Manish Srivastava;Kilian O’Donoghue;Aleksandr Sidun;Herman Alexander Jaeger;Alessandro Ferro;Daragh Crowley;Christian van den Bosch;Marcus Kennedy;Daniel O’Hare;Pádraig Cantillon-Murphy
{"title":"3D Position Tracking Using On-Chip Magnetic Sensing in Image-Guided Navigation Bronchoscopy","authors":"Manish Srivastava;Kilian O’Donoghue;Aleksandr Sidun;Herman Alexander Jaeger;Alessandro Ferro;Daragh Crowley;Christian van den Bosch;Marcus Kennedy;Daniel O’Hare;Pádraig Cantillon-Murphy","doi":"10.1109/TBCAS.2024.3384016","DOIUrl":"10.1109/TBCAS.2024.3384016","url":null,"abstract":"This paper presents a compact and low-cost on-chip sensor and readout circuit. The sensor achieves high-resolution 5-degrees-of-freedom (DoF) tracking (x, y, z, yaw, and pitch). With the help of an external wire wound sensor, it can also achieve high-resolution 6-degrees-of-freedom (DoF) tracking (x, y, z, yaw, pitch, and roll angles). The sensor uses low-frequency magnetic fields to detect the position and orientation of instruments, providing a viable alternative to using X-rays in image-guided surgery. To measure the local magnetic field, a highly miniaturised on-chip magnetic sensor capable of sensing the magnetic field has been developed incorporating an on-chip magnetic sensor coil, analog-front end, continuous-time \u0000<inline-formula><tex-math>$DeltaSigma$</tex-math></inline-formula>\u0000 analog-to-digital converter (ADC), LVDS transmitter, bandgap reference, and voltage regulator. The microchip is fabricated using 65 nm CMOS technology and occupies an area of 1.06 mm\u0000<inline-formula><tex-math>${}^{2}$</tex-math></inline-formula>\u0000, the smallest reported among similar designs to the best of our knowledge. The 5-DoF system accurately navigates with a precision of 1.1 mm within the volume-of-interest (VOI) of 15\u0000<inline-formula><tex-math>$times$</tex-math></inline-formula>\u000015\u0000<inline-formula><tex-math>$times$</tex-math></inline-formula>\u000015 cm\u0000<inline-formula><tex-math>${}^{3}$</tex-math></inline-formula>\u0000. The 6-DoF system achieves a navigation accuracy of 0.8 mm and an angular error of 1.1 degrees in the same VOI. These results were obtained at a 20 Hz update rate in benchtop characterisation. The prototype sensor demonstrates accurate position tracking in real-life pre-clinical \u0000<italic>in-vivo</i>\u0000 settings within the porcine lung of a live swine, achieving a reported worst-case registration accuracy of 5.8 mm.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 5","pages":"1123-1139"},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140567884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Together, We are advance technology","authors":"","doi":"10.1109/TBCAS.2024.3381731","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3381731","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 2","pages":"475-475"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10487130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140340074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IEEE Transactions on Biomedical Circuits and Systems Publication Information","authors":"","doi":"10.1109/TBCAS.2024.3377328","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3377328","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 2","pages":"C2-C2"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10487129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140339932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Blank Page","authors":"","doi":"10.1109/TBCAS.2024.3377332","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3377332","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 2","pages":"C4-C4"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10487133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140340153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Guest Editorial—Selected Papers From the 2023 IEEE International Symposium on Circuits and Systems","authors":"Hanjun Jiang;Ulkuhan Guler;Marco Carminati","doi":"10.1109/TBCAS.2024.3376888","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3376888","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 2","pages":"234-235"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10487138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140339977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TechRxiv: Share Your Preprint Research with the World!","authors":"","doi":"10.1109/TBCAS.2024.3381729","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3381729","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 2","pages":"474-474"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10487131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140340073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IEEE Circuits and Systems Society Information","authors":"","doi":"10.1109/TBCAS.2024.3377330","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3377330","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 2","pages":"C3-C3"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10487135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140340069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tyler Hack;Joel Bisarra;Saeromi Chung;Shekher Kummari;Drew A. Hall
{"title":"Mitigating Medication Tampering and Diversion via Real-Time Intravenous Opioid Quantification","authors":"Tyler Hack;Joel Bisarra;Saeromi Chung;Shekher Kummari;Drew A. Hall","doi":"10.1109/TBCAS.2024.3405815","DOIUrl":"10.1109/TBCAS.2024.3405815","url":null,"abstract":"Opioid tampering and diversion pose a serious problem for hospital patients with potentially life-threatening consequences. The ongoing opioid crisis has resulted in medications used for pain management and anesthesia, such as fentanyl and morphine, being stolen, substituted with a different substance, and abused. This work aims to mitigate tampering and diversion through analytical verification of the administered drug before it enters the patient. We present an electrochemical-based sensor and miniaturized wireless potentiostat that enable real-time intravenous (IV) monitoring of opioids, specifically fentanyl and morphine. The proposed system is connected to an IV drip system during surgery or post-operation recovery. Measurement results of two opioids are presented, including calibration curves and data on the sensor performance concerning pH, temperature, interference, reproducibility, and long-term stability. Finally, we demonstrate real-time fluidic measurements connected to a flow cell to simulate IV administration and a blind study classified using a machine-learning algorithm. The system achieves limits of detection (LODs) of 1.26 µg/mL and 2.75 µg/mL for fentanyl and morphine, respectively, while operating with >1-month battery lifetime due to an optimized ultra-low power 36 µA sleep mode.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 4","pages":"756-770"},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IEEE Transactions on Biomedical Circuits and Systems Publication Information","authors":"","doi":"10.1109/TBCAS.2024.3401335","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3401335","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 3","pages":"C2-C2"},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10540335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141164698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Blank Page","authors":"","doi":"10.1109/TBCAS.2024.3401339","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3401339","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 3","pages":"C4-C4"},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10540336","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141164707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}