Ibrain最新文献

{"title":"Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis","authors":"Xue Zheng,&nbsp;Jing Li,&nbsp;Zhao-Qiong Zhu","doi":"10.1002/ibra.12118","DOIUrl":"10.1002/ibra.12118","url":null,"abstract":"<p>Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti-inflammatory, antioxidant, antiapoptosis, and other aspects. As the global aging process continues to intensify, diseases of the central nervous system, cardiovascular system, and immune system have brought serious economic and mental burdens to families and have become a major challenge for global public health resources. Many studies have proved that gastrodin may be a potential drug for neurological diseases and ischemic injury but its mechanism of action is still unclear. [Correction added on 19 February 2025, after first online publication: In the preceding sentence, “the treatment of various systemic diseases” has been corrected to “neurological diseases and ischemic injury” in this version.]. In this study, the pharmacological action of gastrodin and the possible mechanism of regulating ferroptosis and pyroptosis were reviewed to provide a new treatment and research direction for clinicians and researchers.</p>","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"11 1","pages":"74-83"},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75080195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an innovative minimally invasive primate spinal cord injury model: A case report","authors":"Yong-Min Niu,&nbsp;Jin-Xiang Liu,&nbsp;Hao-Yue Qin,&nbsp;Yi-Fan Liu,&nbsp;Ni-Jiao Huang,&nbsp;Ji-Li Jiang,&nbsp;Yan-Qiu Chen,&nbsp;Si-Jing Chen,&nbsp;Tao Bai,&nbsp;Chang-Wei Yang,&nbsp;Yu Cao,&nbsp;Sheng Liu,&nbsp;Hao Yuan","doi":"10.1002/ibra.12117","DOIUrl":"10.1002/ibra.12117","url":null,"abstract":"<p>Spinal cord injury (SCI) animal models have been widely created and utilized for repair therapy research, but more suitable experimental animals and accurate modeling methodologies are required to achieve the desired results. In this experiment, we constructed an innovative dorsal 1/4 spinal cord transection macaque model that had fewer severe problems, facilitating postoperative care and recovery. In essence, given that monkeys and humans share similar genetics and physiology, the efficacy of this strategy in a nonhuman primate SCI model basically serves as a good basis for its prospective therapeutic use in human SCI.</p>","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 3","pages":"349-356"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41165732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transformation of a low-grade glioma into a glioblastoma along with the development of lung and mediastinal lymph node metastases after repeated craniotomy: A case report","authors":"Yunan Wang,&nbsp;Hua Yang,&nbsp;Jun Su,&nbsp;Xiaobin Jian,&nbsp;Peijie Li,&nbsp;Jianguo Zhou,&nbsp;Wei Hu","doi":"10.1002/ibra.12119","DOIUrl":"10.1002/ibra.12119","url":null,"abstract":"<p>Extracranial metastasis of glioma is extremely rare. Herein, we report a case of glioblastoma that originated and showed stepwise malignant transformation from a low-grade glioma (LGG) along with the presence of lung and mediastinal lymph node metastases after repeated craniotomy. A 30-year-old man presented with hemoptysis. Thoracic computed tomography revealed a space-occupying lesion in the right upper lung with mediastinal nodal and metastases in both lungs; lung cancer was suspected. The patient's medical history showed that he had undergone craniotomy three times in 7 years for a primary LGG disease relapse, and stepwise malignant-transformed high-grade glioma (HGG). However, brain magnetic resonance imaging did not reveal any relapse of intracranial tumors. The diagnosis of extracranial metastatic glioblastoma was confirmed using the morphology and staining results for specific immunohistochemistry markers using the specimen obtained via endobronchial ultrasound transbronchial needle aspiration. Subsequently, the patient received a combination of systemic and local treatments; however, he died of massive hemoptysis after 6 months. The survival time of this glioma patient improved after transformation and metastasis. Detailed descriptions will help us understand the biological behavior of glioma, but more studies are needed to confirm the complex mechanism of extracranial metastasis.</p>","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 3","pages":"385-389"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83250451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral hearing loss caused by anti-NMDA receptor encephalitis with teratoma: A case report","authors":"Guo-Fang Zhang,&nbsp;Tao Liang,&nbsp;Yi-Kun Lv,&nbsp;Zhong Luo,&nbsp;Jun Zhang","doi":"10.1002/ibra.12116","DOIUrl":"10.1002/ibra.12116","url":null,"abstract":"<p>Autoimmune encephalitis (AE) is an autoimmune disease in the central nervous system. Clinical manifestations include cognitive dysfunction, psychiatric-behavioral abnormalities, epilepsy, motor disorders, speech disorders, and memory impairment. Some patients do not have the characteristic clinical manifestations of the disease when they see a doctor, so they are easily diagnosed incorrectly. Autoimmune antibodies originate from genetic and acquired factors. Clinical data have found a correlation between ovarian teratoma and autoimmune encephalitis. This case reports a 34-year-old woman who was diagnosed with teratoma-associated anti-N-methyl-D- aspartate receptor-mediated autoimmune encephalitis called anti-N-methyl-D-aspartate receptor encephalitis with bilateral hearing loss in 2021. Through this case report, clinicians will pay attention to autoimmune encephalitis and raise awareness of the specific clinical manifestations of autoimmune encephalitis, and focus on early identification. It means that clinicians should be familiar with the representative clinical manifestations of the disease.