{"title":"Comment on \"The spectrum of late radiation sequelae in head and neck cancer\".","authors":"Efsun Somay, Sibel Bascil, Duriye Ozturk, Erkan Topkan","doi":"10.4103/jcrt.jcrt_2184_24","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_2184_24","url":null,"abstract":"","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 1","pages":"319-320"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plasmablastic lymphoma with cutaneous manifestations in an immunocompetent man: A rare case report with literature review.","authors":"Dimple Chaudhary, Shramana Mandal, Nidhi Verma, Prerna Arora, Pawanindra Lal","doi":"10.4103/jcrt.jcrt_922_22","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_922_22","url":null,"abstract":"<p><strong>Abstract: </strong>Plasmablastic lymphoma (PBL) is an aggressive lymphoma and is regarded as a subtype of diffuse large B-cell lymphoma (DLBCL). It is generally found in immunosuppressed and transplanted individuals, but very less often in immunocompetent individuals. It shows positivity for Epstein-Barr virus (EBV) infection in 60% of cases. Few cases have been seen in immunocompetent patients, but rarely as cutaneous manifestations. In the recent past, very few studies have discussed the cytological features of PBL. Due to its rarity, diagnosis and management of this unique entity pose a challenge. Moreover, it is also important to differentiate this entity from other close mimics, especially PBL, which morphologically resembles PBL. We hereby present a rare case of aggressive PBL, presenting with multiple cutaneous manifestations, initially diagnosed on aspiration cytology.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 1","pages":"247-250"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epithelial myoepithelial carcinoma: A case report.","authors":"Ravinder Kaur, Wineeta Melgandi, Arun Kumar Rathi, Kishore Singh, Fazlu Rahman, Shramana Mandal","doi":"10.4103/jcrt.jcrt_2721_22","DOIUrl":"10.4103/jcrt.jcrt_2721_22","url":null,"abstract":"<p><strong>Abstract: </strong>Epithelial myoepithelial carcinoma is a rare tumor with the parotid gland being the most common primary site of origin. The tumor may also very rarely originate in minor salivary glands of the soft palate. Due to the rarity of its occurrence and histogenesis, clear-cut therapeutic guidelines are not defined. The present report describes the case of a 56-year-old female patient who was diagnosed to have epithelial myoepithelial carcinoma (EMC) of the minor salivary gland of the soft palate, Stage T2 N0 M0 (Stage group II). The patient was treated with radical radiotherapy followed by adjuvant chemotherapy and is alive with no evidence of disease after 12 months following the end of treatment.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":" ","pages":"182-185"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139543664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sheragaru H Chandrashekhara, Roshni Anand, Ashu S Bhalla, Priyanka Naranje, Kapil Goyal, Deepam Pushpam
{"title":"Lymphatic intervention in the management of chylothorax in FDG-PET/CT negative Hodgkin lymphoma.","authors":"Sheragaru H Chandrashekhara, Roshni Anand, Ashu S Bhalla, Priyanka Naranje, Kapil Goyal, Deepam Pushpam","doi":"10.4103/jcrt.jcrt_1232_23","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_1232_23","url":null,"abstract":"<p><strong>Abstract: </strong>Chylothorax is an infrequent nontraumatic cause of Hodgkin's lymphoma, and chylous pericardial effusion is a rare association. Only a few cases of unilateral chylothorax with chylous pericardial effusion in Positron emission tomography (PET)-negative Hodgkin's lymphoma are documented worldwide. Hence, we report a case of a 21-year-old female with Hodgkin's lymphoma on chemotherapy who presented with breathlessness and facial puffiness. MR lymphangiography revealed obstruction of the terminal part of the thoracic duct with chyloreflux in the left infraclavicular region. Management included both traditional medical and interventional approaches to disrupt the lymphatic network. Intranodal lymphangiography with lipiodol confirmed the MRI findings. Drain output is reduced as lymphangiography can be therapeutic.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 1","pages":"233-236"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"FLASH radiotherapy: Challenges and its future.","authors":"Seema Sharma, Daya Nand Sharma","doi":"10.4103/jcrt.jcrt_1989_24","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_1989_24","url":null,"abstract":"","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 1","pages":"3-4"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rita Yadav, Binita Kumari, Preeti Agarwal, Sonu Singh
{"title":"Report of tall cell variant of papillary thyroid carcinoma in struma ovarii: An exceptional histology finding.","authors":"Rita Yadav, Binita Kumari, Preeti Agarwal, Sonu Singh","doi":"10.4103/jcrt.jcrt_2073_22","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_2073_22","url":null,"abstract":"<p><strong>Abstract: </strong>Malignant struma ovarii (SO) is very rare, and the tall cell variant (TCV) of papillary thyroid carcinoma (PTC) arising in SO is even rarer and an exceptionally unique morphological observation. A 39-year-old woman presented with lower abdominal pain and abdominal swelling. Contrast-enhanced computed tomography (CECT) of the whole abdomen revealed a multiloculated cystic mass with peripheral amorphous calcification, which was arising from the right ovary. The patient underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy. In histology, the ovary was completely replaced by thyroid parenchyma (SO) with areas of papillary thyroid carcinomatous transformation morphologically consistent with tall cell features. On immunohistochemistry (IHC), tumor cells showed expression for TTF-1 and thyroglobulin and were negative for CK19. The patient underwent total thyroidectomy, postoperative radioactive iodine ablation, and levothyroxine suppressive therapy. A three-month follow-up is uneventful. The current case not only provides insight into the diagnosis and morphological aspect of this interestingly rare occurrence but also emphasizes the need for a careful and extensive sampling of ovarian specimens.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 1","pages":"196-199"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Winsome Kumar, Shashwat Lohia, Anu Agrawal, Vikas Yadav
