Journal of cancer research and therapeutics最新文献

{"title":"Adenoid cystic carcinoma of the lacrimal gland: A rare case report with literature review.","authors":"Anurag Singh, Shalini Rawat, Mala Sagar, Uma S Singh","doi":"10.4103/jcrt.jcrt_214_24","DOIUrl":"10.4103/jcrt.jcrt_214_24","url":null,"abstract":"<p><strong>Abstract: </strong>Adenoid cystic carcinoma (ACC) primarily originates from the minor and major salivary glands of the head and neck regions. ACC affecting the eye and orbit (including the lacrimal gland, sac, and duct) was determined to account for about 1.8% of all cases. A poor overall prognosis and a tendency for local recurrence and metastasis despite vigorous therapy characterize lacrimal gland ACCs. There are no clear-cut guidelines for treating these rare tumors in unusual places, but recent literature suggests orbital excision with or without bone removal instead of globe-sparing resection and adjuvant radiation therapy. In this case study, we show an unusual case of an ACC in the left superolateral orbit with the demonstration of clinical, radiological, morphology, and immunohistochemistry findings along with management protocols and a review of the relevant literature.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 3","pages":"716-719"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the cause and effects of objective function variation approach on volumetric modulated arc radiosurgery of solitary brain metastasis for efficient dosimetry.","authors":"Shabbir Ahamed, R Padma Suvarna, Navin Singh","doi":"10.4103/jcrt.jcrt_2205_24","DOIUrl":"10.4103/jcrt.jcrt_2205_24","url":null,"abstract":"<p><strong>Purpose: </strong>To demonstrate the cause and effects of dose gradients in normal brain and resulting plan metrics using varied objective functions for generating efficient volumetric modulated arc radiosurgery plans for solitary brain metastasis.</p><p><strong>Materials and methods: </strong>Normal tissue and dose volume objective function (NTO and DVO) variations were applied to the virtual phantom and 23 solitary brain metastasis (SBM) cases to plan 20 Gray (Gy) doses. Initial testing on the phantom used eight variations manipulating NTO priority (50, 100, 150, 200), end-dose (25% and 10%), and DVO target dose maximum (25 and 27 Gy). Two strategies were then tested on SBM cases. First strategy (S1) used NTO priority = 100, end-dose = 25%, target maximum dose < 25 Gy. The second strategy (S2) tightened NTO and relaxed DVO by changing the corresponding parameters to 200 and 10%, and 27 Gy. Plans were analyzed comparing and correlating relevant metrics.</p><p><strong>Results: </strong>For the phantom case, the mean multi-leaf collimator aperture area (AA) variation between the highest NTO priority S2 plan and lowest priority S1 plan was about 46%, which brought substantial changes to 12 Gy spill outside tumor (V12), efficiency index, and prescription isodose level (PIDL). SBM cases showed about 14% lower PIDL and associated V12 reduction of about 0.7 cm3 for S2 than S1. V12 reduction was explained by AA reduction (r ≥ 0.966). For the studied PTVs, monitor units per Gy (MU/Gy) and AA product were lower for S2 indicating one or either factor was lower.</p><p><strong>Conclusion: </strong>Stringent NTO and relaxed DVO functions cause aperture shrinkage to create dose gradients for overall plan efficacy.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 3","pages":"693-699"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective comparative study of pre-op chemoradiotherapy followed by surgery versus upfront surgery followed by adjuvant chemoradiotherapy in locally advanced borderline resectable oral cavity cancer.","authors":"Aishna, Surabhi Gupta, Akhil Pratap Singh, Varun Agrawal","doi":"10.4103/jcrt.jcrt_1317_24","DOIUrl":"10.4103/jcrt.jcrt_1317_24","url":null,"abstract":"<p><strong>Introduction: </strong>Patients diagnosed with oral cavity cancers (OCCs) often delay seeking medical attention and so always pose a challenge for oncologists. Typically, surgery is the preferred initial treatment option. However, surgical resection may not be feasible in cases of advanced disease. Conversely, radiotherapy (RT) and chemotherapy (CT) have not been widely used as alternatives to surgery for curative treatment or as neoadjuvant therapy.</p><p><strong>Objectives: </strong>This study aims to evaluate the clinical and pathological responses at both primary and regional sites, post-op margin status, and postoperative morbidity in locally advanced borderline resectable oral cavity cancer patients treated with neoadjuvant chemoradiotherapy (NACRT).