Expert opinion on drug delivery最新文献_第2页

Long-acting injectables for the treatment of substance use disorder: a look ahead. 治疗物质使用障碍的长效注射剂：展望。

Expert opinion on drug delivery Pub Date : 2025-06-01 Epub Date: 2025-04-18 DOI: 10.1080/17425247.2025.2493232

Sohyung Lee, Nitin Joshi

引用次数: 0

Redox chemical delivery system: an innovative strategy for the treatment of neurodegenerative diseases. 氧化还原化学传递系统：治疗神经退行性疾病的创新策略。

Expert opinion on drug delivery Pub Date : 2025-06-01 Epub Date: 2025-04-10 DOI: 10.1080/17425247.2025.2489558

Jeevan Lal Prajapati, Yogita Dhurandhar, As Pee Singh, Deepak Kumar Gupta, Vivek Singh Baghel, Umesh Kushwaha, Kamta Prasad Namdeo

{"title":"Redox chemical delivery system: an innovative strategy for the treatment of neurodegenerative diseases.","authors":"Jeevan Lal Prajapati, Yogita Dhurandhar, As Pee Singh, Deepak Kumar Gupta, Vivek Singh Baghel, Umesh Kushwaha, Kamta Prasad Namdeo","doi":"10.1080/17425247.2025.2489558","DOIUrl":"10.1080/17425247.2025.2489558","url":null,"abstract":"Introduction: It is anticipated that the prevalence of illnesses affecting the central nervous system (CNS) will rise significantly due to longer lifespans and changing demography. Age-related decline in brain function and neuronal death are features of neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis, which provide formidable treatment challenges. Because most therapeutic drugs cannot across the blood-brain barrier (BBB) to reach the brain, there are still few treatment alternatives available despite a great deal of research.Areas covered: This study explores the role of redox chemical delivery systems in CNS drug delivery and addresses challenges associated with neurodegenerative disease (ND). Redox Chemical Delivery System offers a promising approach to enhancing leveraging redox reactions that facilitate the transport of therapeutic agents across the BBB. Through the optimization of medication delivery pathways to the brain, this technology has the potential to greatly improve the treatment of ND.Expert opinion: As our understanding of the biological underpinnings of ND deepens, the potential for effective interventions increases. Refining drug delivery strategies, such as RCDS, is essential for advancing CNS therapies from research to clinical practice. These advancements could transform the management of ND, improving both treatment efficacy and patient outcomes.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"805-822"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Targeting Alzheimer's disease pathology: influence of nano-based drug delivery systems loaded with a combination of herbal and synthetic drugs. 靶向阿尔茨海默病病理学：草药和合成药物组合负载的纳米药物传递系统的影响。

Expert opinion on drug delivery Pub Date : 2025-06-01 DOI: 10.1080/17425247.2025.2513440

Mumtaz, Devika Unnithan, Aysha Khan, Ajay Pratap Singh Chauhan, Javed Ali, Mohammad Ahmed Khan

{"title":"Targeting Alzheimer's disease pathology: influence of nano-based drug delivery systems loaded with a combination of herbal and synthetic drugs.","authors":"Mumtaz, Devika Unnithan, Aysha Khan, Ajay Pratap Singh Chauhan, Javed Ali, Mohammad Ahmed Khan","doi":"10.1080/17425247.2025.2513440","DOIUrl":"https://doi.org/10.1080/17425247.2025.2513440","url":null,"abstract":"Introduction: Alzheimer's Disease (AD) is a progressive neurological disordermarked by cognitive decline and memory loss. Current treatments,including acetylcholinesterase inhibitors (AChEIs) and NMDA receptorantagonists, provide only symptomatic relief due to poor Blood BrainBarrier (BBB) permeability and side effects. The integration ofsynthetic and natural drug combinations with nanotechnology offers apromising strategy to enhance drug delivery, efficacy, and overalltherapeutic outcomes.Areascovered: This review explores the integration of herbal and synthetic drugs innano-based delivery systems for AD treatment. It examines co-loadingefficiency, release kinetics, and synergistic therapeutic benefits ofdual-drug formulations. Additionally, it discusses target-specificligand functionalization for improved BBB penetration and neuronaltargeting, alongside a comparative analysis of dual- vs. single-drugformulations and their impact on diseaseprogression and efficacy.Expertopinion: Current treatment options primarily offer symptomatic relief in theirearly stages, while failing to target the multiple neurobiologicalmechanisms responsible for AD progression. In light of this,combining the already established treatments with herbal drugs, wecan leverage their combined effects to enhance treatment efficacy andmitigate side effects. Furthermore, co-loading of synthetic drugs andphytoconstituents within a single nanoformulation can improvesite-specific drug delivery, offer sustained release, and lowersystemic side effects, resulting in better treatment outcomes.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The nasal route for nose-to-brain drug delivery: advanced nasal formulations for CNS disorders. 鼻至脑药物输送的鼻腔途径：用于中枢神经系统疾病的先进鼻腔配方。

