Current health sciences journal最新文献

{"title":"Herbicide Mixture-Driven Neurotoxicity in the Maternal Brain: Combined Exposure Produces Greater-Than-Individual Effects at Regulatory Relevant Doses.","authors":"Adriana Maria Constantinescu, Liliana Cercelaru, Radu Mitrut, Antonia Blendea, Robin Mesnage, Michael Nicolas Antoniou, Daniela Calina, Anca Oana Docea, Bodgan Catalin","doi":"10.12865/CHSJ.52.01.08","DOIUrl":"10.12865/CHSJ.52.01.08","url":null,"abstract":"<p><strong>Background: </strong>Glyphosate is the most widely used herbicide worldwide and is frequently applied with auxinic herbicides such as dicamba and 2,4-dichlorophenoxyacetic acid (2,4-D). Regulatory limits are largely based on single-compound toxicity but real-life exposure occurs as mixtures.</p><p><strong>Objective: </strong>To evaluate whether chronic exposure to regulatory-relevant doses of glyphosate alone or combined with dicamba and 2,4-D during pregnancy and lactation induces neurobehavioral and histopathological alterations in maternal brain tissue.</p><p><strong>Methods: </strong>Pregnant Wistar rat dams were exposed from gestational day-6 to postnatal day-21 to: 0mg/kg/day glyphosate (control group), 0.5mg/kg/day glyphosate (European Union ADI-Gly group), 50mg/kg/day glyphosate (European Union NOAEL-Gly group), or a mixture of glyphosate, dicamba, and 2,4-D at their respective European Union ADI levels (Combination group). Neurobehavioral assessment included open field, elevated plus maze, and forced swim tests. Brain tissues were examined using hematoxylin and eosin staining with semi-quantitative scoring. Statistical analysis employed one-way ANOVA with Dunnett post-hoc comparisons.</p><p><strong>Results: </strong>Grooming behavior increased significantly in the NOAEL-Gly group and more markedly in the Combination group, consistent with anxiety-like alterations, while locomotor and depressive-like behaviors were unchanged. Histopathology revealed neuronal degeneration, perineuronal edema, and vascular congestion, most pronounced in the hippocampus of mixture-exposed dams. Structural alterations paralleled behavioural findings.</p><p><strong>Conclusions: </strong>Chronic exposure to regulatory relevant doses of glyphosate induces maternal neurotoxicity that is amplified by co-exposure to dicamba and 2,4-D, suggesting additive effects and underscoring the need to incorporate mixture toxicity into pesticide risk assessment.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"65-77"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ABO Blood Group and Clinical Outcomes in Acute Pulmonary Embolism: A Retrospective Cohort Study.","authors":"Abdulkader Jamal Eddin, Stefan Iulian Stanciugelu, Arnaldo Dario Damian, Bogdan Petru Miutescu, Oana Elena Tunea, Ioana Monica Mozos","doi":"10.12865/CHSJ.52.01.05","DOIUrl":"10.12865/CHSJ.52.01.05","url":null,"abstract":"<p><strong>Background: </strong>ABO blood group is a well-established determinant of venous thromboembolism risk, largely attributed to differences in circulating von Willebrand factor and factor VIII levels. However, its influence on disease severity and short-term outcomes in acute pulmonary embolism (PE) remains uncertain.</p><p><strong>Methodology: </strong>In this retrospective single-center cohort study, 317 consecutive adult patients hospitalized with a first episode of acute PE were included. ABO blood group was categorized as O versus non-O for the primary analysis. The primary outcome was in-hospital mortality. Secondary outcomes included Pulmonary Embolism Severity Index (PESI) score, thrombus localization on computed tomographic pulmonary angiography (CTPA), systemic thrombolysis, respiratory support requirement, infectious complications, sepsis, and ischemic stroke. Multivariable logistic regression was used to evaluate the independent association between ABO blood group and mortality, adjusting for age, sex, cancer history, and heart failure history.</p><p><strong>Results: </strong>In-hospital mortality occurred in 35 patients (11.0%). Mortality was 14.5% in group O and 10.1% in non-O patients (crude OR 0.66, 95% CI 0.30-1.45; p=0.414). In adjusted analysis, non-O blood group was not independently associated with mortality (adjusted OR 0.67, 95% CI 0.30-1.49; p=0.324). Secondary analyses showed no consistent associations between ABO blood group and baseline severity markers, thrombus localization, or most in-hospital complications.