Expert opinion on drug delivery最新文献_第3页

Dendrimer-mediated targeting of angiogenic biomarkers: therapeutic intervention against cancer. 树枝状聚合物介导的血管生成生物标记物靶向：癌症治疗干预。

Expert opinion on drug delivery Pub Date : 2024-08-01 Epub Date: 2024-09-04 DOI: 10.1080/17425247.2024.2394631

Anchal Pathak, Narendra Kumar Jain, Keerti Jain

{"title":"Dendrimer-mediated targeting of angiogenic biomarkers: therapeutic intervention against cancer.","authors":"Anchal Pathak, Narendra Kumar Jain, Keerti Jain","doi":"10.1080/17425247.2024.2394631","DOIUrl":"10.1080/17425247.2024.2394631","url":null,"abstract":"Introduction: Development of novel vascular networks is a fundamental requirement for tumor growth and progression. In the last decade, biomarkers and underlying molecular pathways of angiogenesis have been intensely investigated to disrupt the initiation and progression of tumor angiogenesis. However, the clinical applications of anti-angiogenic agents are constrained due to toxic side effects, acquired drug resistance, and unavailability of validated biomarkers.Area covered: This review discusses the development of dendrimeric nanocarriers that could be a promising domain to explore for the eradication of current challenges associated with angiogenesis-based cancer therapy. Novel drug-delivery approaches with subtle readouts and better understanding of molecular mechanisms have revealed that dendrimers comprise innate anti-angiogenic activity and incorporation of anti-angiogenic agents or gene-silencing RNA could lead to synergistic anti-angiogenic and anticancer effects with reduced side effects.Expert opinion: Dendrimer-mediated targeting of angiogenic biomarkers has efficiently led to the vascular normalization, and rational linking of dendrimers with anti-angiogenic agent or siRNA or both might be a potential area to eradicate the current challenges of angiogenesis-based cancer therapy. However, drawbacks associated with the dendrimers-mediated targeting of angiogenic biomarkers, such as poor stability or small expression of these biomarkers on the normal cells, limit their application at market scale.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142006184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodegradable nanoplatforms for antigen delivery: part I - state of the art review of polymeric nanoparticles for cancer immunotherapy. 用于抗原递送的生物可降解纳米平台：第一部分--用于癌症免疫疗法的聚合物纳米颗粒的最新进展回顾。

Expert opinion on drug delivery Pub Date : 2024-08-01 Epub Date: 2024-09-08 DOI: 10.1080/17425247.2024.2400293

Estefanía Vega, Jordi Madariaga Burgos, Eliana B Souto, María Luisa García, Montserrat Pujol, Elena Sánchez-López

{"title":"Biodegradable nanoplatforms for antigen delivery: part I - state of the art review of polymeric nanoparticles for cancer immunotherapy.","authors":"Estefanía Vega, Jordi Madariaga Burgos, Eliana B Souto, María Luisa García, Montserrat Pujol, Elena Sánchez-López","doi":"10.1080/17425247.2024.2400293","DOIUrl":"10.1080/17425247.2024.2400293","url":null,"abstract":"Introduction: Polymeric nanoparticles used for antigen delivery against infections and for cancer immunotherapy are an emerging therapeutic strategy in promoting the development of innovative vaccines. Beyond their capability to create targeted delivery systems with controlled release of payloads, biodegradable polymers are utilized for their ability to enhance the immunogenicity and stability of antigens.Areas covered: This review extensively discusses the physicochemical parameters that affect the behavior of nanoparticles as antigen-delivery systems. Additionally, various types of natural and synthetic polymers and recent advancements in nanoparticle-based targeted vaccine production are reviewed.Expert opinion: Biodegradable polymeric nanoparticles have gained major interest in the vaccination filed and have been extensively used to encapsulate antigens against a wide variety of tumors. Moreover, their versatility in terms of tunning their physicochemical characteristics, and their surface, facilitates the targeting to antigen presenting cells and enhances immune response.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treprostinil palmitil inhalation powder leverages endogenous lung enzymes to provide sustained treprostinil. Treprostinil palmitil 吸入粉利用内源性肺部酶提供持续的曲普瑞司替尼。