</p>","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 3","pages":"378-384"},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75912984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basic information about memantine and its treatment of Alzheimer's disease and other clinical applications","authors":"Bin-Can Tang,&nbsp;Ya-Ting Wang,&nbsp;Jie Ren","doi":"10.1002/ibra.12098","DOIUrl":"10.1002/ibra.12098","url":null,"abstract":"<p>Memantine is a noncompetitive moderate-affinity strong voltage-dependent N-methyl-D-aspartate receptor antagonist. It has been used to treat Alzheimer's disease (AD) since 1989. In 2018, it became the second most commonly used drug for the treatment of dementia in the world. AD is nonreversible, and memantine can only relieve the symptoms of AD but not cure it. Over the past half-century, memantine's research and clinical application have been extensively developed. In this review, the basic composition of memantine, the mechanism and limitations of memantine in the treatment of AD, memantine combination therapy, comparison of memantine with other drugs for AD, and clinical studies of memantine in other diseases are reviewed to provide a valuable reference for further research and application of memantine for the treatment of AD.</p>","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 3","pages":"340-348"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41176393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of the treatment and care of decubitus ulcers in macaques with spinal cord injury","authors":"Yong-Min Niu,&nbsp;Hao-Yue Qin,&nbsp;Jin-Xiang Liu,&nbsp;Xin-Yi Li,&nbsp;An-Su Wang,&nbsp;Ling-Xia Sun,&nbsp;Ni-Jiao Huang,&nbsp;Chang-Wei Yang,&nbsp;Yu Cao,&nbsp;Tao Bai,&nbsp;Yang Lan,&nbsp;Sheng Liu,&nbsp;Hao Yuan","doi":"10.1002/ibra.12105","DOIUrl":"10.1002/ibra.12105","url":null,"abstract":"<p>Decubitus ulcers are a common spinal cord injury (SCI) complication that puts patients' lives in danger and has emerged as a more prevalent issue in modern clinical rehabilitation and care. Decubitus ulcers in humans can currently be treated in a number of different ways, but there are fewer studies on how to treat and care for decubitus ulcers in macaques. To treat a 20-year-old adult male macaque monkey with SCI and decubitus ulcers after a quarter transection of the thoracic spinal cord, a number of scientific care procedures and pharmaceutical treatments, such as dietary changes and topical or intravenous administration of medication, were carried out and continuously monitored in real-time. In comparison to the untreated group, we observed a significant improvement in decubitus wound healing in the macaques. In this article, we provide a good protocol for decubitus ulcer care after SCI and suggest that future experimental animal modeling needs to focus on issues such as care for postoperative complications.</p>","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 2","pages":"236-242"},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41126107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tyrosine metabolic reprogramming coordinated with the tricarboxylic acid cycle to drive glioma immune evasion by regulating PD-L1 expression","authors":"Ji-Yan Wang,&nbsp;Xin-Tong Dai,&nbsp;Qing-Le Gao,&nbsp;Hong-Kai Chang,&nbsp;Shuai Zhang,&nbsp;Chang-Liang Shan,&nbsp;Tao He","doi":"10.1002/ibra.12107","DOIUrl":"10.1002/ibra.12107","url":null,"abstract":"<p>Due to the existence of the blood–brain barrier in glioma, traditional drug therapy has a poor therapeutic outcome. Emerging immunotherapy has been shown to have satisfactory therapeutic effects in solid tumors, and it is clinically instructive to explore the possibility of immunotherapy in glioma. We performed a retrospective analysis of RNA-seq data and clinical information in 1027 glioma patients, utilizing machine learning to explore the relationship between tyrosine metabolizing enzymes and clinical characteristics. In addition, we also assessed the role of tyrosine metabolizing enzymes in the immune microenvironment including immune infiltration and immune evasion. Highly expressed tyrosine metabolizing enzymes 4-hydroxyphenylpyruvate dioxygenase, homogentisate 1,2-dioxygenase, and fumarylacetoacetate hydrolase not only promote the malignant phenotype of glioma but are also closely related to poor prognosis. The expression of tyrosine metabolizing enzymes could distinguish the malignancy degree of glioma. More importantly, tyrosine metabolizing enzymes regulate the adaptive immune process in glioma. Mechanistically, multiple metabolic enzymes remodel fumarate metabolism, promote α-ketoglutarate production, induce programmed death-ligand 1 expression, and help glioma evade immune surveillance. Our data suggest that the metabolic subclass driven by tyrosine metabolism provides promising targets for the immunotherapy of glioma.