Ibrain Pub Date : 2023-11-30 DOI: 10.1002/ibra.12137

Santa Sarma, Dhruva J. Deka, Prakash Rajak, Damiki Laloo, Trishna Das, Purbajit Chetia, Dipankar Saha, Alakesh Bharali, Bhargab Deka

{"title":"Potential injectable hydrogels as biomaterials for central nervous system injury: A narrative review","authors":"Santa Sarma, Dhruva J. Deka, Prakash Rajak, Damiki Laloo, Trishna Das, Purbajit Chetia, Dipankar Saha, Alakesh Bharali, Bhargab Deka","doi":"10.1002/ibra.12137","DOIUrl":"https://doi.org/10.1002/ibra.12137","url":null,"abstract":"Numerous modalities exist through which the central nervous system (CNS) may sustain injury or impairment, encompassing traumatic incidents, stroke occurrences, and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Presently available pharmacological and therapeutic interventions are incapable of restoring or regenerating damaged CNS tissue, leading to substantial unmet clinical needs among patients with CNS ailments or injuries. To address and facilitate the recovery of the impaired CNS, cell-based repair strategies encompass multiple mechanisms, such as neuronal replacement, therapeutic factor secretion, and the promotion of host brain plasticity. Despite the progression of cell-based CNS reparation as a therapeutic strategy throughout the years, substantial barriers have impeded its widespread implementation in clinical settings. The integration of cell technologies with advancements in regenerative medicine utilizing biomaterials and tissue engineering has recently facilitated the surmounting of several of these impediments. This comprehensive review presents an overview of distinct CNS conditions necessitating cell reparation, in addition to exploring potential biomaterial methodologies that enhance the efficacy of treating brain injuries.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 4","pages":"402-420"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139047557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress of microglial surface receptors in perioperative neurocognitive disorders 小胶质表面受体在围手术期神经认知障碍中的研究进展。

Ibrain Pub Date : 2023-11-30 DOI: 10.1002/ibra.12136

Chun-Chun Tang, De-Xing Liu, Zhao-Qiong Zhu

{"title":"Research progress of microglial surface receptors in perioperative neurocognitive disorders","authors":"Chun-Chun Tang, De-Xing Liu, Zhao-Qiong Zhu","doi":"10.1002/ibra.12136","DOIUrl":"10.1002/ibra.12136","url":null,"abstract":"Perioperative neurocognitive disorder (PND) is a common complication in the perioperative period, which not only prolongs the hospitalization of patients, increases the cost of treatment, but even increases the postoperative mortality of patients, bringing a heavy burden to families and society. Mechanism exploration involves anesthesia and surgery that lead to microglial activation, promote the synthesis and secretion of inflammatory factors, cause an inflammatory cascade, aggravate nerve cell damage, and lead to cognitive dysfunction. It is believed that microglia-mediated neuroinflammatory responses play a vital role in the formation of PND. Microglia surface receptors are essential mediators for microglia to receive external stimuli, regulate microglial functional status, and carry out intercellular signal transmission. Various microglial surface receptors trigger neuroinflammation, damage neurons, and participate in the development and progression of PND by activating microglia. In this study, the roles of immunoglobulin receptors, chemokine receptors, purinergic receptors, and pattern recognition receptors in microglia surface receptors in PND were reviewed, to provide a reference for the mechanism research, prevention, and treatment of PND.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 4","pages":"450-461"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of perineal neuralgia treated with ultrasound-guided nerve block combined with water separation 超声引导神经阻滞联合水分离治疗会阴神经痛1例

Ibrain Pub Date : 2023-11-14 DOI: 10.1002/ibra.12138

Yong Wang, Min Wang, Rui Jiang, Zhao-Qiong Zhu, Guang-Cai Li

引用次数: 0

Corrections to “Bone marrow mesenchymal stem cells in brain ischemia enhaces axonal regeneration associated with IGF-1” 对 "骨髓间充质干细胞在脑缺血中增强轴突再生与 IGF-1 有关 "的更正

Ibrain Pub Date : 2023-10-10 DOI: 10.1002/ibra.12135

引用次数: 0

Corrections to “Recent advances in bone marrow stromal cell trans-plantation to animals with spinal cord injury” 对 "骨髓基质细胞移植到脊髓损伤动物身上的最新进展 "的更正

Ibrain Pub Date : 2023-10-08 DOI: 10.1002/ibra.12134

引用次数: 0

The mediating role of anxiety and depression in the relationship between coping styles and life satisfaction among frontline medical workers during the COVID-19 pandemic: A cross-sectional study 焦虑和抑郁在 COVID-19 大流行期间前线医务工作者的应对方式与生活满意度之间关系中的中介作用：横断面研究

