Ibrain最新文献 - Book学术

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42-induced neuronal cell models

Ibrain Pub Date : 2025-02-08 DOI: 10.1002/ibra.12192

Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng

{"title":"Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42-induced neuronal cell models","authors":"Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng","doi":"10.1002/ibra.12192","DOIUrl":"https://doi.org/10.1002/ibra.12192","url":null,"abstract":"The aggregation of β-amyloid (Aβ) peptides has been associated with the onset of Alzheimer's disease (AD) by causing neurotoxicity due to oxidative stress and apoptosis. Cordycepin is a natural derivative of the nucleoside adenosine that displays potent antioxidant, antitumor, anti-inflammatory, and neuroprotective properties. However, the mechanism of the neuroprotective effect of cordycepin toward Aβ-induced neurotoxicity, as well as underlying mechanisms, is still unclear. In this study, we found that cordycepin conferred neuroprotection to catecholaminergic PC12 neuronal cell cultures exposed to Aβ1–42-insult by reducing the production of reactive oxygen species, restoring the mitochondrial membrane potential, and inhibiting apoptosis. Cordycepin stimulated the phosphorylation of extracellular signal-regulated kinase (ERK) and cyclic AMP-responsive element-binding protein (CREB) in a time- and concentration-dependent manner. Inhibition of the ERK pathway reduced the neuroprotective effect of cordycepin. Similar results were obtained with hippocampal HT22 neuronal cell cultures. Cumulatively, these findings suggest that cordycepin-induced neuroprotection toward Aβ1–42 neurotoxic insult may involve activation of the ERK/CREB pathway. This study expands our knowledge of the neuroprotective function of cordycepin and suggests that it holds promise as a natural lead compound for drug development in AD.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"11 1","pages":"84-97"},"PeriodicalIF":0.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis

Ibrain Pub Date : 2025-01-07 DOI: 10.1002/ibra.12191

Sirui Chen, Ningning Zhang, Ruirui Zhang, Lan Zhang, Dadong Luo, Junqiang Li, Yaqing Liu, Yunan Wang, Xinyue Duan, Xin Tian, Tiancheng Wang

{"title":"The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis","authors":"Sirui Chen, Ningning Zhang, Ruirui Zhang, Lan Zhang, Dadong Luo, Junqiang Li, Yaqing Liu, Yunan Wang, Xinyue Duan, Xin Tian, Tiancheng Wang","doi":"10.1002/ibra.12191","DOIUrl":"https://doi.org/10.1002/ibra.12191","url":null,"abstract":"This study aimed to investigate the causal relationship between systemic lupus erythematosus (SLE) and juvenile myoclonic epilepsy (JME). Univariable and reverse Mendelian randomization (MR) analyses were performed to investigate the potential causal associations between SLE, systemic autoimmune disorders (SADs), and JME. Two-step mediation MR analysis was further performed to explore indirect factors that may influence the relationship between SLE and JME. Summary data on SADs were extracted from the Integrative Epidemiology Unit Open genome-wide association study database, and summary statistics for JME were acquired from the International League Against Epilepsy Consortium. The inverse-variance weighted (IVW) method was used for primary analysis, supplemented by MR-Egger and weighted median. In the univariable MR analysis, IVW results indicated a causal relationship between SLE and an increased risk of JME (odds ratio = 1.0030, 95% confidence interval, 1.0004–1.0057; p = 0.023). The subsequent mediation MR analysis showed that inflammatory cytokines may not be the mediating factors between SLE and JME, while the inverse MR analysis found no significant relationship. Our study indicated that genetic susceptibility to SLE was causally linked to JME. However, subsequent mediation analysis failed to identify the potential mediators that could influence this relationship. Moreover, evidence suggested that other SADs were not causally associated with JME. This study may provide guidance for screening risk factors for seizures and exploring potential treatments in SLE and JME, and even all SADs and JME.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"11 1","pages":"98-105"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain Pub Date : 2025-01-04 DOI: 10.1002/ibra.12189

Xiaozhuo Li, Kevin Fang, Fengping Wang

引用次数: 0

Neuroanatomical and functional correlates in borderline personality disorder: A narrative review

Ibrain Pub Date : 2024-12-20 DOI: 10.1002/ibra.12190

Giulio Perrotta

引用次数: 0

The effects of a bioavailable curcumin formulation on Alzheimer's disease pathologies: A potential risk for neuroinflammation 生物可利用姜黄素配方对阿尔茨海默病病理的影响：神经炎症的潜在风险。

