Ibrain Pub Date : 2026-03-18 Epub Date: 2026-02-12 DOI: 10.1002/ibra.70014

Rong-song Sun, Sheng-xu Huo, Tian-lin Zhang, Hao-jiang Ying, Jun-hua Wang, Li-na Xu, Xin-lin Luo, Yi Yang, Yuan-dong Hu

{"title":"Development of a predictive model for depressive symptoms in type 2 diabetes mellitus patients under community management: Based on visual function index","authors":"Rong-song Sun, Sheng-xu Huo, Tian-lin Zhang, Hao-jiang Ying, Jun-hua Wang, Li-na Xu, Xin-lin Luo, Yi Yang, Yuan-dong Hu","doi":"10.1002/ibra.70014","DOIUrl":"https://doi.org/10.1002/ibra.70014","url":null,"abstract":"Visual impairment has been recognized as a potential risk factor for depressive symptoms (DS) in diabetes patients, yet the role of visual function in predicting DS remains unexplored. This study aims to develop and validate a predictive model for DS risk in type 2 diabetes mellitus (T2DM) patients in community health settings, incorporating a visual function index (VF14). We conducted a cross-sectional study involving 542 T2DM patients from four community health centers in Guiyang. Univariate and multivariate logistic regressions identified significant predictors, while 10 machine learning algorithms were employed to construct the predictive model. Model performance was assessed using such metrics as receiver operating characteristic curves, accuracy, sensitivity, specificity, F1 score, Brier score, C-index, calibration curves, and decision curve analysis. A restricted cubic spline (RCS) analysis evaluated the score-dependent risk profiles between the VF14 and DS. Key predictors included body mass index (BMI), self-reported glycemic status, age-related macular degeneration, glycated hemoglobin (HbA1c), and VF14. Among the models, the gradient boosting machine exhibited the robust predictive performance, with an area under the curve of 0.73 and sensitivity of 0.72. The Shapley additive explanations analysis identified VF14, BMI, and HbA1c as the top risk factors. RCS analysis revealed a score-dependent risk profile between VF14 and DS risk. This study introduces a clinically interpretable tool for early DS risk stratification in T2DM patients, offering potential for improved risk assessment and timely intervention in community health settings.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"12 1","pages":"123-136"},"PeriodicalIF":0.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147565056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of spinal glial activation in chemotherapy-induced peripheral neuropathy: Focus on microglia and astrocytes 化疗诱导的周围神经病变中脊髓胶质细胞活化的机制：以小胶质细胞和星形胶质细胞为重点

Ibrain Pub Date : 2026-03-18 Epub Date: 2025-12-02 DOI: 10.1002/ibra.70007

Long Gu, Song Cao, Yonghuai Feng

{"title":"Mechanisms of spinal glial activation in chemotherapy-induced peripheral neuropathy: Focus on microglia and astrocytes","authors":"Long Gu, Song Cao, Yonghuai Feng","doi":"10.1002/ibra.70007","DOIUrl":"https://doi.org/10.1002/ibra.70007","url":null,"abstract":"Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication in patients with malignant tumors during chemotherapy. The pathological mechanisms of CIPN remain unclear, and effective preventive and therapeutic strategies are still lacking, posing a major challenge in clinical practice. Aberrant activation of spinal glial cells, particularly microglia and astrocytes, is a key pathological hallmark of CIPN. Evidence from multiple animal models supports a causal link between glial activation and CIPN, suggesting that glial cells may serve as potential therapeutic targets. However, owing to the diversity of chemotherapy agents, the mechanisms of glial activation in CIPN differ and remain insufficiently characterized. This review takes spinal glial activation induced by peripheral nerve injury as its starting point, with a specific focus on microglia and astrocytes. It provides a systematic overview of their roles and mechanisms in CIPN caused by commonly used chemotherapeutic agents. The aim is to deepen understanding of CIPN pathogenesis and provide a foundation for developing targeted therapies.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"12 1","pages":"65-85"},"PeriodicalIF":0.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.70007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147562182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-dependent effect of thrombolytics on likelihood of National Institutes of Health Stroke Scale improvement in minor strokes 溶栓治疗对轻度中风患者美国国立卫生研究院卒中量表改善可能性的年龄依赖性影响

