Current health sciences journal最新文献_第2页

CD133 Immunoexpression in Prostatic Acinar Adenocarcinomas. CD133在前列腺腺泡癌中的免疫表达。

Current health sciences journal Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.12865/CHSJ.52.01.09

Adrian Mihai Stoiculescu, Oana-Iulia Crețu, Bianca Cătălina Andreiana, Alex Emilian Stepan

{"title":"CD133 Immunoexpression in Prostatic Acinar Adenocarcinomas.","authors":"Adrian Mihai Stoiculescu, Oana-Iulia Crețu, Bianca Cătălina Andreiana, Alex Emilian Stepan","doi":"10.12865/CHSJ.52.01.09","DOIUrl":"10.12865/CHSJ.52.01.09","url":null,"abstract":"Prostatic acinar adenocarcinomas (PAA) continue to represent a challenge in terms of incidence and efficiency of screening and targeted therapy programs. The capacity of the tumor cell population to renew itself through differentiation and activation of stem cells constitutes a mechanism of tumor protection and survival, but also of acquisition of aggressive phenotypes. In this study, we analyzed CD133 immunoexpression in 55 cases, in relation to the clinico-epidemiological and histopathological parameters of the tumors. CD133 reactions were present at the nuclear and cytoplasmic level and focally membranous in tumor and stromal cells, both from tumor areas and in the case of non-neoplastic tissue. CD133 showed significantly higher reactions in PAA diagnosed in patients in extreme age groups and with elevated serum PSA values. Immunoreactions were significantly higher in some subtypes of PAA (conventional and colloid), in advanced grading groups and with perineural and lymphovascular invasion. In addition to identifying reservoirs of cells with stem potential, CD133 can be used to identify PAA with aggressive behavior, suggesting a biological connection of the two features and the utility for stratifying patients for therapy.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"78-85"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive Fusion-Guided Transperineal Biopsy Leading to the Diagnosis of Early Prostate Adenocarcinoma After Repeated Negative Evaluations: A Case Report. 认知融合引导下经会阴活检在反复阴性评价后导致早期前列腺癌的诊断：1例报告。

Current health sciences journal Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.12865/CHSJ.52.01.16

Mihai-Alexandru Radu, Andrei Pănuș, Andrei Drocaș, Dragoș Florin Vasile, Nicoleta Alice Drăgoescu, George Mitroi, Cecil Sorin Mirea, Petru Octavian Drăgoescu

{"title":"Cognitive Fusion-Guided Transperineal Biopsy Leading to the Diagnosis of Early Prostate Adenocarcinoma After Repeated Negative Evaluations: A Case Report.","authors":"Mihai-Alexandru Radu, Andrei Pănuș, Andrei Drocaș, Dragoș Florin Vasile, Nicoleta Alice Drăgoescu, George Mitroi, Cecil Sorin Mirea, Petru Octavian Drăgoescu","doi":"10.12865/CHSJ.52.01.16","DOIUrl":"10.12865/CHSJ.52.01.16","url":null,"abstract":"Background: Prostate cancer remains one of the most frequently diagnosed malignancies in men, where early detection is key to curative treatment. Conventional biopsy techniques can miss small or focal lesions, especially in cases with persistently elevated prostate-specific antigen (PSA) levels and uncertain imaging, risking delayed diagnosis.Case report: We present the case of a 69-year-old male who initially presented in 2022 with lower urinary tract symptoms and an elevated PSA level of 26.17ng/ml. He was diagnosed with acute prostatitis and responded favourably to targeted treatment. Over the following two years, his PSA levels remained in the \"gray zone\" (7.24-8.68ng/ml), raising continued clinical suspicion despite normal findings on digital rectal examination (DRE), PIRADS 3 lesions on serial multiparametric magnetic resonance imaging (mpMRI), and two previous transperineal prostate biopsies, including a saturation biopsy-both with benign histopathology. In July 2025, the patient presented for the first time to our center. A new mpMRI again showed a PIRADS 3 lesion in the transitional zone of the right prostatic lobe. Given the persistent suspicion and previous negative results, a transperineal cognitive fusion-guided biopsy was performed, combining MRI-targeted and systematic sampling. Histopathological evaluation identified a 0.55 mm focus of acinar adenocarcinoma with a Gleason score of 7 (3+4).Conclusion: This case illustrates how cognitive fusion-guided biopsy can detect clinically significant prostate cancer in patients who have undergone prior negative standard biopsies. The technique improves diagnostic detection rates and represents a valuable, accessible alternative for centers without computer-assisted fusion platforms.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"132-135"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemothorax in Dialysis Patients: The Importance of History and Differential Diagnoses. 透析患者血胸：病史和鉴别诊断的重要性。

