Expert opinion on drug delivery最新文献_第3页

Strategies for the delivery of RNA therapeutics to diseased heart tissue. 为患病心脏组织提供RNA疗法的策略。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-10-01 Epub Date: 2025-07-31 DOI: 10.1080/17425247.2025.2539960

Letizia Nicoletti, Martina Coletto, Giovanni Paolo Stola, Camilla Paoletti, Elena Marcello, Daniele Testore, Francesca Tivano, Alice Zoso, Clara Mattu, Valeria Chiono

{"title":"Strategies for the delivery of RNA therapeutics to diseased heart tissue.","authors":"Letizia Nicoletti, Martina Coletto, Giovanni Paolo Stola, Camilla Paoletti, Elena Marcello, Daniele Testore, Francesca Tivano, Alice Zoso, Clara Mattu, Valeria Chiono","doi":"10.1080/17425247.2025.2539960","DOIUrl":"10.1080/17425247.2025.2539960","url":null,"abstract":"Introduction: Cardiovascular diseases (CVDs) account for one-third of the global mortality rate. RNA therapeutics have emerged as a promising tool to modulate gene expression and molecular pathways in CVDs. However, their clinical translation is hampered by instability, immunogenicity, and inefficient delivery across anatomical and physiological barriers.Areas covered: This review critically examines emerging strategies for the targeted delivery of RNA therapeutics to the heart, critically analyzing systemic and local barriers. Emphasis is placed on chemical modifications of RNA molecules, encapsulation, biomimetic, and targeted approaches to enhance tissue and cellular targeting. The analysis is supported by a structured literature search encompassing preclinical and translational studies. Challenges to the clinical translation of RNA delivery are highlighted. Research and review articles, as well as clinical trials published between 2008 and 2024 were searched from PubMed, Web-of-Science, and ClinicalTrials.gov.Expert opinion: Local delivery systems are crucial to improve RNA retention and diffusion through the extracellular matrix (ECM), while cell-type - specific strategies targeting cardiomyocytes and fibroblasts can enhance precision within a heterogeneous cardiac microenvironment (CME). These approaches represent a fundamental basis for the rational design of RNA therapeutics to overcome biological barriers and enable efficient, targeted delivery to cardiac tissue.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1583-1598"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can insulin-fusion proteins overcome the current barriers in drug delivery to the brain? 胰岛素融合蛋白能否克服目前药物输送到大脑中的障碍？

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-09-29 DOI: 10.1080/17425247.2025.2566819

Noriyasu Kamei

引用次数: 0

Targeting bacterial biofilms using polymer-stabilized nanoemulsions. 利用聚合物稳定纳米乳剂靶向细菌生物膜。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-09-29 DOI: 10.1080/17425247.2025.2564865

Muhammad Aamir Hassan, Maged Abdelaziz, Sadaf Noor, Pamela Nangmo Kemda, Ayse Tan, Jungmi Park, Vincent M Rotello

{"title":"Targeting bacterial biofilms using polymer-stabilized nanoemulsions.","authors":"Muhammad Aamir Hassan, Maged Abdelaziz, Sadaf Noor, Pamela Nangmo Kemda, Ayse Tan, Jungmi Park, Vincent M Rotello","doi":"10.1080/17425247.2025.2564865","DOIUrl":"10.1080/17425247.2025.2564865","url":null,"abstract":"Introduction: Antimicrobial resistance (AMR) in bacterial infections is a critical global health threat, contributing significantly to increased morbidity and mortality. This challenge is further amplified by biofilms that act as a protective barrier around bacteria, limiting the effective action of antibiotics and host immune responses.Areas covered: This review highlights the potential of nanoemulsion (NE) systems in delivering hydrophobic payloads, particularly essential oils (EOs), into biofilms, negatively charged extracellular polymeric substance (EPS) matrix. While essential oils exhibit strong antimicrobial properties, their effectiveness against biofilms is restricted due to poor bioavailability and limited biofilm penetration.Expert opinion: NE systems employing natural, semisynthetic, and synthetic polymeric scaffolds offer an effective delivery method for EOs, enabling enhanced penetration into the negatively charged EPS matrix of biofilms. These therapeutics have significant potential for treating refractory biofilm-related AMR infections.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1-12"},"PeriodicalIF":5.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in nanoformulations for helminthiasis treatment. 纳米制剂治疗寄生虫病的最新进展。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-09-29 DOI: 10.1080/17425247.2025.2565426

