Ginekologia polska最新文献_第8页

NMR-based serum metabolomics in patients with low-differentiated serous ovarian cancer. 基于核磁共振的低分化浆液性卵巢癌患者血清代谢组学研究。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2025-04-25 DOI: 10.5603/gpl.101741

Mateusz M Klimek, Agnieszka Skorupa, Mateusz Ciszek, Tomasz Cichon, Bartosz Cichon, Lukasz Boguszewicz, Andrzej Witek, Maria Sokol

{"title":"NMR-based serum metabolomics in patients with low-differentiated serous ovarian cancer.","authors":"Mateusz M Klimek, Agnieszka Skorupa, Mateusz Ciszek, Tomasz Cichon, Bartosz Cichon, Lukasz Boguszewicz, Andrzej Witek, Maria Sokol","doi":"10.5603/gpl.101741","DOIUrl":"10.5603/gpl.101741","url":null,"abstract":"Objectives: In this pilot study the proton Nuclear Magnetic Resonance (¹H NMR)-based metabolomics was applied to explore the serum metabolomes of the patients with high-grade serous ovarian carcinoma (HGSOC) and the patients with benign gynaecological disease and to identify the characteristic biomarkers.Material and methods: We analyzed serum samples from 17 HGSOC patients and 14 control patients with benign gynecological conditions. Serum metabolites were profiled using 1H NMR spectroscopy, and multivariate data analyses, including Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA), were performed to identify discriminating metabolites.Results: The multivariate analysis revealed the lower levels of the lipid compounds, choline, branched-chain amino acids, 3-hydroxybutyrate (3HB), acetoacetate, and the higher level of lactate in the sera of the HGSOC patients compared to the control group.Conclusions: NMR-based metabolomic analysis can serve as a supporting method for the detection of ovarian cancer and may be useful as an adjunct to molecular diagnostics.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"437-445"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fetal cardiac function is altered by circumvallate placenta. 胎儿心功能被环瓣胎盘改变。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2024-11-29 DOI: 10.5603/gpl.101714

Oskar Sylwestrzak, Katarzyna Zych-Krekora, Lukasz Sokolowski, Maciej Ziebakowski, Michal Krekora

引用次数: 0

Association between MMP-9-C1562Tpolymorphism and susceptibility to preeclampsia: a systematic review and meta-analysis. MMP-9-C1562T多态性与先兆子痫易感性之间的关系：系统回顾和荟萃分析。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2024-10-16 DOI: 10.5603/gpl.100274

Ruihong Lan, Yang Yang, Jie Song, Hong Yang, Ling Wang, Humin Gong

{"title":"Association between MMP-9-C1562Tpolymorphism and susceptibility to preeclampsia: a systematic review and meta-analysis.","authors":"Ruihong Lan, Yang Yang, Jie Song, Hong Yang, Ling Wang, Humin Gong","doi":"10.5603/gpl.100274","DOIUrl":"10.5603/gpl.100274","url":null,"abstract":"Objectives: This meta-analysis aims to explore the association between MMP-9-C1562T polymorphism and susceptibility to preeclampsia (PE).Material and methods: Four English databases were searched to collect relevant records up to April 2024. The pooled odds ratio (OR) was calculated using Stata 15.0.Results: A total of 10 studies were enrolled in our systematic review. The results showed that genotype CT at MMP-9-C1562T locus increased the risk of PE versus genotype TT (Genotype CT vs TT: OR = 2.32, 95% CI: 1.27-4.24, P = 0.006), but no significant differences were found in other gene models (C vs T: OR = 0.88, 95% CI: 0.71-1.08, P = 0.225; Genotype CC vs TT: OR = 1.51, 95% CI: 0.87-2.61, P = 0.139; Genotype CC + CT vs TT: OR = 1.63, 95% CI: 0.95-2.81, P = 0.079; Genotype CC vs CT + TT: OR = 0.80, 95% CI: 0.63-1.03, P = 0.086). Subgroup analysis by ethnicity showed a statistically significant difference in the heterozygous model in China (Genotype CT vs TT: OR = 2.38, 95% CI: 1.15 -4.91, P = 0.019).Conclusions: Association of MMP-9-C1562T polymorphism with susceptibility to PE exists. Specifically, genotype CT increases the risk of PE versus genotype TT, particularly in Caucasian populations.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"65-71"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The outcomes of the 5 mm versus 11 mm primary trocar in gynecologic surgery - randomised study. 妇科手术中 5 毫米与 11 毫米主套管的对比结果--随机研究。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2025-02-04 DOI: 10.5603/gpl.100621

