Current health sciences journal最新文献_第3页

Phenotypic Classification and Functional Assessment in Knee Osteoarthritis Patients. 膝关节骨性关节炎患者的表型分类和功能评估

Current health sciences journal Pub Date : 2024-04-01 Epub Date: 2024-06-30 DOI: 10.12865/CHSJ.50.02.16

Ovidiu-Florin Fugaru, Dumitru Rădulescu, Mircea-Sebastian Șerbănescu, Magdalena Rodica Trăistaru

{"title":"Phenotypic Classification and Functional Assessment in Knee Osteoarthritis Patients.","authors":"Ovidiu-Florin Fugaru, Dumitru Rădulescu, Mircea-Sebastian Șerbănescu, Magdalena Rodica Trăistaru","doi":"10.12865/CHSJ.50.02.16","DOIUrl":"10.12865/CHSJ.50.02.16","url":null,"abstract":"The purpose of our study was the phenotypic classification of patients with osteoarthritis of the knee (KOA) and the dynamic assessment of functional status, monitored both numerically and in conformity with the International Classification of Functioning, Disability, and Health (ICF-basic set, shortened form). We conducted a prospective study in the Department of Physical Medicine and Rehabilitation, Filantropia Hospital, Craiova, from June of 2022 to November of 2023. In total, 100 patients with KOA were enlisted. Using data from the literature, physiotherapeutic examination, and results from paraclinical examinations, we classified studied patients into the five phenotypic categories: chronic pain (F1), local pathology with predominance of inflammatory mechanisms (F2), local pathology with predominance of metabolic mechanisms of bone and cartilage structures (F3), metabolic disorders (F4) and comorbidities (F5)-primarily chronic venous insufficiency in the lower limbs. We analyzed the values of generic qualifiers (at two evaluation time points) for the most significant elements of the core ICF set, abbreviated form, used in OAG, across each of the five phenotypes. Phenotypes F4 and F5 showed significant improvements across all evaluated functions, indicating increased efficacy in patients with comorbidities and metabolic diseases. Reduction in pain sensation, improvement in joint and muscle mobility, as well as enhancements in functions related to walking, dressing, and hand use, reflect an overall improvement in the quality of life for these patients.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Population Profile of Children in Romania Affected by Burns. 罗马尼亚受烧伤影响儿童的人口概况。

Current health sciences journal Pub Date : 2024-04-01 Epub Date: 2024-06-30 DOI: 10.12865/CHSJ.50.02.17

Denisa Maria Canut, Marius Eugen Ciurea

{"title":"Population Profile of Children in Romania Affected by Burns.","authors":"Denisa Maria Canut, Marius Eugen Ciurea","doi":"10.12865/CHSJ.50.02.17","DOIUrl":"10.12865/CHSJ.50.02.17","url":null,"abstract":"Burns in children represent a significant challenge in the global health domain. The research aims to analyze the profile of children in Romania affected by burns, focusing on demographic characteristics, severity of burns, applied treatment, and impact on parents. Through this analysis, we aim to better understand the factors involved in these cases and provide relevant information for improving the management and care of children with burns. This study aims to explore various aspects related to the healing of burn injuries in pediatric patients in Romania, analyzing data collected through a questionnaire administered to 107 parents. The profile of children in Romania affected by burns is primarily composed of relatively young children, with an average age of 8.7 years and an even distribution between genders. Most come from rural areas, and the degree of burns ranges from first to fourth degree, reflecting a wide range of severity of injuries. Treatment is diverse, with a tendency towards conservative approaches and a significant proportion of cases without complications. Parental satisfaction is not significantly influenced by the type of treatment, indicating a similar perception regardless of the mode of medical intervention. Improving the management and care of children with burns is achieved through adopting a multidisciplinary and integrative perspective. This involves the use of non-pharmacological therapies such as hypnosis and regional anesthesia for pain and anxiety control. Additionally, the inclusion of adjunctive therapies, such as the use of mesenchymal stromal cells and tilapia skin xenograft, contributes to improving the healing process.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Significance of Inflammation in Atrial Fibrillation. 炎症在心房颤动中的意义