</p><p><strong>Conclusions: </strong>In this cohort of patients with acute PE, ABO blood group was not independently associated with short-term mortality or clinically meaningful markers of disease severity, suggesting that ABO phenotype does not substantially influence prognostic stratification once pulmonary embolism is established.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"39-47"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Rectal Wings-Highlighting by Dissection, Contents and Clarifications Regarding the Terminology.","authors":"Iulian-Alexandru Dogaru, Daniela-Elena Gheoca Mutu, Iulian Slavu, Cosmin-Marian Panțu, Zoran-Florin Filipoiu","doi":"10.12865/CHSJ.52.01.11","DOIUrl":"10.12865/CHSJ.52.01.11","url":null,"abstract":"<p><strong>Background: </strong>The rectum is stabilized within the pelvis by connective condensations traditionally termed rectal wings or ligaments, classically divided into lateral and posterior components. Their anatomical definition, composition, and relationship with the mesorectum and pelvic fasciae remain controversial, despite their surgical significance during total mesorectal excision (TME). This study aims to clarify the structure, contents, and topographical relationships of the rectal wings through cadaveric dissection.</p><p><strong>Methodology: </strong>A descriptive anatomical dissection was conducted on four formalin-fixed adult cadavers at the Anatomy Laboratory of \"Carol Davila\" University of Medicine and Pharmacy, Bucharest. The rectum and mesorectum were mobilized according to the TME standard. Dissections were performed under direct vision, preserving the pelvic autonomic nerves. Macroscopic findings were photographed and analyzed to determine the composition and limits of the lateral and posterior rectal wings.</p><p><strong>Results: </strong>The lateral rectal wings were identified as subperitoneal condensations of pelvic connective tissue connecting the mesorectal fascia with the presacral fascia. They enclosed branches of the inferior hypogastric plexus and, occasionally, the middle rectal vessels (absent in all four cases). The posterior rectal wings appeared as sagittal condensations surrounding branches of the middle sacral vessels. Both types of wings merged with the mesorectal fascia at sites where neurovascular elements traversed toward the rectal wall, representing extensions of the sacro-recto-genito-pubic laminae.</p><p><strong>Conclusions: </strong>Both lateral and posterior rectal wings represent regional specializations of the pelvic subperitoneal connective tissue. Their recognition harmonizes anatomical terminology with surgical reality, refining the understanding of pelvic fascial planes critical for nerve-sparing TME.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"95-103"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metrological Analysis of the Trueness of Prosthetic Metal Structures Obtained with Digital Methods.","authors":"Miruna Anghel, Catalin Popa, Alexandra Roiban, Alexandru Andrei Iliescu, Ioana Mitrut, Petre Mărășescu, Iuliana Stan, Daniela Micu, Horia Octavian Manolea","doi":"10.12865/CHSJ.52.01.12","DOIUrl":"10.12865/CHSJ.52.01.12","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the study was to evaluate of the accuracy and trueness of 24 Co-Cr alloy copings obtained through four digital methods in order to obtain the validation and compare the results of two dental dedicated measurement software.</p><p><strong>Material and methods: </strong>In this study, we analyzed 24 crowns made of Cobalt-Chrome using 4 different techniques to obtain the finished piece. The prosthetic pieces had the same design and were divided into 4 study groups (6 per group) depending on the method of obtaining as follows: R- resin, W- wax, M- milling, S- sintering. Each STL file of each crown was superimposed using the alignment functions of both the Medit Crown Fit program and the Meshmixer alignment functions in order to quantify the accuracy by analyzing the deviation from the design.</p><p><strong>Results: </strong>In total, over 6,720 references were generated, with approximately 280 images per layer. The results suggest that both software are capable of producing similar results in terms of deviation from design. The differences are below 0.01 mm, so they can be considered insignificant from a practical point of view. This confirms that both methods are eloquent in evaluating thicknesses regardless of the material.