Ibrain Pub Date : 2023-08-14 DOI: 10.1002/ibra.12123

Yi-Ming Zhuang, Ji-Yang Xu, Kun Zheng, Hong Zhang

{"title":"Research progress of postoperative cognitive dysfunction in cardiac surgery under cardiopulmonary bypass","authors":"Yi-Ming Zhuang, Ji-Yang Xu, Kun Zheng, Hong Zhang","doi":"10.1002/ibra.12123","DOIUrl":"10.1002/ibra.12123","url":null,"abstract":"Cardiopulmonary bypass (CPB) is often used in cardiothoracic surgery because its nonphysiological state causes pathophysiological changes in the body, causing multiorgan and multitissue damage to varying degrees. Postoperative cognitive dysfunction (POCD) is a common central nervous system complication after cardiac surgery. The etiology and mechanism of POCD are not clear. Neuroinflammation, brain mitochondrial dysfunction, cerebral embolism, ischemia, hypoxia, and other factors are related to the pathogenesis of POCD. There is a close relationship between CPB and POCD, as CPB can cause inflammation, hypoxia and reperfusion injury, and microemboli formation, all of which can trigger POCD. POCD increases medical costs, seriously affects patients' quality of life, and increases mortality. Currently, there is a lack of effective treatment methods for POCD. Commonly used methods include preoperative health management, reducing inflammation response during surgery, preventing microemboli formation, and implementing individualized rehabilitation programs after surgery. Strengthening preventive measures can minimize the occurrence of POCD and its adverse effects.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 3","pages":"290-304"},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75458583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Double gene mutations of LRSAM1 and REEP1 and a new REEP1 mutation site found in a patient with amyotrophic lateral sclerosis with subjective paresthesia: A case report LRSAM1和REEP1双基因突变和一个新的REEP1突变位点在肌萎缩侧索硬化症伴有主观感觉异常的患者中发现：1例报告

Ibrain Pub Date : 2023-08-14 DOI: 10.1002/ibra.12125

Ji-Yao Qin, Zun-Lin Zhou, Yuan-Qing Zhou, Ya Chen, Xiao-Yan Yang, Hai-Qing Zhang, Zu-Cai Xu

{"title":"Double gene mutations of LRSAM1 and REEP1 and a new REEP1 mutation site found in a patient with amyotrophic lateral sclerosis with subjective paresthesia: A case report","authors":"Ji-Yao Qin, Zun-Lin Zhou, Yuan-Qing Zhou, Ya Chen, Xiao-Yan Yang, Hai-Qing Zhang, Zu-Cai Xu","doi":"10.1002/ibra.12125","DOIUrl":"10.1002/ibra.12125","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons. Although dyskinesia is the most prominent clinical manifestation of ALS, with an in-depth understanding of disease pathogenesis and clinical detection, more and more ALS patients are found to have nonmotor symptoms, such as sensory impairment. Genetic testing technology has developed rapidly in recent years. New genes have been proven to be involved in the pathogenesis of ALS. However, according to the existing research evidence, no literature has reported that patients with ALS have leucine-rich repeats and sterility α mutations in motif 1 (LRSAM1) and receptor expression accessory protein 1 (REEP1). The mutation sites of REEP1 gene have not been reported, and the simultaneous mutations of two genes have not been reported. In the largest human gene mutation frequency database gnomad, the mutation sites of two genes are currently defined as new heterozygous variants with unclear clinical significance. Therefore, this article reports the clinical data of this case to further deepen the clinicians' understanding of the disease, and may provide evidence for further study of the new genotype–phenotype of LRSAM1 and REEP1.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"11 3","pages":"393-399"},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86594547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gold and silver nanoparticles in Alzheimer's and Parkinson's diagnostics and treatments 阿尔茨海默氏症和帕金森氏症诊断和治疗中的金和银纳米颗粒。

Ibrain Pub Date : 2023-08-14 DOI: 10.1002/ibra.12126

Edoardo Scarpa, Mariafrancesca Cascione, Anna Griego, Paolo Pellegrino, Giorgia Moschetti, Valeria De Matteis

