脑外伤与脑-肠-微生物轴关系的研究进展

Ibrain Pub Date : 2024-03-30 DOI:10.1002/ibra.12153
Jie Yu, Yun-Xin Chen, Jin-Wei Wang, Hai-Tao Wu
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引用次数: 0

摘要

创伤性脑损伤(TBI)是一种致死率和致残率都很高的常见疾病,对人类健康构成严重威胁,因此,有效治疗创伤性脑损伤已成为当务之急。脑-肠-微生物(BGM)轴作为大脑和肠道之间信息交流的双向通讯网络,在神经系统疾病中起着至关重要的作用。本文全面探讨了脑-肠-微生物轴与创伤性脑损伤之间的相互关系,包括其生理效应、基本病理生理学和潜在的治疗策略。文章强调了 BGM 轴的双向调节途径如何为创伤性脑损伤的临床治疗提供新的见解,并强调了对创伤性脑损伤进行高级研究和开发创新临床治疗方法的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Research progress on the relationship between traumatic brain injury and brain-gut-microbial axis

Research progress on the relationship between traumatic brain injury and brain-gut-microbial axis

Traumatic brain injury (TBI) is a common disease with a high rate of death and disability, which poses a serious threat to human health; thus, the effective treatment of TBI has been a high priority. The brain-gut-microbial (BGM) axis, as a bidirectional communication network for information exchange between the brain and gut, plays a crucial role in neurological diseases. This article comprehensively explores the interrelationship between the BGM axis and TBI, including its physiological effects, basic pathophysiology, and potential therapeutic strategies. It highlights how the bidirectional regulatory pathways of the BGM axis could provide new insights into clinical TBI treatment and underscores the necessity for advanced research and development of innovative clinical treatments for TBI.

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