Current health sciences journal最新文献

Recent Advances in the Etiology and Neural Pathways Underlying Attention-Deficit and Hyperactivity Disorder. 注意缺陷和多动障碍的病因学和神经通路研究进展。

Current health sciences journal Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.12865/CHSJ.51.01.02

Monica Grigore, Marius Viorel Ionică, Liliana Pătru, Victor Gheorman, Aurel Popa Wagner

{"title":"Recent Advances in the Etiology and Neural Pathways Underlying Attention-Deficit and Hyperactivity Disorder.","authors":"Monica Grigore, Marius Viorel Ionică, Liliana Pătru, Victor Gheorman, Aurel Popa Wagner","doi":"10.12865/CHSJ.51.01.02","DOIUrl":"10.12865/CHSJ.51.01.02","url":null,"abstract":"The prevalence of mental disorders is increasing across the European Union, with at least one in four individuals expected to experience a psychiatric condition at some point in their lifetime. Notably, men and women often present with distinct symptomatology. Among neuropsychiatric disorders, attention-deficit/hyperactivity disorder (ADHD) is the most common and functionally impairing condition in childhood, affecting approximately 5% of minors. Its persistence into adulthood is substantial, with prevalence estimates reaching up to 3% in adult populations. ADHD is characterized by dysregulated dopaminergic signaling, which disrupts reward processing and motivation. Additionally, disturbances in circadian rhythms contribute to sleep dysregulation and metabolic dysfunction, further exacerbating symptom severity. While both mechanisms have been well-documented, their interaction remains insufficiently explored, particularly regarding its implications for diagnosis and treatment optimization. Future research should systematically examine the interplay between dopaminergic and noradrenergic dysfunction and circadian disruptions in ADHD, particularly in relation to symptom expression and comorbid conditions. Experimental paradigms assessing reward processing may provide valuable insights into dopamine and norepinephrine system alterations, while chronotherapeutic interventions-such as light therapy, sleep regulation, and behavioral adjustments-hold promise as potential therapeutic strategies. By integrating perspectives from neurobiology, chronobiology, and psychopharmacology, a more refined and individualized approach to ADHD management can be developed. Advancing this understanding may not only enhance ADHD treatment strategies but also yield novel therapeutic avenues for addressing its frequently co-occurring conditions.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 1","pages":"14-25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Outcome of Intra-Articular Fracture of Distal End Radius Treated with External Fixator; A Prospective Study. 外固定架治疗桡骨远端关节内骨折的功能效果前瞻性研究。

Current health sciences journal Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.12865/CHSJ.51.01.15

Pardeep Siwach, Surya Vijay Singh, Gyanendra Puri, Jitendra Singh

{"title":"Functional Outcome of Intra-Articular Fracture of Distal End Radius Treated with External Fixator; A Prospective Study.","authors":"Pardeep Siwach, Surya Vijay Singh, Gyanendra Puri, Jitendra Singh","doi":"10.12865/CHSJ.51.01.15","DOIUrl":"10.12865/CHSJ.51.01.15","url":null,"abstract":"Fracture distal end radius is one of the most common fracture treated in orthopedic emergencies. Nearly 1/6th (16%) of all fractures in orthopedic emergencies involve the distal end of the Radius. This is a prospective-interventional study conducted in the department of Orthopedic Surgery, Sanjay Gandhi Memorial Hospital, Mangolpuri, New Delhi with a sample size of the study is thirty patients treated with an external fixator from January 2021 to June 2022. Out of 30 patients, the number of female patients was 16 (53.33%) and the number of male patients was 14 (46.67%). The mean age of the patient was 50.5 years. 27 (90%) out of 30 patients were right-handed people which was a common behavioral finding and thus we expect more right side distal radius fracture in our study. Functional outcome was evaluated with the Gartland & Werley scoring system. 14 patients (46.67%) showed excellent results, 11 patients (36.67%) showed good, 3 patients (10%) showed fair, whereas 2 (6.67%) patients showed poor results. Stiffness was the most common complication seen in 6 patients (20%). From this study, it is concluded that an external fixator is a simple, safe, and cost-effective method for the treatment of distal end radius fracture with a lesser duration of hospital stay. It reduces the fracture by means of ligamentotaxis and maintains the reduction as well as restores the radial length without interfering with the fracture healing process.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 1","pages":"141-150"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymethyl-Methacrylate Hypersensitivity with Associated Folliculitis Decalvans After Cranioplasty: A Case Report. 头颅成形术后聚甲基丙烯酸甲酯过敏伴Decalvans毛囊炎1例报告。