Emin Erhan Dönmez, Zafer Bütün, Eyüpcan Kardas, Fisun Vural

引用次数: 0

Initial paraneoplastic presentation of advanced choriocarcinoma. 晚期绒毛膜癌的初期副肿瘤性表现。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2024-08-14 DOI: 10.5603/gpl.100439

Julia Rudnicka, Aleksandra Urban, Julia Gorny, Anna Danska-Bidzinska, Ewa Romejko-Wolniewicz

引用次数: 0

Transvaginal single posterior incision extraperitoneal bilateral sacrospinous ligament suspension combined with reconstruction of pericervical ring through cervical cerclage. 经阴道单后切口腹膜外双侧骶棘韧带悬吊术，通过宫颈环扎重建宫颈环。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2024-10-16 DOI: 10.5603/gpl.102089

Luo Puying, Yi Sijie, Luo Wenqun, Xiong Yuanhuan

引用次数: 0

Clinical application of synthetic osmotic cervical dilator in labor pre-induction: departmental protocol and literature review. 人工合成渗透性宫颈扩张器在引产前的临床应用：部门规程和文献综述。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2024-11-08 DOI: 10.5603/gpl.100984

Maisa Manasar-Dyrbus, Katarzyna Wilk, Maja Zieba-Domalik, Jakub Staniczek, Rafal Stojko

引用次数: 0

Using the National Nosocomial Infections Surveillance risk index to determine risk factors associated with surgical site infections following gynecologic surgeries. 使用国家医院感染监测风险指数来确定妇科手术后与手术部位感染相关的风险因素。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2023-10-20 DOI: 10.5603/gpl.95073

Dong Wang, Jinlin Wu, Jianjun Deng, Ming Luo, Jie Ruan, Zhan Yang

{"title":"Using the National Nosocomial Infections Surveillance risk index to determine risk factors associated with surgical site infections following gynecologic surgeries.","authors":"Dong Wang, Jinlin Wu, Jianjun Deng, Ming Luo, Jie Ruan, Zhan Yang","doi":"10.5603/gpl.95073","DOIUrl":"10.5603/gpl.95073","url":null,"abstract":"Objectives: We used the National Nosocomial Infections Surveillance (NNIS) risk index to determine risk factors associated with surgical site infections (SSIs) following gynecologic surgeries.Material and methods: A retrospective study was conducted based on the medical records of 185 patients with SSIs, following gynecologic surgeries at a Grade A tertiary gynecologic and obstetric hospital in southwest China during September 2013-June 2021.Results: Suspected risk factors associated with SSIs were: length of hospital stay, age, whether the patient had cancer, whether the patient had chemotherapy or high-dose antibiotic therapy before surgery, duration of surgery, amount of blood loss, and whether a blood transfusion was done. It was found that SSIs were more likely to occur in cancer patients with an NNIS risk index score of 1 and in patients with preoperative chemotherapy and an NNIS risk index score of 2. Among the patients with an NNIS risk index score of 2, the older the patient, the higher incidence of SSIs.Conclusions: Gynecologic surgery teams should pay more attention to the independent risk factors associated with SSIs determined by the NNIS risk index score to prevent SSIs following gynecologic surgeries, thus ensuring patient safety.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the utility of the sFlt-1/PlGF ratio in pregnancy complicated by pre-eclampsia - single-center study. Preliminary analysis. 评估sFlt-1/PlGF比值在妊娠合并子痫前期的应用-单中心研究初步分析。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2025-01-29 DOI: 10.5603/gpl.101484

Justyna A Kuciel, Jagoda N Sarad, Natalia M Mroczek, Andrzej Jaworowski, Magdalena L Kolak, Hubert K Huras

