Conclusion: </strong>The combination of TACE with a single PEI proves to be a safe and effective treatment for HCC in high-risk areas. There was no difference between CBCT-guided and CT-guided outcomes.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 2","pages":"395-400"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Largest dimension of ground-glass nodule-like lung cancer: Comparison of computed tomography imaging and resected pathological specimens.","authors":"Jingyi Gao, Xiaoran Chen, Yingying Zheng, Xia Yang, Guoliang Xue, Nan Wang, Zhichao Li, Qing Sun, Ping Zhou, Qingshi Zeng, Xin Ye","doi":"10.4103/jcrt.jcrt_102_25","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_102_25","url":null,"abstract":"<p><strong>Purpose: </strong>The largest dimension of the tumor (LDT) remains a key determinant of local tumor control regardless of surgical resection, radiotherapy, and image-guided thermal ablation. This prospective study aimed to determine the consistency of LDT by comparing computed tomography (CT) images of ground-glass nodule (GGN)-like lung cancer with resected pathological specimens.</p><p><strong>Materials and methods: </strong>A total of 163 patients (54 males and 109 females, a mean age of 56.2 ± 10.9 years) with 163 lesions demonstrating GGN-like lung cancer (the largest dimension of ≤20 mm, pure GGNs in 49 and mixed GGNs in 114) underwent surgical resection from May 2023 to July 2024, with adenocarcinoma as the pathology type of all included patients. LDT for each patient with GGN-like lung cancer was evaluated by two-dimensional (2D) CT imaging (cross-section, 2D-LDT), a three-dimensional (3D) reconstruction system (3D-LDT), and pathological specimens (P-LDT). R version 4.2.1 software was used for statistical analyses.</p><p><strong>Results: </strong>The median LDT for measuring all lesions with GGN-like lung cancer were 10.0 mm, 11.6 mm, and 11.7 mm in 2D-LDT, 3D-LDT, and P-LDT, respectively. A significant difference was observed in the 2D-LDT compared with the 3D-LDT (P = 0.0002) as well as between the 2D-LDT and P-LDT (P = 0.0000118), but no statistically significant difference was found between the 3D-LDT and P-LDT (P = 0.7394).</p><p><strong>Conclusions: </strong>3D-LDT demonstrated high consistency with P-LDT for determining GGN-like lung cancer of ≤20 mm. Preoperative 2D-CT may be underestimated in comparison with pathological invasive LDT.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 2","pages":"409-416"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A major complication of microwave ablation in a patient with surgically treated ground-glass opacity.","authors":"Chao Xu, Yuan Wang, Yongjie Li, Qingliang Feng","doi":"10.4103/jcrt.jcrt_2479_24","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_2479_24","url":null,"abstract":"<p><strong>Abstract: </strong>A 64-year-old male patient with pulmonary ground-glass opacity (GGO) underwent microwave ablation treatment. An early cavity occurred and induced subsequent serious major complications of pneumothorax and hemothorax. The chest tube intervention was conducted, but the symptoms deteriorated. Finally, pulmonary wedge resection was conducted, and a lung tissue tear of 5 cm was observed during the operation.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 2","pages":"518-521"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restricted cubic spline analysis: Age-dependent relationship between MAGEA12 and hepatocellular carcinoma prognosis.","authors":"Jun Wang, Kefen Zhang, Xiuming Tang, Yinzhu Chen, Zhen Ye","doi":"10.4103/jcrt.jcrt_1690_24","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_1690_24","url":null,"abstract":"<p><strong>Objectives: </strong>Currently, understanding of the nonlinear relationship between age and hepatocellular carcinoma (HCC) prognosis is insufficient. Thus, this study aimed to analyze the relationship between age at HCC diagnosis and overall survival (OS) and identify possible influencing mechanisms.</p><p><strong>Methods: </strong>Clinical data from the TCGA public database were analyzed. Restricted cubic spline and segmented logistic regression were employed to explore the nonlinear relationship between age at diagnosis and mortality risk following hepatectomy. Furthermore, bioinformatics methods were employed to understand the possible mechanisms of this nonlinear relationship at the genetic level.