Ibrain Pub Date : 2023-12-10 DOI: 10.1002/ibra.12143

Nithya Raju, Samyuktha Villavan, Saranya Ravi, Roja Murugesan, Panneerselvam Theivendren, Vennila Jaganathan, Redlin Jani Rajan, K. Karunanithi

{"title":"Clinical effectiveness and treatment satisfaction between two triple‐therapy regimens in treating neuropathic pain: A real‐world data","authors":"Nithya Raju, Samyuktha Villavan, Saranya Ravi, Roja Murugesan, Panneerselvam Theivendren, Vennila Jaganathan, Redlin Jani Rajan, K. Karunanithi","doi":"10.1002/ibra.12143","DOIUrl":"https://doi.org/10.1002/ibra.12143","url":null,"abstract":"Triple‐therapy regimens involving Pregabalin or Gabapentin with nortriptyline and Methylcobalamin have been shown to be efficacious in treating neuropathic pain in clinical trials. This study aims to compare the clinical effectiveness and treatment satisfaction of two triple‐therapy regimens in treating neuropathic pain in a real‐world setting. This prospective, single‐center, observational study compared the efficacy, safety, and treatment satisfaction of triple therapy in Pregabalin triple therapy versus Gabapentin triple therapy for patients with neuropathic pain. The primary outcome measured the reduction in mean Self‐Administered Leeds Assessment of Neuropathic Symptoms and Signs pain score value from the baseline to 12 weeks posttreatment. The secondary outcome measured the treatment satisfaction for both therapies using the Treatment Satisfaction Questionnaire for Medication version 1.4. Of 264 patients who received either treatment group, during the third follow‐up, it became evident that Group A Pregabalin triple therapy yielded a significantly more substantial reduction in neuropathic pain (60.61%) when compared to Group B Gabapentin triple therapy (12.88%). Furthermore, patients expressed markedly higher levels of satisfaction and convenience with the Pregabalin treatment (p ≤ 0.001). Our study's findings, encompassing both clinical effectiveness and treatment satisfaction, unequivocally demonstrate that Group A surpasses Group B in ameliorating neuropathic symptoms and signs. Pregabalin is a more effective and convenient treatment for neuropathic pain than Gabapentin, with no significant difference in side effects. Clinicians should consider Pregabalin as a first‐line treatment option for neuropathic pain, especially for patients not responding to Gabapentin or who seek a more convenient option.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"3 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138585328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Protective effect of isoflurane preconditioning on neurological function in rats with HIE” 对 "异氟醚预处理对 HIE 大鼠神经功能的保护作用 "的更正

Ibrain Pub Date : 2023-12-04 DOI: 10.1002/ibra.12142

引用次数: 0

Stauntonia chinensis injection relieves neuropathic pain by increasing the expression of PSD-95 and reducing the proliferation of phagocytic microglia Stauntonia chinensis 注射液通过增加 PSD-95 的表达和减少吞噬性小胶质细胞的增殖来缓解神经性疼痛

Ibrain Pub Date : 2023-11-30 DOI: 10.1002/ibra.12140

Wenwen Deng, Helin Zou, Li Qian, Senio Campos de Souza, Qian Chen, Song Cao

{"title":"Stauntonia chinensis injection relieves neuropathic pain by increasing the expression of PSD-95 and reducing the proliferation of phagocytic microglia","authors":"Wenwen Deng, Helin Zou, Li Qian, Senio Campos de Souza, Qian Chen, Song Cao","doi":"10.1002/ibra.12140","DOIUrl":"https://doi.org/10.1002/ibra.12140","url":null,"abstract":"Neuroinflammation induced by engulfment of synapses by phagocytic microglia plays a crucial role in neuropathic pain. Stauntonia chinensis is extracted from Stauntonia chinensis DC, which has been used as a traditional Chinese medicine to control trigeminal neuralgia or sciatica. However, the specific anti-neuralgia mechanism of Stauntonia chinensis is unknown. In this study, the analgesic effect of Stauntonia chinensis injection (SCI) in mice with neuropathic pain and the possible mechanisms are explored. We find that a local injection of 0.1 mL Stauntonia chinensis for 14 days can considerably relieve mechanical hyperalgesia and thermal hyperalgesia in mice with sciatic chronic constriction injury (CCI). Immunofluorescence staining shows that SCI reduces neuroinflammation in the spinal cord of CCI mice. RNA sequencing reveals that the expression of postsynaptic density protein 95 (PSD-95), a postsynaptic scaffold protein, is downregulated in the spinal cord of CCI mice, but upregulated after SCI administration. Immunofluorescence experiments also demonstrate that SCI administration reverses microglia proliferation and PSD-95 downregulation in CCI mice. These data suggest that SCI relieves neuropathic pain by increasing the expression of PSD-95 and reducing the proliferation of phagocytic microglia.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"10 1","pages":"3-18"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140297287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “the effective doses of remimazolam besylate in the procedural sedation of endoscopic retrograde cholangiopancreatography” 更正 "苯磺酸雷马唑仑在内镜逆行胰胆管造影术镇静程序中的有效剂量"

