Expert opinion on drug delivery最新文献_第2页

Novel strategies in topical delivery for psoriasis treatment: nanocarriers and energy-driven approaches.

Expert opinion on drug delivery Pub Date : 2025-04-01 Epub Date: 2025-03-02 DOI: 10.1080/17425247.2025.2472968

Cheng-Yu Lin, Zih-Chan Lin, Yen-Tzu Chang, Tsai-Jie Lin, Jia-You Fang

{"title":"Novel strategies in topical delivery for psoriasis treatment: nanocarriers and energy-driven approaches.","authors":"Cheng-Yu Lin, Zih-Chan Lin, Yen-Tzu Chang, Tsai-Jie Lin, Jia-You Fang","doi":"10.1080/17425247.2025.2472968","DOIUrl":"10.1080/17425247.2025.2472968","url":null,"abstract":"Introduction: Psoriasis is characterized by abnormal differentiation and hyperproliferation of epidermal keratinocytes. This condition presents significant challenges for effective drug delivery. In addition to overcoming the thickness of the skin, topical treatments must navigate the complex hydrophobic and hydrophilic properties of the skin barrier. Recent advancements in nanocarrier technologies, including energy-driven methods and microneedles that penetrate the stratum corneum, present promising strategies for enhancing drug permeation through tailored physicochemical properties. A literature search was performed using the databases of Google Scholar, PubMed, and ScienceDirect.Areas covered: This review highlights recent studies on novel topical delivery methods for psoriasis treatment, addressing current therapeutic options and their limitations. We provide a comprehensive overview of chemical nanoformulations and explore physical strategies to improve delivery rates. Furthermore, we discuss the advantages of various formulations that can carry different types of payloads, offering patients diverse strategies for symptom management. The review covers conventional treatments, emphasizing advancements in nanoparticle design and novel macromolecular drugs. This includes Ribonucleic acid (RNA)-based therapies that protect macromolecular drugs from rapid clearance in the body.Expert opinion: We argue that intelligent design approaches can enhance efficacy across delivery applications while allowing for precision in treatment strategies, ultimately improving patient outcomes.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"565-581"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable pulsatile drug delivery hydrogels: how do we get to the clinic?

Expert opinion on drug delivery Pub Date : 2025-04-01 Epub Date: 2025-02-25 DOI: 10.1080/17425247.2025.2472001

Kayla Baker, Todd Hoare

引用次数: 0

Development of an intranodal drug delivery system using a mouse model with lymphadenopathy: novel discoveries and clinical application.

Expert opinion on drug delivery Pub Date : 2025-04-01 Epub Date: 2025-03-25 DOI: 10.1080/17425247.2025.2471982

Tetsuya Kodama, Ariunbuyan Sukhbaatar

{"title":"Development of an intranodal drug delivery system using a mouse model with lymphadenopathy: novel discoveries and clinical application.","authors":"Tetsuya Kodama, Ariunbuyan Sukhbaatar","doi":"10.1080/17425247.2025.2471982","DOIUrl":"10.1080/17425247.2025.2471982","url":null,"abstract":"Introduction: The low drug delivery rate of systemic chemotherapy to metastatic lymph nodes (LNs) may be due to tumor growth without tumor neovascularization in the LNs, loss of existing blood vessels and lymph sinuses due to the tumor growth, and increased intranodal pressure. The lymphatic drug delivery system (LDDS) is a method of injecting anticancer drugs directly into the LNs and can overcome these problems. The world's first specific clinical study using the LDDS for head and neck cancer started in 2024 in Japan. In this review, the background of the development of LDDS up to the present clinical trials is described.Areas covered: The MXH10/Mo-lpr/lpr (MXH10/Mo/lpr) recombinant inbred model mouse, vascular and lymphatic flow through LNs, the clinical N0 (cN0) LN model, preclinical studies of the LDDS, and its clinical application to treat head and neck cancer.Expert opinion: Conventionally, hematogenous and lymphatic administration have been the focus of attention for drug delivery to LNs. The LDDS is a method for injecting drugs directly to LNs, so it is important to develop a solvent and injecting method that can increase the uniformity of drug distribution within LNs.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"555-564"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local delivery of steroids to inner ear via medical device INCAT (the Inner Ear Catheter) in partial deafness patients during cochlear implantation - preliminary results and a feasibility study.