Ibrain Pub Date : 2024-12-11 DOI: 10.1002/ibra.12187

Shaun Cade, Clive Prestidge, Xin-Fu Zhou, Larisa Bobrovskaya

{"title":"The effects of a bioavailable curcumin formulation on Alzheimer's disease pathologies: A potential risk for neuroinflammation","authors":"Shaun Cade, Clive Prestidge, Xin-Fu Zhou, Larisa Bobrovskaya","doi":"10.1002/ibra.12187","DOIUrl":"10.1002/ibra.12187","url":null,"abstract":"Alzheimer's disease (AD) is a common cause of dementia characterized by the presence of two proteinaceous deposits in the brain. These pathologies may be a consequence of complex interactions between neurons and glia before the onset of cognitive impairments. Curcumin, a bioactive compound found in turmeric, is a promising candidate for AD because it alleviates neuropathologies in mouse models of the disease. Although its clinical efficacy has been hindered by low oral bioavailability, the development of new formulations may overcome this limitation. The purpose of this study was to determine the effects of a bioavailable curcumin formulation in a mouse model of AD. The formulation was administered to mice in drinking water after encapsulation into micelles using a previously validated method. A neuropathological assessment was performed to determine if it slows or alters the course of the disease. Cognitive performance was not included because it had already been assessed by a previous study. The bioavailable curcumin formulation was unable to alter the size or number of amyloid plaques in a transgenic mouse model. In addition, mechanisms that regulate amyloid beta production were unchanged, suggesting that the disease had not been altered. The number of reactive astrocytes in the hippocampus and dentate gyrus was not altered by curcumin. However, protein levels of glial fibrillary acidic protein were increased overall in the brain, suggesting that it may have aggravated neuroinflammation. Therefore, a higher dosage, despite its enhanced oral bioavailability, may have a potential risk for neuroinflammation.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 4","pages":"500-518"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Protective effect of isoflurane preconditioning on neurological function in rats with HIE” 对“异氟醚预处理对HIE大鼠神经功能的保护作用”的修正

Ibrain Pub Date : 2024-12-08 DOI: 10.1002/ibra.12188

引用次数: 0

Research progress on the depth of anesthesia monitoring based on the electroencephalogram

Ibrain Pub Date : 2024-12-06 DOI: 10.1002/ibra.12186

Xiaolan He, Tingting Li, Xiao Wang

{"title":"Research progress on the depth of anesthesia monitoring based on the electroencephalogram","authors":"Xiaolan He, Tingting Li, Xiao Wang","doi":"10.1002/ibra.12186","DOIUrl":"https://doi.org/10.1002/ibra.12186","url":null,"abstract":"General anesthesia typically involves three key components: amnesia, analgesia, and immobilization. Monitoring the depth of anesthesia (DOA) during surgery is crucial for personalizing anesthesia regimens and ensuring precise drug delivery. Since general anesthetics act primarily on the brain, this organ becomes the target for monitoring DOA. Electroencephalogram (EEG) can record the electrical activity generated by various brain tissues, enabling anesthesiologists to monitor the DOA from real-time changes in a patient's brain activity during surgery. This monitoring helps to optimize anesthesia medication, prevent intraoperative awareness, and reduce the incidence of cardiovascular and other adverse events, contributing to anesthesia safety. Different anesthetic drugs exert different effects on the EEG characteristics, which have been extensively studied in commonly used anesthetic drugs. However, due to the limited understanding of the biological basis of consciousness and the mechanisms of anesthetic drugs acting on the brain, combined with the effects of various factors on existing EEG monitors, DOA cannot be accurately expressed via EEG. The lack of patient reactivity during general anesthesia does not necessarily indicate unconsciousness, highlighting the importance of distinguishing the mechanisms of consciousness and conscious connectivity when monitoring perioperative anesthesia depth. Although EEG is an important means of monitoring DOA, continuous optimization is necessary to extract characteristic information from EEG to monitor DOA, and EEG monitoring technology based on artificial intelligence analysis is an emerging research direction.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"11 1","pages":"32-43"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of the central nervous system immune response and neuroinflammation via Wnt signaling in health and neurodegenerative diseases 在健康和神经退行性疾病中通过Wnt信号调节中枢神经系统免疫反应和神经炎症。