Current health sciences journal Pub Date : 2024-01-01 Epub Date: 2024-03-31 DOI: 10.12865/CHSJ.50.01.08

Ciprian Rachieru, Daniel-Florin Lighezan, Lucian Petrescu, Georgică Târtea, Emilia Violeta Goanță, Roxana Buzas, Liviu Cirin, Dragoș Cozma

{"title":"The Significance of Inflammation in Atrial Fibrillation.","authors":"Ciprian Rachieru, Daniel-Florin Lighezan, Lucian Petrescu, Georgică Târtea, Emilia Violeta Goanță, Roxana Buzas, Liviu Cirin, Dragoș Cozma","doi":"10.12865/CHSJ.50.01.08","DOIUrl":"10.12865/CHSJ.50.01.08","url":null,"abstract":"Aim: The aim of the study was to assess the inflammatory status in individuals diagnosed with atrial fibrillation (Afi) and establish an association between this status and the clinicopathological features.Material and methods: Our study was conducted retrospectively and initially involved 278 patients. However, after excluding 27 patients, we ultimately ended up with 167 patients who had an inflammatory status and 84 patients who did not have an inflammatory status. These patients were then analyzed.Results: Patients who had inflammation showed higher values for the CHA2DS2-VASc and HAS-BLED scores (P= 0.0132 for CHA2DS2-VASc and P= 0.0024 for HAS-BLED). Also, it was observed that patients with associated inflammation exhibited an increase in both the volume and the area of the left atrium. Patients with hypertension had a higher prevalence of inflammation, with heart failure and with ischemic heart disease. It is worth noting that patients with atrial fibrillation and increased inflammatory status exhibited higher rates of stroke (22.75% vs 10.71% in patients without inflammation, odds ratio = 2.455, 95% confidence interval 1.161 to 5.425, p = 0.0253).Conclusions: Our research has demonstrated that patients diagnosed with atrial fibrillation and exhibiting a heightened inflammatory status also present association with other comorbidities, including hypertension, heart failure, ischemic heart disease, and stroke.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cattel and Blumgart Anastomosis: Comparison of Pancreatojejunostomy Techniques in Patients with Pancreatic Cancer. Cattel和Blumgart吻合术：胰腺癌患者胰空肠吻合术技术的比较。

Current health sciences journal Pub Date : 2024-01-01 Epub Date: 2024-03-31 DOI: 10.12865/CHSJ.50.01.03

Sergio Isidro Gamboa-Hoil, Ricardo Gamboa-Gutierrez, Patricia Bolado-Garcia, Alejandro Medina-Campos

{"title":"Cattel and Blumgart Anastomosis: Comparison of Pancreatojejunostomy Techniques in Patients with Pancreatic Cancer.","authors":"Sergio Isidro Gamboa-Hoil, Ricardo Gamboa-Gutierrez, Patricia Bolado-Garcia, Alejandro Medina-Campos","doi":"10.12865/CHSJ.50.01.03","DOIUrl":"10.12865/CHSJ.50.01.03","url":null,"abstract":"Backround: Pancreaticojejunal anastomosis has a high risk of pancreatic leakage, which several surgical techniques have been described. Our main objective is to determine what is the association of postoperative pancreatic leakage in patients undergoing pancreaticoduodenectomy according to the pancreaticojejunal anastomosis technique used (Cattel vs Blumgart)?Material and methods: Historical cohort, all cancer patients undergoing pancreaticoduodenectomy were included. From April 2020 to May 2021, Cattel technique was used; from June 2021 to June 2022, Blumgart technique was used. All procedures were performed by a single board-certified surgical oncologist at Oncology Hospital.Results: 24 patients (11 men and 13 women). The first 9 procedures were performed with the Cattel technique, starting from procedure 10, the Blumgart technique was used. No differences were observed regarding the consistency of the pancreas (p=0.28) or the size of the duct (p=0.51) between the two groups. Pancreatic leakage was observed in 100% with the Cattel technique and in 6.7% with the Blumgart technique (p= 0.0001). An amylase value was observed in the left drainage at 6 days > 200 U/L with the Cattel technique and < 200 U/L with Blumgart (p=0.0001). Intraoperative bleeding (Cattel 1200 ml vs. Blumgart 400 ml, p= 0.03) and 90-day mortality (Cattel 33.3% vs. Blumgart 0%, Log-Rank: 0.022) also showed a difference in favor of Blumgart technique. Blumgart technique is a protective factor for the presence of pancreatic leakage (RR 0.06, 95% CI 0.01-0.44, p=0.0001).Discussion: A lower risk of pancreatic leakage was found using the Blumgart technique, compared to the Cattel technique.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological and Clinical Aspects in a Cohort of Colorectal Cancer Patients. 一组结直肠癌患者的流行病学和临床方面。