</p><p><strong>Conclusions: </strong>The measurement module integrated into 3D dental data allows for the precise quantification of various dental parameters, including interdental distances, angles, lengths and surfaces. This functionality is extremely valuable for prosthetic restorations, dental sizing and occlusion analysis, providing essential information for dental treatment planning.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"104-117"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic and Inflammatory Disorders-Main Influencers of Psoriatic Arthritis Activity.","authors":"Larisa Ionela Suiu, Paulina Lucia Ciurea, Cristina Elena Bita, Francesco Porta, Florentin Ananu Vreju","doi":"10.12865/CHSJ.52.01.06","DOIUrl":"10.12865/CHSJ.52.01.06","url":null,"abstract":"<p><strong>Background: </strong>Psoriatic arthritis is a systemic, potentially severe condition associated with multiple comorbidities. It is characterized by peripheral and axial joint involvement, enthesitis, and association with various comorbidities.</p><p><strong>Objective: </strong>This study aims to identify some of the determinants of the severity of psoriatic arthritis. We studied the prevalence and common pathogenic mechanisms of various comorbidities associated with PsA.</p><p><strong>Methods: </strong>We studied 103 patients diagnosed with psoriatic arthritis. 69 met the inclusion criteria. We evaluated the disease activity index DAPSA, ESH, CRP, BMI, uric acid, cholesterol, triglycerides. Disease duration and type of joint involvement were also included.</p><p><strong>Results: </strong>The patients in the studied group had an average age of 54.75 (sd±10.02) years and there were 36 (55.38%) women. Duration of the diseases 8.254 (sd±5.307) years and an average of DAPSA values of 20.58 (sd±8.522).</p><p><strong>Clinical manifestations: </strong>37 (56.92%) had peripheral damage; 6 (9.23%) had axial damage and 22 (33.85%) had mixed axial and peripheral damage. Inflammatory markers: ESR with an average serum value of 39.55 (sd±26.43) mm/h and average CRP values of 17.69mg/L (sd±28.71). The body mass index-an average value of 29.69Kg/m² (sd±5.979). Biological markers: uric acid with an average serum value of 9.832 mg/dl (sd±2.089), triglycerides 262.6 mg/dl (sd±41.58) and cholesterol 319.8mg/dl (sd±56.14).</p><p><strong>Conclusions: </strong>Serum levels of uric acid, cholesterol, triglycerides, ESR, and CRP influence psoriatic arthritis activity and response to treatment.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"48-54"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Acute Biliary Pancreatitis in Practice Setting of a Multidisciplinary Hospital.","authors":"Ana-Laura Dima, Daniel Iulian Voiculescu, Ana-Laura Manda, Dragos Virgil Davitoiu","doi":"10.12865/CHSJ.52.01.10","DOIUrl":"10.12865/CHSJ.52.01.10","url":null,"abstract":"<p><p>Management of acute biliary pancreatitis involves collaboration between medical specialties-surgery, gastroenterology, interventional endoscopy, intensive care in different algorithms. We conducted an analytical retrospective study of 139 subjects diagnosed with acute biliary pancreatitis admitted in the time interval between January 2017 and September 2025. Pancreatitis form was mild or moderate in 128 cases and severe from the onset in 11 cases. All patients benefited from early conservative treatment and most (109) from ERCP and/or cholecystectomy during hospitalization, with favorable outcome in all cases of mild and moderate pancreatitis. Statistical analysis showed that for predictors of severe disease, prolonged evolution and poor outcome at admission, only glycemia was significantly higher in patients with unfavorable evolution (p=0.031). At 48 hours, statistically significant differences were identified for urea (p=0.0047), fibrinogen (p=0.041), lipase (p=0.049), and glycemia (p=0.01). At 72 hours, significant differences persisted for urea (p=0.0024), fibrinogen (p=0.018), and lipase (p=0.016). Exploratory predictive analysis performed showed urea at 72 hours with the strongest positive association with unfavorable clinical outcome (OR 1.06) in the logistic regression model, while Random Forest analysis identified urea at 72 hours, lipase at 72 hours, and admission laboratory parameters as the most relevant contributors to unfavorable clinical evolution. Both tested models have limited predictive performance, and the findings should be interpreted as exploratory. The results emphasize the value of a stepwise, multidisciplinary management strategy combined with dynamic biological assessment for optimizing therapeutic decisions and prognostic evaluation in acute biliary pancreatitis.