</p><p><strong>Results: </strong>The results indicated a nonlinear relationship between age at diagnosis and OS, with the age of 60 years identified as a critical point. Segmented regression showed that age ≥60 years is an unfavorable prognostic factor. The \"DNA mismatch repair\" pathway was considerably enriched in patients aged <60 years. However, the gene mutation rate of \"APOB,\" \"MUC16,\" \"ALB,\" and \"PCLO\" and the median tumor mutation burden were relatively more evident in patients aged ≥60 years. MGEA12 was more highly expressed in tumor tissues than in normal ones, particularly in patients aged ≥60 years. The survival rate of the high-expression group was lower than that of the low-expression group. At the mRNA level, the MGEA12 expression in Huh-7 and SUN449 was higher than that in the HSC-LX2 cell line.</p><p><strong>Conclusion: </strong>A nonlinear relationship was found between age at HCC diagnosis and OS, with the age of 60 years being the critical point. MGEA12 may affect the prognosis of elderly people.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 2","pages":"457-464"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral and intestinal flora translocation and tumor development.","authors":"Zhiyuan Ye, Linglin Gao, Zhi Guo, Qiang Wang","doi":"10.4103/jcrt.jcrt_50_24","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_50_24","url":null,"abstract":"<p><strong>Abstract: </strong>Cancer metastasis is the leading cause of death in patients. In recent years, there has been a growing recognition of the role of tumor-associated microflora in tumor metastasis. The connection between oral and gut microflora and the tumor microenvironment has also been extensively studied. The migration of oral and gut microflora is closely associated with tumor development. Although there is awareness regarding the significant impact of microbial communities on human health, the focus on their relationship with host organisms, particularly those related to tumor-associated microflora, remains inadequate. As an integral part of the body, the host microflora is crucial for regulating the cancer risk and preventing tumor recurrence. The oral-gut axis plays an indispensable role in human immunity, and many types of cancers, such as colorectal, pancreatic, and breast, are significantly influenced by their internal microbial communities. However, further exploration into the mechanisms underlying the role of the intratumoral microflora in cancer is necessary to achieve a comprehensive understanding. We have summarized and analyzed related articles in PubMed. This article reviews the impact of the oral-gut axis on the human immune system, explores the relationship between the translocation of the oral and intestinal flora and the tumor microenvironment, analyzes the specific mechanisms involved in the translocation of the oral and intestinal microflora during the evolution and progression of tumors, and elaborates on the correlations between the occurrence and development of tumors and the changes in the microflora. Finally, a summary of these abovementioned points is provided.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 2","pages":"323-333"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective evaluation of small bowel dose and acute gastrointestinal toxicity during pelvic radiotherapy for gynaecologic malignancies.","authors":"Febin Antony, Maria Philip, C Jomon Raphael, K Mathew Varghese, B Rajkrishna, Mathew P Jiniw, Minu Boban, Varun Narayan","doi":"10.4103/jcrt.jcrt_2378_24","DOIUrl":"10.4103/jcrt.jcrt_2378_24","url":null,"abstract":"<p><strong>Introduction: </strong>Acute gastrointestinal (GI) toxicity is common in patients receiving pelvic radiotherapy (RT) and the small bowel (SB) is a dose-limiting organ at risk. There is a quandary in the dose constraints for SB while using intensity-modulated radiotherapy (IMRT) for gynecological malignancies.</p><p><strong>Objectives: </strong>To investigate the correlation between the radiation dose received by SB and the incidence of acute lower GI toxicities, and to identify dose parameters that may reduce toxicity risk.</p><p><strong>Materials and methods: </strong>Fifty-eight patients diagnosed with gynecological cancers and received RT with IMRT technique were analyzed in this prospective observational study. Oral contrast was administered during the simulation scan as per institution protocol. The individual SB loops were delineated as per Radiation Therapy Oncology Group (RTOG) consensus guidelines. The volume of SB (cc) receiving 10, 15, 20, 30, and 40 Gy were analyzed. Grades of acute GI toxicities were assessed weekly according to RTOG scoring criteria. The odds of developing GI toxicities were analyzed using a logistic regression test.</p><p><strong>Results: </strong>Out of the study population, 26 patients (45%) were diagnosed with carcinoma of the cervix, and 32 patients (55%) were diagnosed with carcinoma of the endometrium. 