Ibrain Pub Date : 2025-12-01 DOI: 10.1002/ibra.70008

Tarun Thomas, Michael J. Dubinski, Omnea Elgendy, Sonali Vij, Lucas P. Garfinkel, Karan Patel, Jesse M. Thon, Pratit D. Patel, Hamza A. Shaikh, Jane Khalife, Hermann C. Schumacher, Khalid A. Hanafy, Tudor G. Jovin, Manisha Koneru

{"title":"Age-dependent effect of thrombolytics on likelihood of National Institutes of Health Stroke Scale improvement in minor strokes","authors":"Tarun Thomas, Michael J. Dubinski, Omnea Elgendy, Sonali Vij, Lucas P. Garfinkel, Karan Patel, Jesse M. Thon, Pratit D. Patel, Hamza A. Shaikh, Jane Khalife, Hermann C. Schumacher, Khalid A. Hanafy, Tudor G. Jovin, Manisha Koneru","doi":"10.1002/ibra.70008","DOIUrl":"https://doi.org/10.1002/ibra.70008","url":null,"abstract":"The appropriate acute treatment strategy for minor ischemic stroke, defined as National Institutes of Health Stroke Scale scores <math></math>5, is not as well-defined. Prior studies have demonstrated mixed results regarding the effects of neurovascular interventions on minor stroke patients for optimizing the chances of symptomatic improvement. We performed a retrospective single-center study across 6 years to determine the association between thrombolytics and the likelihood of clinical symptom improvement by 24 h in minor stroke patients across ages. Margin plots were derived from multivariable regression analyses. Of 1172 minor stroke patients, in patients <70 years of age, there was greater than 50% likelihood of improvement with any type of thrombolytic administration. When substratifying by type of thrombolytic, there is greater than 50% odds of improvement in patients <80 years of age treated with alteplase and <70 years of age treated with tenecteplase. Thus, the association between age and likelihood of benefit after thrombolytic treatment in minor stroke patients highlights particular minor stroke subpopulations, particularly younger patients, who may benefit from thrombolytic treatment.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"11 4","pages":"504-511"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.70008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nipocalimab-aahu in generalised myasthenia gravis: A new Fc receptor-targeted option for antibody-positive patients Nipocalimab-aahu治疗广泛性重症肌无力：抗体阳性患者新的Fc受体靶向选择

Ibrain Pub Date : 2025-11-27 DOI: 10.1002/ibra.70006

Jawairya Muhammad Hussain, Anoosha Ashfaq, Azka Shahid, Fatima Mudassir

{"title":"Nipocalimab-aahu in generalised myasthenia gravis: A new Fc receptor-targeted option for antibody-positive patients","authors":"Jawairya Muhammad Hussain, Anoosha Ashfaq, Azka Shahid, Fatima Mudassir","doi":"10.1002/ibra.70006","DOIUrl":"https://doi.org/10.1002/ibra.70006","url":null,"abstract":"Myasthenia gravis (MG) is an autoimmune disorder driven by pathogenic IgG autoantibodies, leading to muscle weakness and impaired quality of life. Conventional immunosuppressant therapies are often limited by side effects and incomplete efficacy. Nipocalimab-aahu (N-a), recently FDA-approved, is a novel neonatal Fc receptor (FcRn) antagonist that reduces circulating IgG levels, targeting the underlying disease mechanism. This review synthesizes evidence on N-a's efficacy, safety, and clinical positioning. Phase 2 and 3 trials (Vivacity-MG/MG3) demonstrated that N-a significantly improves the Myasthenia Gravis Activities of Daily Living (MG-ADL) score compared to placebo, with a favorable safety profile. The most common adverse events were nasopharyngitis and headache, with no increased serious infection risk or clinically significant hypoalbuminemia. Compared to other biologics, N-a offers a distinct mechanism, selective IgG reduction without broad immunosuppression and a convenient bi-weekly dosing regimen. While it shows promise for reduced systemic immunosuppression and potentially greater efficacy in MG-ADL improvement than some alternatives, cross-trial comparisons are limited. Key limitations include the need for long-term safety data and more research in underrepresented populations, including pediatric and seronegative patients. In conclusion, N-a represents a significant advancement in generalized MG (gMG) treatment, providing a targeted, effective, and well-tolerated option that addresses a key unmet need for patients with acetylcholine receptor (AChR) or muscle-specific kinase (MuSK) antibody-positive disease.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"11 4","pages":"524-530"},"PeriodicalIF":0.0,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145739952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perturbed synaptic adhesion molecules signaling in neurodevelopmental disorders: The impact of metal neurotoxicity 神经发育障碍中突触粘附分子信号紊乱：金属神经毒性的影响