Expert opinion on drug delivery Pub Date : 2025-04-01 Epub Date: 2025-02-25 DOI: 10.1080/17425247.2025.2466773

Magdalena B Skarżyńska, Elżbieta Gos, Piotr H Skarżyński, Artur Lorens, Adam Walkowiak, Henryk Skarżyński

{"title":"Local delivery of steroids to inner ear via medical device INCAT (the Inner Ear Catheter) in partial deafness patients during cochlear implantation - preliminary results and a feasibility study.","authors":"Magdalena B Skarżyńska, Elżbieta Gos, Piotr H Skarżyński, Artur Lorens, Adam Walkowiak, Henryk Skarżyński","doi":"10.1080/17425247.2025.2466773","DOIUrl":"10.1080/17425247.2025.2466773","url":null,"abstract":"Background: The primary aim was to assess the effectiveness and safety of three different algorithms of using steroids and inner ear catheter (INCAT) MED-EL® in partial deafness patients who underwent cochlear implantation. The secondary goal was the assessment of the impact of the depth of INCAT on hearing preservation after cochlear implantation.Research design and methods: There were three algorithms of steroid administration: 1) methylprednisolone 62.5 mg/ml (solution), 3 patients; 2) methylprednisolone 40 mg/ml (suspension), 4 patients; 3) dexamethasone 4 mg/ml (solution), 3 patients. Pure tone audiometry (0.125-8 kHz) was performed preoperatively, 1 and 6 months post-op. Hearing preservation was assessed according to the HEARRING group formula. Impedance measurements were taken at two days, 1 and 6 months after surgery.Results: Patients treated with methylprednisolone 40 mg/ml in suspension showed the best hearing preservation (50% complete and 50% partial preservation) 1 month post-op and later remained the most favorable. The lowest impedance was found in this group both 1 and 6 months post-op. A shorter INCAT insertion depth appeared to be more favorable than a longer one.Conclusion: Our results suggest that patients treated with methylprednisolone 40 mg/ml (suspension) had better hearing outcomes compared to the other two medications.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"599-607"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olfaction and drug delivery to the human olfactory airspace: current challenges and recent advances.

Expert opinion on drug delivery Pub Date : 2025-04-01 Epub Date: 2025-02-27 DOI: 10.1080/17425247.2025.2467784

Dennis Onyeka Frank-Ito

{"title":"Olfaction and drug delivery to the human olfactory airspace: current challenges and recent advances.","authors":"Dennis Onyeka Frank-Ito","doi":"10.1080/17425247.2025.2467784","DOIUrl":"10.1080/17425247.2025.2467784","url":null,"abstract":"Introduction: Olfactory function, despite its critical role in human survival and quality of life, is often underappreciated. This could be associated with the fact that symptoms of olfactory dysfunction rarely occur in isolation as they are frequently concomitant with comorbidities. Furthermore, effective treatments for olfactory dysfunction largely remain elusive, and no standardized clinical practice for treating this dysfunction currently exist, thus complicating the initiation of appropriate therapeutic modalities. Intranasal administration of topical medication targeting the olfactory cleft represents a safe, noninvasive and potentially efficacious approach, but several challenges impede effective drug delivery.Areas covered: This review highlights the importance of human olfaction, assessment of olfactory function, underlying sources of olfactory dysfunction, and challenges involved in developing long-term and effective treatment modalities, particularly in the administration of topical medication to the olfactory cleft intranasally. Advancements in both device-related and administration-related modalities designed to enhance intranasal drug delivery are discussed.Expert opinion: Clinical management typically prioritizes comorbid conditions, relegating symptoms pertaining olfactory dysfunction to ancillary concerns. Device manufacturers for intranasal administration likewise underestimate the complexity and variabilities of the nasal cavity, and how these impact drug transport. Synergistic implementation of device and formulation strategies can potentially yield enhanced olfactory cleft drug delivery.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"511-524"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

4D printing biological stimuli-responsive hydrogels for tissue engineering and localized drug delivery applications - part 1.

