Ibrain Pub Date : 2024-06-01 DOI: 10.1002/ibra.12165

Yang-Yang Zhao, Li-Xia Yang, Shuang-Yu Que, Lei-Xing An, Abeer A. Teeti, Shun-Wu Xiao

{"title":"Systemic mechanism of Panax noteginseng saponins in antiaging based on network pharmacology combined with experimental validation","authors":"Yang-Yang Zhao, Li-Xia Yang, Shuang-Yu Que, Lei-Xing An, Abeer A. Teeti, Shun-Wu Xiao","doi":"10.1002/ibra.12165","DOIUrl":"10.1002/ibra.12165","url":null,"abstract":"This study aims to investigate the systemic mechanism of Panax notoginseng saponins (PNS) in antiaging using network pharmacology combined with experimental validation. String database and Cytoscape3.7.2 were used to perform the protein–protein interaction (PPI) and construct genes network. The key target genes were analyzed using gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Then, the aging-related genes were verified by reverse-transcription polymerase chain reaction in SAM-P/8 mice, and performed molecular docking with the main components of PNS. Moreover, it produced cluster between Hub genes and differential genes. A total of 169 crossover genes were obtained, and the results of GO and KEGG indicated that the antiaging effect of PNS was mediated by apoptosis, cancer, and neurodegeneration and that five of the eight Hub genes had good binding activity with the main components of PNS. In addition, animal experiments reported that MAP2, MAPKK4, RAB6A, and Sortilin-1 have different levels of expression in the brain tissues of aging mice, and bind well docking with the main active components of PNS. However, there was no crossover between the 169 PNS intersecting genes and the four differential genes, while they yielded a link from PPI in which MAP2K4 was only linked to AKT1 and CASP3; MAP2 was only linked to AKT1 and CASP3; RAB6A was only linked to AKT1; but Sortlin-1 did not link to the Hub genes. In summary, the antiaging effect of PNS is associated with the eight Hub genes and four differential genes. All of them consist of a cluster or group that is possibly related to the antiaging effect of PNS.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 4","pages":"519-535"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141281644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy 炎症介质在癫痫发病机制中的研究进展

Ibrain Pub Date : 2024-05-29 DOI: 10.1002/ibra.12162

Yue Yu, Fei-Ji Sun

引用次数: 0

Evidence-based management strategies for endocrine complications after pituitary adenoma surgery 垂体腺瘤术后内分泌并发症的循证管理策略

Ibrain Pub Date : 2024-05-23 DOI: 10.1002/ibra.12156

Xiaoju Miao, Zhongmin Fu, Xian Luo, Jun Wang, Zhangzhu Ren, Yuanyuan Wang, Guoping Mei, Shunwu Xiao

{"title":"Evidence-based management strategies for endocrine complications after pituitary adenoma surgery","authors":"Xiaoju Miao, Zhongmin Fu, Xian Luo, Jun Wang, Zhangzhu Ren, Yuanyuan Wang, Guoping Mei, Shunwu Xiao","doi":"10.1002/ibra.12156","DOIUrl":"10.1002/ibra.12156","url":null,"abstract":"This study aims to provide a clinical reference for the management of endocrine complications in pituitary tumor patients by synthesizing recent evidence for domestic and international management strategies. Based on the PIPOST (Population, Intervention, Professional, Outcome, Setting, and Type of Evidence) framework, evidence-based medicine targets were determined. Electronic decision support systems, guideline websites, and databases were searched to identify the best evidence on postoperative endocrine complications in pituitary tumors. The PICO (Patient, Intervention, Comparison, Outcome) principle was used to construct the search strategy, and the studies from the past 10 years (July 2013 to July 2023) were included. A total of 11 articles were included, including four guidelines, two expert consensus statements, one systematic review, one best practice article, and three randomized controlled trials. We obtained evidence on five aspects (endocrine assessment, secondary adrenal insufficiency management, water metabolism disorder management, special population management, and follow-up management) with a total of 30 pieces of evidence. Clinical healthcare professionals should focus on the care and follow-up of patients with postoperative complications, such as adrenal insufficiency, temporary or permanent diabetes insipidus, and hyponatremia. Future research should involve large sample sizes, long-term follow-ups, and multicenter studies to further clarify the protocols for fluid restriction, diet, and hormone use.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"11 2","pages":"245-258"},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141106335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green silver nanoparticles: Prospective nanotools against neurodegenerative cell line model 绿色银纳米粒子：针对神经退行性细胞系模型的前瞻性纳米工具