Ibrain Pub Date : 2025-11-04 DOI: 10.1002/ibra.70005

Toheeb O. Oyerinde, Victor E. Anadu, Tobiloba S. Olajide, Ileje I. Ukwubile, Olayemi K. Ijomone, Kingsley A. Iteire, Michael Aschner, Omamuyovwi M. Ijomone

{"title":"Perturbed synaptic adhesion molecules signaling in neurodevelopmental disorders: The impact of metal neurotoxicity","authors":"Toheeb O. Oyerinde, Victor E. Anadu, Tobiloba S. Olajide, Ileje I. Ukwubile, Olayemi K. Ijomone, Kingsley A. Iteire, Michael Aschner, Omamuyovwi M. Ijomone","doi":"10.1002/ibra.70005","DOIUrl":"https://doi.org/10.1002/ibra.70005","url":null,"abstract":"Synaptic adhesion molecules (SAMs) are glycoproteins localized on neuronal surfaces, primarily expressed at synaptic plasma membranes. SAMs play a role in inducing formation, maturation, plasticity, and assembly of synaptic connections, which are vital for normal neurodevelopment. SAMs link the pre- and post-synaptic compartments and assist in inter-synaptic signaling and recognition. An increasing variety of SAMs, including neurexins and neuroligins, immunoglobulin (Ig) domain proteins-like synaptic cell adhesion molecule (SynCAM) and neural cell adhesion molecule, receptor phosphotyrosine kinases and phosphatases, as well as various leucine-rich repeat proteins, have been identified. Neurodevelopmental disorders (NDDs), like autism, attention deficit hyperactivity disorder, intellectual disabilities, and cerebral palsy, have been associated with altered SAMs. NDDs are characterized by a spectrum of challenges stemming from abnormal brain development. The etiology of these disorders involves the interaction between genes and environmental factors, such as metals. This review aims to provide a comprehensive overview of the literature, highlighting the role of SAMs in NDDs and potential mechanisms via which neurotoxic metals may contribute to the pathogenesis of NDDs that could involve perturbations in SAMs. Understanding these interconnections will assist in identifying therapeutic targets for these disorders.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"11 4","pages":"403-421"},"PeriodicalIF":0.0,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145732860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent applications of magnetic iron oxide nanoparticles for cerebral blood volume quantification in functional magnetic resonance imaging 磁性氧化铁纳米颗粒脑血容量定量在功能磁共振成像中的最新应用