</p><p><strong>Methods: </strong>Fifty-seven patients presenting with locally advanced borderline resectable OCC were randomly assigned to Arm A (neoadjuvant chemoradiotherapy followed; surgery was performed after 2 to 6 weeks) and Arm B (definite surgery followed by adjuvant radiotherapy with or without chemotherapy).</p><p><strong>Results: </strong>In our study, out of 26 patients in Arm A, 3 (11.53%) and 16 (69.55%) had pathological complete responses at the primary and nodal sites, respectively, and 19 (73.77%) and 5 (21.75%) had partial responses at the primary and nodal sites, respectively. A significant difference was observed in margin negativity compared with the standard arm; 22 (84.60%) patients achieved negative margin post-NACRT. Postoperative morbidity was comparable in both arms.</p><p><strong>Conclusion: </strong>The research findings indicate that the combination of NACRT and subsequent surgery is a viable option, resulting in favorable pathological complete responses. Given the significance of response to chemoradiotherapy as a prognostic indicator, these outcomes could potentially lead to improved disease-free survival rates in the future.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 3","pages":"567-575"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A giant peritoneal mesothelioma extending to the pelvic floor: A case report and review of the literature.","authors":"Mathew Thomas, Harikrishnan Nandakumar, Parth Sampat, Stephen Graziano","doi":"10.4103/jcrt.jcrt_247_24","DOIUrl":"10.4103/jcrt.jcrt_247_24","url":null,"abstract":"<p><strong>Abstract: </strong>Malignant peritoneal mesothelioma (MPM) is a rare malignancy originating from the peritoneal serosa and is the second most common site of mesothelioma after the pleura. Localized disease presents as a focal circumscribed mass, whereas diffuse disease is usually associated with ascites and may metastasize to abdominal and pelvic lymph nodes. Cytoreductive surgery with heated intraperitoneal chemotherapy has been shown to improve progression-free survival and overall survival. Systemic chemotherapy with pemetrexed and platinum-based chemotherapy has also demonstrated a good treatment response. Recently, there has been an increased interest in the use of immune checkpoint inhibitors in the treatment of MPM. We present the case of a 59-year-old female with progressively worsening abdominal pain and constipation, who on further evaluation was found to have a huge MPM (17.3 × 17.1 × 13.3 cm) extending into the pelvic cavity with associated compression of the vagina, sigmoid colon, and ureters complicated by bilateral hydronephrosis. The tumor was deemed unresectable, and the patient was started on dual immunotherapy with ipilimumab and nivolumab. The patient had symptomatic improvement and a reduction in tumor size to 15.1 × 11 × 8.6 cm. Despite the initial response, the disease progressed (15.6 × 13.8 × 23.8 cm) and the patient ultimately succumbed to it. This case highlights the unique presentation of a massive localized MPM and emphasizes the need for further research to optimize treatment strategies.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 3","pages":"739-742"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of curative surgery and adjuvant radiation therapy in salivary duct carcinoma.","authors":"Divyani Chowdhury, Nivedita Sarkar, Pasupuleti H H M Sai Hanuman, Avinaba Sinha, Sudipta Pati, Sanjoy Chatterjee, Prateek V Jain, Pattatheyil Arun, Paromita Roy, Indu Arun, Indranil Mallick","doi":"10.4103/jcrt.jcrt_1842_24","DOIUrl":"10.4103/jcrt.jcrt_1842_24","url":null,"abstract":"<p><strong>Introduction: </strong>Salivary duct carcinoma (SDC) forms an uncommon and aggressive subtype of salivary gland neoplasms with early recurrences and metastases. Their treatment includes surgery and adjuvant radiotherapy. They overexpress androgen receptors (AR) and human epidermal receptor 2 (HER2), similar to breast carcinomas. There is limited data on SDCs treated with curative intent from Asia.</p><p><strong>Objective: </strong>In this retrospective analysis, we reviewed SDCs treated between 2012 and 2022. The aim of this study was to study the outcome of SDCs in patients who were treated with curative intent. The primary objectives of the study were to study the overall survival (OS) and disease-free survival (DFS) in patients of salivary duct cancer treated with curative intent, compare OS and DFS among various groups, and identify certain critical clinical or pathological attributes that may affect disease outcomes.</p><p><strong>Materials and methods: </strong>Patient demographics, tumor characteristics, treatment details, and outcomes were recorded for 48 patients in REDCap (electronic data collection system) and all eligible patients were contacted for survival status.