IEEE transactions on biomedical circuits and systems最新文献_第9页

Together, We are advance technology 我们共同推动技术进步

IEEE transactions on biomedical circuits and systems Pub Date : 2024-03-28 DOI: 10.1109/TBCAS.2024.3401823

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IEEE Circuits and Systems Society Information 电气和电子工程师学会电路与系统协会信息

IEEE transactions on biomedical circuits and systems Pub Date : 2024-03-28 DOI: 10.1109/TBCAS.2024.3401337

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TechRxiv: Share Your Preprint Research with the World! TechRxiv：与世界分享您的预印本研究成果！

IEEE transactions on biomedical circuits and systems Pub Date : 2024-03-28 DOI: 10.1109/TBCAS.2024.3401821

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Charge-Mode Neural Stimulator With a Capacitor-Reuse Residual Charge Detector and Active Charge Balancing for Epileptic Seizure Suppression 带电容重复使用剩余电荷检测器和主动电荷平衡功能的电荷模式神经刺激器，用于抑制癫痫发作。

IEEE transactions on biomedical circuits and systems Pub Date : 2024-03-21 DOI: 10.1109/TBCAS.2024.3380055

Shuenn-Yuh Lee;Zhan-Xian Liao;I-Ting Feng;Hao-Yun Lee;Chou-Ching Lin

{"title":"Charge-Mode Neural Stimulator With a Capacitor-Reuse Residual Charge Detector and Active Charge Balancing for Epileptic Seizure Suppression","authors":"Shuenn-Yuh Lee;Zhan-Xian Liao;I-Ting Feng;Hao-Yun Lee;Chou-Ching Lin","doi":"10.1109/TBCAS.2024.3380055","DOIUrl":"10.1109/TBCAS.2024.3380055","url":null,"abstract":"This study proposes a charge-mode neural stimulator for electrical stimulation systems that utilizes a capacitor-reuse technique with a residual charge detector and achieves active charge balancing simultaneously. The design is mainly used for epilepsy suppression systems to achieve real-time symptom relief during seizures. A charge-mode stimulator is adopted in consideration of the complexity of circuit design, the high voltage tolerance of transistors, and system integration requirements in the future. The residual charge detector allows users to understand the current stimulus situation, enabling them to make optimal adjustments to the stimulation parameters. On the basis of the information on actual stimulation charge, active charge balancing can effectively prevent the accumulation of mismatched charges on electrode impedance. The capacitor- and phase-reuse techniques help realize high integration of the overall stimulator circuit in consideration of the commonality of the use of a capacitor and charging/discharging phase in the stimulation circuit and charge detector. The proposed charge-mode neural stimulator is implemented in a TSMC 0.18 µm 1P6M CMOS process with a core area of 0.2127 mm\u00002\u0000. Measurement results demonstrate the accuracy of the stimulation’s functionality and the programmable stimulus parameters. The effectiveness of the proposed charge-mode neural stimulator for epileptic seizure suppression is verified through animal experiments.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 5","pages":"1065-1078"},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Energy-Efficient Wireless Power Receiver With One-Step Adiabatic-Bipolar-Supply Generating for Implantable Electrical Stimulation Applications 用于植入式电刺激应用的一步绝热-双极供电高能效无线电源接收器

IEEE transactions on biomedical circuits and systems Pub Date : 2024-03-20 DOI: 10.1109/TBCAS.2024.3379208

Kai Cui;Xiaoya Fan;Yanzhao Ma

{"title":"An Energy-Efficient Wireless Power Receiver With One-Step Adiabatic-Bipolar-Supply Generating for Implantable Electrical Stimulation Applications","authors":"Kai Cui;Xiaoya Fan;Yanzhao Ma","doi":"10.1109/TBCAS.2024.3379208","DOIUrl":"10.1109/TBCAS.2024.3379208","url":null,"abstract":"This paper presents an energy-efficient wireless power receiver for implantable electrical stimulation applications, which can achieve one-step adiabatic bipolar-supply that is generated by a hybrid single-stage dual-output regulating (SSDOR) rectifiers. The structure using only four switches overcomes the disadvantages that the two output voltage values in the traditional dual-output rectifiers are close to each other. A constant-current (CC) controlled adiabatic dynamic voltage scaling (DVS) technique is proposed to minimize the voltage headroom of the stimulating drivers and improve the stimulation efficiency significantly. In addition, the receiver adopts only one general constant on-time (COT) low-frequency control to adjust the stimulation current, reducing both the power consumption and the complexity of the control circuits. The proposed receiver has been fabricated in a 0.18 \u0000<inline-formula><tex-math>$mu$</tex-math></inline-formula>\u0000m BCD process with \u0000<inline-formula><tex-math>$pm$</tex-math></inline-formula>\u00006 V voltage compliance and 2.5 mA maximum stimulating current. With a current range from \u0000<inline-formula><tex-math>$pm$</tex-math></inline-formula>\u00001.5 mA to \u0000<inline-formula><tex-math>$pm$</tex-math></inline-formula>\u00002.5 mA, the measured maximum average headroom voltage is only 80 mV and the peak total efficiency of the receiver is 85.6\u0000<inline-formula><tex-math>$%$</tex-math></inline-formula>\u0000. The functionalities of the proposed receiver have been successfully verified through \u0000<inline-formula><tex-math>$in ,vitro$</tex-math></inline-formula>\u0000 experiments.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 5","pages":"1112-1122"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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An Event-Based Neural Compressive Telemetry With >11× Loss-Less Data Reduction for High-Bandwidth Intracortical Brain Computer Interfaces 一种基于事件的神经压缩遥测技术，可为高带宽皮层内脑计算机接口提供大于 11 倍的无损数据减少。