33 patients (57%) also received concurrent chemotherapy. Overall, Grade I, II, and III GI toxicities were observed in 32%, 62%, and 5% of patients, respectively. None of the patients developed GI toxicity during weeks 1 and 2 of RT. A significantly higher incidence of ≥grade 2 GI toxicity was observed with a mean SB-V30 Gy >210 cc (P = 0.001) and SB-V40 Gy >103 cc (P = 0.001). Patients with SB-V30 Gy ≥210 cc had 2.2 times higher odds of developing ≥ grade 2 enteritis compared to those with SB-V30 Gy <210 cc (OR = 2.2; 95% CI, 1.5-6.3; P = 0.003). Likewise, the odds of developing ≥grade 2 enteritis were 2.9 times higher in patients with SB-V40 Gy ≥103 cc compared to those with SB-V40 Gy <103 cc (OR = 2.90; 95% CI, 2.1-5.1; P = 0.002).</p><p><strong>Conclusions: </strong>Higher radiation doses to individual SB loops lead to a decrease in cellular reserves of intestinal mucosa resulting in ≥grade 2 acute GI toxicity in patients receiving IMRT for gynecological malignancies.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 3","pages":"644-648"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Target volume definition of lung cancer between PET-CT and CT-based dosimetric planning.","authors":"Priya Tawri, Shankar L Jakhar, Guman Singh, Neeti Sharma, H S Kumar, M Athiyaman, A Hemalatha, Rajshekhar Agnivashya, Kanika Jain","doi":"10.4103/jcrt.jcrt_1448_24","DOIUrl":"10.4103/jcrt.jcrt_1448_24","url":null,"abstract":"<p><strong>Background: </strong>Lung cancer is the most common cancer worldwide with an incidence and mortality of 12.4% and 18.7%, respectively. Positron emission tomography-computed tomography (PET-CT) helps in both downstaging T criteria and upstaging disease by detection of distant extrathoracic or nonregional nodal metastases.</p><p><strong>Aim: </strong>The study is intended to compare target volume definitions between PET-CT and CT-based dosimetric planning for lung carcinoma patients on specific treatment planning parameters like tumor volumes and the number and location of involved nodes.</p><p><strong>Methodology: </strong>It was a prospective observational study done on 50 histologically proven, non-small-cell lung carcinoma patients. Two sets of target volumes were contoured independently - one based on the fused PET-CT images and the other based on CT alone.</p><p><strong>Results: </strong>The gross tumor volume on CT-based contours was 130.84 cc and that with PET was 95.84 cc, with an overall mean reduction of 35 cc on PET-CT as compared to CT, which was statistically significant with a P value of 0.004. A similar trend was seen with clinical target volume with a P value of 0.005. There was no significant difference seen in the normal tissue dose, represented by V20 (P = 0.418), mean lung dose (P = 0.185), and mean esophageal dose (P = 0.142) between PET-CT and CT-derived plans.</p><p><strong>Conclusion: </strong>FDG-F18 PET-CT is a valuable tool in the management of patients with non-small-cell lung cancer. It demonstrated advantages in reducing radiation doses to critical organs compared to CT, suggesting improved sparing of normal tissues while maintaining effective tumor targeting.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 3","pages":"547-550"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the efficacy of automated machine learning enhanced planning system and a comparative analysis with manual planning system.","authors":"Anand Jadhav, Ajinkya Gupte, Sachin Rasal, Omkar Awate, Prasad Raj Dandekar","doi":"10.4103/jcrt.jcrt_1373_24","DOIUrl":"10.4103/jcrt.jcrt_1373_24","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The aim of radiotherapy treatment is to deliver a high dose of radiation precisely to the target volume while minimizing exposure to the surrounding organs at risk. This approach maximizes the likelihood of tumor control and reduces the risk of adverse side effects. Treatment planning systems (TPS) are crucial in achieving this goal. However, the manual planning process is time-consuming, resource-intensive, and subject to variability based on the skill and experience of individual planners. Automated planning aims to reduce inter-plan variation and planning duration while maintaining or improving plan quality. Varian Medical Systems introduced the Ethos platform, an automated planning and delivery system utilizing an Intelligent Optimization Engine (IOE). This study evaluates the efficacy of automated plan generation using the Varian Ethos IOE for prostate cancer treatment, compared with plans generated using the Eclipse TPS with the anisotropic analytical algorithm (AAA).