Current health sciences journal Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.12865/CHSJ.51.01.18

Artur Eduardo Martio, Octávio Ruschel Karam, Laura Zambonato Costamilan, Valeska Balen Ronsoni, Renan Mathias Ferreira Saltiél, Paulo Moacir Mesquita Filho

引用次数: 0

The Role of miRNAs and Epigenetic Factors in Non-Alcoholic Fatty Liver Disease - a Systematic Review. mirna和表观遗传因子在非酒精性脂肪性肝病中的作用——系统综述

Current health sciences journal Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.12865/CHSJ.51.01.04

Victor Constantin Stoica, Mihai Mircea Diculescu, Mircea Mănuc, Ileana Constantinescu, Iuliana Petronela Gârdan, Adrian Daniel Gârdan

{"title":"The Role of miRNAs and Epigenetic Factors in Non-Alcoholic Fatty Liver Disease - a Systematic Review.","authors":"Victor Constantin Stoica, Mihai Mircea Diculescu, Mircea Mănuc, Ileana Constantinescu, Iuliana Petronela Gârdan, Adrian Daniel Gârdan","doi":"10.12865/CHSJ.51.01.04","DOIUrl":"10.12865/CHSJ.51.01.04","url":null,"abstract":"Non-alcoholic liver disease is affecting approximately a quarter of the global population, with a significant morbidity and mortality rate. The present paper takes into discussion a systematic review of the literature concerning the role that microRNAs (miRNAs) and epigenetic factors can have in relation with NAFLD. Using PRISMA methodology guidelines, the systematic review offers a comprehensive image of the relevant scientific literature that explains the complex role of miRNAs in relation with NAFLD. Throughout the process of reviewing there has been highlighted seven different subtopics that can synthetize the nature and the content of the different studies: the role of miRNAs in fibrosis and liver disease progression; use of microRNAs as biomarkers for diagnosing steatotic liver disease; microRNAs and targeted therapies for NAFLD (Nonalcoholic fatty liver disease) /NASH (Non-alcoholic Steatohepatitis); metabolic regulation and obesity via microRNAs; interaction of miRNAs with other factors at the molecular level in disease pathogenesis; the role of miRNAs in systemic inflammation and effects on various other organs and the role of miRNAs as regulators and highly specialized epigenetic factors affecting NAFLD pathogenesis and evolution. Overall, this review presents diverse approaches on microRNAs and gives a background for future applied research that can explain and test their potential as biomarkers for diagnosing and understanding disease mechanisms, particularly in populations exposed to historical nutritional imbalances.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 1","pages":"37-52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromosome Abnormality Detection Rates of QF-PCR in Early Pregnancy Loss. QF-PCR对早期妊娠丢失染色体异常检出率的影响。

Current health sciences journal Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.12865/CHSJ.51.01.06

Gabriela Popescu-Hobeanu, Mihai-Gabriel Cucu, Anca-Lelia Riza, Ioana Streata, Razvan Mihail Plesea, Stefania Dorobantu, Adina Barbu, Lucian George Zorila, Marina Dinu, Anda Lorena Dijmarescu, Stefania Tudorache, Dominic Iliescu, Florin Burada