Current health sciences journal Pub Date : 2024-01-01 Epub Date: 2024-03-31 DOI: 10.12865/CHSJ.50.01.14

Alina Elena Ciobanu, Cristina Maria Marginean, Cristian Mesina, Tudor-Adrian Balseanu, Daniela Ciobanu, Mirela Marinela Florescu

{"title":"Epidemiological and Clinical Aspects in a Cohort of Colorectal Cancer Patients.","authors":"Alina Elena Ciobanu, Cristina Maria Marginean, Cristian Mesina, Tudor-Adrian Balseanu, Daniela Ciobanu, Mirela Marinela Florescu","doi":"10.12865/CHSJ.50.01.14","DOIUrl":"10.12865/CHSJ.50.01.14","url":null,"abstract":"We conducted a retrospective, observational study, based on 91 patients diagnosed with colorectal cancer (CRC), hospitalized and evaluated within the Surgical and the 2nd Internal Medicine Clinic, the Clinical Emergency County Hospital Craiova, between October 2020 and October 2022. We aimed in this study to analyze the epidemiological aspects and clinical characteristics of patients with CRC. In our study group, the patients' ages were between 30-89 years, with mean a of 68.06 (±9.39) years. The incidence of CRC cases in young patients was relatively low. 56.04% of all patients lived in urban areas. In 57.14% of cases, tumors were found on the left colon. The histopathological (HP) examination revealed the net predominance of adenocarcinoma. Depending on the HP grade, the tumor formations were represented predominantly by moderate and poorly differentiated tumors, having G2 and G3 grades. The T3 tumors predominated the total tumors identified. We observed that obstructions have the highest percentages on the left colon, while haemorrhages and perforations have higher percentages on the right side of the colon. The results obtained in our study largely validated the hypothesis proposed at the beginning of the study, according to which, using the clinical, paraclinical, and HP data, we can create a typology of the patient with CRC, from the Craiova Reference Center, to guide us in identifying some measures to decrease the percentage of CRC, as well as to improve the efficiency of the surgical treatment for these cases.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic Resonance Imaging in COVID-19 Associated Rhino-Sinusal Mucormycosis. 与 COVID-19 相关的犀牛口腔黏液瘤病的磁共振成像。

Current health sciences journal Pub Date : 2024-01-01 Epub Date: 2024-03-31 DOI: 10.12865/CHSJ.50.01.10

Mircea Viorel Ciurea, Ionuț Isaia Jeican, Nicolae Balica, Daniela Vrânceanu, Silviu Albu

{"title":"Magnetic Resonance Imaging in COVID-19 Associated Rhino-Sinusal Mucormycosis.","authors":"Mircea Viorel Ciurea, Ionuț Isaia Jeican, Nicolae Balica, Daniela Vrânceanu, Silviu Albu","doi":"10.12865/CHSJ.50.01.10","DOIUrl":"10.12865/CHSJ.50.01.10","url":null,"abstract":"Rhino-sinusal mucormycosis is an acute invasive fungal infection rarely encountered in the clinical setting, occurring in severe immunosuppressed patients. However, in patients suffering from COVID-19 disease a dramatic increase in the incidence of mucormycosis has been recorded. The aim of the study is to discuss the MRI findings of patients with COVID-19 associated mucormycosis. This is a retrospective review of 10 hospitalized and operated patients in three Otolaryngologic Departments between the 1st of February 2021 and the 30th of October 2021. All patients presented nasal mucormycosis, histologically verified along with documented SARS-CoV-2 positive RT-PCR test. The sinus involvement, extra sinus spread and peri-sinus invasion were documented in all patients. The correlation between MRI and intra-operative findings was also assessed. The black turbinate sign and peri-antral soft tissue infiltration are early MRI signs characteristic of mucormycosis. Moreoever, MRI has a significantly high positive predictive value for intra-operative findings in COVID-19 associated mucormycosis.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indication and Timing of Cholecystectomy in Acute Biliary Pancreatitis - Systematic Review. 急性胆源性胰腺炎胆囊切除术的适应症和时机 - 系统性综述。

