Ginekologia polska最新文献_第8页

Evaluation of transforming growth factor-beta 1 concentrations in serum, peritoneal and endometrioma fluid in women operated on for ovarian endometriosis as a biomarker of endometrioma. 卵巢子宫内膜异位症手术妇女血清、腹膜和子宫内膜异位症液中转化生长因子- β 1浓度作为子宫内膜异位症的生物标志物的评估

IF 1

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2025-05-26 DOI: 10.5603/gpl.97117

Mariusz Wojtowicz, Dariusz Zdun, Aleksander J Owczarek, Violetta Skrzypulec-Plinta, Magdalena Olszanecka-Glinianowicz

{"title":"Evaluation of transforming growth factor-beta 1 concentrations in serum, peritoneal and endometrioma fluid in women operated on for ovarian endometriosis as a biomarker of endometrioma.","authors":"Mariusz Wojtowicz, Dariusz Zdun, Aleksander J Owczarek, Violetta Skrzypulec-Plinta, Magdalena Olszanecka-Glinianowicz","doi":"10.5603/gpl.97117","DOIUrl":"10.5603/gpl.97117","url":null,"abstract":"Objectives: Some studies indicate the role of transforming growth factor-beta 1 (TGF-beta 1) in the development of endometriosis. However, the lack is studies assessed its plasma levels as a biomarker of endometrioma. Therefore, this study aimed to analyze plasma, peritoneal, and endometrioma fluid TGF-beta 1 concentrations in women operated on for ovarian endometriosis.Material and methods: A cross-sectional cohort study involved 56 women operated on for ovarian endometriosis. Body mass, height, and waist circumference were measured, as well as body mass index (BMI) being calculated. Plasma, peritoneal, and endometrioma fluid TGF-beta 1 concentrations were determined by enzyme-linked immunosorbent assay (ELISA).Results: Levels TGF-beta 1 were significantly higher in plasma than in both fluids (1286.1 pg/mL vs 114.7 pg/mL; p < 0.001 and 114.7 pg/mL vs 33.6 pg/mL; p < 0.001) and in endometrioma fluid than in peritoneal fluid (114.7 pg/mL vs 33.6 pg/mL; p < 0.001). There were also positive correlations between TGF-beta 1 levels in endometrioma and peritoneal fluids and plasma (r = 0.46; p < 0.001; r = 0.30; p < 0.05, respectively). There were no associations between TGF-beta 1 in plasma, endometrioma, peritoneal fluid, and endometriosis stage.Conclusions: Our results suggest that plasma TGF-beta 1 concentration can be considered as a biomarker of endometrioma.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"739-743"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Irisin - a new biomarker for endometrial cancer? 鸢尾素——子宫内膜癌的新生物标志物？

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Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2025-05-26 DOI: 10.5603/gpl.104455

Monika Szarszewska, Janina Markowska, Marian Grybos, Anna Grybos, Andrzej Marszalek, Anna Malicka-Durczak, Violetta Filas, Michal Michalak, Anna Markowska

引用次数: 0

The attitudes of pregnant or breastfeeding polish women towards COVID-19 vaccinations: a cross-sectional survey study. 波兰孕妇或哺乳期妇女对COVID-19疫苗接种的态度：一项横断面调查研究

IF 1

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2025-04-14 DOI: 10.5603/gpl.103797

Hanna Dancewicz, Anita Kwiatkowska, Joanna Gebarowska, Carlo Bienkowski, Maria Pokorska-Spiewak