{"title":"Chromosome Abnormality Detection Rates of QF-PCR in Early Pregnancy Loss.","authors":"Gabriela Popescu-Hobeanu, Mihai-Gabriel Cucu, Anca-Lelia Riza, Ioana Streata, Razvan Mihail Plesea, Stefania Dorobantu, Adina Barbu, Lucian George Zorila, Marina Dinu, Anda Lorena Dijmarescu, Stefania Tudorache, Dominic Iliescu, Florin Burada","doi":"10.12865/CHSJ.51.01.06","DOIUrl":"10.12865/CHSJ.51.01.06","url":null,"abstract":"Early pregnancy loss (EPL) is the most common form of miscarriage and establishing its exact etiology is vital for the proper prognosis and management of possible future pregnancies. The aim of our study was to assess the incidence and types of chromosome abnormalities in product-of-conception (POC) samples analyzed by Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR). Two hundred fifty-seven POC samples meeting EPL criteria were referred to the Human Genomics Laboratory of the University of Medicine and Pharmacy of Craiova, Romania. DNA was extracted from both POC tissue and maternal blood samples, while PCR products were migrated on the ABI3730xl platform. A total of 124 samples were successfully analyzed, 46 cases (37.1%) showing various types of abnormalities, while no aneuploidies were found in the remaining 78 samples (62.9%). The most common abnormalities were monosomy X, followed by triploidy, trisomy 18, 16 and 15. The basic QF-PCR kit had an overall detection rate of 25.8%, but the detection rate rose to 37.1% when employing the extended kit. Our study proves that QF-PCR can be used as a first approach in the genetic analysis of POC, followed by conventional karyotyping (KT) or Chromosomal Microarray Analysis (CMA) as follow-up. QF-PCR is able to identify maternal cell contamination, as well as provide timely results.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 1","pages":"62-71"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlations of Peri-Implant Parameters with Plaque and Inflammation Indices in Posterior Fixed Implant-Prosthetic Rehabilitation: A Cross-Sectional Study. 后路固定种植体-假体康复中种植体周围参数与斑块和炎症指数的相关性：一项横断面研究。

Current health sciences journal Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.12865/CHSJ.51.01.12

Alexandra Davidescu, Norina Forna, Doriana Agop-Forna, Cristina Dascălu, Mihaela-Monica Scutariu

{"title":"Correlations of Peri-Implant Parameters with Plaque and Inflammation Indices in Posterior Fixed Implant-Prosthetic Rehabilitation: A Cross-Sectional Study.","authors":"Alexandra Davidescu, Norina Forna, Doriana Agop-Forna, Cristina Dascălu, Mihaela-Monica Scutariu","doi":"10.12865/CHSJ.51.01.12","DOIUrl":"10.12865/CHSJ.51.01.12","url":null,"abstract":"Purpose: The aim of the study was to analyze the peri-implant clinical and radiological parameters and their correlations with the plaque index (mPI) and the inflammation index (GI) in fixed implant-prosthetic therapy.Materials and method: This research was a retrospective study including 48 patients with posterior partial edentulism (age: mean 63.04±10.723 years) treated by implant-supported metal-ceramic bridges, with a mean 6.19 years follow-up. A total of 166 implants were evaluated by clinical (peri-implant pocket depth-PPD) and radiological (peri-implant marginal bone loss-MBL) examen. Plaque index (mPI) and inflammation index (GI) were recorded for each implant site. Mean values of PPD, MBL (mesial), MBL (distal) were assessed. A comparative analysis was conducted regarding relation between PPD and MBL values (distal and mesial) in relation to the mPI and GI indices using the non-parametric Mann-Whitney and Kruskal-Wallis tests. Correlations between the variables PPD, MBL (mesial), and MBL (distal) for the entire study group were calculated by Pearson linear correlation coefficient.Results: There were very high positive correlations between pocket depth and mesial marginal bone loss (r=0.951, p<0.001; 95% CI: 0.934-0.964); pocket depth and distal marginal bone loss (r=0.961, p<0.001; 95% CI: 0.947-0.971), and mesial and distal bone loss values (r=0.935, p<0.001; 95% CI: 0.913-0.952).Conclusion: The findings indicate that peri-implant bone loss and pocket depth are strongly correlated and significantly influenced by plaque accumulation and inflammation, highlighting the critical role of the patients' oral hygiene in maintaining peri-implant tissue health.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 1","pages":"112-120"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Incidence of Different Types of Malocclusions in Patients with Early Loss of Temporary Teeth. 早期临时牙缺失患者不同类型错牙合发生率的评价。

Current health sciences journal Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.12865/CHSJ.51.01.13

Raluca Uleanu Biciușcă, Doriana Agop-Forna, Daniel Cioloca, Alina Adumitroaie, Vasilica Toma