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"86-94"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Eating Disorders between Exercisers and Non-Exercisers among Nursing Personnel: A Cross-Sectional Analytical Study.","authors":"Agila Yoganandame, Vembu Krishnasamy","doi":"10.12865/CHSJ.52.01.03","DOIUrl":"10.12865/CHSJ.52.01.03","url":null,"abstract":"<p><strong>Background: </strong>Eating disorders are mental health conditions characterized by unhealthy eating behaviors that adversely affect physical and emotional well-being. This study assessed the risk of eating disorders among nursing personnel, comparing exercisers and non-exercisers, and explored associations between selected factors and eating disorder risk in both groups.</p><p><strong>Methodology: </strong>A cross-sectional analytical study was conducted among nursing personnel. The risk of eating disorders was assessed using the SCOFF Questionnaire. A total of 422 participants who met the inclusion criteria and consented to participate were included. Statistical analysis was performed using STATA version 14. Descriptive statistics were used to summarize the data, and the Chi-square test was used to assess associations, with statistical significance set at p<0.05.</p><p><strong>Results: </strong>A total of 422 participants were included, with a mean age of 32.98±6.38 years. Among non-exercisers, 33.22% were at risk of eating disorders compared with 24.79% among exercisers. Overall, 30.81% of participants were at risk, while 69.19% had no risk. A significant association was observed between BMI and eating disorder risk among non-exercisers (p<0.001), with a higher proportion of risk among participants with BMI≥25.</p><p><strong>Conclusion: </strong>The findings suggest that eating disorder risk was associated with higher BMI and marital status among non-exercisers. Regular screening, promotion of physical activity, and education on healthy dietary practices may help improve the well-being of nursing personnel.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"21-29"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Silent Giant: A Case of Giant Submandibular Sialolithiasis with Minimal Symptoms.","authors":"Giulia Francesca Maltese, Francesco Luppi, Michele Domenico Spampinato, Roberto DE Giorgio, Matteo Guarino","doi":"10.12865/CHSJ.52.01.15","DOIUrl":"10.12865/CHSJ.52.01.15","url":null,"abstract":"<p><strong>Background: </strong>Sialolithiasis is a common condition affecting the salivary glands, typically presenting with pain and swelling, typically during meals. giant sialoliths (>15mm) are rare and usually symptomatic, often requiring surgical intervention.</p><p><strong>Case presentation: </strong>We report the case of a patient who remained completely asymptomatic despite harbouring a 35 x 20mm ovoidal sialolith in the submandibular gland. the patient presented to the emergency department with sudden onset of submandibular pain during the night prior to admission. Clinical examination and imaging confirmed the presence of a large, well-defined, spherical calculus. Remarkably, the stone was manually removed by an otolaryngologist without the need of surgical intervention or anaesthesia.</p><p><strong>Discussion: </strong>This case is notable for the unusually large size and spherical shape of the sialolith, the absence of prior symptoms, and the successful non-surgical removal. such presentations are extremely rare and highlight the importance of considering sialolithiasis even in atypical clinical scenarios.</p><p><strong>Conclusion: </strong>This case contributes to the limited literature on asymptomatic giant sialoliths and supports the feasibility of non-invasive management in select cases.