Ibrain Pub Date : 2025-10-11 DOI: 10.1002/ibra.70004

Giorgio Capuzzello, Antonella Antonelli, Rosaria Rinaldi, Riccardo Di Corato

{"title":"Recent applications of magnetic iron oxide nanoparticles for cerebral blood volume quantification in functional magnetic resonance imaging","authors":"Giorgio Capuzzello, Antonella Antonelli, Rosaria Rinaldi, Riccardo Di Corato","doi":"10.1002/ibra.70004","DOIUrl":"https://doi.org/10.1002/ibra.70004","url":null,"abstract":"The use of iron oxide nanoparticles (IONPs) in magnetic resonance imaging (MRI) and the study of brain functions using MRI have been continuously evolving for more than 30 years. This contribution aims to explore the recent applications of magnetic IONPs in the study of the brain through functional MRI (fMRI), particularly focusing on their use in a specific parameter, that is, the cerebral blood volume (CBV), whose measurements are valued for their higher sensitivity and spatial specificity with respect to blood oxygen level-dependent (BOLD) fMRI analyses. This study will summarize the basis of the fMRI technique, explaining the types of experiments commonly conducted, the parameters involved, and discussing the main techniques that exploit magnetic nanoparticles and other materials as contrast agents, along with their potential applications in the imaging field. CBV measurements will be explained in general theoretical terms and compared with other methods. The key elements of magnetic nanoparticle production, including the most commonly used synthesis procedures and coating options, will be reported. Finally, the discussion will focus on how CBV-weighted (CBVw) images acquired using IONPs are currently being utilized in research.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"11 4","pages":"439-456"},"PeriodicalIF":0.0,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.70004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interaction between pain and mental disorders: An interdisciplinary analysis through bibliometrics 疼痛和精神障碍之间的相互作用：通过文献计量学的跨学科分析

Ibrain Pub Date : 2025-09-29 DOI: 10.1002/ibra.70003

Zhimin Tan, Qiyu He, Xian Zhang, Jiarong Feng, Yuxin He, Xiaoqiang Li

{"title":"The interaction between pain and mental disorders: An interdisciplinary analysis through bibliometrics","authors":"Zhimin Tan, Qiyu He, Xian Zhang, Jiarong Feng, Yuxin He, Xiaoqiang Li","doi":"10.1002/ibra.70003","DOIUrl":"https://doi.org/10.1002/ibra.70003","url":null,"abstract":"The evolving research on the interactions between pain and mental disorders underscores the critical role of neuroimmune interplay in shaping pain perception and mental illness progression. This study employs bibliometric analysis to scrutinize the research landscape, identify emerging hotspots, and forecast future directions. A systematic review of literature from 2014 to 2023 was conducted using CiteSpace software for co-citation analysis, keyword co-occurrence, and burst detection to identify research hotspots and trends. The study examined developmental trends in pain and psychiatric disorder research, highlighting major research institutions and key themes. It unveils pivotal contributors and collaborative networks, showing significant growth in recent years. Emphasis is placed on neuroinflammation and neuroimmunomodulation interactions with mental illnesses. Keyword and thematic clustering analyses highlight the roles of microglial activation, inflammatory mediators, neurotransmitters, and emotional regulation processes. This study paves the way for future inquiries into neuroimmune mechanisms, the development of personalized treatment strategies, and an interdisciplinary approach to enrich our understanding of the biopsychosocial model in these conditions. Future studies should delve deeper into the molecular intricacies of these interactions to develop more effective therapeutic strategies, aiming to enhance patients' quality of life.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"11 4","pages":"476-491"},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.70003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145739814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotional recognition while watching emotional videos: Based on electroencephalography signal analysis and machine learning models 观看情绪视频时的情绪识别：基于脑电图信号分析和机器学习模型