Current health sciences journal Pub Date : 2024-01-01 Epub Date: 2024-03-31 DOI: 10.12865/CHSJ.50.01.16

Suzana Măceș Piele, Silviu Daniel Preda, Ștefan Pătrașcu, Stylliani Laskou, Konstantinos Sapalidis, Daniela Dumitrescu, Valeriu Șurlin

{"title":"Indication and Timing of Cholecystectomy in Acute Biliary Pancreatitis - Systematic Review.","authors":"Suzana Măceș Piele, Silviu Daniel Preda, Ștefan Pătrașcu, Stylliani Laskou, Konstantinos Sapalidis, Daniela Dumitrescu, Valeriu Șurlin","doi":"10.12865/CHSJ.50.01.16","DOIUrl":"10.12865/CHSJ.50.01.16","url":null,"abstract":"Acute biliary pancreatitis (ABP) poses significant challenges in determining the optimal timing and approach for cholecystectomy, particularly in mild, moderately severe, and severe forms. This article reviews the existing literature on cholecystectomy timing and its impact on outcomes in ABP. A systematic literature search yielded 41 relevant articles from PubMed and Scopus databases. In mild ABP, early cholecystectomy within 72 hours of onset is increasingly favoured due to reduced technical difficulty and lower risk of recurrent pancreatitis. Conversely, delayed cholecystectomy, although traditionally practiced, may lead to higher recurrence rates and prolonged hospital stays. For moderate severe ABP, evidence remains limited, but early cholecystectomy appears to decrease hospital stay without increasing perioperative complications. In severe ABP, consensus suggests delaying cholecystectomy until peripancreatic collections resolve, typically 6 to 10 weeks post-onset, to minimize surgical morbidity. The role of endoscopic retrograde cholangiopancreatography (ERCP) alongside cholecystectomy remains contentious, with guidelines recommending its use in specific scenarios such as cholangitis or biliary obstruction. However, routine ERCP in mild ABP lacks robust evidence and may increase complications. Challenges persist regarding the management of residual choledocholithiasis post-ABP, highlighting the need for improved diagnostic criteria and management protocols. Overall, this review underscores the evolving landscape of cholecystectomy timing in ABP and provides insights into current best practices and areas for future research.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual Response of HDL-Chol Level and Body Weight to Atorvastatin: A Case Report. 高密度脂蛋白胆固醇水平和体重对阿托伐他汀的异常反应：一份病例报告。

Current health sciences journal Pub Date : 2024-01-01 Epub Date: 2024-03-31 DOI: 10.12865/CHSJ.50.01.19

Jack Edward Liu

引用次数: 0

Breast MRI-the Importance of Type II and III Dynamic Curves Evaluation and Framing in BI-RADS 4C and 5 Score. 乳腺 MRI--BI-RADS 4C 和 5 评分中 II 型和 III 型动态曲线评估和取景的重要性。

Current health sciences journal Pub Date : 2024-01-01 Epub Date: 2024-03-31 DOI: 10.12865/CHSJ.50.01.06

Marian Răzvan Bălan, Luana Corina Lascu, Daniela Dumitrescu, Eugen Osiac, Cristiana Iulia Dumitrescu, Iulia Băilescu, Mădălin Cristian Moraru, Suzana Măceș, Ilona Mihaela Liliac, Mihai Popescu