IEEE transactions on biomedical circuits and systems Pub Date : 2024-03-18 DOI: 10.1109/TBCAS.2024.3378973

Yuming He;Stan van der Ven;Hua-Peng Liaw;Chengyao Shi;Pietro Russo;Marios Gourdouparis;Mario Konijnenburg;Stefano Traferro;Martijn Timmermans;Carolina Mora Lopez;Pieter Harpe;Eugenio Cantatore;Elisabetta Chicca;Yao-Hong Liu

{"title":"An Event-Based Neural Compressive Telemetry With >11× Loss-Less Data Reduction for High-Bandwidth Intracortical Brain Computer Interfaces","authors":"Yuming He;Stan van der Ven;Hua-Peng Liaw;Chengyao Shi;Pietro Russo;Marios Gourdouparis;Mario Konijnenburg;Stefano Traferro;Martijn Timmermans;Carolina Mora Lopez;Pieter Harpe;Eugenio Cantatore;Elisabetta Chicca;Yao-Hong Liu","doi":"10.1109/TBCAS.2024.3378973","DOIUrl":"10.1109/TBCAS.2024.3378973","url":null,"abstract":"Intracortical brain-computer interfaces offer superior spatial and temporal resolutions, but face challenges as the increasing number of recording channels introduces high amounts of data to be transferred. This requires power-hungry data serialization and telemetry, leading to potential tissue damage risks. To address this challenge, this paper introduces an event-based neural compressive telemetry (NCT) consisting of 8 channel-rotating Δ-ADCs, an event-driven serializer supporting a proposed ternary address event representation protocol, and an event-based LVDS driver. Leveraging a high sparsity of extracellular spikes and high spatial correlation of the high-density recordings, the proposed NCT achieves a compression ratio of >11.4×, while consumes only 1 µW per channel, which is 127× more efficient than state of the art. The NCT well preserves the spike waveform fidelity, and has a low normalized RMS error <23% even with a spike amplitude down to only 31 µV.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 5","pages":"1100-1111"},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Ultra-Compact Pulse Charger for Lithium Polymer Battery With Simple Built-in Resistance Compensation in Biomedical Applications 用于锂聚合物电池的超紧凑型脉冲充电器，内置生物医学应用中的简单电阻补偿。

IEEE transactions on biomedical circuits and systems Pub Date : 2024-03-16 DOI: 10.1109/TBCAS.2024.3401846

Yemin Kim;Junhyuck Lee;Byunghun Lee

{"title":"Ultra-Compact Pulse Charger for Lithium Polymer Battery With Simple Built-in Resistance Compensation in Biomedical Applications","authors":"Yemin Kim;Junhyuck Lee;Byunghun Lee","doi":"10.1109/TBCAS.2024.3401846","DOIUrl":"10.1109/TBCAS.2024.3401846","url":null,"abstract":"Active implantable medical devices (AIMDs) rely on batteries for uninterrupted operation and patient safety. Therefore, it is critical to ensure battery safety and longevity. To achieve this, constant current/constant voltage (CC/CV) methods have been commonly used and research has been conducted to compensate for the effects of built-in resistance (BIR) of batteries. However, conventional CC/CV methods may pose the risk of lithium plating. Furthermore, conventional compensation methods for BIR require external components, complex algorithms, or large chip sizes, which inhibit the miniaturization and integration of AIMDs. To address this issue, we have developed a pulse charger that utilizes pulse current to ensure battery safety and facilitate easy compensation for BIR. A comparison with previous research on BIR compensation shows that our approach achieves the smallest chip size of 0.0062 mm\u00002\u0000 and the lowest system complexity using 1-bit ADC. In addition, we have demonstrated a reduction in charging time by at least 44.4% compared to conventional CC/CV methods, validating the effectiveness of our system’s BIR compensation. The compact size and safety features of the proposed charging system make it promising for AIMDs, which have space-constrained environments.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 4","pages":"746-755"},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward a Wireless Image Sensor for Real-Time Fluorescence Microscopy in Cancer Therapy 开发用于癌症治疗实时荧光显微镜的无线图像传感器

IEEE transactions on biomedical circuits and systems Pub Date : 2024-03-12 DOI: 10.1109/TBCAS.2024.3374886

Rozhan Rabbani;Hossein Najafiaghdam;Micah Roschelle;Efthymios Philip Papageorgiou;Biqi Rebekah Zhao;Mohammad Meraj Ghanbari;Rikky Muller;Vladimir Stojanović;Mekhail Anwar