Expert opinion on drug delivery Pub Date : 2025-04-01 Epub Date: 2025-02-18 DOI: 10.1080/17425247.2025.2466772

Alireza Sadraei, Seyed Morteza Naghib, Navid Rabiee

{"title":"4D printing biological stimuli-responsive hydrogels for tissue engineering and localized drug delivery applications - part 1.","authors":"Alireza Sadraei, Seyed Morteza Naghib, Navid Rabiee","doi":"10.1080/17425247.2025.2466772","DOIUrl":"10.1080/17425247.2025.2466772","url":null,"abstract":"Introduction: The advent of 3D printing has revolutionized biomedical engineering, yet limitations in creating dynamic human tissues remain. The emergence of 4D printing, which introduces time as a fourth dimension, offers new possibilities by enabling the production of adaptable, stimuli-responsive structures. A thorough literature search was performed across various databases, including Google Scholar, PubMed, Scopus, and Web of Science, to identify pertinent studies published up to 2025. The search parameters were confined to articles published in English that concentrated on peer-reviewed clinical studies.Areas covered: This review explores the transition from 3D to 4D printing and focuses on stimuli-responsive materials, particularly hydrogels, which react to environmental changes. The literature search examined recent studies on the interaction of these materials with biological stimuli, emphasizing their application in tissue engineering and drug delivery applications.Expert opinion: 4D printing, combined with smart materials, holds immense promise for advancing biomedical treatments, including customized therapies and regenerative medicine. However, technological challenges must be addressed to realize its full potential.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"471-490"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

4D printing chemical stimuli-responsive hydrogels for tissue engineering and localized drug delivery applications - part 2.

Expert opinion on drug delivery Pub Date : 2025-04-01 Epub Date: 2025-02-19 DOI: 10.1080/17425247.2025.2466768

Alireza Sadraei, Seyed Morteza Naghib, Navid Rabiee

{"title":"4D printing chemical stimuli-responsive hydrogels for tissue engineering and localized drug delivery applications - part 2.","authors":"Alireza Sadraei, Seyed Morteza Naghib, Navid Rabiee","doi":"10.1080/17425247.2025.2466768","DOIUrl":"10.1080/17425247.2025.2466768","url":null,"abstract":"Introduction: The incorporation of 4D printing alongside chemical stimuli-responsive hydrogels represents a significant advancement in the field of biomedical engineering, effectively overcoming the constraints associated with conventional static 3D-printed structures. Through the integration of time as the fourth dimension, 4D printing facilitates the development of dynamic and adaptable structures that can react to chemical alterations in their surroundings. This innovation presents considerable promise for sophisticated tissue engineering and targeted drug delivery applications.Areas covered: This review examines the function of chemical stimuli-responsive hydrogels within the context of 4D printing, highlighting their distinctive ability to undergo regulated transformations when exposed to particular chemical stimuli. An in-depth examination of contemporary research underscores the collaborative dynamics between these hydrogels and their surroundings, focusing specifically on their utilization in biomimetic scaffolds for tissue regeneration and the advancement of intelligent drug delivery systems.Expert opinion: The integration of 4D printing technology with chemically responsive hydrogels presents exceptional prospects for advancements in tissue engineering and targeted drug delivery, facilitating the development of personalized and adaptive medical solutions. Although the potential is promising, it is essential to address challenges such as material optimization, biocompatibility, and precise control over stimuli-responsive behavior to facilitate clinical translation and scalability.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"491-510"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in optimizing siRNA delivery to hepatocellular carcinoma cells. 优化肝癌细胞 siRNA 传输的最新进展。

Expert opinion on drug delivery Pub Date : 2025-03-30 DOI: 10.1080/17425247.2025.2484287

Ralf Weiskirchen, Sabine Weiskirchen, Chiara Grassi, Bruna Scaggiante, Mario Grassi, Domenico Tierno, Alice Biasin, Nhung Hai Truong, Thanh Dang Minh, Maja Cemazar, Giorgia Pastorin, Federica Tonon, Gabriele Grassi