</p><p><strong>Statistical analysis: </strong>Statistical analysis was done using SPSS software and survival analysis using the log-rank test and Cox regression.</p><p><strong>Results: </strong>After a median follow-up of 13.8 months ranging from 0.5 to 125.2 months, median DFS and OS were 11.4 and 13.8 months. Node (s) positive patients showed numerically inferior DFS, 66.6% vs. 81.7% at one year and 22.8% vs. 67.4% at two years (P = 0.061) with a hazard ratio (HR) 2.23 (95% confidence interval [CI]: 0.94-5.29, P = 0.068) and inferior OS, 91.7% vs. 100% at one year and 72.2% vs. 86.7% at two years (P = 0.068) with HR 3.41 (95% CI: 0.84-13.79, P = 0.085). Patients with extranodal extension had numerically inferior DFS, 59.1% vs. 85.9% (P = 0.119) with HR 1.96 (95% CI of 0.82-4.68, P = 0.126) and lower OS, 90.9% vs. 100% (P = 0.112) at one year with HR 2.96 (95% CI of 0.72-12.02, P = 0.129). Despite the large numerical difference, the P value was not statistically significant due to limited sample size.</p><p><strong>Conclusion: </strong>Salivary duct cancers, even when treated curatively, have early and distant failures. Over-expression of HER2-neu and AR provide an opportunity to improve the outcomes of curative intent treatment for this cancer with targeted agents and robust data is required to investigate the role of adjuvant endocrine or HER-2 targeted therapies.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 3","pages":"670-677"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dosimetric study to evaluate the inverse planning simulated annealing (IPSA) and hybrid inverse planning optimization (HIPO) algorithms in HDR brachytherapy of cervical cancer.","authors":"V Gogul Priean, Lalit Mohan Aggarwal, Ankur Mourya, Sunil Choudhary, Syed M Shajid, Abhijit Mandal, Ankita Singh","doi":"10.4103/jcrt.jcrt_1335_24","DOIUrl":"10.4103/jcrt.jcrt_1335_24","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the effectiveness of the inverse planning simulated annealing (IPSA) and hybrid inverse planning optimization (HIPO) algorithms in interstitial HDR brachytherapy for treatment of cervical cancer.</p><p><strong>Methods and materials: </strong>A dosimetric study was conducted on 46 cervical cancer patients who underwent multi catheter interstitial cervical HDR brachytherapy using the Martinez Universal Perineal Interstitial Template (MUPIT). Dosimetric parameters, plan evaluation indices, and mean treatment time were assessed for each algorithm. All the parameters were compared using statistical analysis.</p><p><strong>Results: </strong>With HIPO, significant improvements were observed in D90, D100, V100, and V200 (P < 0.05). Additionally, HIPO plans demonstrated lower doses to the bladder (B2cc) as compared to IPSA plans, whereas IPSA plans exhibited lower rectum (R2cc) and sigmoid (S2cc) doses, with statistical significance observed only for sigmoid doses. HIPO plans had better results in the plan evaluation indices such as CI, COIN, DHI, DNR, ODI, EI, NV100, GFB, GFR, GF, PQI1, PQI2, and PQS with statistical significance (P < 0.05) except for GFS. Moreover, HIPO plans had shorter mean treatment time compared to IPSA plans by 5.52 seconds, although this difference did not reach statistical significance. It was found that HIPO plans demonstrated superior dose-volumetric parameters for the high-risk clinical target volume (HR-CTV).</p><p><strong>Conclusions: </strong>In conclusion, HIPO emerged as the preferred algorithm for interstitial cervical HDR brachytherapy due to improved dose distribution in HR-CTV and plan quality as well.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 3","pages":"576-582"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current trends in media and their role in cancer care.","authors":"Rohan Kapoor, M D Ray","doi":"10.4103/jcrt.jcrt_2349_24","DOIUrl":"10.4103/jcrt.jcrt_2349_24","url":null,"abstract":"","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 3","pages":"775-776"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duodenal obstruction secondary to metastatic breast cancer.","authors":"Robert S O'Neill, Andrew Field, Bong Sik M Kim, Jorgen S Ferguson, Simon Ghaly, Rachel F Dear","doi":"10.4103/jcrt.jcrt_2022_24","DOIUrl":"10.4103/jcrt.jcrt_2022_24","url":null,"abstract":"<p><strong>Abstract: </strong>Breast cancer is the most common malignancy affecting females and is a leading cause of cancer-related mortality worldwide. The most common sites of metastatic disease are bone, liver, lung and brain, with the gastrointestinal