Comparing long-term survival prognosis with surgery-based systemic treatment of gastrointestinal stromal tumors: A population-based study.

Abstract

Background: To date, the optimal sequence of systemic therapy (ST) and surgical resection for gastrointestinal stromal tumors (GISTs) remains unknown. This study aimed to compare the long-term outcomes of different ST approaches when combined with surgery.

Subject and methods: Data on GISTs were retrospectively collected from the Surveillance, Epidemiology, and End Results database. The patients were divided into three groups: preoperative ST, postoperative ST, and their combination. The Cox proportional-hazards model was used to analyze risk factors for overall survival (OS) and cancer-specific survival (CSS). Furthermore, the Kaplan-Meier method was employed to compare survival differences in OS and CSS. To minimize the confounding factors, a 1:1:1 propensity score matching method was used. The results of the subgroup analyses were displayed using forest plots.

Results: Among the 3774 patients, 518 (13.7%) received preoperative ST, 2799 (74.2%) received postoperative ST, and 457 (12.1%) received combined therapy. The median survival times were 42, 60, and 41 months for the preoperative ST, postoperative ST, and combined therapy groups, respectively. Kaplan-Meier curves showed no significant differences in OS and CSS among the groups before and after matching. Cox regression analysis, with adjustment for variables, revealed no survival advantage among the groups. Subgroup analyses showed that male patients, patients with localized disease, and patients with a tumor size <75 mm could achieve an OS benefit from postoperative ST (P < 0.05).

Conclusion: Surgery-based systemic therapies provide a comparable long-term survival prognosis for patients with GISTs. In addition, some patients may achieve an OS benefit from postoperative ST.