Expert opinion on drug delivery Pub Date : 2024-08-01 Epub Date: 2024-09-12 DOI: 10.1080/17425247.2024.2395444

Tam Nguyen, Christina Chang, David Cipolla, Vladimir Malinin, Walter Perkins, Veronica Viramontes, Junguo Zhou, Michel Corboz

引用次数: 0

Lipid-based nanosystems for wound healing. 用于伤口愈合的脂基纳米系统。

Expert opinion on drug delivery Pub Date : 2024-08-01 Epub Date: 2024-09-11 DOI: 10.1080/17425247.2024.2391473

Rita Cortesi, Maddalena Sguizzato, Francesca Ferrara

{"title":"Lipid-based nanosystems for wound healing.","authors":"Rita Cortesi, Maddalena Sguizzato, Francesca Ferrara","doi":"10.1080/17425247.2024.2391473","DOIUrl":"10.1080/17425247.2024.2391473","url":null,"abstract":"Introduction: Wounds, resulting from traumas, surgery, burns or diabetes, are important medical problems due to the complexity of wound healing process regarding healing times and healthcare costs. Nanosystems have emerged as promising candidates in this field thank to their properties and versatile applications in drugs delivery.Areas covered: Lipid-based nanosystems (LBN) are described for wound treatment, highlighting their different behaviors when interacting with the cutaneous tissue. The role of nanosystems in delivering mostly natural compounds on skin as well as the technological and engineering strategies to increase their efficiency in wound healing effect are reviewed. Finally, in vitro, ex-vivo and in vivo studies are reported.Expert opinion: LBN have shown promise in addressing the challenges of wound healing as they can improve the stability of drugs used in wound therapy, leading to higher efficacy and fewer adverse effects as compared to traditional formulations. LBNs being involved in the inflammatory and proliferation stages of the wound healing process, enable the modification of wound healing through multiple ways. In addition, the use of new technologies, including 3D bioprinting and photobiomodulation, may lead to potential breakthroughs in wound healing. This would provide clinicians with more potent forms of therapy for wound healing.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D printed dosage forms, where are we headed? 3D 打印剂型，我们将何去何从？

Expert opinion on drug delivery Pub Date : 2024-07-24 DOI: 10.1080/17425247.2024.2379943

Ishwor Poudel, Nur Mita, R Jayachandra Babu

{"title":"3D printed dosage forms, where are we headed?","authors":"Ishwor Poudel, Nur Mita, R Jayachandra Babu","doi":"10.1080/17425247.2024.2379943","DOIUrl":"10.1080/17425247.2024.2379943","url":null,"abstract":"Introduction: 3D Printing (3DP) is an innovative fabrication technology that has gained enormous popularity through its paradigm shifts in manufacturing in several disciplines, including healthcare. In this past decade, we have witnessed the impact of 3DP in drug product development. Almost 8 years after the first USFDA approval of the 3D printed tablet Levetiracetam (Spritam), the interest in 3DP for drug products is high. However, regulatory agencies have often questioned its large-scale industrial practicability, and 3DP drug approval/guidelines are yet to be streamlined.Areas covered: In this review, major technologies involved with the fabrication of drug products are introduced along with the prospects of upcoming technologies, including AI (Artificial Intelligence). We have touched upon regulatory updates and discussed the burning limitations, which require immediate focus, illuminating status, and future perspectives on the near future of 3DP in the pharmaceutical field.Expert opinion: 3DP offers significant advantages in rapid prototyping for drug products, which could be beneficial for personalizing patient-based pharmaceutical dispensing. It seems inevitable that the coming decades will be marked by exponential growth in personalization, and 3DP could be a paradigm-shifting asset for pharmaceutical professionals.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intranasal delivery of glucagon-like peptide-1 to the brain for obesity treatment: opportunities and challenges. 将胰高血糖素样肽-1 经鼻内输送到大脑以治疗肥胖症：机遇与挑战。