Ibrain Pub Date : 2025-09-19 DOI: 10.1002/ibra.70002

Afshin S. Asl, Sahar Karimpour

{"title":"Emotional recognition while watching emotional videos: Based on electroencephalography signal analysis and machine learning models","authors":"Afshin S. Asl, Sahar Karimpour","doi":"10.1002/ibra.70002","DOIUrl":"https://doi.org/10.1002/ibra.70002","url":null,"abstract":"Depending on the impact of emotions on a person's performance and emotional disorders that can be the main cause of many mental illnesses, as well as the desire of technology to design machines that are able to change their performance according to a person's emotional states, the study of electroencephalography (EEG) signals to analyze the different dimensions of human emotions has become increasingly significant. Based on machine learning models, this study was designed to identify the five emotions of relaxation, happiness, motivation, sadness and fear using EEG signal analysis. EEG data were collected from 23 male master's students at Tabriz University, aged 24–31, as they watched five videos designed to elicit different emotional responses. After preprocessing to remove noise and artifacts, we extracted statistical and frequency-domain features from the raw signal. The features were labeled and selected using statistical tests. In the final step, five different emotions were classified using decision tree, linear discriminant analysis (LDA), Naive Bayes, support vector machine (SVM), K-nearest neighbor (KNN), ensemble, logistic regression and neural network. It has been verified that ensemble and decision tree models had the highest accuracy with 95.38% and 91.77%.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"11 3","pages":"347-363"},"PeriodicalIF":0.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.70002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic regulation in cognitive impairment: Focus on N6-methyladenosine modification and its potential role in perioperative neurocognitive disorders 认知障碍的表观遗传调控：n6 -甲基腺苷修饰及其在围手术期神经认知障碍中的潜在作用

Ibrain Pub Date : 2025-09-11 DOI: 10.1002/ibra.70000

Ting Liu, Xiao-Juan Yang, Lin Zhou, Mi Gan, Ting-Ting He, Sen Hong, Yan-Yan Feng, Gao Su, You-Xiao Zhao, Ying Cao, Qing-Fan Zeng

{"title":"Epigenetic regulation in cognitive impairment: Focus on N6-methyladenosine modification and its potential role in perioperative neurocognitive disorders","authors":"Ting Liu, Xiao-Juan Yang, Lin Zhou, Mi Gan, Ting-Ting He, Sen Hong, Yan-Yan Feng, Gao Su, You-Xiao Zhao, Ying Cao, Qing-Fan Zeng","doi":"10.1002/ibra.70000","DOIUrl":"https://doi.org/10.1002/ibra.70000","url":null,"abstract":"N6-methyladenosine (m6A), the most abundant internal modification in mammalian mRNA, plays a critical role in cognitive function by dynamically regulating gene expression. This narrative review examines m6A's role in cognitive processes and its potential impact on perioperative neurocognitive disorders (PNDs), which encompass a spectrum including postoperative delirium, delayed neurocognitive recovery, and postoperative cognitive dysfunction. The m6A regulatory machinery—comprising methyltransferases (“writers”), demethylases (“erasers”), and recognition proteins (“readers”)—modulates neuronal development, synaptic plasticity, and cognitive processes by influencing mRNA stability, translation, and degradation. Evidence from animal models indicates that m6A dysregulation contributes to neuroinflammation, neurodegeneration, and neuronal injury, which are pathophysiological mechanisms implicated in PNDs. Notably, anesthetic agents and surgical stress have been shown to alter hippocampal m6A levels, and manipulation of m6A-related proteins may ameliorate cognitive deficits. While these findings suggest potential mechanistic connections, direct evidence specifically linking m6A modifications to PNDs pathogenesis remains preliminary and largely based on preclinical models. Further research is needed to establish causal relationships, identify m6A-modified targets relevant to PNDs pathology, and evaluate m6A as a potential biomarker or therapeutic target. This review provides a foundation for understanding how m6A modification may influence perioperative cognitive outcomes and identifies promising avenues for future investigation.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"11 3","pages":"332-346"},"PeriodicalIF":0.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic parallels between borderline and bipolar patients in psychopathology: Similarities, differences, comorbidities, neural correlates, and a new proposal for the Perrotta Border-Bipolar Profile Diagnostic Questionnaire 边缘型人格障碍和双相情感障碍患者在精神病理学上的诊断相似之处：相似点、差异、合并症、神经相关性，以及对Perrotta边缘型人格障碍诊断问卷的新建议

Ibrain Pub Date : 2025-09-02 DOI: 10.1002/ibra.70001

Giulio Perrotta, Simona Grilli, Stefano Eleuteri, Irene Petruccelli

引用次数: 0

Ibrain最新文献