Correlation between HbA1c Levels and Periodontal Bacterial Load in Diabetic Patients with Fixed Retainers.

Current health sciences journal Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI:10.12865/CHSJ.50.04.11

Mihaela Mariș, Sorana Maria Bucur, Marius Mariș, Mariana Păcurar, Manuela Chibelean, Dorin Nenovici, Kamel Earar

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Abstract

Background: Fixed orthodontic retainers can promote biofilm accumulation, increasing periodontal risks in patients with type 2 diabetes. This study examines the relationship between glycated hemoglobin (HbA1c) levels and bacterial load before and after oral hygiene intervention.

Methods: Forty diabetic patients (HbA1c: 6.5%-9%) were divided into Group I (18-30 years, n=18) and Group II (>30 years, n=22). Periodontal samples were analyzed using micro-IDent® PCR tests. Pearson's correlation and linear regression assessed associations between HbA1c and bacterial load.

Results: Pre-intervention bacterial loads were 66 (Group I) and 128 (Group II). Post-intervention, they decreased significantly to 34 and 93 (p≤0.05). HbA1c showed a strong pre-intervention correlation with bacterial load (r=0.78, p=0.002), decreasing post-intervention (r=0.42, p=0.08). Each 1% HbA1c increase correlated with a 20.3-unit rise pre-intervention (R²=0.61) and 8.2 units post-intervention (R²=0.18).

Conclusion: Fixed retainers facilitate bacterial colonization, worsening periodontal inflammation in diabetic patients. Glycemic control and regular oral hygiene interventions are essential for reducing bacterial load and preventing complications.

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固定固位体糖尿病患者HbA1c水平与牙周细菌负荷的相关性

背景：固定的正畸固位器可以促进生物膜的积累，增加2型糖尿病患者的牙周风险。本研究探讨了口腔卫生干预前后糖化血红蛋白（HbA1c）水平与细菌负荷之间的关系。方法：40例糖尿病患者（HbA1c: 6.5% ~ 9%）分为I组（18 ~ 30岁，n=18）和II组（10 ~ 30岁，n=22）。使用micro-IDent®PCR检测牙周样本。Pearson相关和线性回归评估了HbA1c与细菌负荷之间的关系。结果：干预前细菌负荷分别为66（ⅰ组）和128（ⅱ组），干预后细菌负荷分别为34和93 （p≤0.05）。干预前HbA1c与细菌负荷有较强的相关性（r=0.78, p=0.002），干预后HbA1c降低（r=0.42, p=0.08）。HbA1c每升高1%，干预前升高20.3个单位（R²=0.61），干预后升高8.2个单位（R²=0.18）。结论：固定固位器易细菌定植，加重糖尿病患者牙周炎症。血糖控制和定期口腔卫生干预对于减少细菌负荷和预防并发症至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Current health sciences journal

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