Current health sciences journal Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.12865/CHSJ.52.01.13

Marina Cabrio, Maria Clara Ribeiro Silva, Murilo Vidotto Leite, Andrea Antunes Cetlin

引用次数: 0

Spontaneous Closure of High-Output Duodenal Enteroatmospheric Fistula with Fistuloclysis: Case Report. 自行关闭高输出量十二指肠肠大气瘘管造瘘术1例。

Current health sciences journal Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.12865/CHSJ.52.01.14

Saulo Bueno DE Azeredo, Francesca Dal Sochio Gobbato, Marcelo DA Mota Iglesias, Giovanna Dal Sochio Gobbato, Eduarda Vogel Wollmeister, Maria Fernanda Guadagnin

{"title":"Spontaneous Closure of High-Output Duodenal Enteroatmospheric Fistula with Fistuloclysis: Case Report.","authors":"Saulo Bueno DE Azeredo, Francesca Dal Sochio Gobbato, Marcelo DA Mota Iglesias, Giovanna Dal Sochio Gobbato, Eduarda Vogel Wollmeister, Maria Fernanda Guadagnin","doi":"10.12865/CHSJ.52.01.14","DOIUrl":"10.12865/CHSJ.52.01.14","url":null,"abstract":"High-output duodenal enteroatmospheric fistulas (EAFs) are a formidable surgical challenge associated with high morbidity and mortality. Fistuloclysis, the reinfusion of proximal intestinal effluent into the distal bowel, is a management strategy aimed at preserving gut function and mitigating catabolism. We report the successful management of a 71-year-old male who developed a high-output (1,300 mL/day) duodenal EAF following a distal partial gastrectomy with Roux-en-Y reconstruction. Fistuloclysis was initiated on postoperative day seven via a feeding jejunostomy. Over a 14-day treatment period, the patient's nutritional status markedly improved, and fistula output progressively decreased to 25 mL/day. This effective effluent control resulted in the spontaneous functional closure of the tract, obviating the need for immediate surgical intervention. The patient was discharged with a granulating tract and remained recurrence-free at outpatient follow-up. This case highlights fistuloclysis as a safe and effective alternative to parenteral nutrition in managing complex duodenal EAFs. The technique was critical in reversing the patient's catabolic state, controlling fistula output, and facilitating spontaneous closure. We advocate for its early consideration in the multidisciplinary management of these challenging fistulas.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"122-127"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of AI Assistance on Radiologist Accuracy for Lung Nodule Detection on Chest CT. 人工智能辅助对胸部CT诊断肺结节准确性的影响

Current health sciences journal Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.12865/CHSJ.52.01.04

Cristina Mihaela Ciofiac, Mihai Alexandru Ene, Mihai Lucian Florescu, Rossy Vlăduț Teică, Ioana Andreea Gheonea