{"title":"The attitudes of pregnant or breastfeeding polish women towards COVID-19 vaccinations: a cross-sectional survey study.","authors":"Hanna Dancewicz, Anita Kwiatkowska, Joanna Gebarowska, Carlo Bienkowski, Maria Pokorska-Spiewak","doi":"10.5603/gpl.103797","DOIUrl":"10.5603/gpl.103797","url":null,"abstract":"Objectives: Pregnant women are at higher risk of severe course of COVID-19. The vaccination against COVID-19 is recommended in pregnant and breastfeeding women. The aim of the study was to assess the attitude towards vaccination against COVID-19 among Polish pregnant or breastfeeding women.Material and methods: A cross-sectional survey study was performed from April 20th, 2021, to October 23rd, 2021, using an online questionnaire distributed via social media. Women who weren't Polish or didn't live in Poland were excluded from the study.Results: The study group consisted of 662 women. Their median age was 32.5 years (interquartile range IQR: 27.25-33.75 years). Most of the women lived in acity with over 500000 inhabitants (333/662, 50.30%), were in a relationship (658/662, 99.40%), had higher education (559/662, 84.44%), were currently employed (326/662, 49.25%), but not in a medical field (574/662, 86.71%). Willingness to be vaccinated was expressed in 231/662 (34.89%) of the surveyed women. A positive attitude towards vaccinations was more common among women working in the medical field (p = 0.006679), with higher education (p = 0.000054), who trusted their doctors (p = 0.003900), thought that vaccines against COVID-19 were effective (p < 0.00001), and those afraid of COVID-19 (p < 0.00001).Conclusions: The study showed that only one third of the surveyed women wanted to be vaccinated against COVID-19. Women working in the medical field, with higher education, who trusted their doctors, thought that vaccines against COVID-19 were effective, and those afraid of COVID-19 were more prone to be vaccinated against COVID-19 with recommended vaccines. Educational role of healthcare workers might be crucial for increasing the COVID-19 vaccine coverage in pregnant and breastfeeding women.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"758-764"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the role of human chorionic gonadotropin increment in the 48 h prior methotrexate treatment for predicting the treatment success: a retrospective cohort study. 评估人绒毛膜促性腺激素在48小时甲氨蝶呤治疗前预测治疗成功的作用：一项回顾性队列研究。

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Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2025-07-04 DOI: 10.5603/gpl.103858

Lanxin Liu, Xiaofeng Wang, Zhen Huang, Huajing Yang, Weijian Zeng, Qin Lin, Mi Han

{"title":"Evaluating the role of human chorionic gonadotropin increment in the 48 h prior methotrexate treatment for predicting the treatment success: a retrospective cohort study.","authors":"Lanxin Liu, Xiaofeng Wang, Zhen Huang, Huajing Yang, Weijian Zeng, Qin Lin, Mi Han","doi":"10.5603/gpl.103858","DOIUrl":"10.5603/gpl.103858","url":null,"abstract":"Objectives: To evaluate the role of human chorionic gonadotropin (hCG) change in the 48 h prior to methotrexate treatment as a predictor for treatment success of ectopic pregnancy.Material and methods: This was a retrospective cohort study. A total of 179 women who diagnosed with ectopic pregnancy and given a single dose (50 mg/m²) of methotrexate were included in this study from January 1, 2016 to December 31, 2017. Serum hCG levels and clinical data were collected and compared between the success and failure groups, the percentage increment of hCG levels during the 48 hours prior to methotrexate injection was used to create a receiver operating characteristic (ROC) curve to determine the optimal cut-off value for predicting treatment success.Results: The success rate of treating ectopic pregnancy with a single dose of methotrexate was 70.9%. The optimal cut-off value for percentage increment of serum hCG levels before methotrexate injection was determined to be 12.56%, with a specificity of 60.66% and sensitivity of 55.69%. The area under the receiver operating characteristic curve (AUC) was 0.646 (p < 0.01).Conclusions: A lower 2-day hCG percentage increment before methotrexate injection was found to be associated with successful treatment of ectopic pregnancy, with a cut-off value of 12.56%. However, caution should be exercised when deciding on methotrexate treatment versus surgery for ectopic pregnancy patients.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"734-738"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Folic acid versus folinic acid during methotrexate treatment for low-risk gestational trophoblastic neoplasia. 在甲氨蝶呤治疗低风险妊娠滋养细胞肿瘤期间，叶酸与亚叶酸的比较。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2025-02-04 DOI: 10.5603/gpl.101142

Mehmet Şükrü Budak, Süleyman Cemil Oğlak, Sedat Akgöl, Behzat Can, Kevser Arkan, Ali Deniz Erkmen, Mesut Ali Halisçelik, Adnan Budak, Şeyhmus Tunç, Gökhan Bolluk, Emine Zeynep Yılmaz, Özgür Akbayır