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"128-131"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Spontaneous Activity on Laryngeal Electromyography for Recovery of Vocal Fold Motion: A Systematic Review of Observational Studies.","authors":"Shirley Tarabichi, Carmen Aurelia Mogoanta, Codrut Sarafoleanu","doi":"10.12865/CHSJ.52.01.02","DOIUrl":"10.12865/CHSJ.52.01.02","url":null,"abstract":"<p><p>Background-Vocal fold motion impairment resulting from laryngeal nerve injury poses a recurring prognostic dilemma in clinical practice. While laryngeal electromyography (LEMG) has been increasingly adopted as an objective tool for neuromuscular assessment, the specific prognostic value of spontaneous activity for predicting recovery of vocal fold motion remains incompletely defined. This systematic review aimed to evaluate the relationship between the presence of spontaneous activity on LEMG and subsequent vocal fold motion recovery across observational studies. Methods-A systematic search of MEDLINE (via PubMed), Embase, Scopus and the Cochrane Library databases was conducted in accordance with PRISMA guidelines, covering publications up to March 2026. Results-Across the included studies, the presence of spontaneous activity on LEMG-particularly fibrillation potentials-was consistently associated with poor recovery of vocal fold motion. Patients demonstrating active denervation potentials showed significantly lower rates of meaningful functional recovery compared to those in whom spontaneous activity was absent. This association held across multiple etiological subgroups, including post-surgical and idiopathic cases, though the strength of the relationship varied with the timing of LEMG relative to injury onset and the duration of follow-up. Conclusions-Spontaneous activity on LEMG represents a clinically meaningful predictor of unfavorable prognosis for vocal fold motion recovery. Standardization of LEMG protocols and reporting criteria across future studies remains essential to strengthen the evidence base in this field.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"7-20"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Potential Correlations Between Oxidative Stress Markers and Inflammatory Pivotal Factors in Children with Hematological Malignancies.","authors":"Cezar Ilie Foia, Eric Oliviu Cosovanu, Larisa Ghemiș, Andra Melissa Tarțău, Daniel Cioloca, Alin Dumitru Ciubotaru, Alina Elena Adumitroaie","doi":"10.12865/CHSJ.52.01.07","DOIUrl":"10.12865/CHSJ.52.01.07","url":null,"abstract":"<p><strong>Background: </strong>Hematological malignancies are associated to immune status alterations and an amplified systemic and local immune response, which can have a significant impact on oral health, especially concerning gingival and periodontal status. Along with cytokines, which play an important role in regulating local and systemic inflammation, oxidative stress factors also reflect a critical involvement in the evolution of periodontal alterations, especially in association to systemic conditions such as leukemia. This study aims to investigate certain inflammatory markers (such as IL-1β, IL-6, IL-17α and TGF-β) as well as oxidative stress factors (SOD, MDA, 8-OHdG), in order to identify any correlations between the two, in a comparative manner, in children with leukemia and individuals without this malignant disease.</p><p><strong>Methodology: </strong>The study evaluated inflammatory markers and oxidative stress factors both in plasma and gingival crevicular fluid of 97 children (47 in the study group, suffering from leukemia and 50 in the control group, without the oncological condition or any other inflammatory systemic disease).</p><p><strong>Results: </strong>In plasma, MDA seems to be the most powerful association, rising along with increased plasmatic values of IL-1β, IL-17α and TGF-β. In GCF, SOD and 8-OHdG associate with inflammatory indicators, suggesting a complex synergy between cytokine expression and oxidative stress mechanisms.</p><p><strong>Conclusions: </strong>Our analysis showed significant associations between the evaluated inflammatory markers and oxidative stress factors, both in plasma and gingival crevicular fluid. These observations might underline a potential role of certain biomarkers to act out as indicators of a complex interconnection between inflammatory status and oxidative stress.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"55-64"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}