{"title":"Evaluation of the Incidence of Different Types of Malocclusions in Patients with Early Loss of Temporary Teeth.","authors":"Raluca Uleanu Biciușcă, Doriana Agop-Forna, Daniel Cioloca, Alina Adumitroaie, Vasilica Toma","doi":"10.12865/CHSJ.51.01.13","DOIUrl":"10.12865/CHSJ.51.01.13","url":null,"abstract":"The aim of the study is to identify the dental somato-facial anomalies in young patients with early loss of temporary teeth, with the identification of crowding and other present clinical entities. The study was carried out on a working batch of 635 subjects who referred to the Pediatric Dentistry Clinic in Iasi and the private dental practice for various dental treatments, without any obvious dysfunctional subjective symptomatology. Out of 635 subjects,254 were female (40%) and 381 male patients (60%), distributed in the rural area (n=157; 24.7%) and urban area (n=478; 75.3%). By applying the selection criteria, the aim was to avoid issues of differential diagnosis with other disorders of the orofacial system. The mean age of the girls in the group was 8.26±1.840 years and the mean age of the boys was 8.77±1.856 years; the mean age of the rural children was 8.88±1.962 years, with an average of 8.46±1.823 years for the urban children. Dental malocclusions represent complex clinical entity, capable of producing functional, aesthetic and psychological disharmonies. Malocclusions can be caused by a combination of factors, in which the early loss of temporary teeth, the frequency of vicious habits, without excluding genetic determinism, are particularly important. The disorders that occur in the case of malocclusion may be aesthetic, masticatory, speech impairments, temporomandibular joint dysfunctions and social integration disorders.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 1","pages":"121-129"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pineal Cyst Associated with Apoplexy and Hydrocephalus: A Case Report. 松果体囊肿合并中风和脑积水1例报告。

Current health sciences journal Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.12865/CHSJ.51.01.19

Daniel Marchi Kieling, Amanda Hedel Koerich, Romildo Antonio Dos Santos Júnior, Paulo Moacir Mesquita Filho

引用次数: 0

Acute Pancreatitis after Major Spine Surgery: A Case Study. 大脊柱手术后急性胰腺炎：一个案例研究。

Current health sciences journal Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.12865/CHSJ.51.01.17

Konstantinos Zygogiannis, Petros Christoforos Christakakis, Ioannis Chatzikomninos, Dimitrios Koulalis, Anastasios Kalampokis

引用次数: 0

Blood Donation Attitudes and Knowledge of Medical School Students at the University of Crete, Greece: An Intra-Institutional Exploration. 希腊克里特岛大学医学院学生的献血态度和知识：一项机构内的探索。

Current health sciences journal Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.12865/CHSJ.51.01.05

Maria-Tzeni Athanasaki, Panagiotis Volkos, Manolis Linardakis, Emmanouil K Symvoulakis

{"title":"Blood Donation Attitudes and Knowledge of Medical School Students at the University of Crete, Greece: An Intra-Institutional Exploration.","authors":"Maria-Tzeni Athanasaki, Panagiotis Volkos, Manolis Linardakis, Emmanouil K Symvoulakis","doi":"10.12865/CHSJ.51.01.05","DOIUrl":"10.12865/CHSJ.51.01.05","url":null,"abstract":"In the last decade, demand for blood has been increased internationally, while there is a consistent shortage of regular blood donors. Medical students are a potential pool of regular blood donors. The present study investigated the attitudes and knowledge of undergraduate medical students, regarding blood donation. During the May of 2023 data from 320 medical students of the University of Crete, Greece who were studying from the first to the sixth year were analyzed. It was a cross-sectional observational study and data collection was performed by completing an anonymous questionnaire with socio-demographic items and the Blood Donation Attitudes and Knowledge Scale. Three hundred twenty undergraduate students participated in this study. Sophomores accounted for 20.3& (n=65). Only 25.9& of the participants donated blood repeatedly. Most students (99.4&; p<0.001) believed that donating blood was a good act and 87.5& reported that religious beliefs should not influence blood donation (both p<0.001). The frequency of students in the 4th-6th year who achieved a high score in Attitudes and Knowledge scale was higher compared to the 1st-3rd year students (23.6% vs. 10.6%, p=0.002). Higher score on Attitudes and Knowledge about Donation was significantly associated with increased year of study (r=0.196, p<0.001). Moderate levels of Attitudes and Knowledge Scale about Blood Donation were reported with a significant tendency to increase along the years of study. Perhaps, medical students may mature their perception towards blood donation alongside with their training advancement in Medicine.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 1","pages":"53-61"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0