Ibrain Pub Date : 2023-11-30 DOI: 10.1002/ibra.12141

引用次数: 0

Bibliometric analysis of cerebral organoids and diseases in the last 10 years 过去 10 年有关脑器质性病变的文献计量分析

Ibrain Pub Date : 2023-11-30 DOI: 10.1002/ibra.12139

Bo-Yan Luo, Ke-Qian Liu, Ji-Sheng Fan

{"title":"Bibliometric analysis of cerebral organoids and diseases in the last 10 years","authors":"Bo-Yan Luo, Ke-Qian Liu, Ji-Sheng Fan","doi":"10.1002/ibra.12139","DOIUrl":"https://doi.org/10.1002/ibra.12139","url":null,"abstract":"Cerebral organoids have emerged as a powerful tool for mirroring the brain developmental processes and replicating its unique physiology. This bibliometric analysis aims to delineate the burgeoning trends in the application of cerebral organoids in disease research and offer insights for future investigations. We screened all relevant literature from the Web of Science on cerebral organoids in disease research during the period 2013–2022 and analyzed the research trends in the field using VOSviewer, CiteSpace, and Scimago Graphica software. According to the search strategy, 592 articles were screened out. The United States of America (USA) was the most productive, followed by China and Germany. The top nine institutions in terms of the number of publications include Canada and the United States, with the University of California, San Diego (USA), having the highest number of publications. The International Journal of Molecular Sciences was the most productive journal. Knoblich, Juergen A., and Lancaster, Madeline A. published the highest number of articles. Keyword cluster analysis showed that current research trends focused more on induced pluripotent stem cells to construct organoid models of cerebral diseases and the exploration of their mechanisms and therapeutic modalities. This study provides a comprehensive summary and analysis of global research trends in the field of cerebral organoids in diseases. In the past decade, the number of high-quality papers in this field has increased significantly, and cerebral organoids provide hope for simulating nervous system diseases (such as Alzheimer's disease).","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 4","pages":"431-445"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139047556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential injectable hydrogels as biomaterials for central nervous system injury: A narrative review 作为治疗中枢神经系统损伤的生物材料的潜在可注射水凝胶：叙述性综述

Ibrain Pub Date : 2023-11-30 DOI: 10.1002/ibra.12137

Santa Sarma, Dhruva J. Deka, Prakash Rajak, Damiki Laloo, Trishna Das, Purbajit Chetia, Dipankar Saha, Alakesh Bharali, Bhargab Deka