Ibrain Pub Date : 2024-05-23 DOI: 10.1002/ibra.12157

Valeria De Matteis, Simona Martano, Paolo Pellegrino, Chiara Ingrosso, Daniele Costa, Stefano Mazzotta, Jose L. Toca-Herrera, Rosaria Rinaldi, Mariafrancesca Cascione

{"title":"Green silver nanoparticles: Prospective nanotools against neurodegenerative cell line model","authors":"Valeria De Matteis, Simona Martano, Paolo Pellegrino, Chiara Ingrosso, Daniele Costa, Stefano Mazzotta, Jose L. Toca-Herrera, Rosaria Rinaldi, Mariafrancesca Cascione","doi":"10.1002/ibra.12157","DOIUrl":"10.1002/ibra.12157","url":null,"abstract":"Neurodegenerative diseases represent an increasingly burdensome challenge of the past decade, primarily driven by the global aging of the population. Ongoing efforts focus on implementing diverse strategies to mitigate the adverse effects of neurodegeneration, with the goal of decelerating the pathology progression. Notably, in recent years, it has emerged that the use of nanoparticles (NPs), particularly those obtained through green chemical processes, could constitute a promising therapeutic approach. Green NPs, exclusively sourced from phytochemicals, are deemed safer compared to NPs synthetized through conventional chemical route. In this study, the effects of green chemistry-derived silver NPs (AgNPs) were assessed in neuroblastoma cells, SHSY-5Y, which are considered a pivotal model for investigating neurodegenerative diseases. Specifically, we used two different concentrations (0.5 and 1 µM) of AgNPs and two time points (24 and 48 h) to evaluate the impact on neuroblastoma cells by observing viability reduction and intracellular calcium production, especially using 1 µM at 48 h. Furthermore, investigation using atomic force microscopy (AFM) unveiled an alteration in Young's modulus due to the reorganization of cortical actin following exposure to green AgNPs. This evidence was further corroborated by confocal microscopy acquisitions as well as coherency and density analyses on actin fibers. Our in vitro findings suggest the potential efficacy of green AgNPs against neurodegeneration; therefore, further in vivo studies are imperative to optimize possible therapeutic protocols.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 2","pages":"123-133"},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141107082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amyloid-β in Alzheimer's disease: Structure, toxicity, distribution, treatment, and prospects 阿尔茨海默病中的淀粉样蛋白-β：结构、毒性、分布、治疗和前景

Ibrain Pub Date : 2024-05-23 DOI: 10.1002/ibra.12155

Yifan Yu, Shilong Yu, Giuseppe Battaglia, Xiaohe Tian

{"title":"Amyloid-β in Alzheimer's disease: Structure, toxicity, distribution, treatment, and prospects","authors":"Yifan Yu, Shilong Yu, Giuseppe Battaglia, Xiaohe Tian","doi":"10.1002/ibra.12155","DOIUrl":"10.1002/ibra.12155","url":null,"abstract":"Amyloid-β (Aβ) is a pivotal biomarker in Alzheimer's disease (AD), attracting considerable attention from numerous researchers. There is uncertainty regarding whether clearing Aβ is beneficial or harmful to cognitive function. This question has been a central topic of research, especially given the lack of success in developing Aβ-targeted drugs for AD. However, with the Food and Drug Administration's approval of Lecanemab as the first anti-Aβ medication in July 2023, there is a significant shift in perspective on the potential of Aβ as a therapeutic target for AD. In light of this advancement, this review aims to illustrate and consolidate the molecular structural attributes and pathological ramifications of Aβ. Furthermore, it elucidates the determinants influencing its expression levels while delineating the gamut of extant Aβ-targeted pharmacotherapies that have been subjected to clinical or preclinical evaluation. Subsequently, a comprehensive analysis is presented, dissecting the research landscape of Aβ across the domains above, culminating in the presentation of informed perspectives. Concluding reflections contemplate the supplementary advantages conferred by nanoparticle constructs, conceptualized within the framework of multivalent theory, within the milieu of AD diagnosis and therapeutic intervention, supplementing conventional modalities.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 3","pages":"266-289"},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141103669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial cellular senescence and tau accumulation: An interplay full of opportunities? 内皮细胞衰老和 tau 累积：充满机遇的相互作用？