tract less commonly implicated. Intestinal metastasis from breast cancer is rare, with vast majority of patients being asymptomatic. Diagnosis can often be delayed due to gastrointestinal symptoms perceived to be secondary to treatment rather than malignancy. Unfortunately, intestinal metastasis is associated with a poor prognosis with the median survival being 12 months. We present the case of a 53-year-old female with a diagnosed history of metastatic breast cancer who presented to our institution with nausea, vomiting and abdominal pain and was subsequently diagnosed with a small bowel obstruction secondary to duodenal metastasis after endoscopic ultrasound-guided tissue acquisition. She was managed conservatively with chemotherapy resulting in resolution of her small bowel obstruction.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 3","pages":"755-757"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare presentation of a cutaneous metastasis from an undifferentiated pleomorphic sarcoma.","authors":"M Harish, Ambedkar Yadala, Rashmi P Joshi, R Parameswari","doi":"10.4103/jcrt.jcrt_1771_24","DOIUrl":"10.4103/jcrt.jcrt_1771_24","url":null,"abstract":"<p><strong>Abstract: </strong>Undifferentiated pleomorphic sarcoma, a rare and aggressive soft tissue sarcoma, commonly affects the extremities and has a high propensity for local recurrence and metastasis. This case study presents a 57-year-old male with UPS in the right forearm, which progressed to rare cutaneous metastasis on the right chest wall following initial treatment. Despite undergoing wide local excision, flap reconstruction, and adjuvant radiation, the patient later developed disseminated metastases, including in the lungs, bones, liver, and skin. Immunohistochemistry confirmed metastatic pleomorphic sarcoma, leading to palliative chemotherapy. This case highlights the rarity of cutaneous metastasis in UPS, documented in less than 1% of cases, and underscores the diagnostic challenges posed by undifferentiated or poorly differentiated sarcomas. Timely diagnosis and multidisciplinary treatment are crucial in managing this aggressive malignancy, particularly when it presents with rare metastasis patterns. Further research is necessary to better understand UPS and improve therapeutic strategies.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 3","pages":"743-745"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging-based skeletal muscle quality and clinical outcomes in Indian older patients with cancer: A retrospective analysis.","authors":"Abhijith Rajaram Rao, Vanita Noronha, Anant Ramaswamy, Ratan Dhekle, Anita Kumar, Anupa Pillai, Pallavi Pratisad Rane, Nivedita Chakrabarty, Abhishek Mahajan, Kumar Prabhash","doi":"10.4103/jcrt.jcrt_906_24","DOIUrl":"10.4103/jcrt.jcrt_906_24","url":null,"abstract":"<p><strong>Objectives: </strong>Computer tomography (CT) measurements of cross-sectional area and density reflect muscle performance and function, but their use is limited in practice. We aimed to evaluate the association of CT-based skeletal muscle quality (qSMQ) with geriatric assessment (GA) and outcomes in older Indian patients with cancer.</p><p><strong>Methods: </strong>Retrospective observational study in the geriatric oncology clinic in Mumbai, India. Patients aged ≥60 years with cancer who had undergone GA and had CT scan were included. To evaluate skeletal muscle quality, region of interest was drawn on bilateral paraspinal muscle at L3 vertebral level, one section above and below.</p><p><strong>Results: </strong>Between June 2018 and November 2021, 277 patients were included. At a median follow-up of 23.8 (21.4-28.4) months, 174 deaths had occurred. Using the lower quartile as a cutoff to define poor and good qSMQ, the median overall survivals were 10.7 and 17.5 months in the patients with poor and good qSMQ, respectively (P = 0.124), which was significant after adjusting for body mass index (BMI), primary tumor, metastasis, and performance status (hazard ratio (HR): 1.53; 1.08-2.18, P = 0.017). The likelihood ratio test (LR-test) comparing the full model (qSMQ with nested model) with the nested model (age, sex, BMI, primary tumor, performance status) found that the addition of qSMQ was a significantly better fit (P = 0.015).</p><p><strong>Discussion: </strong>The utilization of CT scans for older Indian patients with cancer is an effective and crucial means of evaluating skeletal muscle quality. It is closely associated with anthropometric measures, frailty, and overall survival (OS).</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 3","pages":"649-656"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}