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引用次数: 0
摘要
如今，随着社会医疗体系的发展，老龄化社会的趋势日益明显。阿尔茨海默病（AD）的发病率也呈上升趋势。阿尔茨海默病是一种神经退行性疾病，任何年龄段的人都有可能患病。多年来，科学家们一直致力于发现阿尔茨海默病的病因。DNA 甲基化是哺乳动物最常见的表观遗传机制之一，在包括肿瘤在内的多种疾病的发病机制中发挥着重要作用。研究表观基因组或DNA甲基化的化学变化，可以帮助我们了解环境和生活对疾病的影响，如吸烟、抑郁和更年期，这可能会影响人们患老年痴呆症或其他疾病的几率。最近的研究发现了一些关键基因，如 ANK1、RHBDF2、ABCA7 和 BIN1，它们将 DNA 甲基化与阿兹海默症联系起来。本综述将重点阐明DNA甲基化与AD发病机制之间的关系，并对可能的靶向治疗方法进行展望。
DNA methylation: The epigenetic mechanism of Alzheimer's disease
Nowadays, with the development of the social health care system, there is an increasing trend towards an aging society. The incidence of Alzheimer's disease (AD) is also on the rise. AD is a kind of neurodegenerative disease that can be found in any age group. For years, scientists have been committing to discovering the cause of AD. DNA methylation is one of the most common epigenetic mechanisms in mammals and plays a vital role in the pathogenesis of several diseases, including tumors. Studying chemical changes in the epigenome, or DNA methylation can help us understand the effects of our environment and life on diseases, such as smoking, depression, and menopause, which may affect people's chances of developing Alzheimer's or other diseases. Recent studies have identified some crucial genes like ANK1, RHBDF2, ABCA7, and BIN1, linking DNA methylation to AD. This review focuses on elucidating the relationship between DNA methylation and the pathogenesis of AD and provides an outlook on possible targeted therapeutic modalities.
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