{"title":"Toward a Wireless Image Sensor for Real-Time Fluorescence Microscopy in Cancer Therapy","authors":"Rozhan Rabbani;Hossein Najafiaghdam;Micah Roschelle;Efthymios Philip Papageorgiou;Biqi Rebekah Zhao;Mohammad Meraj Ghanbari;Rikky Muller;Vladimir Stojanović;Mekhail Anwar","doi":"10.1109/TBCAS.2024.3374886","DOIUrl":"10.1109/TBCAS.2024.3374886","url":null,"abstract":"We present a mm-sized, ultrasonically powered lensless CMOS image sensor as a progress towards wireless fluorescence microscopy. Access to biological information within the tissue has the potential to provide insights guiding diagnosis and treatment across numerous medical conditions including cancer therapy. This information, in conjunction with current clinical imaging techniques that have limitations in obtaining images continuously and lack wireless compatibility, can improve continual detection of multicell clusters deep within tissue. The proposed platform incorporates a 2.4 × 4.7 mm\u00002\u0000 integrated circuit (IC) fabricated in TSMC 0.18 µm, a micro laser diode (µLD), a single piezoceramic and off-chip storage capacitors. The IC consists of a 36 × 40 array of capacitive trans-impedance amplifier-based pixels, wireless power management and communication via ultrasound and a laser driver all controlled by a Finite State Machine. The piezoceramic harvests energy from the acoustic waves at a depth of 2 cm to power up the IC and transfer 11.5 kbits/frame via backscattering. During \u0000<italic>Charge-Up,\u0000 the off-chip capacitor stores charge to later supply a high-power 78 mW µLD during \u0000<italic>Imaging\u0000. Proof of concept of the imaging front end is shown by imaging distributions of CD8 T-cells, an indicator of the immune response to cancer, \u0000<italic>ex vivo,\u0000 in the lymph nodes of a functional immune system (BL6 mice) against colorectal cancer consistent with the results of a fluorescence microscope. The overall system performance is verified by detecting 140 µm features on a USAF resolution target with 32 ms exposure time and 389 ms ultrasound backscattering.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 5","pages":"1050-1064"},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140066385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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An Ultra-Low Power Fixed-Window Level Crossing ADC for ECG Recording 用于心电图记录的超低功耗固定窗口电平转换 ADC。

IEEE transactions on biomedical circuits and systems Pub Date : 2024-03-12 DOI: 10.1109/TBCAS.2024.3376642

Mahdi Ghasemi;Nassim Ravanshad;Hamidreza Rezaee-Dehsorkh

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Multi-resonator Wireless Inductive Power Link for Wearables on the 2D Surface and Implants in 3D Space of the Human Body 用于人体二维表面可穿戴设备和三维空间植入物的多谐振器无线感应供电链路。

IEEE transactions on biomedical circuits and systems Pub Date : 2024-03-11 DOI: 10.1109/TBCAS.2024.3375794

Reepa Saha;Zohreh Kaffash;S. Abdollah Mirbozorgi

{"title":"Multi-resonator Wireless Inductive Power Link for Wearables on the 2D Surface and Implants in 3D Space of the Human Body","authors":"Reepa Saha;Zohreh Kaffash;S. Abdollah Mirbozorgi","doi":"10.1109/TBCAS.2024.3375794","DOIUrl":"10.1109/TBCAS.2024.3375794","url":null,"abstract":"This paper presents a novel resonance-based, adaptable, and flexible inductive wireless power transmission (WPT) link for powering implantable and wearable devices throughout the human body. The proposed design provides a comprehensive solution for wirelessly delivering power, sub-micro to hundreds of milliwatts, to deep-tissue implantable devices (3D space of human body) and surface-level wearable devices (2D surface of human skin) safely and seamlessly. The link comprises a belt-fitted transmitter (Belt-Tx) coil equipped with a power amplifier (PA) and a data demodulator unit, two resonator clusters (to cover upper-body and lower-body), and a receiver (Rx) unit that consists of Rx load and resonator coils, rectifier, microcontroller, and data modulator units for implementing a closed-loop power control (CLPC) mechanism. All coils are tuned at 13.56 MHz, Federal Communications Commission (FCC)-approved industrial, scientific, and medical (ISM) band. Novel customizable configurations of resonators in the clusters, parallel for implantable devices and cross-parallel for wearable devices and vertically oriented implants, ensure uniform power delivered to the load, PDL, enabling natural Tx power localization toward the Rx unit. The proposed design is modeled, simulated, and optimized using ANSYS HFSS software. The Specific Absorption Rate (SAR) is calculated under 1.5 W/kg, indicating the design’s safety for the human body. The proposed link is implemented, and its performance is characterized. For both the parallel cluster (implant) and cross-parallel cluster (wearable) scenarios, the measured results indicate: 1) an upper-body PDL exceeding 350 mW with a Power Transfer Efficiency (PTE) reaching 25%, and 2) a lower-body PDL surpassing 360 mW with a PTE of up to 20%, while covering up to 92% of the human body.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 5","pages":"1024-1036"},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140103055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0