Ibrain最新文献_第8页

The role of the basal forebrain in general anesthesia 基底前脑在全身麻醉中的作用。

Ibrain Pub Date : 2022-12-03 DOI: 10.1002/ibra.12082

Yi-Ting Peng, Cheng-Dong Yuan, Yi Zhang

引用次数: 0

Protective effect of isoflurane preconditioning on neurological function in rats with HIE 异氟醚预处理对HIE大鼠神经功能的保护作用

Ibrain Pub Date : 2022-12-03 DOI: 10.1002/ibra.12081

Yi Fei-Sun, Miao Huang, Hao-Yue Qin, Senio Campos de SouzaHan, Han Xue, Yu-Ying Wang, Yi-Bo Wang

{"title":"Protective effect of isoflurane preconditioning on neurological function in rats with HIE","authors":"Yi Fei-Sun, Miao Huang, Hao-Yue Qin, Senio Campos de SouzaHan, Han Xue, Yu-Ying Wang, Yi-Bo Wang","doi":"10.1002/ibra.12081","DOIUrl":"10.1002/ibra.12081","url":null,"abstract":"Hypoxic–ischemic encephalopathy (HIE) is an important cause of neonatal death and disability, which can lead to long-term neurological and motor dysfunction. Currently, inhalation anesthetics are widely used in surgery, and some studies have found that isoflurane (ISO) may have a positive effect on neuroprotection. In this paper, we investigated whether ISO pretreatment has a neuroprotective effect on the neurological function of HIE rats. Here, 7-day-old neonatal rats were randomly divided into a sham group, a hypoxic–ischemic (HI) group, and an ISO pretreatment (pretreatment) group. The pretreatment group was pretreated with 2% ISO for 1 h, followed by the HI group to establish an HI animal model. The HI‑induced neurological injury was evaluated by Zea‑Longa scores and triphenyltetrazolium (TTC) staining. Neuronal number and histomorphological changes were observed with Nissl staining and Hematoxylin–eosin (HE) staining. In addition, motor learning memory function was evaluated by the Morris water maze (MWM), the Y-maze, and the rotarod tests. HI induced severe neurological dysfunction, brain infarction, and cell apoptosis as well as obvious neuron loss in neonatal rats. In the MWM, the rats in the pretreatment group showed a decrease in escape latency (p = 0.042), indicating that pretreatment with ISO could improve the learning ability of HI rats. The results of Nissl staining showed that in the HI group, there was an irregular arrangement of neurons and nuclear fixation; however, the cell damage was significantly reduced and the total number of neurons was increased after ISO pretreatment (p < 0.001). In conclusion, ISO pretreatment improved cognitive function and attenuated HI-induced reduction of Nissl-positive cells and spatial memory impairment, suggesting that pretreatment with ISO before HI modeling could reduce neuronal cell death in the hippocampus after HI.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"8 4","pages":"500-515"},"PeriodicalIF":0.0,"publicationDate":"2022-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41165719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dyslexia with and without Irlen syndrome: A study of influence on abilities and brain-derived neurotrophic factor level 伴有和不伴有Irlen综合征的诵读困难：对能力和脑源性神经营养因子水平影响的研究。

Ibrain Pub Date : 2022-12-01 DOI: 10.1002/ibra.12080

Ehab R. Abdelraouf, Ayman Kilany, Mohamed E. Elhadidy, Hala M. Zeidan, Amal Elsaied, Ola M. Eid, Mostafa M. El-Saied, Rasha Anwar, Neveen H. Nashaat

{"title":"Dyslexia with and without Irlen syndrome: A study of influence on abilities and brain-derived neurotrophic factor level","authors":"Ehab R. Abdelraouf, Ayman Kilany, Mohamed E. Elhadidy, Hala M. Zeidan, Amal Elsaied, Ola M. Eid, Mostafa M. El-Saied, Rasha Anwar, Neveen H. Nashaat","doi":"10.1002/ibra.12080","DOIUrl":"10.1002/ibra.12080","url":null,"abstract":"The presence of comorbid Irlen syndrome (IS) in children with developmental dyslexia (DD) may have an impact on their reading and cognitive abilities. Furthermore, the brain-derived neurotrophic factor (BDNF) was reported to be expressed in brain areas involved in cognitive and visual processing. The aim of this study was to evaluate some cognitive abilities of a group of dyslexic children with IS and to measure and compare the plasma BDNF level to dyslexic children without IS and neurotypical (NT) children. The participants were 60 children with DD (30 in the DD + IS group; 30 in the DD group) and 30 NT children. The Irlen reading perceptual scale, the Stanford Binet intelligence scale, 4th ed, the dyslexia assessment test, and the Illinois test of psycholinguistic abilities were used. The BDNF level was measured using the enzyme-linked immunosorbent assay. One-minute writing and visual closure deficits were more prevalent, while phonemic segmentation deficits were less prevalent in the DD + IS group compared to the DD group. The BDNF level in the DD groups was lower than that in NT children (p < 0.001). Some reading and non-reading tasks were influenced by the presence of a coexisting IS. The reduced BDNF level could play a role in the deficits noticed in the abilities of children with DD.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 1","pages":"32-42"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41170991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental study of different dehydration methods in the process of preparing frozen brain sections 制备冷冻脑切片过程中不同脱水方法的实验研究