{"title":"Gold and silver nanoparticles in Alzheimer's and Parkinson's diagnostics and treatments","authors":"Edoardo Scarpa, Mariafrancesca Cascione, Anna Griego, Paolo Pellegrino, Giorgia Moschetti, Valeria De Matteis","doi":"10.1002/ibra.12126","DOIUrl":"10.1002/ibra.12126","url":null,"abstract":"Neurodegenerative diseases (NDs) impose substantial medical and public health burdens on people worldwide and represent one of the major threats to human health. The prevalence of these age-dependent disorders is dramatically increasing over time, a process intrinsically related to a constantly rising percentage of the elderly population in recent years. Among all the NDs, Alzheimer's and Parkinson's are considered the most debilitating as they cause memory and cognitive loss, as well as severely affecting basic physiological conditions such as the ability to move, speak, and breathe. There is an extreme need for new and more effective therapies to counteract these devastating diseases, as the available treatments are only able to slow down the pathogenic process without really stopping or resolving it. This review aims to elucidate the current nanotechnology-based tools representing a future hope for NDs treatment. Noble metal nano-systems, that is, gold and silver nanoparticles (NPs), have indeed unique physicochemical characteristics enabling them to deliver any pharmacological treatment in a more effective way within the central nervous system. This can potentially make NPs a new hope for reversing the actual therapeutic strategy based on slowing down an irreversible process into a more effective and permanent treatment.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 3","pages":"298-315"},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41180784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA methylation: The epigenetic mechanism of Alzheimer's disease DNA 甲基化：阿尔茨海默病的表观遗传学机制

Ibrain Pub Date : 2023-08-10 DOI: 10.1002/ibra.12121

Hao-Yue Qin, Jiao-Yan Liu, Chang-Le Fang, Yan-Ping Deng, Ying Zhang

引用次数: 0

The interaction between instrumental activities of daily living and dual sensory function on cognition among the elderly in China: A cross-sectional survey 中国老年人日常生活工具性活动与认知双重感觉功能的互动：一项横断面调查。

Ibrain Pub Date : 2023-08-09 DOI: 10.1002/ibra.12124

Heting Liang, Zhixia Jiang, Xiaoling Yang, Shuang Li, Xiaoling Zhao, Yongya Dai, Siqin Liu, Yumeng Zhang, Xiaoli Yuan

{"title":"The interaction between instrumental activities of daily living and dual sensory function on cognition among the elderly in China: A cross-sectional survey","authors":"Heting Liang, Zhixia Jiang, Xiaoling Yang, Shuang Li, Xiaoling Zhao, Yongya Dai, Siqin Liu, Yumeng Zhang, Xiaoli Yuan","doi":"10.1002/ibra.12124","DOIUrl":"10.1002/ibra.12124","url":null,"abstract":"To explore the interaction of instrumental activities of daily living (IADLs) and dual sensory function on cognition in the elderly. A cross-sectional survey was conducted in six general hospitals in China, from October 2022 to December 2022. Data collection included general information, IADLs scale, self-reported sensory function questionnaire, and mini-mental state examination (MMSE). Binary logistic regression was used to examine the association between factors and cognition. The interactive effect was evaluated by synergy index (S), relative excess risk due to interaction (RERI), and attributable proportion due to interaction (AP). The odds ratio (OR) of IADLs decline in cognition is 4.412 (95% confidence interval [CI]: 3.633–5.358, p < 0.001); the OR of dual sensory difficulty on cognition is 2.502 (95% CI: 1.272–4.921, p = 0.008). The OR of interaction between IADLs decline and dual sensory difficulty on cognition is 13.737 (95% CI: 9.726–19.400, p < 0.001). RERI (95% CI) = 7.823 (3.230–12.417), AP (95% CI) = 0.570 (0.392–0.747), S (95% CI) = 2.593 (1.616–4.160). IADLs decline and dual sensory difficulty are associated with cognitive decline. IADLs decline and dual sensory difficulty have interaction with cognitive decline; the interaction is greater than the sum effect of those two on cognitive decline independently. Sensory and IADLs assessment can be used as early screening items for cognition among the elderly. In addition, protecting sensory function and maintaining IADLs in the elderly can help protect their cognition.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 3","pages":"281-289"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Routes and methods of neural stem cells injection in cerebral ischemia 脑缺血时神经干细胞注射的途径和方法。

Ibrain Pub Date : 2023-08-06 DOI: 10.1002/ibra.12122

Xing-Yu Yang, Xiao Zhang, Jun-Feng Cao, Mei Wu, Sheng-Yan Chen, Li Chen

引用次数: 0

Study on the efficacy of compound porcine cerebroside and ganglioside injection in patients with ischemic stroke: A randomized, single-center, open-label, prospective study 复方猪脑苷神经节苷注射液对缺血性脑卒中患者的疗效研究：一项随机、单中心、开放标签、前瞻性研究

Ibrain Pub Date : 2023-07-15 DOI: 10.1002/ibra.12120

Ya Chen, Xia Zhang, Hai-Qing Zhang, Zhong Luo, Xue-Jiao Zhou, Tao Liang, Fei Yang, Jun Zhang, Zu-Cai Xu