</p>","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 2","pages":"133-147"},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging-related histone modification changes in brain function","authors":"Yanwen Ding,&nbsp;Chengxi Liu,&nbsp;Yi Zhang","doi":"10.1002/ibra.12106","DOIUrl":"10.1002/ibra.12106","url":null,"abstract":"<p>Aging can be defined as a decline of physiological function that is more difficult to reverse, characterized by the loss of the physiological integrity of tissues, organs, and cells of an organism over time. Normal aging is associated with structural and functional changes in the brain, involving neuronal apoptosis, synaptic structure, neurotransmission, and metabolism alterations, leading to impairment in sleep, cognitive functions, memory, learning, and motor and sensory systems. Histone modification is a significant aging-related epigenetic change that influences synaptic and mitochondrial function and immune and stress responses in the brain. This review discusses the changes in histone modifications that occur during brain aging, specifically methylation and acetylation, and the associated changes in gene transcription and protein expression. We observed that genes related to synaptic and mitochondrial function are downregulated in the aging brain, while genes related to immune response and inflammatory functions are upregulated.</p>","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 2","pages":"205-213"},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41171614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrifty effect of subanesthetic-dose S-ketamine on postoperative opioids and its safety and analgesic effectiveness: A prospective, triple-blind, randomized controlled, polycentric clinical trial","authors":"Jun Ding,&nbsp;Yun-Mei Yu,&nbsp;Man Luo,&nbsp;Xu Fang,&nbsp;Dan-Dan Tan,&nbsp;Han-Rui Qin,&nbsp;Xue-Feng Ren,&nbsp;Yong-Guo Zhang,&nbsp;Tao Luo,&nbsp;Lei Chen,&nbsp;Wan-Qiu Yu,&nbsp;Zhao-Qiong Zhu","doi":"10.1002/ibra.12104","DOIUrl":"10.1002/ibra.12104","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate the thrifty effects of subanesthetic-dose S-ketamine on postoperative opioids and its safety and analgesic efficacy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Four-hundred and twenty patients were divided into the control group (CON group), the S-ketamine 0.2 mg/kg group (ES0.2 group), and the S-ketamine 0.3 mg/kg group (ES0.3 group) randomly. Major indicators include the Visual Analogue Scale (VAS), the times of compression with analgesic pumps after surgery, and analgesic drug consumption from anesthesia induction to 48 h after surgery. Minor records include vital signs, the use of vasoactive drugs, the Ramsay scores, the occurrence of adverse events including nervous system reaction, and the patient's satisfaction with anesthesia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with the CON group, VAS scores decreased in the ES0.2 and ES0.3 groups (<i>p</i> &lt; 0.05). At 10 min after extubation, the VAS scores of the ES0.3 group were lower than that of the ES0.2 group (<i>p</i> &lt; 0.05). The total number of compression with analgesic pumps of the ES0.3 group was lower than that of the CON group (<i>p</i> &lt; 0.05). The opioid consumption after surgery of the ES0.3 group was lower than those of the CON group and the ES0.2 group (<i>p</i> &lt; 0.05). The ES0.3 group's heart rate (HR) was faster but the use of vasoactive, drug consumption was less than the other two groups (<i>p</i> &lt; 0.05). There were no significant differences in the incidence of postoperative adverse events and anesthetic satisfaction among the three groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Subanesthetic-dose S-ketamine at 0.2–0.3 mg/kg especially the 0.3 mg/kg in general anesthesia induction can safely and effectively reduce postoperative pain and save postoperative opioid consumption.</p>\u0000 </section>\u0000 </div>","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 2","pages":"171-182"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41160237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scutellarein treats neuroblastoma by regulating the expression of multiple targets","authors":"Chen-Yang Zhai,&nbsp;Ji-Sheng Fan,&nbsp;Rong-Ping Zhang","doi":"10.1002/ibra.12100","DOIUrl":"10.1002/ibra.12100","url":null,"abstract":"<p>The aim of this study is to investigate the effect of scutellarein on the proliferation of neuroblastoma cells and the underlying mechanism. Six cell lines were used with drug intervention. Cell Counting Kit-8 was used to select the best, namely, SH-SY5Y, and then its IC₅₀ value was determined. To further investigate the mechanism of scutellarin affecting SH-SY5Y proliferation, quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression levels of 11 factors. Scutellarin administration with 300 μM significantly reduced the number of SH-SY5Y, especially on the 3rd day of exposure to scutellarin. The IC₅₀ value of scutellarin in SH-SY5Y cells was determined to be 117.8 μM. But the practical results showed that 300 μM was the optimal concentration of scutellarin. qRT-PCR further detected upregulated maternally expressed gene 3 (MEG3), oncogene c-Fos (c-FOS), and c-jun and downregulated M2 isoform of pyruvate kinase (PKM2), non-SMC Condensin I Complex Subunit H (NCAPH), epidermal growth factor receptor (EGFR), transforming growth factor (TGF)-β1, and TGF-α, suggesting that scutellarin with 300 μM volume inhibited the survival of SH-SY5Y by regulating the expression of these 8 factors. Scutellarin could be a novel drug for the treatment of neuroblastoma, and its underlying mechanism may be related to the upregulated levels of MEG3, c-FOS, and c-jun and downregulated the expression of PKM2, NCAPH, EGFR, TGF-β1, and TGF-α.</p>","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 3","pages":"345-355"},"PeriodicalIF":0.0,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79298717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}