Ibrain Pub Date : 2022-11-29 DOI: 10.1002/ibra.12075

Hong-Su Zhou, Jing Li, Yi-Huan Guan, Hua He, Li-Ren Huang Fu

{"title":"Experimental study of different dehydration methods in the process of preparing frozen brain sections","authors":"Hong-Su Zhou, Jing Li, Yi-Huan Guan, Hua He, Li-Ren Huang Fu","doi":"10.1002/ibra.12075","DOIUrl":"10.1002/ibra.12075","url":null,"abstract":"This study aimed to provide a recommendable protocol for the preparation of brain cryosections of rats to reduce and avoid ice crystals. We have designed five different dewatering solutions (Scheme 1: dehydrate with 15%, 20%, and 30% sucrose–phosphate-buffered saline solution; Scheme 2: 20% sucrose and 30% sucrose; Scheme 3: 30% sucrose; Scheme 4: 10%, 20%, and 30% sucrose; and Scheme 5: the tissue was dehydrated with 15% and 30% sucrose polyacetate I until it sank to the bottom, followed by placement in 30% sucrose polyacetate II) to minimize the formation of ice crystals. Cryosections from different protocols were stained with Nissl staining and compared with each other by density between cells and the distance of intertissue spaces. The time required for the dehydration process from Scheme 1 to Scheme 5 was 24, 23, 24, 24, and 33 h, respectively. Density between cells gradually decreased from Scheme 1 to Scheme 5, and the distance of intertissue spaces was differentiated and irregular in different schemes according to the images of Nissl staining. We recommend the dewatering method of Scheme 4 (the brain tissues were dehydrated in 10%, 20% and 30% sucrose solution in turn until the tissue samples were completely immersed in the solution and then immersed in the next concentration solution for dehydration).","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 2","pages":"164-171"},"PeriodicalIF":0.0,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86912704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feasibility study of use of desflurane combined with dexmedetomidine in inhibiting postoperative neurocognitive disorders in elderly patients under general anesthesia: A perspective study 使用地氟醚联合右美托咪定抑制全身麻醉下老年患者术后神经认知障碍的可行性研究：透视研究

Ibrain Pub Date : 2022-11-23 DOI: 10.1002/ibra.12073

Yue Hu, Yong Ye, Hui Lin, Jun-Jie Chen, Ting-Ting Sun, Gong-Wei Zhang, Na Wang, Yuan-Hang Shu, Xue Gong, Fei-Fei Ran, Jia-Li Zhang, Yong Tao

{"title":"Feasibility study of use of desflurane combined with dexmedetomidine in inhibiting postoperative neurocognitive disorders in elderly patients under general anesthesia: A perspective study","authors":"Yue Hu, Yong Ye, Hui Lin, Jun-Jie Chen, Ting-Ting Sun, Gong-Wei Zhang, Na Wang, Yuan-Hang Shu, Xue Gong, Fei-Fei Ran, Jia-Li Zhang, Yong Tao","doi":"10.1002/ibra.12073","DOIUrl":"10.1002/ibra.12073","url":null,"abstract":"This study aimed to explore whether the combined application of desflurane and dexmedetomidine (Dex) reduces the occurrence of postoperative neurocognitive disorders (PND) in patients. We selected patients in our hospital who underwent surgery under general anesthesia, and divided them into two groups: Dex and desflurane (Dex + Des) and desflurane (Des) groups. The data of patients were collected and the Mini-Mental State Examination (MMSE) score was used to assess cognitive status. The blood cell counts were determined preoperatively and on postoperative days 1, 3, and 6, and the percentage of neutrophils and lymphocytes were also recorded. The statistical methods used were the independent-samples t-test and the χ2 test. Pearson's correlation was used to analyze the correlation between PND and inflammation. The incidence of PND in the Dex + Des group was lower than that in the Des group. The postoperative MMSE scores in the Dex + Des group were higher than those in the Des group (p = 0.032). The percentage of neutrophils in the Dex + Des group was significantly lower than that in the Des group on the first and third days after surgery (p = 0.007; p = 0.028). The MMSE scores on the first day after surgery were negatively correlated with the multiple changes in white blood counts and the percentage of neutrophils (r = −0.3038 and −0.3330). Dex combined with Des reduced the incidence of PND and reduced the postoperative inflammatory cell counts.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 2","pages":"186-196"},"PeriodicalIF":0.0,"publicationDate":"2022-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84034053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive impairment induced by sevoflurane anesthesia is mediated by the cholinergic system after gastrointestinal surgery in older patients: A randomized, controlled trial 老年胃肠道手术后，七氟醚麻醉引起的认知障碍是由胆碱能系统介导的：随机对照试验