Expert opinion on drug delivery Pub Date : 2025-06-01 Epub Date: 2025-04-07 DOI: 10.1080/17425247.2025.2489553

Paraskevi Papakyriakopoulou, Georgia Valsami

{"title":"The nasal route for nose-to-brain drug delivery: advanced nasal formulations for CNS disorders.","authors":"Paraskevi Papakyriakopoulou, Georgia Valsami","doi":"10.1080/17425247.2025.2489553","DOIUrl":"10.1080/17425247.2025.2489553","url":null,"abstract":"Introduction: The nasal route offers a feasible alternative to oral and/or parenteral administration, providing a noninvasive route to achieve nose-to-brain drug delivery involving the olfactory and trigeminal nerves, and facilitating local or systemic drug action. Conventional liquid nasal dosage forms have not managed to bridge the gaps of precise dosing and targeted central nervous system (CNS) delivery, while more sophisticated formulation approaches are being explored for brain targeting, aiming to enhance bioavailability and therapeutic efficacy.Areas covered: This review focuses on preclinical and clinical evaluation of microemulsions, in-situ gels, nasal powders, and nanocarrier-based formulations. Key pharmacokinetic and pharmacodynamic findings are discussed to evaluate their potential and limitations in improving drug bioavailability and CNS targeting. The existing regulatory framework for approval of products for nose-to-brain drug delivery is also addressed and relative hurdles are discussed.Expert opinion: While nasal drug delivery holds great promise for CNS therapeutics, key challenges remain, including formulation stability, mucosal permeability, patient adherence. Future research should prioritize improving targeting efficiency, overcoming mucociliary clearance, developing user-friendly pharmaceutical products. Personalized medicine and smart delivery systems could further enhance drug targeting and minimize side effects. Continued research and regulatory advancements are essential to fully realize nasal delivery's perspective in CNS therapeutics.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"823-839"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Recent advancements and future applications of intrauterine drug delivery systems. 宫内给药系统的最新进展和未来应用。

Expert opinion on drug delivery Pub Date : 2025-06-01 Epub Date: 2025-04-09 DOI: 10.1080/17425247.2025.2490266

Ashwin Abhang, Diane J Burgess

{"title":"Recent advancements and future applications of intrauterine drug delivery systems.","authors":"Ashwin Abhang, Diane J Burgess","doi":"10.1080/17425247.2025.2490266","DOIUrl":"10.1080/17425247.2025.2490266","url":null,"abstract":"Introduction: Intrauterine devices (IUDs) are drug-device combination products that are placed inside the uterus above the endometrium. IUDs contain a therapeutic agent used for contraception and have been shown to have other therapeutic benefits. Over the past century, intrauterine drug delivery systems (IUDDS) have revolutionized women's health, and they hold immense growth potential in the future for new developments in the therapeutic areas beyond contraception.Areas covered: The aim of this review is to offer a comprehensive description of the history, development, and current state of IUDDS, next-generation IUDDS, and future applications of IUDDS in therapeutic areas beyond contraception such as multi-purpose prevention technologies, hormone replacement therapy, endometriosis, uterine fibroids, and endometrial cancer.Expert opinion: The uterus's unique features make it an ideal site for controlled, prolonged, and localized delivery of drugs, ensuring maximum concentration at the target site. Currently, IUDs are the most widely used contraceptive method. Future IUDDS hold the potential to deliver therapeutic agents for broader therapeutic areas for women's health, potentially aiding in the treatment of various diseases and disorders of the female reproductive system. Further research in development, characterization, and translation is warranted to ensure IUDDS reach their potential in many areas of women's health.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"841-856"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Closed-loop therapy: recent advancements and potential predictors of glycemic outcomes. 闭环治疗：最近的进展和潜在的预测血糖结局。

Expert opinion on drug delivery Pub Date : 2025-06-01 Epub Date: 2025-04-18 DOI: 10.1080/17425247.2025.2492363