{"title":"Impact of AI Assistance on Radiologist Accuracy for Lung Nodule Detection on Chest CT.","authors":"Cristina Mihaela Ciofiac, Mihai Alexandru Ene, Mihai Lucian Florescu, Rossy Vlăduț Teică, Ioana Andreea Gheonea","doi":"10.12865/CHSJ.52.01.04","DOIUrl":"10.12865/CHSJ.52.01.04","url":null,"abstract":"Background: Accurate identification of pulmonary nodules as early-stage lung cancers is crucial to decrease the number of deaths and illnesses caused by lung cancer. Artificial Intelligence has the potential to enhance diagnostic accuracy and specificity in detecting lung cancer.Methods: Chest CT scanning from 300 patients with an age range between 40 and 80 years old were analysed comparing the pulmonary nodules detection rate (number of lung nodules) between AI-assisted reading, non-AI-assisted reading and the AI-system report standalone. Detected nodules, missed nodules (false negatives), and false-positive findings were analysed.Results: AI-assisted radiologists missed significantly fewer nodules (p<0.001) and achieved an almost perfect correlation (r~1.00) with expert reference values, reducing the mean absolute error (MAE) from 9.78 to 0.46. Additionally, AI increased detection sensitivity from 60% to 98% and reduced false negatives from 3,083 to 145, optimizing both diagnostic accuracy and efficiency.Conclusions: AI-assisted reading has shown to be beneficial in the detection of lung nodules compared to relying solely on radiologist observation. This suggests that an AI-powered system for evaluating lung nodules has the potential to become a valuable assistant tool in clinical practice. By combining the skills of radiologists with AI assistance, a new approach may emerge, leading to enhanced detection of lung nodules and encouraging the integration of AI in lung cancer screening initiatives.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"30-38"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148038740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strength of Omics in Uncovering Sepsis Mechanisms-A Perspective. 组学在揭示脓毒症机制中的优势——一个视角。

Current health sciences journal Pub Date : 2025-10-01 Epub Date: 2025-12-31 DOI: 10.12865/CHSJ.51.04.01

Stefania Dorobantu, Andra Grigorescu, Andrian Fratea, Bogdan Mirauta, Adriana Neghina, George Bica, Adela Neacsu, Florentina Dumitrescu, Ioana Streata, Mihai Netea, Anca-Lelia Riza

{"title":"Strength of Omics in Uncovering Sepsis Mechanisms-A Perspective.","authors":"Stefania Dorobantu, Andra Grigorescu, Andrian Fratea, Bogdan Mirauta, Adriana Neghina, George Bica, Adela Neacsu, Florentina Dumitrescu, Ioana Streata, Mihai Netea, Anca-Lelia Riza","doi":"10.12865/CHSJ.51.04.01","DOIUrl":"10.12865/CHSJ.51.04.01","url":null,"abstract":"Background: Sepsis is a significant life-threatening condition due to a dysregulated response to infection. Large datasets yield unprecedented views and transformative insights into processes through various computational frameworks. Our aim was to highlight significant contributions from genomics, transcriptomics, proteomics in the field of sepsis, as modeled from human data. We are showcasing key findings in each omics that have improved the understanding of sepsis pathophysiology, while presenting a perspective from the group's own contribution to the field.Discussion and conclusions: Each of the presented omics has advanced our mechanistic understanding on sepsis pathogenicity, biomarker identification for diagnosis, prognosis, and molecular stratification purposes. Multi-omics sepsis research shows strong input from genomics, transcriptomics, proteomics. These have revealed mechanistic links and produce robust endotypes but faces challenges on the path to clinical integration. Integrative sepsis studies combine large-scale omics, paired sampling, and computational multi-omics frameworks to link molecular layers to phenotype. Addressing gaps in standardization, and age/ethnicity representation could yield actionable biomarkers, stratified therapies and improved outcomes.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 4","pages":"425-436"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Baseline Low-Dose CT Findings in a High-Risk Romanian Population: First Experience with Lung Cancer Screening. 基线低剂量CT发现在高危罗马尼亚人群：肺癌筛查的第一次经验。

Current health sciences journal Pub Date : 2025-10-01 Epub Date: 2025-12-31 DOI: 10.12865/CHSJ.51.04.12

Cristina Mihaela Ciofiac, Mihai Alexandru Ene, Lucian Mihai Florescu, Rossy Vlăduț Teică, Alexandru Olaru, Ioana Andreea Gheonea