{"title":"Breast MRI-the Importance of Type II and III Dynamic Curves Evaluation and Framing in BI-RADS 4C and 5 Score.","authors":"Marian Răzvan Bălan, Luana Corina Lascu, Daniela Dumitrescu, Eugen Osiac, Cristiana Iulia Dumitrescu, Iulia Băilescu, Mădălin Cristian Moraru, Suzana Măceș, Ilona Mihaela Liliac, Mihai Popescu","doi":"10.12865/CHSJ.50.01.06","DOIUrl":"10.12865/CHSJ.50.01.06","url":null,"abstract":"Background: Breast Magnetic Resonance Imaging (MRI) offers the highest sensitivity in detecting breast cancer among existing clinical and imaging techniques, making it a crucial component of breast imaging protocols. This study aims to investigate MRI importance in correlation with previous imaging discordant procedures performed as echography and/or mammography to evaluate characteristics and framing in high-risk BI-RADS 4C or 5 categories based on morphological features and kinetic curves of masses found in the breasts of patients from our database.Methods: A retrospective study with related statistical analysis was performed on a group of 33 cases, selected from a total of 488 patients who underwent breast MRI examinations at SPAD Imaging International S.R.L. Craiova, between 01.01.2021 and 31.12.2023, aged between 33 and 75 years. In all patients, MRI images parameters were analysed.Results: In 33 patients, 23 had a single lesion and 10 had multiple lesions, 9 of them in the ipsilateral breast and, as a particularity, one of them, located in the contralateral breast. In 21 of the total patients with multiple or single lesions they had type III curves, which were classified in the BI-RADS 5 category, considering both criteria-morphology and type of curve, where the other previous techniques had not mentioned an increased risk, hence revealing that the situation in a percentage of 63.63 in the case of MRI investigation proved to be clearly superior.Conclusion: Combining both kinetic and morphologic criteria can enhance the diagnostic accuracy of MRI in breast lesion evaluation.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11157347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative Analysis of Vitamin D2 and Ergosterol in Yeast-Based Supplements Using High-Performance Liquid Chromatography with Ultraviolet Detection. 利用紫外检测法高效液相色谱法定量分析酵母补充剂中的维生素 D2 和麦角甾醇

Current health sciences journal Pub Date : 2024-01-01 Epub Date: 2024-03-31 DOI: 10.12865/CHSJ.50.01.12

Iulia-Alexandra Paliu, Andrei Bita, Magdalena Diaconu, Andrei-Adrian Tica

{"title":"Quantitative Analysis of Vitamin D2 and Ergosterol in Yeast-Based Supplements Using High-Performance Liquid Chromatography with Ultraviolet Detection.","authors":"Iulia-Alexandra Paliu, Andrei Bita, Magdalena Diaconu, Andrei-Adrian Tica","doi":"10.12865/CHSJ.50.01.12","DOIUrl":"10.12865/CHSJ.50.01.12","url":null,"abstract":"Owing to ergosterol content, after UV irradiation yeast become a well-known source of ergocalciferol (vitamin D2). Additionally, pharmaceutical yeast-based supplements may represent a suitable option for treating hypovitaminosis, especially in patients adhering to a vegan diet. Using the high-performance liquid chromatography-ultraviolet (HPLC-UV) methodology our study sought to analyse three commercially available yeast-based vitamin D2 supplements while comparing the effect of UV-C irradiation (254 nm) on yeast biomass derived from the brewing process and pure ergosterol. The two compounds were precisely separated under the described conditions in an efficient and quick manner with a retention time (Rt) of 4.152 ± 0.018 minutes for vitamin D2 and 5.097 ± 0.013 minutes for ergosterol. However, when approaching the quantitative analysis, based on our findings, it appears that the pharmaceutical supplements deviate from the declared amount of substance indicated on the label. 15 minutes of UV-C irradiation generates vitamin D2 in yeast biomass with a conversion rate of 1.78%. Also, high content of ergosterol, beside vitamin D2 formation after irradiation, may trigger the appearance of secondary products such as tachysterol.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0