Ibrain Pub Date : 2024-05-09 DOI: 10.1002/ibra.12154

Doriana Oliveri, Giorgia Moschetti, Anna Griego, Edoardo Scarpa

引用次数: 0

Research progress on the relationship between traumatic brain injury and brain-gut-microbial axis 脑外伤与脑-肠-微生物轴关系的研究进展

Ibrain Pub Date : 2024-03-30 DOI: 10.1002/ibra.12153

Jie Yu, Yun-Xin Chen, Jin-Wei Wang, Hai-Tao Wu

引用次数: 0

Accuracy and efficacy of ultrasound-guided puncture (vs. computed tomography-guided) in cervical medial branch blocks for cervicogenic pain: A randomized controlled study 超声引导下穿刺（与计算机断层扫描引导下）治疗颈椎内侧支阻滞治疗颈源性疼痛的准确性和有效性：随机对照研究

Ibrain Pub Date : 2024-03-17 DOI: 10.1002/ibra.12151

Jie Tian, Xin-Yan Li, Yan Yin, Nan Zhao, Hong Xiao, Hui Liu

{"title":"Accuracy and efficacy of ultrasound-guided puncture (vs. computed tomography-guided) in cervical medial branch blocks for cervicogenic pain: A randomized controlled study","authors":"Jie Tian, Xin-Yan Li, Yan Yin, Nan Zhao, Hong Xiao, Hui Liu","doi":"10.1002/ibra.12151","DOIUrl":"10.1002/ibra.12151","url":null,"abstract":"Cervical medial branch block (CMBB) has been recognized as an effective treatment for cervicogenic pain. Previous studies mostly used ultrasound-guided out-of-plane puncture for CMBB, while this prospective study was designed to investigate the efficacy of ultrasound-guided in-plane puncture, specifically focusing on the new target of CMBB for cervical pain. This study includes two parts: the accuracy study (N = 15, CMBB was completed by ultrasound and confirmed by computed tomography [CT], in which a good distribution percentage of the analgesic solution was observed) and the efficacy study (N = 40, CMBB was completed by ultrasound or CT, while the proportion of pain relief (numerical rating scale) decrease by more than 50% postoperatively was analyzed). The results showed that the good distribution percentage of the analgesic solution was 97.8%. Furthermore, in the early period (30 min and 2 h postoperatively), the proportion of patients with pain relief was lower in the ultrasound group than that in the CT group, especially at 2 h postoperatively (52% vs. 94%). However, at 24 h postoperatively and later, the proportion of patients with pain relief gradually stabilized to about 60%–70%, and lasted for about 2 weeks to 1 month. Therefore, the new target for CMBB, guided by ultrasound in-plane, offers high visibility and accuracy. A single CMBB performed under ultrasound guidance resulted in pain relief comparable to that of a CT-guided procedure (1 day to 1 month postoperatively). This study indicated that CMBB guided by ultrasound in-plane could be regarded as a promising approach for treatment of cervicogenic pain.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 1","pages":"34-45"},"PeriodicalIF":0.0,"publicationDate":"2024-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140235155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role and limitation of cell therapy in treating neurological diseases 细胞疗法在治疗神经系统疾病中的作用和局限性