Ibrain Pub Date : 2023-09-25 DOI: 10.1002/ibra.12133

Gui-Fang Chen, Ye-Ping Zhang, Zhi-Jie Wei, Xin-Lan Zhang, Jun Liu, Juan Peng, Zu-Cai Xu, Chang-Yin Yu, Jun Zhang

{"title":"The mediating role of anxiety and depression in the relationship between coping styles and life satisfaction among frontline medical workers during the COVID-19 pandemic: A cross-sectional study","authors":"Gui-Fang Chen, Ye-Ping Zhang, Zhi-Jie Wei, Xin-Lan Zhang, Jun Liu, Juan Peng, Zu-Cai Xu, Chang-Yin Yu, Jun Zhang","doi":"10.1002/ibra.12133","DOIUrl":"10.1002/ibra.12133","url":null,"abstract":"This study aimed to examine the mediating role of anxiety and depression in the relationship between coping styles and life satisfaction among frontline medical workers during the COVID-19 pandemic. Five hundred and fourteen frontline medical workers from Zunyi were recruited to complete questionnaires, including the Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), Satisfaction with Life Scale (SWLS), and Simplified Coping Style Questionnaire (SCSQ). SPSS 24.0 was used to measure the characteristics of anxiety, depression, life satisfaction, and coping styles. We found that the prevalence rates of anxiety and depression among study participants were 22.57% and 18.29%, respectively. Besides, anxiety was positively correlated with depression; anxiety and depression were positively correlated with passive coping style but negatively correlated with life satisfaction and active coping style; life satisfaction was positively correlated with active coping style and negatively correlated with passive coping style (all p < 0.001). Moreover, anxiety and depression mediated the relationship between coping styles and life satisfaction. Anxiety accounted for 18.6% of the effect of active coping style and 35.48% of the effect of passive coping style on life satisfaction. Depression accounted for 48.84% of the effect of active coping style and 67.74% of the effect of passive coping style on life satisfaction. The present study provides novel insights into the effect of subclinical anxiety and depression on frontline medical workers in the pandemic area. Anxiety and depression yielded a mediating effect on the relationship between coping styles and life satisfaction.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 4","pages":"390-401"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135816334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular network mechanism of Shexiang Huayu Xingnao granules in treating intracerebral hemorrhage 射香化瘀颗粒治疗脑出血的分子网络机制

Ibrain Pub Date : 2023-09-10 DOI: 10.1002/ibra.12131

Ke-Qian Liu, Xue Bai, Ji-Lin Chen, Guo-Jiao Chen, Muhammad Ameen Jamal, Yu-Qi He

{"title":"Molecular network mechanism of Shexiang Huayu Xingnao granules in treating intracerebral hemorrhage","authors":"Ke-Qian Liu, Xue Bai, Ji-Lin Chen, Guo-Jiao Chen, Muhammad Ameen Jamal, Yu-Qi He","doi":"10.1002/ibra.12131","DOIUrl":"10.1002/ibra.12131","url":null,"abstract":"We aim to explore the pharmacological efficacy and molecular network mechanism of Shexiang Huayu Xingnao granules (SX granules) in the treatment of intracerebral hemorrhage (ICH) based on experiments and network pharmacology. After the ICH model establishment, the behavioral functions of rats were assessed by the modified neurological severity score (mNSS), the wire suspension test, and the rotarod test. Brain histomorphological changes were observed using 2,3,5-triphenyl tetrazolium chloride (TTC), hematoxylin–eosin (HE), Nissl, and TdT-mediated dUTP nick end labeling (TUNEL) combined with neuronal nuclear (NEUN) immunofluorescence staining. The cross-targets of SX granules and ICH were obtained using network pharmacology, gene ontology (GO) enrichment analysis, and Kyoto encyclopedia of genes and genomes (KEGG) signaling pathway analysis were performed. Then, the obtained Hub genes were verified using real-time quantitative polymerase chain reaction (RT-qPCR). The mNSS score was reduced and the duration to remain wire suspended increased in the SX group. In the morphological experiment, SX granules reduced brain tissue damage, neuronal apoptosis, and the number of astrocytes in the ICH rats. Moreover, 607 targets of drug–disease intersection were obtained by network pharmacology, and 10 Hub genes were found. SX granules regulated the expression of HRAS, MAPK3, and STAT3 in ICH condition. In conclusion, SX granules improved behavioral dysfunction, abnormal alterations in brain tissue, and cell morphology in ICH rats, and potential molecular mechanism was linked with the expression of multiple genes.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 2","pages":"172-185"},"PeriodicalIF":0.0,"publicationDate":"2023-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136072251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wnt signaling in synaptogenesis of Alzheimer's disease Wnt信号在阿尔茨海默病突触发生中的作用。