{"title":"Baseline Low-Dose CT Findings in a High-Risk Romanian Population: First Experience with Lung Cancer Screening.","authors":"Cristina Mihaela Ciofiac, Mihai Alexandru Ene, Lucian Mihai Florescu, Rossy Vlăduț Teică, Alexandru Olaru, Ioana Andreea Gheonea","doi":"10.12865/CHSJ.51.04.12","DOIUrl":"10.12865/CHSJ.51.04.12","url":null,"abstract":"Background: Low-dose computed tomography (LDCT) screening has demonstrated significant reductions in lung cancer mortality among high-risk individuals. However, data from Eastern European populations remain scarce, and no national screening program currently exists in Romania.Objective: To describe the baseline demographic characteristics, LDCT findings, and incidental pulmonary abnormalities in a high-risk Romanian cohort undergoing the first round of lung cancer screening.Methods: This single-center, observational study included 42 participants aged 43-76 years (mean 56.4), all of whom underwent baseline LDCT during one month in 2025. Participants were categorized according to the Lung-RADS system, and incidental findings were recorded. Descriptive statistical analysis was performed for demographic and imaging variables.Results: The cohort included 27 smokers (63%), 11 former smokers (26%), and 4 never-smokers (9%), with a mean BMI of 28.3. Most participants (81%) were classified as Lung-RADS 1-2, while 4 participants (9%) had Lung-RADS 3-4 findings requiring closer follow-up. The most frequent incidental pulmonary abnormalities were fibrosis (63%), followed by emphysema (5%), pulmonary infection (5%), and others (2%).Conclusion: Baseline LDCT screening in this Romanian high-risk cohort revealed a predominance of low-risk nodules and smoking-related lung changes. These findings highlight both clinical feasibility and the need for structured lung cancer screening implementation at the national level.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 4","pages":"534-542"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison between Pulmonary Rehabilitation and Dance in Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Clinical Trial. 慢性阻塞性肺疾病患者肺康复与舞蹈的比较：一项随机对照临床试验。

Current health sciences journal Pub Date : 2025-10-01 Epub Date: 2025-12-31 DOI: 10.12865/CHSJ.51.04.10

Thaís Ferreira DE Andrade Lima, Luís Felipe DA Fonseca Reis, Hebert Olímpio Júnior, Samantha Santos Pereira, Gustavo Pinheiro Montani DE Souza Diniz, Juliana Ivan Soares, Cláudia Henrique DA Costa, Yves Raphael DE Souza, Agnaldo José Lopes

{"title":"Comparison between Pulmonary Rehabilitation and Dance in Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Clinical Trial.","authors":"Thaís Ferreira DE Andrade Lima, Luís Felipe DA Fonseca Reis, Hebert Olímpio Júnior, Samantha Santos Pereira, Gustavo Pinheiro Montani DE Souza Diniz, Juliana Ivan Soares, Cláudia Henrique DA Costa, Yves Raphael DE Souza, Agnaldo José Lopes","doi":"10.12865/CHSJ.51.04.10","DOIUrl":"10.12865/CHSJ.51.04.10","url":null,"abstract":"Although dance is understudied in the context of chronic obstructive pulmonary disease (COPD), it is a physical activity that can improve individuals' psychological state and physical function. The aim of this research was to compare the impact of physical training using dance versus pulmonary rehabilitation (PR) on functional capacity, lung and muscle function, and quality of life (QoL) in COPD patients. This randomized controlled clinical trial involved 11 patients who underwent dance (DG) and 11 patients who underwent PR (PRG). The patients were evaluated using the following assessments: the mMRC scale, the COPD Assessment Test (CAT), the Short Form-36 (SF-36), the Hospital Anxiety and Depression Scale (HADS), spirometry, handgrip strength (HGS), the 1-repetition maximum (1-RM) test, and the 6-minute walk test (6MWT). In the intra-group comparison, the DG showed an increase in 6-minute walking distance (6MWD) (p=0.003), a reduction in the mMRC scale, and an improvement in the SF-36 physical functioning and vitality domains. In the intra-group comparison, the PRG showed an increase in 6MWD (p=0.007), a reduction in the mMRC scale, an increase in HGS, an increase in the 1-RM test, and an improvement in all SF-36 domains. In the comparison between groups, the PRG showed an improvement in QoL in the following domains: general perceptions of health and limitations of physical and emotional roles. In conclusion, for patients with COPD, a dance program has the potential to improve functional capacity, the degree of dyspnea, and QoL. However, when compared to a PR, dance is less effective in addressing muscle dysfunction.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 4","pages":"511-521"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Brain-Face Connection in Holoprosencephaly: Case Report and Literature Review. 无前脑畸形的脑面连接：病例报告及文献复习。

Current health sciences journal Pub Date : 2025-10-01 Epub Date: 2025-12-31 DOI: 10.12865/CHSJ.51.04.16