Ibrain Pub Date : 2022-11-17 DOI: 10.1002/ibra.12079

Xing-Xing Liu, Qing-Xu Yang, Yi Guo, Miao He, Zhen-He Yu, Qi Tian, Zhao-Qiong Zhu

{"title":"Cognitive impairment induced by sevoflurane anesthesia is mediated by the cholinergic system after gastrointestinal surgery in older patients: A randomized, controlled trial","authors":"Xing-Xing Liu, Qing-Xu Yang, Yi Guo, Miao He, Zhen-He Yu, Qi Tian, Zhao-Qiong Zhu","doi":"10.1002/ibra.12079","DOIUrl":"10.1002/ibra.12079","url":null,"abstract":"Delayed neurocognitive recovery after surgery is associated with increased morbidity and mortality. However, its mechanism of action remains controversial and complex. A prospective, double-blind, randomized controlled trial was performed at the Affiliated Hospital of Zunyi Medical University. Older patients (aged 65 years and older) who underwent gastrointestinal surgery were randomly divided into sevoflurane-based or propofol-based anesthesia groups. The Mini-Mental State Examination was performed to evaluate cognitive function. Peripheral venous blood was collected to test the levels of choline acetyltransferase and acetylcholinesterase. A total of 75 patients were enrolled and 30 patients in each group completed the study. On Day 1 postoperation, patients in the sevoflurane group showed worse performance on the Mini-Mental State Examination than patients in the propofol group. Lower blood choline acetyltransferase concentrations and higher acetylcholinesterase concentrations were observed in patients who had sevoflurane anesthesia than in patients who had propofol anesthesia 1 day postoperative. At 3 days postoperation, patients with sevoflurane- or propofol-based general anesthesia did not differ regardless of Mini-Mental State Examination score or choline acetyltransferase and acetylcholinesterase levels. Sevoflurane-based anesthesia has short-term delayed neurocognitive recovery in older surgical patients, which may be related to central cholinergic system degeneration.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 3","pages":"366-374"},"PeriodicalIF":0.0,"publicationDate":"2022-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89464528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suppression of SAMSN1 contributes to neuroprotection in neonatal rats suffering from hypoxic–ischemic encephalopathy injury SAMSN1的抑制有助于对缺氧缺血性脑病损伤的新生大鼠的神经保护。

Ibrain Pub Date : 2022-11-12 DOI: 10.1002/ibra.12078

Yi-Bo Wang, Zong-Jin Gan, Jun-Yan Zhang, Somjit Wanchana, Xi-Liang Guo

{"title":"Suppression of SAMSN1 contributes to neuroprotection in neonatal rats suffering from hypoxic–ischemic encephalopathy injury","authors":"Yi-Bo Wang, Zong-Jin Gan, Jun-Yan Zhang, Somjit Wanchana, Xi-Liang Guo","doi":"10.1002/ibra.12078","DOIUrl":"10.1002/ibra.12078","url":null,"abstract":"This article aims to detect the effect of SAM domain, SH3 domain, and nuclear localization signal 1 (SAMSN1) in neonatal rats with neurological dysfunction induced by hypoxia and ischemia (HI). The HI model was created using 7-day postnatal rats. Zea-longa score was utilized to validate the neurological injury after HI. Then, the differentially expressed genes (DEGs) were detected by gene sequencing and bioinformatics analysis methods. The oxygen and glucose deprivation (OGD) models were established in the SY5Y cells and fetal human cortical neurons. In addition, SAMSN1-small interfering RNA, methyl thiazolyl tetrazolium assay, and cell growth curve were employed to evaluate the cell viability variation. Obviously, Zea-longa scores increased in rats with HI insult. Subsequently, SAMSN1 was screened out, and it was found that SAMSN1 was strikingly upregulated in SY5Y cells and fetal neurons post-OGD. Interestingly, we found that SAMSN1 silencing could markedly enhance cell viability and cell growth after OGD. These data suggested that downregulation of SAMSN1 may exert a neuroprotective effect on damaged neurons after HI by improving cell viability and cell survival, which provides a potential theoretical basis for clinical trials in the future to treat neonatal hypoxic–ischemic encephalopathy.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 1","pages":"3-12"},"PeriodicalIF":0.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A typically progressive dissection of the internal carotid artery with recurrent hiccups: A case report with continuous 2-year data recording 典型的颈内动脉进行性夹层伴反复打嗝：一例连续2年数据记录的病例报告。