Chloë Royston, Roman Hovorka, Charlotte K Boughton

{"title":"Closed-loop therapy: recent advancements and potential predictors of glycemic outcomes.","authors":"Chloë Royston, Roman Hovorka, Charlotte K Boughton","doi":"10.1080/17425247.2025.2492363","DOIUrl":"10.1080/17425247.2025.2492363","url":null,"abstract":"Introduction: Hybrid closed-loop systems have become the standard of care for managing type 1 diabetes (T1D). Both clinical trials and real-world data have demonstrated that these systems improve glycemic control without increasing the risk of hypoglycemia, while also reducing the overall burden of T1D management. A systematic literature search was conducted using PubMed for studies including individuals with T1D that were published until the end of 2024.Areas covered: In this review, we summarize the safety and efficacy of currently available hybrid closed-loop systems, drawing from key clinical trials and real-world data analyses. We also highlight recent advancements in closed-loop systems, discuss their limitations and barriers to access, and explore future directions for automated insulin delivery. Finally, we explore potential predictors of outcomes for people with T1D to better understand why some individuals respond better to closed-loop systems than others.Expert opinion: Closed-loop systems are advancing rapidly, with a growing focus on enhancing automation through fully closed-loop systems to improve glycemic control and further reduce the burden of management. Identifying the predictors that influence how individuals respond to closed-loop therapy will enable these systems to be optimized. It is crucial to ensure widespread and equitable access to this advanced technology.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"875-892"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Nanovector approach for co-delivery of Alectinib and Hesperidin via inhalational for lung cancer treatment: development, characterization, and preclinical studies. 吸入给药阿勒替尼和橙皮苷用于肺癌治疗的纳米载体方法：发展、表征和临床前研究。

Expert opinion on drug delivery Pub Date : 2025-06-01 Epub Date: 2025-04-08 DOI: 10.1080/17425247.2025.2487585

Saeem Ahmad, Shahnaj Bano, Nasr A Emad, Shadab Alam, Anjali Rathee, Iqra Zai, Jayamanti Pandit, Mohd Aqil, Yasmin Sultana

{"title":"Nanovector approach for co-delivery of Alectinib and Hesperidin via inhalational for lung cancer treatment: development, characterization, and preclinical studies.","authors":"Saeem Ahmad, Shahnaj Bano, Nasr A Emad, Shadab Alam, Anjali Rathee, Iqra Zai, Jayamanti Pandit, Mohd Aqil, Yasmin Sultana","doi":"10.1080/17425247.2025.2487585","DOIUrl":"10.1080/17425247.2025.2487585","url":null,"abstract":"Background: The current study aims to fabricate Nanostructured Lipid Carriers for the co-delivery of Alectinib and Hesperidin (ALB-HSD NLC) for non-small cell lung Cancer (NSCLC) via an inhalational route.Research design and method: The ALB-HSD NLC was fabricated using Melt emulsification followed by the sonication method and optimized using a central composite design. The optimized formulation was evaluated for various in vitro and in vivo studies.Results: The optimized ALB-HSD NLC had satisfactory results for particle size, Zeta Potential, PDI, and entrapment efficiency. The drug release was more than 2.5-fold higher compared to drugs suspension over 72 hr. A549 human lung cell line study shows IC50 for ALB and HSD, were 2.289 µg/mL and 73.52 µg/mL, and the dose-dependent toxicity was 0.0209 μg/mL and 0.5213 μg/mL for ALB-HSD NLC formulation and ALB HSD Suspension, respectively, after 72 hr. The Pharmacokinetic study has demonstrated improved AUC0-t (1.38, 1.57-fold) of ALB and HSD from NLC compared to drug suspension. In vivo studies give significant results on the syngeneic model.Conclusions: The prepared ALB-HSD NLC could be promising drug carriers, and they succeeded in delivering small and efficient doses of ALB and HSD to treat NSCLC.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"893-908"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Current research and future potential of thermogels for sustained drug delivery. 热凝胶用于持续给药的当前研究和未来潜力。

Expert opinion on drug delivery Pub Date : 2025-06-01 Epub Date: 2025-04-16 DOI: 10.1080/17425247.2025.2486350

Pek Yin Michelle Yew, Qianyu Lin, Cally Owh, Pei Lin Chee, Xian Jun Loh

{"title":"Current research and future potential of thermogels for sustained drug delivery.","authors":"Pek Yin Michelle Yew, Qianyu Lin, Cally Owh, Pei Lin Chee, Xian Jun Loh","doi":"10.1080/17425247.2025.2486350","DOIUrl":"10.1080/17425247.2025.2486350","url":null,"abstract":"Introduction: Drug administration is ubiquitous in the healthcare field, and it is crucial to optimize drug delivery methods to improve drug efficacy, reduce systemic toxicity, and enhance patient compliance Thermogels have shown immense potential in drug delivery due to their injectability, biocompatibility, and ability to provide localized and sustained drug release.Area covered: This paper discusses the unique properties of thermogel in relation to drug kinetics and their suitability as a carrier. Different considerations and applications of thermogel drug delivery systems (DDS) were highlighted and their challenges to enter the market discussed. A comprehensive literature search was conducted using major databases such as PubMed, Scopus, and Web of Science. The search employed relevant keywords to identify studies on thermogel DDS. Clinicaltrials.gov was also utilized to determine the current state of clinical studies.Expert opinion: Nonetheless, thermogel holds great promise for the future in DDS with research achieving greater heights in terms of complexity and clinical pursuits. Their flexibility in fabrication and modularity manner makes it a great material to tailor to different drug delivery applications and to be integrated into various biomedical disciplinaries.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"769-786"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in nanocrystals for arthritis drug delivery. 纳米晶体用于关节炎药物递送的最新进展。