Andreea Florentina Stancioi-Cismaru, Florentina Gratiela Dita, Razvan Cosmin Pana, Marina Dinu, Maria Adelina Cioponea, Robert Mihai Robu, Razvan Grigoras Capitanescu, Ovidiu Costinel Sirbu, Bianca Catalina Andreiana, Stefania Tudorache

{"title":"The Brain-Face Connection in Holoprosencephaly: Case Report and Literature Review.","authors":"Andreea Florentina Stancioi-Cismaru, Florentina Gratiela Dita, Razvan Cosmin Pana, Marina Dinu, Maria Adelina Cioponea, Robert Mihai Robu, Razvan Grigoras Capitanescu, Ovidiu Costinel Sirbu, Bianca Catalina Andreiana, Stefania Tudorache","doi":"10.12865/CHSJ.51.04.16","DOIUrl":"10.12865/CHSJ.51.04.16","url":null,"abstract":"Background and objectives: Holoprosencephaly (HPE) is a congenital brain malformation caused by the incomplete division of the forebrain during early embryogenesis. It results in a spectrum of structural abnormalities, ranging from alobar to lobar forms, and milder, more difficult to diagnose variants. Alobar HPE is often associated with midline craniofacial defects due to shared developmental origins. Both malformations are amenable at the first trimester anomaly scan. Case report and systematic review: We present a late diagnosed and complex case, subject of major obstetric complications. The late booking prenatal ultrasound examination revealed alobar HPE associating facial and great vessels anomalies. Subsequently, severe sudden hemorrhage due to central placenta praevia required emergency cesarean section. Neonatal death occurred shortly after birth. We performed a literature review on HPE cases associated with facial defects, aiming to highlight the broad spectrum of cerebral malformations, their associated outcomes, and to analyze maternal and fetal features.Results: We identified and analyzed 26 studies, including 34 fetuses/neonates. The most severe and common form-the alobar type, was diagnosed prenatally in 22 cases (64.71%). There were 16 reported births and 16 terminations of pregnancy. The neonatal outcome was unfavorable in all alobar HPE cases. In non-alobar forms, neonatal survival beyond several months postpartum was reported in two cases.Conclusions: HPE is a severe congenital brain malformation, most often lethal. Alobar form can be diagnosed in early pregnancy. Survival beyond the neonatal period is rare and associated with significant neurological impairment.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 4","pages":"564-574"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxychloroquine-Induced Hypoglycemia in a Non-Diabetic Patient with Chronic Kidney Disease and Rheumatoid Arthritis. 羟氯喹致慢性肾病和类风湿关节炎的非糖尿病患者低血糖

Current health sciences journal Pub Date : 2025-10-01 Epub Date: 2025-12-31 DOI: 10.12865/CHSJ.51.04.15

Kevan English

{"title":"Hydroxychloroquine-Induced Hypoglycemia in a Non-Diabetic Patient with Chronic Kidney Disease and Rheumatoid Arthritis.","authors":"Kevan English","doi":"10.12865/CHSJ.51.04.15","DOIUrl":"10.12865/CHSJ.51.04.15","url":null,"abstract":"Hydroxychloroquine (HCQ) is an immunomodulatory medication commonly used to treat several autoimmune diseases. Due to its tendency to change insulin metabolism by increasing production and reducing clearance, HCQ can cause hypoglycemia in patients with or without diabetes, albeit this is rare. There is documented evidence of HCQ-induced hypoglycemia in the literature. However, none to our knowledge has reported this adverse effect in a patient with chronic kidney disease not undergoing dialysis. We describe the case of an 81-year-old woman who went to the emergency room for care after experiencing abrupt dizziness and unconsciousness. Pertinent history includes four prior episodes of hypoglycemia after the recent initiation of HCQ for rheumatoid arthritis. Fasting glucose was <40 mg/dL on presentation. Given the appearance of symptoms after the initiation of the medication and the absence of symptoms with normal glucose upon discontinuation, it was concluded that HCQ was the likely culprit for the recurrent episodes of hypoglycemia. Physicians should be aware of this rare but possible adverse effect of HCQ, especially in older patients and patients with chronic kidney disease. Prompt elimination of the medication can reduce the risk of some of the devastating consequences of hypoglycemia.","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"51 4","pages":"560-563"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0