{"title":"2024 Index IEEE Transactions on Biomedical Circuits and Systems Vol. 18","authors":"","doi":"10.1109/TBCAS.2024.3519932","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3519932","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 6","pages":"1385-1410"},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10810376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tingting Wei;Hang Chen;Jiahui Lai;Jinhua Ni;Xiaoyang Zeng;Zhiliang Hong
{"title":"A 153.4 dB-DR PPG Recording IC With Extended Counting and Hardware Reuse","authors":"Tingting Wei;Hang Chen;Jiahui Lai;Jinhua Ni;Xiaoyang Zeng;Zhiliang Hong","doi":"10.1109/TBCAS.2024.3517834","DOIUrl":"10.1109/TBCAS.2024.3517834","url":null,"abstract":"Photoplethysmogram (PPG) is widely used in wearable devices for health monitoring. High-precision signals are essential for medical diagnostics. However, motion artifacts in these devices can cause significant ambient light variation during PPG recording. This paper presents an accurate PPG recording front end with enhanced ambient light rejection (ALR). Quantization noise in a second-order sigma-delta modulator (SDM), used for direct current conversion, is reduced by extended counting of the modulator's residue. The first integrator of the SDM and the residue analog-to-digital converter (ADC) are reused in ALR circuits. The correlated double sampling (CDS) technique is enhanced by applying a first-order approximation of ambient light. Gain error in the residue ADC is reduced by charge compensation. The PPG front-end, implemented in a 180 nm process, achieves a dynamic range (DR) of 153.4 dB within a bandwidth of 20 Hz. The system operates with a minimum 1.28% duty cycle. Measurements of heart rate and blood oxygen at the fingertip and wrist verify the functionality of the PPG front end.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"19 4","pages":"839-849"},"PeriodicalIF":4.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TechRxiv: Share Your Preprint Research with the World!","authors":"","doi":"10.1109/TBCAS.2024.3511193","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3511193","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 6","pages":"1382-1382"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10783937","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Blank Page","authors":"","doi":"10.1109/TBCAS.2024.3511176","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3511176","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 6","pages":"C4-C4"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10783941","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IEEE Transactions on Biomedical Circuits and Systems Publication Information","authors":"","doi":"10.1109/TBCAS.2024.3485302","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3485302","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 6","pages":"C2-C2"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10783938","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Together, We are advance technology","authors":"","doi":"10.1109/TBCAS.2024.3511197","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3511197","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 6","pages":"1384-1384"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10783940","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IEEE Circuits and Systems Society Information","authors":"","doi":"10.1109/TBCAS.2024.3511174","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3511174","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 6","pages":"C3-C3"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10783933","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Programmable CMOS DEP Chip for Cell Manipulation","authors":"Wen-Yue Lin;Lin-Hung Lai;Yi-Wei Lin;Chen-Yi Lee","doi":"10.1109/TBCAS.2024.3514874","DOIUrl":"10.1109/TBCAS.2024.3514874","url":null,"abstract":"This work presents a programmable CMOS DEP chip that allows real-time control over the spatial distribution of DEP force, enabling controlled cell movement on the chip surface, from single-cell manipulation to multi-cell patterning. Implemented on a standard 0.18 <inline-formula><tex-math>$boldsymbol{mu}$</tex-math></inline-formula>m CMOS process without post-processing, the chip features a 128 <inline-formula><tex-math>$boldsymbol{times}$</tex-math></inline-formula> 128 array of individually controllable 10 <inline-formula><tex-math>$boldsymbol{mu}$</tex-math></inline-formula>m microelectrodes with 0.28 <inline-formula><tex-math>$boldsymbol{mu}$</tex-math></inline-formula>m spacing. Utilizing Metal 5 electrodes in a 1P6M process, the chip achieves particle manipulation speeds up to 27 <inline-formula><tex-math>$boldsymbol{mu}$</tex-math></inline-formula>m/s while operating at only 1.8 V, preserving cell viability as confirmed through post-DEP assessments. The implementation of time-sharing patterns enhances manipulation precision by creating distinct boundaries between phases. Experiments demonstrate the chip's capabilities in particle patterning, concentration control, and single-particle manipulation, all performed sequentially on the same chip. Additionally, stem cell aggregation control demonstration offers possibilities for future differentiation studies. With its reconfigurability, this DEP chip offers promising solutions to technical challenges in cell preparation, drug screening, and other biological applications.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"19 4","pages":"827-838"},"PeriodicalIF":4.9,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10791877","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Guest Editorial: Selected Papers From the 2024 IEEE International Solid-State Circuits Conference","authors":"Alison Burdett;Maysam Ghovanloo;Roman Genov;Mehdi Kiani","doi":"10.1109/TBCAS.2024.3507312","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3507312","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 6","pages":"1194-1196"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10783936","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Max L. Wang;Pyungwoo Yeon;Mohammad Mofidfar;Christian Chamberlayne;Haixia Xu;Justin P. Annes;Richard N. Zare;Amin Arbabian
{"title":"A Wireless Implantable Closed-Loop Electrochemical Drug Delivery System","authors":"Max L. Wang;Pyungwoo Yeon;Mohammad Mofidfar;Christian Chamberlayne;Haixia Xu;Justin P. Annes;Richard N. Zare;Amin Arbabian","doi":"10.1109/TBCAS.2024.3507022","DOIUrl":"10.1109/TBCAS.2024.3507022","url":null,"abstract":"Wireless implantable drug delivery systems (DDSs) enable targeted, on-demand drug release to maximize therapeutic efficacy. Ultrasound has been proposed to wirelessly power and control millimeter-sized deeply implantable DDSs, but initial demonstrations encountered challenges in power transfer and release control reliability in dynamic <italic>in vivo</i> environments. In this work, we present a closed-loop implantable DDS using ultrasound wireless power and communication in conjunction with an electrochemical drug release mechanism. The system consists of piezoelectric transducers for wireless power and data transmission, a drug delivery module containing drug-loaded electroresponsive nanoparticles, and a custom CMOS integrated circuit for closed-loop drug release using a programmable potentiostat capable of providing potentials up to <inline-formula><tex-math>$boldsymbol{pm}$</tex-math></inline-formula>1.5 V and sensing current up to <inline-formula><tex-math>$boldsymbol{pm}$</tex-math></inline-formula>100 <inline-formula><tex-math>$boldsymbol{mu}$</tex-math></inline-formula>A. The chip also improves power transfer robustness by enabling ultrasound power combining and rectifier voltage feedback which can be used to adapt the power transmitter and minimize misalignment. Closed-loop release control is tested <italic>in vitro</i> using the wirelessly powered DDS at 8 cm depth by adjusting the potentiostat stimulus voltage based on feedback of redox current into fluorescein-loaded nanoparticles, resulting in consistent 2 <inline-formula><tex-math>$boldsymbol{mu}$</tex-math></inline-formula>g release across different fluorescein loading concentrations and a 39<inline-formula><tex-math>$%$</tex-math></inline-formula> reduction in release amount variation. These results demonstrate the effectiveness of closed-loop release control in enabling precise and reliable drug delivery.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"19 4","pages":"777-790"},"PeriodicalIF":4.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}