Ibrain Pub Date : 2024-03-12 DOI: 10.1002/ibra.12152

Yu-Qi Li, Peng-Fei Li, Qian Tao, Issam J. A. Abuqeis, Yan-Bin Xiyang

{"title":"Role and limitation of cell therapy in treating neurological diseases","authors":"Yu-Qi Li, Peng-Fei Li, Qian Tao, Issam J. A. Abuqeis, Yan-Bin Xiyang","doi":"10.1002/ibra.12152","DOIUrl":"10.1002/ibra.12152","url":null,"abstract":"The central role of the brain in governing systemic functions within human physiology underscores its paramount significance as the focal point of physiological regulation. The brain, a highly sophisticated organ, orchestrates a diverse array of physiological processes encompassing motor control, sensory perception, cognition, emotion, and the regulation of vital functions, such as heartbeat, respiration, and hormonal equilibrium. A notable attribute of neurological diseases manifests as the depletion of neurons and the occurrence of tissue necrosis subsequent to injury. The transplantation of neural stem cells (NSCs) into the brain exhibits the potential for the replacement of lost neurons and the reconstruction of neural circuits. Furthermore, the transplantation of other types of cells in alternative locations can secrete nutritional factors that indirectly contribute to the restoration of nervous system equilibrium and the mitigation of neural inflammation. This review summarized a comprehensive investigation into the role of NSCs, hematopoietic stem cells, mesenchymal stem cells, and support cells like astrocytes and microglia in alleviating neurological deficits after cell infusion. Moreover, a thorough assessment was undertaken to discuss extant constraints in cellular transplantation therapies, concurrently delineating indispensable model-based methodologies, specifically on organoids, which were essential for guiding prospective research initiatives in this specialized field.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 1","pages":"93-105"},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140250044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IGF2BP2 modulates autophagy and serves as a prognostic marker in glioma IGF2BP2 可调节自噬，是胶质瘤的预后标志物

Ibrain Pub Date : 2024-03-11 DOI: 10.1002/ibra.12150

Ning Li, Limei Deng, Yuming Zhang, Xilian Tang, Bingxi Lei, Qingyu Zhang

{"title":"IGF2BP2 modulates autophagy and serves as a prognostic marker in glioma","authors":"Ning Li, Limei Deng, Yuming Zhang, Xilian Tang, Bingxi Lei, Qingyu Zhang","doi":"10.1002/ibra.12150","DOIUrl":"https://doi.org/10.1002/ibra.12150","url":null,"abstract":"Glioma, a malignant brain tumor originating from neural glial cells, presents significant treatment challenges. However, the underlying mechanisms of glioma development are not fully understood, and effective targets are lacking. This study provides insights into the role of insulin-like growth factor 2 messenger RNA-binding protein 2 (IGF2BP2) in glioma progression and its therapeutic potential. Our analysis illustrated that elevated IGF2BP2 expression associated with significantly shorter survival among patients with low-grade glioma (LGG) in The Cancer Genome Atlas (TCGA) database. IGF2BP2 depletion led to compromised cell viability, G0/G1 phase arrest, and reduced colony-formation ability. Furthermore, ultrastructural analysis and mCherry-GFP-LC3 reporter assay revealed an increased abundance of autophagosomes upon IGF2BP2 knockdown. Western blot analysis corroborated these findings by showing reduced p62 levels coupled with increased LC3-ІІ/LC3-I ratio upon IGF2BP2 knockdown. A multicolor immunohistochemistry assay demonstrated the positive correlation between IGF2BP2 and p62 expression in glioma patient samples. Additionally, our analysis suggested a link between IGF2BP2 expression and drug-resistant markers in TCGA-LGG samples, and Cell Counting Kit-8 cell viability assay revealed that knockdown of IGF2BP2 sensitized cells to temozolomide treatment. This comprehensive exploration unveils the role of IGF2BP2 in glioma progression, shedding light on autophagy modulation and chemosensitization strategies for glioma therapy.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 1","pages":"19-33"},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140297260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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