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;Fifteen retrospective patients diagnosed with prostate cancer, treated with a dose of 60 Gy in 20 fractions to the prostate, were included. Treatment approved Eclipse plans were recalculated and reoptimized with the same objective function, and then exported to the Ethos TPS. The Ethos TPS generates a total of five plans-7-, 9-, and 12-field IMRT plans, and 2- and 3-arc VMAT plans, respectively, maintaining fixed beam geometry. Two additional plans were also generated on Ethos: one maintaining identical parameters from Eclipse for calculation purposes, and a second involving re-optimization. The primary objective was to assess the number of prespecified dose constraints met, while the secondary objective was to compare dosimetric parameters, such as target coverage, dose conformity, dose homogeneity, and OAR sparing between the Ethos and Eclipse plans.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;There was no statistically significant difference between the Eclipse plan and the Ethos-generated plans in meeting the prespecified criteria. For PTV coverage, mean values for V95 &gt; 95% were achieved across all plans. The mean values for V105 &lt; 5% were well below the threshold, indicating minimal hotspots. The conformity index (CI) was close to 1, and the homogeneity index (HI) was close to 0 across all plans, indicating good dose distribution and uniformity. OAR sparing for the urinary bladder, rectum, and penile bulb was within acceptable limits, meeting dose constraints in all plans. Monitor unit (MU) values were higher for Ethos plans compared to Eclipse but remained within clinically acceptable ranges.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The Ethos TPS, using its IOE, demonstrated the capability to generate high-quality radiotherapy plans for prostate cancer that are comparable to those produced by the Eclipse TPS. This suggests that the automated planning system can effectively reduce planning time and resource co","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 3","pages":"593-601"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mathematical analysis of gamma index on pretreatment patient-specific quality assurance with octavius 4D rotational phantom for 2d and 3d space.","authors":"Shilpa Tiwari, Vindhyavasini Prasad Pandey, Teerthraj Verma, Devi Prasad Pandey, Ghizal Firdous Ansari","doi":"10.4103/jcrt.jcrt_1766_24","DOIUrl":"10.4103/jcrt.jcrt_1766_24","url":null,"abstract":"<p><strong>Introduction: </strong>Gamma index is one of the widely used metrics to evaluate the patient-specific quality assurance parameters for the delivery of accepted treatment plans. The dimensionality of gamma metric has changed from two-dimensional to three-dimensional with due course of time, and presently, we are in a verge to assess the three-dimensional metric in a volumetric scale. The present study aimed at determining the mathematical relationship between 2D, 3D, and 3D volumetric gamma index for patient-specific quality assurance parameters using the Octavius 4D rotational phantom.</p><p><strong>Methods and materials: </strong>Twenty-five patients planned with volumetric modulated radiotherapy for different sites were selected for the study to analyze the pretreatment parameters correlation using 2D- Array 1500 rotational Octavius phantom. The data were collected in both local and global dose modes at 5%/5 mm, 4%/4 mm, 3%/3 mm, and 2%/2 mm for 2D, 3D, and Volmetric 3D gamma index. The passing criterion of Gamma <=1.0 is applicable throughout the study.</p><p><strong>Results: </strong>A significant jump in the passing rate percentage was found from 2D planar to 3D planar mode analysis. Decreased passing percentage values in both local and global modes from 3D planar to 3D volumetric mode analysis were recorded. The 2D and 3D planar analysis shows a significant level of correlation which is less pronounced in 3D planar to 3D volumetric gamma metric evaluation.</p><p><strong>Conclusion: </strong>The radiotherapy centers having the license for 2D planar gamma index analysis can retrace the results into 3D planar analysis, which is always a better passing percentage rate, and no such implication of 3D volumetric analysis was found as the passing rate significantly shows a high degree of entropy in results. The effective use of 3D volumetric gamma metric can be appreciable if the CT overlay parameter is used in assessment and qualitatively the quantification can be predicted.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 3","pages":"657-663"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}