Ibrain Pub Date : 2022-11-09 DOI: 10.1002/ibra.12074

Zong-Min Zhang, Xin-Xin Yang, Li Ling, Man-Hong Zhou

引用次数: 0

The effective doses of remimazolam besylate in the procedural sedation of endoscopic retrograde cholangiopancreatography 苯磺酸雷马唑仑在内镜逆行胰胆管造影术中镇静的有效剂量。

Ibrain Pub Date : 2022-11-09 DOI: 10.1002/ibra.12072

Dan-Dan Tan, Jin Gu, Juan Li, Wan-Qiu Yu, De-Xing Liu, Li-Jin Zhao, Guo-Hua Zhu, Xin-Xin Yang, Jin Tian, Qi Tian, Zhao-Qiong Zhu

{"title":"The effective doses of remimazolam besylate in the procedural sedation of endoscopic retrograde cholangiopancreatography","authors":"Dan-Dan Tan, Jin Gu, Juan Li, Wan-Qiu Yu, De-Xing Liu, Li-Jin Zhao, Guo-Hua Zhu, Xin-Xin Yang, Jin Tian, Qi Tian, Zhao-Qiong Zhu","doi":"10.1002/ibra.12072","DOIUrl":"10.1002/ibra.12072","url":null,"abstract":"This study aimed to determine the values of the half-effective dose (ED50) and 95% effective dose (ED95) of remimazolam besylate used in the procedural sedation of endoscopic retrograde cholangiopancreatography (ERCP). Sixty patients who fulfilled the inclusion and exclusion criteria of this study were selected. Sufentanil was administered intravenously and remimazolam besylate was administered 2 min later. ERCP treatment was feasible when the modified alertness/sedation (MOAA/S) score was ≤2. If choking or movement occurred during duodenoscope placement, it was considered as a positive reaction. The dose was increased in the next patient; otherwise, it was considered as a negative reaction, and the dose was reduced in the next patient. The ED50 and ED95 values and 95% confidence interval (CI) of remimazolam besylate were calculated by Probit regression analysis. All 60 patients completed the trial. The ED50 and ED95 values of remimazolam besylate were 0.196 and 0.239 mg/kg, respectively, for the procedural sedation of ERCP. The time of MOAA/S score ≤ 2 was (82.58 ± 21.70) s, and the mean time of awakening was (9.03 ± 5.64) min. Transient hypotension was observed in two patients without medical intervention. The ED50 and ED95 values of remimazolam besylate used in the procedural sedation of ERCP were 0.196 and 0.239 mg/kg, and the dose of the medications has definite efficacy and good safety.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 3","pages":"290-297"},"PeriodicalIF":0.0,"publicationDate":"2022-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41160622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroscience of consciousness in the locked-in syndrome: Prognostic and diagnostic review 闭锁综合征中的意识神经科学:预后和诊断回顾

Ibrain Pub Date : 2022-11-07 DOI: 10.1002/ibra.12077

Berenika Maciejewicz

{"title":"Neuroscience of consciousness in the locked-in syndrome: Prognostic and diagnostic review","authors":"Berenika Maciejewicz","doi":"10.1002/ibra.12077","DOIUrl":"10.1002/ibra.12077","url":null,"abstract":"The neurological illness known as a locked-in syndrome is brought on by damage to the brainstem, usually as a consequence of a stroke. It is characterized by total paralysis with intact consciousness and cognitive capacity. The subjective experiences of people with locked-in syndrome are poorly understood. Presently, there is no systematic evaluation developed to describe them. The most compelling resources come from individuals’ own words; however, only a small fraction of these accounts have been explored. When it comes to bioethics, locked-in syndrome protocols are almost completely absent. Investigations on how people with this condition feel about their sense of continuity are of importance. Utilizing the locked-in syndrome to pose questions on embodied cognition and levels of consciousness could serve as a lens through which to examine problems in the phenomenology of neuroparalysis and communication. Care and quality of patients’ lives might be improved by an effort to understand this condition better, and ontological questions like “what makes a person a person?,” “what makes a person appear in continuity?,” and “what are the dynamics of embodiment and intersubjectivity?” might be better explored through that lens. This article aims to explore some biomedical factors that contribute to locked-in syndrome and offers some prognostic and diagnostic recommendations for this rare condition.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"8 4","pages":"476-480"},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41158676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0