Expert opinion on drug delivery Pub Date : 2024-07-01 Epub Date: 2024-08-05 DOI: 10.1080/17425247.2024.2387110

Tanisha Tabassum Sayka Khan, Zara Sheikh, Simin Maleknia, Farshad Oveissi, Ali Fathi, Terence Abrams, Hui Xin Ong, Daniela Traini

{"title":"Intranasal delivery of glucagon-like peptide-1 to the brain for obesity treatment: opportunities and challenges.","authors":"Tanisha Tabassum Sayka Khan, Zara Sheikh, Simin Maleknia, Farshad Oveissi, Ali Fathi, Terence Abrams, Hui Xin Ong, Daniela Traini","doi":"10.1080/17425247.2024.2387110","DOIUrl":"10.1080/17425247.2024.2387110","url":null,"abstract":"Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), approved by the US FDA for obesity treatment, are typically administered subcutaneously, an invasive method leading to suboptimal patient adherence and peripheral side effects. Additionally, this route requires the drug to cross the restrictive blood-brain barrier (BBB), limiting its safety and effectiveness in weight management and cognitive addiction disorders. Delivering the drug intranasally could overcome these drawbacks.Areas covered: This review summarizes GLP-1 RAs used as anti-obesity agents, focusing on the intranasal route as a potential pathway to deliver these biomolecules to the brain. It also discusses strategies to overcome challenges associated with nasal delivery.Expert opinion: Nose-to-brain (N2B) pathways can address limitations of the subcutaneous route for GLP-1 RAs. However, peptide delivery to the brain is challenging due to nasal physiological barriers and the drug's physicochemical properties. Innovative approaches, such as cell permeation enhancers, mucoadhesive systems, and nanocarriers in nasal formulations, along with efficient drug delivery devices, show promising preclinical results. Despite this, successful preclinical data does not guarantee clinical effectiveness, highlighting the need for comprehensive clinical investigations to optimize formulations and fully utilize the nose-to-brain interface for peptide delivery.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translational hurdles in anti-asthmatic nanomedicine development. 抗哮喘纳米药物开发中的转化障碍。

Expert opinion on drug delivery Pub Date : 2024-07-01 Epub Date: 2024-07-28 DOI: 10.1080/17425247.2024.2385092

Muhammad Waseem Akram, Tin Wui Wong

引用次数: 0

Recent advances in in vitro models simulating the female genital tract toward more effective intravaginal therapeutic delivery. 模拟女性生殖道的体外模型在提高阴道内给药效率方面的最新进展。

Expert opinion on drug delivery Pub Date : 2024-07-01 Epub Date: 2024-07-22 DOI: 10.1080/17425247.2024.2380338

Bruna Silva, Eduardo F Marques, Andreia C Gomes

{"title":"Recent advances in in vitro models simulating the female genital tract toward more effective intravaginal therapeutic delivery.","authors":"Bruna Silva, Eduardo F Marques, Andreia C Gomes","doi":"10.1080/17425247.2024.2380338","DOIUrl":"10.1080/17425247.2024.2380338","url":null,"abstract":"Introduction: Intravaginal drug delivery has emerged as a promising avenue for treating a spectrum of systemic and local female genital tract (FGT) conditions, using biomaterials as carriers or scaffolds for targeted and efficient administration. Much effort has been made to understand the natural barriers of this route and improve the delivery system to achieve an efficient therapeutic response.Areas covered: In this review, we conducted a comprehensive literature search using multiple databases (PubMed Scopus Web of Science Google Scholar), to discuss the potential of intravaginal therapeutic delivery, as well as the obstacles unique to this route. The in vitro cell models of the FGT and how they can be applied to probing intravaginal drug delivery are then analyzed. We further explore the limitations of the existing models and the possibilities to make them more promising for delivery studies or biomaterial validation. Complementary information is provided by in vitro acellular techniques that may shed light on mucus-drug interaction.Expert opinion: Advances in 3D models and cell cultures have enhanced our understanding of the FGT, but they still fail to replicate all variables. Future research should aim to use complementary methods, ensure stability, and develop consistent protocols to improve therapy evaluation and create better predictive in vitro models for women's health.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Healing with herbs: an alliance with 'nano' for wound management. 用草药治疗：与 "纳米 "结盟进行伤口管理。