{"title":"Folic acid versus folinic acid during methotrexate treatment for low-risk gestational trophoblastic neoplasia.","authors":"Mehmet Şükrü Budak, Süleyman Cemil Oğlak, Sedat Akgöl, Behzat Can, Kevser Arkan, Ali Deniz Erkmen, Mesut Ali Halisçelik, Adnan Budak, Şeyhmus Tunç, Gökhan Bolluk, Emine Zeynep Yılmaz, Özgür Akbayır","doi":"10.5603/gpl.101142","DOIUrl":"10.5603/gpl.101142","url":null,"abstract":"Objectives: To evaluate and compare the treatment results of folinic acid (FA) and folic acid (F) added to the chemotherapy protocol to reduce the toxicity due to methotrexate (MTX) in the treatment of low-risk gestational trophoblastic neoplasia (GTN) patients.Material and methods: Patients treated for low-risk GTN at two reference centers between January 2000 and March 2023 were included in this retrospective study. Patients were divided into two groups, MTX/FA and MTX/F. Both groups received 50 mg/day MTX on days 1, 3, 5, 7 of treatment. On days 2, 4, 6, 8 of treatment 0.1 mg/kg folinic acid was administered to the MTX/FA group, and 20 mg/day folic acid was administered to the MTX/F group to reduce MTX toxicity. The groups were compared according to treatment success, resistance, and the development of toxicity.Results: Among 102 low-risk GTN patients included in the study, 64.7% (n = 66) were in the MTX/FA, while the remaining 35.3% (n = 36) were in the MTX/F group. There was no significant difference between MTX/FA and MTX/F groups regarding treatment success, resistance, and toxicity rates (84.8%, 13.6%, 1.6% vs 83.3%, 13.8%, 2.7%), respectively.Conclusions: Replacement of folinic acid with folic acid in low-risk GTN patients to reduce the toxicity that may develop associated with MTX treatment resulted in similar treatment success rates. Still, no significant change was observed regarding toxicity and resistance. There is a need for comprehensive prospective studies to further elucidate this relationship.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"200-205"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategies to reduce cesarean deliveries: surveying Polish obstetricians on external cephalic version practices. 减少剖宫产的策略：调查波兰产科医生的头外版本做法。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2024-11-29 DOI: 10.5603/gpl.102550

Maisa Manasar-Dyrbus, Agnieszka Drosdzol-Cop, Szymon Stojko, Rafal Stojko, Jakub Staniczek

{"title":"Strategies to reduce cesarean deliveries: surveying Polish obstetricians on external cephalic version practices.","authors":"Maisa Manasar-Dyrbus, Agnieszka Drosdzol-Cop, Szymon Stojko, Rafal Stojko, Jakub Staniczek","doi":"10.5603/gpl.102550","DOIUrl":"10.5603/gpl.102550","url":null,"abstract":"Objectives: The cross-sectional survey was conducted aiming to evaluate the knowledge and experiences of the Polish obstetricians and gynecologists regarding the External Cephalic Version (ECV) and investigate their practices concerning this procedure.Material and methods: An online survey constituting author-created questionnaire with 22 questions, was distributed among gynecologists and obstetricians. The questionnaire evaluated participants' knowledge about ECV, work experiences, and workplace practices.Results: Out of 461 respondents, 56.20% were specialists in gynecology and obstetrics. Elective cesarean section (CS) was preferred by 78.70% for primiparas and 73.50% for multiparas with non-cephalic presentation, while ECV would be chosen by 21.3% and 23.6%, respectively. While 73.80% knew centers performing ECV, only 16.70% had actively participated in the procedure. Major differences in the experiences and knowledge regarding ECV were observed based on work experience, and workplace reference level. Experienced physicians showed higher concerns about ECV complications and emergency CS risks. The most common concerns regarding the procedure referred to periprocedural pain, perceived low efficacy, and complications, and were more prevalent among respondents with longer experience and from lower-reference centers.Conclusions: The study demonstrated that among Polish obstetricians for term pregnancies with non-cephalic presentation, elective cesarean section is preferred over ECV, especially among experienced practitioners. Knowledge about ECV was relatively low, indicating a need for improved educational efforts. Addressing concerns about ECV's safety and efficacy, particularly through enhanced training and anesthesia options, could promote its adoption and reduce CS rates.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"271-281"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robotic surgery in operative gynecology - dawn of New Era or technological whim? 妇科手术中的机器人手术——新时代的曙光还是技术的突发奇想？

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Ginekologia polska Pub Date : 2025-01-01 DOI: 10.5603/gpl.108187

Filip A Dabrowski

引用次数: 0

The challenge of Mevalonate Kinase Deficiency as one of the causes of nonimmune hydrops fetalis. 甲羟戊酸激酶缺乏作为非免疫性水肿胎儿原因之一的挑战。

IF 1

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2025-05-12 DOI: 10.5603/gpl.104678

Aleksandra Mikolajczak, Katarzyna Bernat-Sitarz

引用次数: 0

The impact of mismatch repair (MMR), p53, and LCAM-1 immunohistochemical expression on prognosis in low-risk endometrial cancer. 错配修复（MMR）、p53 和 LCAM-1 免疫组化表达对低危子宫内膜癌预后的影响。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2025-02-18 DOI: 10.5603/gpl.101983