{"title":"Potential injectable hydrogels as biomaterials for central nervous system injury: A narrative review","authors":"Santa Sarma, Dhruva J. Deka, Prakash Rajak, Damiki Laloo, Trishna Das, Purbajit Chetia, Dipankar Saha, Alakesh Bharali, Bhargab Deka","doi":"10.1002/ibra.12137","DOIUrl":"https://doi.org/10.1002/ibra.12137","url":null,"abstract":"Numerous modalities exist through which the central nervous system (CNS) may sustain injury or impairment, encompassing traumatic incidents, stroke occurrences, and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Presently available pharmacological and therapeutic interventions are incapable of restoring or regenerating damaged CNS tissue, leading to substantial unmet clinical needs among patients with CNS ailments or injuries. To address and facilitate the recovery of the impaired CNS, cell-based repair strategies encompass multiple mechanisms, such as neuronal replacement, therapeutic factor secretion, and the promotion of host brain plasticity. Despite the progression of cell-based CNS reparation as a therapeutic strategy throughout the years, substantial barriers have impeded its widespread implementation in clinical settings. The integration of cell technologies with advancements in regenerative medicine utilizing biomaterials and tissue engineering has recently facilitated the surmounting of several of these impediments. This comprehensive review presents an overview of distinct CNS conditions necessitating cell reparation, in addition to exploring potential biomaterial methodologies that enhance the efficacy of treating brain injuries.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 4","pages":"402-420"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139047557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of perineal neuralgia treated with ultrasound‐guided nerve block combined with water separation 超声引导神经阻滞联合水分离治疗会阴神经痛1例

Ibrain Pub Date : 2023-11-14 DOI: 10.1002/ibra.12138

Yong Wang, Min Wang, Rui Jiang, Zhao‐Qiong Zhu, Guang‐Cai Li

引用次数: 0

Corrections to “Bone marrow mesenchymal stem cells in brain ischemia enhaces axonal regeneration associated with IGF-1” 对 "骨髓间充质干细胞在脑缺血中增强轴突再生与 IGF-1 有关 "的更正

Ibrain Pub Date : 2023-10-10 DOI: 10.1002/ibra.12135

引用次数: 0

Corrections to “Recent advances in bone marrow stromal cell trans-plantation to animals with spinal cord injury” 对 "骨髓基质细胞移植到脊髓损伤动物身上的最新进展 "的更正

Ibrain Pub Date : 2023-10-08 DOI: 10.1002/ibra.12134

引用次数: 0

The mediating role of anxiety and depression in the relationship between coping styles and life satisfaction among frontline medical workers during the COVID-19 pandemic: A cross-sectional study 焦虑和抑郁在 COVID-19 大流行期间前线医务工作者的应对方式与生活满意度之间关系中的中介作用：横断面研究

Ibrain Pub Date : 2023-09-25 DOI: 10.1002/ibra.12133

Gui-Fang Chen, Ye-Ping Zhang, Zhi-Jie Wei, Xin-Lan Zhang, Jun Liu, Juan Peng, Zu-Cai Xu, Chang-Yin Yu, Jun Zhang

{"title":"The mediating role of anxiety and depression in the relationship between coping styles and life satisfaction among frontline medical workers during the COVID-19 pandemic: A cross-sectional study","authors":"Gui-Fang Chen, Ye-Ping Zhang, Zhi-Jie Wei, Xin-Lan Zhang, Jun Liu, Juan Peng, Zu-Cai Xu, Chang-Yin Yu, Jun Zhang","doi":"10.1002/ibra.12133","DOIUrl":"10.1002/ibra.12133","url":null,"abstract":"This study aimed to examine the mediating role of anxiety and depression in the relationship between coping styles and life satisfaction among frontline medical workers during the COVID-19 pandemic. Five hundred and fourteen frontline medical workers from Zunyi were recruited to complete questionnaires, including the Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), Satisfaction with Life Scale (SWLS), and Simplified Coping Style Questionnaire (SCSQ). SPSS 24.0 was used to measure the characteristics of anxiety, depression, life satisfaction, and coping styles. We found that the prevalence rates of anxiety and depression among study participants were 22.57% and 18.29%, respectively. Besides, anxiety was positively correlated with depression; anxiety and depression were positively correlated with passive coping style but negatively correlated with life satisfaction and active coping style; life satisfaction was positively correlated with active coping style and negatively correlated with passive coping style (all p < 0.001). Moreover, anxiety and depression mediated the relationship between coping styles and life satisfaction. Anxiety accounted for 18.6% of the effect of active coping style and 35.48% of the effect of passive coping style on life satisfaction. Depression accounted for 48.84% of the effect of active coping style and 67.74% of the effect of passive coping style on life satisfaction. The present study provides novel insights into the effect of subclinical anxiety and depression on frontline medical workers in the pandemic area. Anxiety and depression yielded a mediating effect on the relationship between coping styles and life satisfaction.","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":"9 4","pages":"390-401"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135816334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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