Gold and silver nanoparticles in Alzheimer's and Parkinson's diagnostics and treatments

Ibrain Pub Date : 2023-08-14 DOI:10.1002/ibra.12126
Edoardo Scarpa, Mariafrancesca Cascione, Anna Griego, Paolo Pellegrino, Giorgia Moschetti, Valeria De Matteis
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Abstract

Neurodegenerative diseases (NDs) impose substantial medical and public health burdens on people worldwide and represent one of the major threats to human health. The prevalence of these age-dependent disorders is dramatically increasing over time, a process intrinsically related to a constantly rising percentage of the elderly population in recent years. Among all the NDs, Alzheimer's and Parkinson's are considered the most debilitating as they cause memory and cognitive loss, as well as severely affecting basic physiological conditions such as the ability to move, speak, and breathe. There is an extreme need for new and more effective therapies to counteract these devastating diseases, as the available treatments are only able to slow down the pathogenic process without really stopping or resolving it. This review aims to elucidate the current nanotechnology-based tools representing a future hope for NDs treatment. Noble metal nano-systems, that is, gold and silver nanoparticles (NPs), have indeed unique physicochemical characteristics enabling them to deliver any pharmacological treatment in a more effective way within the central nervous system. This can potentially make NPs a new hope for reversing the actual therapeutic strategy based on slowing down an irreversible process into a more effective and permanent treatment.

Abstract Image

阿尔茨海默氏症和帕金森氏症诊断和治疗中的金和银纳米颗粒。
神经退行性疾病给世界各地的人们带来了巨大的医疗和公共卫生负担,是对人类健康的主要威胁之一。随着时间的推移,这些年龄依赖性疾病的患病率急剧上升,这一过程与近年来老年人口比例不断上升有着内在联系。在所有的NDs中,阿尔茨海默氏症和帕金森氏症被认为是最令人衰弱的,因为它们会导致记忆和认知丧失,并严重影响基本的生理条件,如移动、说话和呼吸的能力。目前迫切需要新的、更有效的治疗方法来对抗这些毁灭性疾病,因为现有的治疗方法只能在没有真正停止或解决的情况下减缓致病过程。这篇综述旨在阐明当前基于纳米技术的工具,代表着NDs治疗的未来希望。贵金属纳米系统,即金和银纳米颗粒(NP),确实具有独特的物理化学特性,使其能够在中枢神经系统内以更有效的方式提供任何药物治疗。这可能会使NP成为扭转基于减缓不可逆转过程的实际治疗策略的新希望,成为更有效和永久的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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