Potential injectable hydrogels as biomaterials for central nervous system injury: A narrative review

Ibrain Pub Date : 2023-11-30 DOI:10.1002/ibra.12137
Santa Sarma, Dhruva J. Deka, Prakash Rajak, Damiki Laloo, Trishna Das, Purbajit Chetia, Dipankar Saha, Alakesh Bharali, Bhargab Deka
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引用次数: 0

Abstract

Numerous modalities exist through which the central nervous system (CNS) may sustain injury or impairment, encompassing traumatic incidents, stroke occurrences, and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Presently available pharmacological and therapeutic interventions are incapable of restoring or regenerating damaged CNS tissue, leading to substantial unmet clinical needs among patients with CNS ailments or injuries. To address and facilitate the recovery of the impaired CNS, cell-based repair strategies encompass multiple mechanisms, such as neuronal replacement, therapeutic factor secretion, and the promotion of host brain plasticity. Despite the progression of cell-based CNS reparation as a therapeutic strategy throughout the years, substantial barriers have impeded its widespread implementation in clinical settings. The integration of cell technologies with advancements in regenerative medicine utilizing biomaterials and tissue engineering has recently facilitated the surmounting of several of these impediments. This comprehensive review presents an overview of distinct CNS conditions necessitating cell reparation, in addition to exploring potential biomaterial methodologies that enhance the efficacy of treating brain injuries.

Abstract Image

作为治疗中枢神经系统损伤的生物材料的潜在可注射水凝胶:叙述性综述
中枢神经系统(CNS)可能通过多种方式受到损伤或损害,包括外伤、中风以及阿尔茨海默病和帕金森病等神经退行性疾病。目前可用的药物和治疗干预措施无法恢复或再生受损的中枢神经系统组织,导致中枢神经系统疾病或损伤患者的大量临床需求得不到满足。为了解决和促进受损中枢神经系统的恢复,基于细胞的修复策略包含多种机制,如神经元替代、治疗因子分泌和促进宿主大脑可塑性。尽管多年来基于细胞的中枢神经系统修复作为一种治疗策略取得了进展,但其在临床环境中的广泛应用仍面临巨大障碍。最近,细胞技术与利用生物材料和组织工程的再生医学的进步相结合,促进了其中一些障碍的克服。本综述概述了需要细胞修复的中枢神经系统的不同情况,并探讨了提高脑损伤治疗效果的潜在生物材料方法。
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CiteScore
0.90
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