{"title":"A rare case of synchronous cervical squamous cell carcinoma and invasive ductal carcinoma of breast.","authors":"Winsome Kumar, Shashwat Lohia, Anu Agrawal, Vikas Yadav","doi":"10.4103/jcrt.jcrt_2653_23","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_2653_23","url":null,"abstract":"<p><strong>Abstract: </strong>Multiple primary neoplasms in the same patient can be of synchronous and metachronous types and are related to common etiologies and common genetic factors. We present a case report of 56-year-old female with the synchronous primary of breast and cervix and the unique challenges we faced in the management. Breast and cervical malignancies have contrasting risk factors and hence lies the significance of this synchronous presentation. The only identifiable commonality lies in the STK gene. We also present a review of the literature regarding similar presentations and a discussion on the possible source of origin of such a unique scenario.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 1","pages":"281-283"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samarpita Mohanty, Sangram Pradhan, Divya Patil, Razi A Khwaja, Jivanshu Jain, Kamlesh Bagul, Santosh Tambe, Sangeeta Kakoti, Jayant S Goda
{"title":"Evaluation of three-dimensional setup errors using cone beam computed tomography (CBCT) for mediastinal lymphoma treated with volumetric modulated arc radiotherapy (VMAT) and deep inspiratory breath-hold (DIBH) technique.","authors":"Samarpita Mohanty, Sangram Pradhan, Divya Patil, Razi A Khwaja, Jivanshu Jain, Kamlesh Bagul, Santosh Tambe, Sangeeta Kakoti, Jayant S Goda","doi":"10.4103/jcrt.jcrt_1218_24","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_1218_24","url":null,"abstract":"<p><strong>Background: </strong>Deep Inspiration Breath Holding (DIBH) for mediastinal lymphomas can potentially reduce late toxicities, especially cardiovascular and pulmonary toxicities, yet the geographical miss of target volume remains an area of concern. We conducted a study to derive optimal CTV-PTV margins for adequate coverage in mediastinal lymphomas treated with DIBH technique.</p><p><strong>Methods and materials: </strong>Thirty patients with mediastinal lymphoma treated with radiotherapy using DIBH were included in this prospective study. Cone Beam Computed Tomography (CBCT) images were used as image guidance, and rigid registration was done with planning CT. The setup errors in anteroposterior (AP), supero-inferior (SI), and mediolateral (ML) directions were recorded. The random errors (σ) and systematic errors (Σ) were calculated using Stroom's and Van Herk's formulae to derive the PTV margins.</p><p><strong>Results: </strong>Four hundred nine CBCT registrations were analyzed. The median number of registrations per patient was 14 (range: 5-25). The random errors were 0.227 cm, 0.308 cm, and 0.232 cm in AP, SI, and ML directions, respectively, while the systematic errors were 0.366 cm, 0.370 cm, and 0.316 cm, respectively. The CTV-PTV margins were 0.7 cm (AP), 0.9 cm (SI), and 0.7 cm (ML) as per Stroom's and 0.8 cm (AP), 1.0 cm (SI), 0.8 cm (ML) as per Van Herk's formulae.</p><p><strong>Conclusion: </strong>An asymmetric PTV margin of 1.0 cm longitudinally and 0.8 cm both anterior-posteriorly and laterally is adequate to cover setup uncertainties for patients treated with mediastinal radiotherapy using the DIBH technique at our center. The setup margins can further be reduced with daily image guidance and an online correction protocol.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 1","pages":"104-110"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Swetha Muvva, Priyathersini Nagarajan, Arthi Arun, Sri Gayathri Shanmugam
{"title":"Double trouble: Synchronous T-cell lymphoma and colonic adenocarcinoma.","authors":"Swetha Muvva, Priyathersini Nagarajan, Arthi Arun, Sri Gayathri Shanmugam","doi":"10.4103/jcrt.jcrt_302_23","DOIUrl":"10.4103/jcrt.jcrt_302_23","url":null,"abstract":"<p><strong>Abstract: </strong>Synchronous tumors consisting of colorectal adenocarcinoma and lymphoma are infrequent and pose a tricky situation to the clinicians for the management. We present a case of a 67-year-old male ex-alcoholic who presented with loss of appetite, weight loss for 3 weeks, high fever, abdominal pain for 2 days, and difficulty in passing stool for 1 month. Upon examination and further investigations, a diagnosis of stage 4 peripheral T-cell lymphoma, moderately differentiated sigmoid colon adenocarcinoma with liver metastasis, and SIADH-tumor associated was made. In light of the case's metastatic disease, the tumor board opted to proceed with stenting for the sigmoid colon mass and chemotherapy for the peripheral T-cell lymphoma. It is certain that with the development of regular screening programs and extensive evaluation across the country, early identification and diagnosis can lead to efficient treatment plans and can improve the prognosis significantly.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 1","pages":"223-225"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Myelomatous pleural effusion: An atypical initial presentation.","authors":"Simran J Thakkar, Namita Padwal, Niteen Karnik","doi":"10.4103/jcrt.jcrt_2730_22","DOIUrl":"https://doi.org/10.4103/jcrt.jcrt_2730_22","url":null,"abstract":"<p><strong>Abstract: </strong>Malignant pleural effusion is usually due to metastatic involvement of the pleura from primary malignancies of the lung, breast, ovaries, sarcoma, lymphomas and mesothelioma. Pleural effusion as an initial presentation of multiple myeloma (MM) is extremely rare (<1%) and is associated with a poor prognosis. Here, we present a case of a 50-year-old male who presented with unilateral massive pleural effusion, lung mass, renal failure and anaemia secondary to MM.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 1","pages":"189-192"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}