João Paulo Figueiró Longo, Josué de Moraes

{"title":"Recent advances in nanoformulations for helminthiasis treatment.","authors":"João Paulo Figueiró Longo, Josué de Moraes","doi":"10.1080/17425247.2025.2565426","DOIUrl":"10.1080/17425247.2025.2565426","url":null,"abstract":"Introduction: Recent advances in nanoformulations are reshaping the treatment landscape for helminthiasis by addressing critical challenges such as drug resistance, poor bioavailability, and off-target effects.Areas covered: This review examines current innovations in nanotechnology applied to anthelmintic therapy, with a particular focus on lipid- and polymer-based systems designed to enhance drug solubility, stability, and targeted delivery. A comprehensive literature search was performed to identify recent developments, highlight preclinical and translational studies, and evaluate the performance of solid lipid nanoparticles, nanoemulsions, and self-nanoemulsifying drug delivery systems. Relevant articles were retrieved from peer-reviewed journals indexed in PubMed, Scopus, and Web of Science, covering publications up to June 2025.Expert opinion: The integration of nanotechnologies into helminthiasis treatment offers promising therapeutic advantages but faces important challenges related to industrial scalability, regulatory approval, and implementation in low-resource settings. Addressing these issues requires coordinated efforts between academia, industry, and public health stakeholders. The review outlines key considerations for technology transfer and commercialization, underscoring the importance of cost-effectiveness, patient acceptability, and cross-sector collaboration to ensure the successful translation of nanomedicine-based solutions for neglected tropical diseases.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1-16"},"PeriodicalIF":5.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid carrier-based intranasal delivery of calcium channel blockers for Alzheimer's disease. 基于脂质载体的钙通道阻滞剂鼻内给药治疗阿尔茨海默病。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-09-26 DOI: 10.1080/17425247.2025.2564130

Sunil Jog, Sayali Dighe, Khushali Nathani, Akanksha Waghmare, Shubhada V Mangrulkar, Sujata P Sawarkar, Abdelwahab Omri

{"title":"Lipid carrier-based intranasal delivery of calcium channel blockers for Alzheimer's disease.","authors":"Sunil Jog, Sayali Dighe, Khushali Nathani, Akanksha Waghmare, Shubhada V Mangrulkar, Sujata P Sawarkar, Abdelwahab Omri","doi":"10.1080/17425247.2025.2564130","DOIUrl":"10.1080/17425247.2025.2564130","url":null,"abstract":"Background: Felodipine (FLD) is an L-type calcium channel blocker with pronounced neuroprotection against Alzheimer's disease (AD). Unfortunately, the efficacy of FLD has been impeded by limited solubility, poor bioavailability, and sub-optimal accumulation. Thus, the current study unfolds the potential of nanostructured lipid carriers based on in-situ gel of FLD (FLD-NLCs gel) to ameliorate dementia.Methods: The FLD-contained NLCs were prepared using the microemulsion-sonication method and further integrated into thermosensitive gel comprised poloxamer 407 and HPMC K4M. The formulation was evaluated by ex-vivo permeation study, cell culture studies, and in-vivo efficacy study. The toxicity of formulation was assessed by HET-CAM assay, and nasal cilitoxicity study.Results: The optimized FLD-NLCs had nanoscaled dimension, spherical shape, and augmented %EE (~96%). The FLD-NLCs gel displayed biphasic release, with ~1.3-fold higher permeation as relative to free FLD. The HET-CAM assay and cell culture study revealed compatible nature of formulation. The in-vivo biochemical, neurotransmitter, and inflammatory marker determination revealed neuroprotective and restorative potential of the FLD-NLCs gel.Conclusions: The repurposing tactic of FLD presents a viable concept to combat AD. Also, the NLC-based temperature responsive intranasal gel exemplifies a practical approach to augment the efficacy of FLD.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1-15"},"PeriodicalIF":5.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomedicine-based TRPV1 targeting for osteoarthritis therapy: promise and pitfalls. 基于纳米医学的TRPV1靶向治疗骨关节炎：希望和缺陷。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-09-25 DOI: 10.1080/17425247.2025.2565423

Qing Yao, Yifan Qiu, Haoxiong Guan, Yuzhi Zhang, Ruijie Chen, Longfa Kou

引用次数: 0

Solvent-exchange-based in situ forming implants: advances and challenges as long-lasting formulations. 基于溶剂交换的原位成形植入物：作为长效配方的进步和挑战。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-09-25 DOI: 10.1080/17425247.2025.2565422

Irene Lozza, Ana Isabel Fraguas-Sánchez, Cristina Martín-Sabroso, Ana Isabel Torres-Suárez

{"title":"Solvent-exchange-based in situ forming implants: advances and challenges as long-lasting formulations.","authors":"Irene Lozza, Ana Isabel Fraguas-Sánchez, Cristina Martín-Sabroso, Ana Isabel Torres-Suárez","doi":"10.1080/17425247.2025.2565422","DOIUrl":"10.1080/17425247.2025.2565422","url":null,"abstract":"Introduction: In situ forming implants (ISFIs) are long-acting drug delivery systems that solidify at the injection site, creating a depot for sustained drug release from days to months. Compared with preformed implants, ISFIs offer unique advantages, including easier and more convenient administration and simpler manufacturing. Among the different types, solvent-based ISFIs are the most extensively studied and developed formulations.Areas covered: This review analyses advances in solvent-based ISFIs at both preclinical and clinical levels, with emphasis on formulation strategies and therapeutic applications. A literature search was conducted using PubMed and WOS. EMA and FDA databases were also consulted.Expert opinion: Solvent-based ISFIs represent an important strategy for achieving long-lasting effects with a single administration independent of patient compliance. Their main impact has been in mental and substance use disorders, but they are also useful for local effects. To date, one formulation has been approved for periodontitis, though applications in ocular diseases and osteoarthritis are anticipated. A key formulation challenge is to reduce the initial drug release. Most marketed formulations are based on PLGA/PLA dissolved in NMP. Recently, DMSO and PEGylated-based-ISFIs have been approved, which generally provide better drug release control and will likely lead to the development of new formulations.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1-17"},"PeriodicalIF":5.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of a high efficacy single shot injection of artemisinin combination for effective antimalarial therapy. 高效单针注射青蒿素联合治疗疟疾的潜力。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-09-25 DOI: 10.1080/17425247.2025.2565416