Expert opinion on drug delivery Pub Date : 2024-07-01 Epub Date: 2024-08-08 DOI: 10.1080/17425247.2024.2388214

Preksha Vinchhi, Wong Tin Wui, Mayur M Patel

{"title":"Healing with herbs: an alliance with 'nano' for wound management.","authors":"Preksha Vinchhi, Wong Tin Wui, Mayur M Patel","doi":"10.1080/17425247.2024.2388214","DOIUrl":"10.1080/17425247.2024.2388214","url":null,"abstract":"Introduction: Wound healing is an intricate and continual process influenced by numerous factors that necessitate suitable environments to attain healing. The natural ability of wound healing often gets altered by several external and intrinsic factors, leading to chronic wound occurrence. Numerous wound dressings have been developed; however, the currently available alternatives fail to coalesce in all conditions obligatory for rapid skin regeneration.Area covered: An extensive review of articles on herbal nano-composite wound dressings was conducted using PubMed, Scopus, and Google Scholar databases, from 2006 to 2024. This review entails the pathophysiology and factors leading to non-healing wounds, wound dressing types, the role of herbal bio-actives for wound healing, and the advantages of employing nanotechnology to deliver herbal actives. Numerous nano-composite wound dressings incorporated with phytoconstituents, herbal extracts, and essential oils are discussed.Expert opinion: There is a strong substantiation that several herbal bio-actives possess anti-inflammatory, antimicrobial, antioxidant, analgesic, and angiogenesis promoter activities that accelerate the wound healing process. Nanotechnology is a promising strategy to deliver herbal bio-actives as it ascertains their controlled release, enhances bioavailability, improves permeability to underlying skin layers, and promotes wound healing. A combination of herbal actives and nano-based dressings offers a novel arena for wound management.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141880020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing. 关于辅料特性在从药粉到片剂的连续生产中的作用的重要评论。

Expert opinion on drug delivery Pub Date : 2024-07-01 Epub Date: 2024-08-12 DOI: 10.1080/17425247.2024.2384698

Pauline H M Janssen, Sara Fathollahi, Bastiaan H J Dickhoff, Henderik W Frijlink

{"title":"Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing.","authors":"Pauline H M Janssen, Sara Fathollahi, Bastiaan H J Dickhoff, Henderik W Frijlink","doi":"10.1080/17425247.2024.2384698","DOIUrl":"10.1080/17425247.2024.2384698","url":null,"abstract":"Introduction: The pharmaceutical industry is gradually changing batch-wise manufacturing processes to continuous manufacturing processes, due to the advantages it has to offer. The final product quality and process efficiency of continuous manufacturing processes is among others impacted by the properties of the raw materials. Existing knowledge on the role of raw material properties in batch processing is however not directly transferable to continuous processes, due to the inherent differences between batch and continuous processes.Areas covered: A review is performed to evaluate the role of excipient properties for different unit operations used in continuous manufacturing processes. Unit operations that will be discussed include feeding, blending, granulation, final blending, and compression.Expert opinion: Although the potency of continuous manufacturing is widely recognized, full utilization still requires a number of challenges to be addressed effectively. An expert opinion will be provided that discusses those challenges and potential solutions to overcome those challenges. The provided overview can serve as a framework for the pharmaceutical industry to push ahead process optimization and formulation development for continuous manufacturing processes.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0