Expert opinion on drug delivery Pub Date : 2025-05-31 DOI: 10.1080/17425247.2025.2505758

Luca Morici, Olivier Jordan, Eric Allémann, Carlos Rodríguez-Nogales

{"title":"Recent advances in nanocrystals for arthritis drug delivery.","authors":"Luca Morici, Olivier Jordan, Eric Allémann, Carlos Rodríguez-Nogales","doi":"10.1080/17425247.2025.2505758","DOIUrl":"10.1080/17425247.2025.2505758","url":null,"abstract":"Introduction: More than 500 million people worldwide suffer from arthritis, experiencing daily pain and inflammation. Current treatments for osteoarthritis (OA) and rheumatoid arthritis (RA) are palliative, offering only symptom relief. No disease-modifying OA drugs (DMOADs) capable of restoring joint functionality and regenerating the cartilage matrix have yet been approved by the FDA or EMA.Areas covered: This review highlights recent advances in nanocrystals (NCs) for arthritis drug delivery, including conventional nanosuspensions and novel transdermal microneedles. Special attention is given to intra-articular DMOADs formulated as NC-in-microparticles, designed to extend drug release over months. Papers and reviews with the mentioned contents and published over the last 5 years were included in the review process.Expert opinion: New DMOADs and disease-modifying antirheumatic drugs (DMARDs) are often poorly water-soluble, limiting their clinical progress. The versatility of NCs and nanosuspensions offers a potential advantage over other types of nanoparticles, as they can be adapted to various delivery systems, administration routes, and types of arthritis. Due to the avascular nature of cartilage, exploring the intra-articular route for OA management is essential. Implementing cartilage-targeted strategies or using stimuli-responsive hydrogels can further enhance their therapeutic potential.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Recent advances in antibacterial nanoformulations for endodontic applications. 牙髓应用抗菌纳米制剂的最新进展。

Expert opinion on drug delivery Pub Date : 2025-05-30 DOI: 10.1080/17425247.2025.2511963

Tiago Dionísio, Pedro Brandão, Vanessa Machado, João Botelho, José João Mendes, Pedro Fonte

{"title":"Recent advances in antibacterial nanoformulations for endodontic applications.","authors":"Tiago Dionísio, Pedro Brandão, Vanessa Machado, João Botelho, José João Mendes, Pedro Fonte","doi":"10.1080/17425247.2025.2511963","DOIUrl":"10.1080/17425247.2025.2511963","url":null,"abstract":"Introduction: Nanotechnology offers a promising avenue for developing new biomedical materials and improving existing dental techniques, particularly in endodontics. Advances in antibacterial nanoformulations could revolutionize root canal treatment by overcoming challenges such as anatomical complexity, bacterial biofilms, and disinfectant resistance. Nanoparticles in disinfectants and sealers enhance infection control, while in regenerative therapies, they aid in bioactive compound release and scaffold enhancement.Areas covered: This review explores recent research developments in antibacterial nanoformulations tailored for endodontic applications. It covers the principles of endodontic therapy, current protocols, efficacy rates, limitations, and the potential benefits and drawbacks of nanoparticle integration. Additionally, it discusses different nanoparticle types, their efficacy, biocompatibility, and mechanisms of action against endodontic pathogens. The references examined in this review are primarily drawn from studies conducted over the last decade, ensuring an up-to-date perspective on the topic.Expert opinion: We provide an overview of the transformative potential of antibacterial nanoformulations in endodontics, highlighting their advantages over conventional methods, which often show low effectiveness against endodontic flora, application challenges, and high reactivity with biological tissues. Chitosan, silver, and poly(lactic-co-glycolic acid) nanoparticles have shown strong antimicrobial activity and superior dentinal penetration. Integration into irrigants, sealers, and regenerative scaffolds, enhance efficacy while maintaining or improving material properties. Ongoing research is essential to optimize their design, ensure safety, and support regulatory approval. These innovations may redefine clinical standards and improve treatment outcomes in endodontics.","PeriodicalId":94004,"journal":{"name":"Expert opinion on drug delivery","volume":" ","pages":"1-20"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0