{"title":"Study on the efficacy of compound porcine cerebroside and ganglioside injection in patients with ischemic stroke: A randomized, single-center, open-label, prospective study","authors":"Ya Chen, Xia Zhang, Hai-Qing Zhang, Zhong Luo, Xue-Jiao Zhou, Tao Liang, Fei Yang, Jun Zhang, Zu-Cai Xu","doi":"10.1002/ibra.12120","DOIUrl":"10.1002/ibra.12120","url":null,"abstract":"Compound porcine perebroside and ganglioside injection (CPCGI) was used to treat stroke. The study was initiated because of the high incidence of low-does CPCGI use in our area. However, no research has confirmed the effectiveness of CPCGI below the standard dose. Therefore, the aim of this study was to provide a reference for the clinical selection of different dose treatments. We collected ischemic stroke patients and divided them into three groups (low-dose group: Group A = 4 mL, Group B = 6 mL, standard-dose group: Group C = 10 mL). The modified Rankin Scale (mRS) scores, the National Institutes of Health Stroke Scale (NIHSS) scores, and the Barthel Index (BI) scores were performed before treatment and 14 days and 90 days post CPCGI treatment. For 90 days, the primary outcomes were calculated including the degree of disability, neurological recovery, and activities of daily living. All data were compared between pretherapy and posttreatment and among groups. NIHSS, mRS and BI scores improved on 14 and 90 days in each group. Group B and C improved than Group A on 14 and 90 days. The difference between groups B and C was not statistically significant. On 90 days, there were differences in the degree of disability, the recovery of neurological function, and the ability of daily living among groups. No drug-related adverse reactions occurred in the groups. Although 4 or 6 mL CPCGI had some neuroprotective effects, the standard dose of 10 mL CPCGI had the best effect on reducing the degree of disability and improving abilities of daily living.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"11 3","pages":"364-374"},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80607080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis 天麻素的药理作用：对铁下垂和焦下垂神经系统疾病及其机制的认识

Ibrain Pub Date : 2023-07-13 DOI: 10.1002/ibra.12118

Xue Zheng, Jing Li, Zhao-Qiong Zhu

引用次数: 0

Development of an innovative minimally invasive primate spinal cord injury model: A case report 一种创新的微创灵长类脊髓损伤模型的开发：一例报告。

Ibrain Pub Date : 2023-07-10 DOI: 10.1002/ibra.12117

Yong-Min Niu, Jin-Xiang Liu, Hao-Yue Qin, Yi-Fan Liu, Ni-Jiao Huang, Ji-Li Jiang, Yan-Qiu Chen, Si-Jing Chen, Tao Bai, Chang-Wei Yang, Yu Cao, Sheng Liu, Hao Yuan

引用次数: 0

Transformation of a low-grade glioma into a glioblastoma along with the development of lung and mediastinal lymph node metastases after repeated craniotomy: A case report 反复开颅手术后，低级别胶质瘤转变为胶质母细胞瘤，并出现肺部和纵隔淋巴结转移：病例报告

Ibrain Pub Date : 2023-07-06 DOI: 10.1002/ibra.12119

Yunan Wang, Hua Yang, Jun Su, Xiaobin Jian, Peijie Li, Jianguo Zhou, Wei Hu

{"title":"Transformation of a low-grade glioma into a glioblastoma along with the development of lung and mediastinal lymph node metastases after repeated craniotomy: A case report","authors":"Yunan Wang, Hua Yang, Jun Su, Xiaobin Jian, Peijie Li, Jianguo Zhou, Wei Hu","doi":"10.1002/ibra.12119","DOIUrl":"10.1002/ibra.12119","url":null,"abstract":"Extracranial metastasis of glioma is extremely rare. Herein, we report a case of glioblastoma that originated and showed stepwise malignant transformation from a low-grade glioma (LGG) along with the presence of lung and mediastinal lymph node metastases after repeated craniotomy. A 30-year-old man presented with hemoptysis. Thoracic computed tomography revealed a space-occupying lesion in the right upper lung with mediastinal nodal and metastases in both lungs; lung cancer was suspected. The patient's medical history showed that he had undergone craniotomy three times in 7 years for a primary LGG disease relapse, and stepwise malignant-transformed high-grade glioma (HGG). However, brain magnetic resonance imaging did not reveal any relapse of intracranial tumors. The diagnosis of extracranial metastatic glioblastoma was confirmed using the morphology and staining results for specific immunohistochemistry markers using the specimen obtained via endobronchial ultrasound transbronchial needle aspiration. Subsequently, the patient received a combination of systemic and local treatments; however, he died of massive hemoptysis after 6 months. The survival time of this glioma patient improved after transformation and metastasis. Detailed descriptions will help us understand the biological behavior of glioma, but more studies are needed to confirm the complex mechanism of extracranial metastasis.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 3","pages":"385-389"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83250451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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