Ibrain Pub Date : 2024-12-02 DOI: 10.1002/ibra.12185

Kevin Fang

{"title":"Modulation of the central nervous system immune response and neuroinflammation via Wnt signaling in health and neurodegenerative diseases","authors":"Kevin Fang","doi":"10.1002/ibra.12185","DOIUrl":"10.1002/ibra.12185","url":null,"abstract":"The immune response in the central nervous system (CNS) is a highly specialized and tightly regulated process essential for maintaining neural health and protecting against pathogens and injuries. The primary immune cells within the CNS include microglia, astrocytes, T cells, and B cells. They work together, continuously monitor the CNS environment for signs of infection, injury, or disease, and respond by phagocytosing debris, releasing cytokines, and recruiting other immune cells. In addition to providing neuroprotection, these immune responses must be carefully balanced to prevent excessive inflammation that can lead to neuronal damage and contribute to neurodegenerative diseases. Dysregulated immune responses in the CNS are implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Wnt signaling is a crucial pathway in the CNS that regulates various cellular processes critical for brain development, function, and maintenance. Despite enhancing immune responses in the health CNS, dysregulated Wnt signaling exacerbates neuroinflammation in the neurodegenerative brains. This review summarized the role of Wnt signaling in regulating immune response under different conditions. We then examined the role of immune response in healthy brains and during the development of neurodegenerative diseases. We also discussed therapeutic intervention in various neurodegenerative diseases through the modulation of the Wnt signaling pathway and neuroinflammation and highlighted challenges and limitations in current clinical trials.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 4","pages":"462-476"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress on the use of the optical coherence tomography system for the diagnosis and treatment of central nervous system tumors

Ibrain Pub Date : 2024-11-22 DOI: 10.1002/ibra.12184

Jiuhong Li, Ziba Ayi, Gonggong Lu, Haibo Rao, Feilong Yang, Jing Li, Jiachen Sun, Junlin Lu, Xulin Hu, Si Zhang, Xuhui Hui

{"title":"Research progress on the use of the optical coherence tomography system for the diagnosis and treatment of central nervous system tumors","authors":"Jiuhong Li, Ziba Ayi, Gonggong Lu, Haibo Rao, Feilong Yang, Jing Li, Jiachen Sun, Junlin Lu, Xulin Hu, Si Zhang, Xuhui Hui","doi":"10.1002/ibra.12184","DOIUrl":"https://doi.org/10.1002/ibra.12184","url":null,"abstract":"In central nervous system (CNS) surgery, the accurate identification of tumor boundaries, achieving complete resection of the tumor, and safeguarding healthy brain tissue remain paramount challenges. Despite the expertise of neurosurgeons, the infiltrative nature of the tumors into the surrounding brain tissue often hampers intraoperative differentiation between tumorous and non-tumorous tissue, thus hindering total tumor removal. Optical coherence tomography (OCT), with its unique advantages of high-resolution imaging, efficient image acquisition, real-time intraoperative detection, and radiation-free and noninvasive properties, offers accurate diagnostic capabilities and invaluable intraoperative guidance for minimally invasive CNS tumor diagnosis and treatment. Various OCT systems have been employed in neurological tumor research, including polarization-sensitive OCT systems, orthogonal polarization OCT systems, Doppler OCT systems, and OCT angiography systems. In addition, OCT-based diagnostic and therapeutic techniques have been explored for the surgical resection of CNS tumors. This review aims to compile and evaluate the research progress surrounding the principles of OCT systems and their applications in CNS tumors, providing insights into potential future research avenues and clinical applications.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"11 1","pages":"3-18"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interplay between epitranscriptomic RNA modifications and neurodegenerative disorders: Mechanistic insights and potential therapeutic strategies 表转录组 RNA 修饰与神经退行性疾病之间的相互作用：机理认识和潜在治疗策略。

Ibrain Pub Date : 2024-11-11 DOI: 10.1002/ibra.12183

Muhammad Abu Talha Safdar Hashmi, Hooriya Fatima, Sadia Ahmad, Amna Rehman, Fiza Safdar

{"title":"The interplay between epitranscriptomic RNA modifications and neurodegenerative disorders: Mechanistic insights and potential therapeutic strategies","authors":"Muhammad Abu Talha Safdar Hashmi, Hooriya Fatima, Sadia Ahmad, Amna Rehman, Fiza Safdar","doi":"10.1002/ibra.12183","DOIUrl":"10.1002/ibra.12183","url":null,"abstract":"Neurodegenerative disorders encompass a group of age-related conditions characterized by the gradual decline in both the structure and functionality of the central nervous system (CNS). RNA modifications, arising from the epitranscriptome or RNA-modifying protein mutations, have recently been observed to contribute significantly to neurodegenerative disorders. Specific modifications like N6-methyladenine (m6A), N1-methyladenine (m1A), 5-methylcytosine (m5C), pseudouridine and adenosine-to-inosine (A-to-I) play key roles, with their regulators serving as crucial therapeutic targets. These epitranscriptomic changes intricately control gene expression, influencing cellular functions and contributing to disease pathology. Dysregulation of RNA metabolism, affecting mRNA processing and noncoding RNA biogenesis, is a central factor in these diseases. This review underscores the complex relationship between RNA modifications and neurodegenerative disorders, emphasizing the influence of RNA modification and the epitranscriptome, exploring the function of RNA modification enzymes in neurodegenerative processes, investigating the functional consequences of RNA modifications within neurodegenerative pathways, and evaluating the potential therapeutic advancements derived from assessing the epitranscriptome.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 4","pages":"395-426"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0