{"title":"Evaluation of the utility of the sFlt-1/PlGF ratio in pregnancy complicated by pre-eclampsia - single-center study. Preliminary analysis.","authors":"Justyna A Kuciel, Jagoda N Sarad, Natalia M Mroczek, Andrzej Jaworowski, Magdalena L Kolak, Hubert K Huras","doi":"10.5603/gpl.101484","DOIUrl":"10.5603/gpl.101484","url":null,"abstract":"Objectives: To evaluate relationship between sFlt-1/PlGF ratio, clinical characteristics and outcomes of pre-eclampsia.Material and methods: Retrospective analysis of 29 pregnant women with pre-eclampsia who had measured sFlt-1/PlGF ratio was conducted using electronic medical records from Obstetrics and Perinatology ward of University Hospital in Cracow.Results: Women median age: 33.5 years, number of pregnancies: one 52%, two 15%, three 18%,more than three 15%, number of deliveries: one 59.3%, two 37%, three 3.7%, median body mass index during hospitalization: 29.4 kg/m². Chronic diseases apart from hypertension: 67% of women (diabetes 37%, hypothyroidism 26%, obesity 11%). Median newborns birth weight: 1640 g, median Apgar score at 5 minutes: 8, median umbilical cord blood pH: 7.32. Fetal growth restriction: 28.6% of cases. All deliveries were by c-section. Median gestational age at delivery: 32 weeks. sFlt-1/PlGF ratio was inversely correlated with gestational age at delivery (r = -0.42, p = 0.02). The median sFlt-1/PlGF ratio was higher in women with severe pre-eclampsia (n = 15) than in those with mild pre-eclampsia (n = 14) (211 vs. 57, p < 0.001). sFlt-1/PlGF ratio of > 85 had a sensitivity of 80% and a specificity of 71% for predicting severe pre-eclampsia.Conclusions: sFlt-1/PlGF ratio is useful in assessing the severity and prognosis of pre-eclampsia. sFlt-1/PlGF ratio should not be used as a sole criterion for making clinical decisions, but as an adjunct to other clinical and laboratory parameters.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"148-152"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Folic acid versus folinic acid during methotrexate treatment for low-risk gestational trophoblastic neoplasia. 在甲氨蝶呤治疗低风险妊娠滋养细胞肿瘤期间，叶酸与亚叶酸的比较。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2025-02-04 DOI: 10.5603/gpl.101142

Mehmet Şükrü Budak, Süleyman Cemil Oğlak, Sedat Akgöl, Behzat Can, Kevser Arkan, Ali Deniz Erkmen, Mesut Ali Halisçelik, Adnan Budak, Şeyhmus Tunç, Gökhan Bolluk, Emine Zeynep Yılmaz, Özgür Akbayır

{"title":"Folic acid versus folinic acid during methotrexate treatment for low-risk gestational trophoblastic neoplasia.","authors":"Mehmet Şükrü Budak, Süleyman Cemil Oğlak, Sedat Akgöl, Behzat Can, Kevser Arkan, Ali Deniz Erkmen, Mesut Ali Halisçelik, Adnan Budak, Şeyhmus Tunç, Gökhan Bolluk, Emine Zeynep Yılmaz, Özgür Akbayır","doi":"10.5603/gpl.101142","DOIUrl":"10.5603/gpl.101142","url":null,"abstract":"Objectives: To evaluate and compare the treatment results of folinic acid (FA) and folic acid (F) added to the chemotherapy protocol to reduce the toxicity due to methotrexate (MTX) in the treatment of low-risk gestational trophoblastic neoplasia (GTN) patients.Material and methods: Patients treated for low-risk GTN at two reference centers between January 2000 and March 2023 were included in this retrospective study. Patients were divided into two groups, MTX/FA and MTX/F. Both groups received 50 mg/day MTX on days 1, 3, 5, 7 of treatment. On days 2, 4, 6, 8 of treatment 0.1 mg/kg folinic acid was administered to the MTX/FA group, and 20 mg/day folic acid was administered to the MTX/F group to reduce MTX toxicity. The groups were compared according to treatment success, resistance, and the development of toxicity.Results: Among 102 low-risk GTN patients included in the study, 64.7% (n = 66) were in the MTX/FA, while the remaining 35.3% (n = 36) were in the MTX/F group. There was no significant difference between MTX/FA and MTX/F groups regarding treatment success, resistance, and toxicity rates (84.8%, 13.6%, 1.6% vs 83.3%, 13.8%, 2.7%), respectively.Conclusions: Replacement of folinic acid with folic acid in low-risk GTN patients to reduce the toxicity that may develop associated with MTX treatment resulted in similar treatment success rates. Still, no significant change was observed regarding toxicity and resistance. There is a need for comprehensive prospective studies to further elucidate this relationship.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"200-205"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0