Padma V Devarajan, Maharukh T Rustomjee

引用次数: 0

MXenes-loaded gelatin hydrogels as wound dressings. 含mxenes的明胶水凝胶作为伤口敷料。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-09-24 DOI: 10.1080/17425247.2025.2566815

Ruifang Yu, Lu Chen, Xiang Zhang, Xiaoli Jiang, Xiaodong Liu

{"title":"MXenes-loaded gelatin hydrogels as wound dressings.","authors":"Ruifang Yu, Lu Chen, Xiang Zhang, Xiaoli Jiang, Xiaodong Liu","doi":"10.1080/17425247.2025.2566815","DOIUrl":"https://doi.org/10.1080/17425247.2025.2566815","url":null,"abstract":"Background: In the present study, we fabricated a multifunctional hydrogel nanocomposite for wound healing applications.Research design and methods: Computational simulations were employed to optimize gelatin and synthesize Ti3AlC2 (104) and clarify gelatin adsorption behavior on Ti3AlC2 (104). The experiments concentrated on the synthesis, characterization, and integration of Mxene into a gelatin hydrogel. The MTT assay, hemolysis assay, and antibacterial assay were performed to assess the in vitro biological activities of the hydrogels, and a full-thickness wound was induced on a rat for the animal experiments.Results: The chosen composite exhibited a satisfactory docking score, with a binding energy of - 115.408 kcal mol-1. The results showed that the synthesized MXenes had a zeta potential of + 24.5 ± 3.2 mV and a hydrodynamic size of 2.091 ± 0.32 μm. The hydrogel that was made had a porous structure, was biodegradable, and could soak up much water. The biological test showed the hydrogel was biocompatible, hemocompatible, and antibacterial. The animal trials demonstrated that the MXene-loaded gelatin hydrogel expedited wound healing.Conclusions: The fabricated gelatin hydrogel loaded with MXenes nanocomposite can be applied to contaminated wounds to eradicate the contamination and accelerate the healing process.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-phase exenatide delivery system: PLGA nanoparticles embedded in thermosensitive PLGA-PEG-PLGA hydrogel for sustained glycemic control. 双相艾塞那肽递送系统：PLGA纳米颗粒嵌入热敏PLGA- peg -PLGA水凝胶，用于持续血糖控制。

IF 5.4

Expert opinion on drug delivery Pub Date : 2025-09-24 DOI: 10.1080/17425247.2025.2564870

Shu Pan, Nan Dong, Haoyang Yuan, Yu Zhang, Haibing He, Tian Yin, Yanjiao Wang, Jingxin Gou, Xing Tang

{"title":"Dual-phase exenatide delivery system: PLGA nanoparticles embedded in thermosensitive PLGA-PEG-PLGA hydrogel for sustained glycemic control.","authors":"Shu Pan, Nan Dong, Haoyang Yuan, Yu Zhang, Haibing He, Tian Yin, Yanjiao Wang, Jingxin Gou, Xing Tang","doi":"10.1080/17425247.2025.2564870","DOIUrl":"10.1080/17425247.2025.2564870","url":null,"abstract":"Background: Glucagon-like peptide-1 (GLP-1) receptor agonists have demonstrated significant clinical efficacy in recent years for the treatment of type 2 diabetes mellitus (T2DM) and obesity. However, their widespread application remains constrained by limitations such as low oral bioavailability and poor patient compliance due to frequent injections. This study developed a biphasic delivery system (Ex-NPs-gel) integrating poly(lactic-co-glycolic acid)-poly(ethylene glycol)-poly(lactic-co-glycolic acid) (PLGA-PEG-PLGA) thermosensitive hydrogel with nanoparticles (NPs) for sustained-release injectable formulations.Methods: Exenatide-loaded nanoparticles (Ex-NPs) were prepared via the double emulsion solvent evaporation method and encapsulated into PLGA-PEG-PLGA hydrogel. The prepared NPs and hydrogel composite were subsequently evaluated for their physicochemical properties and in vitro/in vivo performance.Results: In vitro studies demonstrated that Ex-NPs-gel achieved sustained exenatide release over 31 days with an initial burst release below 9% within the first 24 h. In T2DM rat models, a single administration induced fasting blood glucose stabilization for over 15 days and restored hepatic/pancreatic functions.Conclusions: This system overcomes technical bottlenecks of conventional PLGA carriers and single-phase gels through modulation of release kinetics, offering a biocompatible and clinically translatable solution for long-acting polypeptide delivery.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1-15"},"PeriodicalIF":5.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0