Ibrain Pub Date : 2023-09-06 DOI: 10.1002/ibra.12130

Cheng-Ting Zhang, Joy Wang, Wen-Yuan Wang

{"title":"Wnt signaling in synaptogenesis of Alzheimer's disease","authors":"Cheng-Ting Zhang, Joy Wang, Wen-Yuan Wang","doi":"10.1002/ibra.12130","DOIUrl":"10.1002/ibra.12130","url":null,"abstract":"Alzheimer's disease (AD), recognized as the leading cause of dementia, occupies a prominent position on the list of significant neurodegenerative disorders, representing a significant global health concern with far-reaching implications at both individual and societal levels. The primary symptom of Alzheimer's disease is a decrease in synaptic potency along with synaptic connection loss. Synapses, which act as important linkages between neuronal units within the cerebral region, are critical in signal transduction processes essential to orchestrating cognitive tasks. Synaptic connections act as critical interconnections between neuronal cells inside the cerebral environment, facilitating critical signal transduction processes required for cognitive functions. The confluence of axonal and dendritic filopodial extensions culminates in the creation of intercellular connections, coordinated by various signals and molecular mechanisms. The progression of synaptic maturation and plasticity is a critical determinant in maintaining mental well-being, and abnormalities in these processes have been linked to the development of neurodegenerative diseases. Wnt signaling pathways are important to the orchestration of synapse development. This review examines the complicated interplay between Wnt signaling and dendritic filopodia, including an examination of the regulatory complexities and molecular machinations involved in synaptogenesis progression. Then, these findings are contextualized within the context of AD pathology, allowing for the consideration of prospective therapeutic approaches based on the findings and development of novel avenues for future scientific research.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 3","pages":"316-325"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in the treatment and prevention of peripheral neuropathy after multiple myeloma treatment 治疗和预防多发性骨髓瘤治疗后周围神经病变的最新进展

Ibrain Pub Date : 2023-09-06 DOI: 10.1002/ibra.12132

Dan Wen, Song Cao, Yonghuai Feng

引用次数: 0

The role of cannabinoid CB1 receptors in the antinociceptive and reparative actions of mesenchymal stem cells in rats with peripheral neuropathic pain 大麻素CB1受体在周围神经性疼痛大鼠间充质干细胞的镇痛和修复作用中的作用。

Ibrain Pub Date : 2023-08-24 DOI: 10.1002/ibra.12129

Anna-Maria V. Yerofeyeva, Sergey V. Pinchuk, Svetlana N. Rjabceva, Alla Y. Molchanova

{"title":"The role of cannabinoid CB1 receptors in the antinociceptive and reparative actions of mesenchymal stem cells in rats with peripheral neuropathic pain","authors":"Anna-Maria V. Yerofeyeva, Sergey V. Pinchuk, Svetlana N. Rjabceva, Alla Y. Molchanova","doi":"10.1002/ibra.12129","DOIUrl":"10.1002/ibra.12129","url":null,"abstract":"Mesenchymal stem cells (MSCs) can produce antinociceptive and reparative effects. Presumably, the MSCs-induced antinociception may be partly due to the involvement of the endocannabinoid system. The study aimed to evaluate the antinociceptive and reparative effects of adipose-derived MSCs (ADMSCs) upon pharmacological modulation of cannabinoid CB1 receptor in peripheral tissues or on ADMSCs' membranes in a rat model of peripheral neuropathy. ADMSCs were injected into the area of rat sciatic nerve injury (i) with no additional treatments, (ii) at the tissue CB1 receptor activation by endogenous agonist anandamide (AEA) or blockade with a selective AM251 antagonist; and (iii) preincubated with AEA or AM251. The evaluation of CB1 receptor activity involved analyzing nociceptive responses, gait parameters, and histology. Transplantation of ADMSCs upon activation of CB1 receptors, both on AMSCs' membranes or in the area of nerve injury, accelerated the analgesia and recovery of dynamic gait parameters, abolished static gait disturbances, and promoted the fastest nerve regeneration. Only blockade of CB1 receptors on ADMSCs shortened ADMSCs-induced analgesia and decreased the number of preserved nerve fibers. CB1 receptors on ADMSCs significantly contribute to their pain-relieving and tissue-repairing capabilities by stimulating the growth factors secretion and suppressing the release of pro-inflammatory cytokines. Peripheral CB1 receptors do not significantly influence ADMSC-induced antinociception.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 3","pages":"245-257"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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