{"title":"Recent advances in optimizing siRNA delivery to hepatocellular carcinoma cells.","authors":"Ralf Weiskirchen, Sabine Weiskirchen, Chiara Grassi, Bruna Scaggiante, Mario Grassi, Domenico Tierno, Alice Biasin, Nhung Hai Truong, Thanh Dang Minh, Maja Cemazar, Giorgia Pastorin, Federica Tonon, Gabriele Grassi","doi":"10.1080/17425247.2025.2484287","DOIUrl":"10.1080/17425247.2025.2484287","url":null,"abstract":"Introduction: Hepatocellularcarcinoma (HCC), the primary form of liver cancer, is the second leading cause of cancer-related deaths worldwide. Current therapies have limited effectiveness, particularly in advanced stages of the disease, highlighting the need for innovative treatment options. Small-interfering RNA(siRNA) molecules show great promise as a therapeutic solution since they can inhibit the expression of genes promoting HCC growth. Their cost-effective synthesis has further encouraged their potential use as novel drugs. However, siRNAs are vulnerable to degradation in biological environments, necessitating protective delivery systems. Additionally, targeted delivery to HCC is critical for optimal efficacy and minimal undesired side effects.Areacovered: This review addresses the challenges associated with the delivery of siRNA toHCC, discussing and focusing on delivery systems based on lipid and polymeric nanoparticles in publications from the past five years.Expert opinion: Future nano particles will need to effectively cross the vessel wall, migrate through the extracellular matrix and finally cross the HCC cell membrane. This may be achieved by optimizing nanoparticle size, the equipment of nanoparticles withHCC targeting moieties and loading nanoparticles with siRNAs againstHCC-specific oncogenes.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current research and future potential of thermogels for sustained drug delivery. 热凝胶用于持续给药的当前研究和未来潜力。

Expert opinion on drug delivery Pub Date : 2025-03-29 DOI: 10.1080/17425247.2025.2486350

Pek Yin Michelle Yew, Qianyu Lin, Cally Owh, Pei Lin Chee, Xian Jun Loh

{"title":"Current research and future potential of thermogels for sustained drug delivery.","authors":"Pek Yin Michelle Yew, Qianyu Lin, Cally Owh, Pei Lin Chee, Xian Jun Loh","doi":"10.1080/17425247.2025.2486350","DOIUrl":"https://doi.org/10.1080/17425247.2025.2486350","url":null,"abstract":"Introduction: Drug administration is ubiquitous in the healthcare field, and it is crucial to optimize drug delivery methods to improve drug efficacy, reduce systemic toxicity, and enhance patient compliance Thermogels have shown immense potential in drug delivery due to their injectability, biocompatibility, and ability to provide localized and sustained drug release.Area covered: This paper discusses the unique properties of thermogel in relation to drug kinetics and their suitability as a carrier. Different considerations and applications of thermogel drug delivery systems (DDS) were highlighted and their challenges to enter the market discussed. A comprehensive literature search was conducted using major databases such as PubMed, Scopus, and Web of Science. The search employed relevant keywords to identify studies on thermogel DDS. Clinicaltrials.gov was also utilized to determine the current state of clinical studies.Expert opinion: Nonetheless, thermogel holds great promise for the future in DDS with research achieving greater heights in terms of complexity and clinical pursuits. Their flexibility in fabrication and modularity manner makes it a great material to tailor to different drug delivery applications and to be integrated into various biomedical disciplinaries.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Particle surface coating for dry powder inhaler formulations.

Expert opinion on drug delivery Pub Date : 2025-03-26 DOI: 10.1080/17425247.2025.2482052

Yijing Huang, Chanakya D Patil, Kinnari Santosh Arte, Qi Tony Zhou, Li Lily Qu

{"title":"Particle surface coating for dry powder inhaler formulations.","authors":"Yijing Huang, Chanakya D Patil, Kinnari Santosh Arte, Qi Tony Zhou, Li Lily Qu","doi":"10.1080/17425247.2025.2482052","DOIUrl":"10.1080/17425247.2025.2482052","url":null,"abstract":"Introduction: The development of dry powder inhalers (DPIs) is challenging due to the need for micronized particles to achieve lung delivery. The high specific surface area of micronized particles renders them cohesive and adhesive. Addition of certain excipients like magnesium stearate has been reported to coat the particles and improve the aerosolization in the carrier-based DPI. Therefore, application of particle coating in DPI developments has been investigated and expanded over the years, along with the growing need of high-dose carrier-free DPIs.Area covered: In addition to modifying inter-particulate forces, particle coating has also been demonstrated to effectively provide moisture resistance, modify particle morphology, improve the stability of biologics, alter dissolution behaviors for DPI developments. These different coating functions have been discussed in the current work. Moreover, various coating techniques including solvent-based coating, dry coating, and vapor coating, as well as coating characterization have been summarized in the present review.Expert opinion: The extent of particle coating is critical to DPI performance; however, there is a demand for advanced characterization techniques to quantify and understand the coating quality. Further advancements in coating materials, methods, characterization techniques are needed to better relate coating properties to performance, especially for complex drug modalities.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0