Şener Gezer, Büşra Yaprak Bayrak, Müzeyyen Dilşad Eser, Esra Betül Tunce

{"title":"The impact of mismatch repair (MMR), p53, and LCAM-1 immunohistochemical expression on prognosis in low-risk endometrial cancer.","authors":"Şener Gezer, Büşra Yaprak Bayrak, Müzeyyen Dilşad Eser, Esra Betül Tunce","doi":"10.5603/gpl.101983","DOIUrl":"10.5603/gpl.101983","url":null,"abstract":"Objectives: To investigate the relationship between mismatch repair (MMR) deficiency, TP53, and L1 cell adhesion molecule (L1CAM) immunohistochemical staining and their impact on progression-free survival (PFS) and overall survival (OS) in low-risk endometrial cancer.Material and methods: A total of 253 low-risk endometrial cancer patients were retrospectively screened. Immunohistochemical stains were applied to tumor tissue samples to assess MMR deficiency, TP53, and L1CAM expression, and survival analysis were performed.Results: The expected PFS time was 78.6 months for the MMR-proficient group and 70.3 months for the MMR-deficient group (p = 0.011). OS was 71.6 months for the MMR-proficient group and 68.2 months for the MMR-deficient group (p = 0.755). L1CAM overexpression was associated with a poorer PFS, 62.7 months compared to 77.7 months (p = 0.039). However, there was no statistically significant difference in OS, 58.5 months versus 72.1 months, respectively (p = 0.242). p53 abnormal (p53-abn) staining was associated with a worse prognosis in terms of PFS, 62.8 months versus 77.7 months (p = 0.035), and OS, 43.4 months versus 73 months, respectively (p < 0.001), compared to patients with wild-type staining. No significant statistical relationship was observed in survival times concerning tumor diameter, grade, and lymphadenectomy status. In a multivariate analysis, MMR deficiency emerged as an independent poor prognostic factor for PFS, while p53-abn was identified as an independent poor prognostic factor for OS.Conclusions: p53-abn staining was associated with a poor prognosis for both PFS and OS in low-risk endometrial cancer patients. Meanwhile, MMR deficiency and L1CAM positivity were found to be associated solely with a poorer prognosis for PFS.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"446-453"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hysteroscopic isthmocele resection: evaluating quality of life and symptom improvements based on isthmocele volume. 宫腔镜峡部切除：评估生活质量和基于峡部体积的症状改善。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2025-05-12 DOI: 10.5603/gpl.102045

Mehmet Faruk Olcenoglu, Merve Olcenoglu, Mesut Onal, Ayse Zehra Ozdemir

{"title":"Hysteroscopic isthmocele resection: evaluating quality of life and symptom improvements based on isthmocele volume.","authors":"Mehmet Faruk Olcenoglu, Merve Olcenoglu, Mesut Onal, Ayse Zehra Ozdemir","doi":"10.5603/gpl.102045","DOIUrl":"10.5603/gpl.102045","url":null,"abstract":"Objectives: To investigate grade 3 isthmocele resection performed via hysteroscopy and the impact of isthmocele size on symptoms caused by isthmocele and quality of life.Material and methods: This retrospective study included patients with grade 3 isthmocele who underwent hysteroscopy between January 2014 and June 2022. Age, body mass index, obstetric & gynecologic characteristics, operation duration, complications, and pre- and postoperative hemoglobin levels were recorded. Quality of life was assessed using the 36-Item Short Form Survey (SF-36). Patients were divided into two groups based on isthmocele volume: < 36 mm² and ≥ 36 mm².Results: A total of 47 women with a mean age of 36.6 ± 4.7 were included in the study. Twenty-two (46.81%) had an isthmocele size of < 36 mm² while 25 (53.19%) were in the ≥ 36 mm² group. There were no significant differences between the groups in terms of demographic and surgical characteristics, and there were no complications. Both groups demonstrated significant improvements in menstrual bleeding length, severity of postmenstrual spotting, frequency of postcoital bleeding, dyspareunia and dysmenorrhea, analgesic use, and quality of life. Compared to the < 36 mm² group, the ≥ 36 mm² group had significantly higher frequency of preoperative analgesic use (p = 0.041), better postoperative quality of life (p = 0.031), and greater improvement in quality of life (p = 0.028).Conclusions: Hysteroscopic isthmocele resection is an effective and safe method for treating isthmocele and achieves considerable improvements in symptoms and quality of life. Patients with larger isthmoceles experience greater improvements in several parameters, suggesting the inclusion of isthmocele volume in treatment decisions.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"454-461"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0