Current health sciences journal最新文献

{"title":"Cutaneous Tuberculosis in a 22-Day-Old Neonate:A Diagnostic Challenge and Case Report.","authors":"Arisha Imran, Syeda Wareesha Fareeduddin Shah, Syed Abdul Rafayuddin Shah, Muhammad Rafique, Huda Raja","doi":"10.12865/CHSJ.52.02.277","DOIUrl":"10.12865/CHSJ.52.02.277","url":null,"abstract":"<p><strong>Background: </strong>Cutaneous tuberculosis (CTB) is a rare extrapulmonary manifestation of tuberculosis, particularly in neonates. Its diagnosis is often challenging due to non-specific presentations that can mimic common conditions.</p><p><strong>Clinical description: </strong>We report the case of a 22-day-old male neonate who presented to the emergency room with fever and a scalp swelling following a reported fall from bed. Initial assessment suggested a subcutaneous abscess. The patient did not respond to multiple courses of intravenous antibiotics. A blood culture grew Burkholderia species, but targeted therapy also failed. Incision and drainage were performed, and pus GeneXpert testing was positive for Mycobacterium tuberculosis, despite a negative tuberculin skin test and clear chest X-ray. A final diagnosis of cutaneous tuberculosis (tuberculous chancre) was established.</p><p><strong>Management & outcome: </strong>Anti-tuberculosis therapy (ATT) was initiated, leading to the complete resolution of the swelling and full recovery.</p><p><strong>Conclusion: </strong>This case underscores the diagnostic challenges of neonatal CTB. It highlights the importance of considering tuberculosis in the differential diagnosis of non-resolving abscesses in infants, especially in endemic areas, and demonstrates the critical role of molecular diagnostics like GeneXpert in achieving a timely diagnosis.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 2","pages":"277-280"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Admission Acute Brain Dysfunction and In-ICU Mortality in a Single-Center Pre-Vaccination Romanian COVID-19 Cohort:A Retrospective Observational Analysis.","authors":"Alexandru Ionut Neacsu, Alexandra-Daniela Rotaru-Zavaleanu, Marius-Bogdan Novac, Lucretiu Radu, Eugen Osiac","doi":"10.12865/CHSJ.51.02.185","DOIUrl":"10.12865/CHSJ.51.02.185","url":null,"abstract":"<p><strong>Background: </strong>Critically ill COVID-19 patients frequently develop organ dysfunction and acute brain dysfunction with features overlapping sepsis-associated encephalopathy (SAE). Real-world cohorts from Eastern European intensive care during the pre-vaccination period are scarce.</p><p><strong>Methods: </strong>We retrospectively analysed 389 consecutive adults with RT-PCR-confirmed SARS-CoV-2 admitted to a single regional Romanian tertiary ICU during 2020-2021, entirely preceding population-level vaccination. Organ dysfunction was defined as admission SOFA≥2, and acute brain dysfunction was op-erationalised from admission Glasgow Coma Scale and neurological SOFA (the acute brain dysfunction [ABD] proxy). Associations with in-ICU mortality were examined descriptively, with pre-specified sensitivity analyses restricted to non-ventilated pa-tients to address sedation confounding.</p><p><strong>Results: </strong>In-ICU mortality was 65.8%. The ABD proxy was present in 49.6% of the cohort; mortality was 96.9% in ABD-proxy-positive patients versus 45.9% in those with preserved consciousness, an absolute difference of 51.0 percentage points, which was of similar magnitude (49.4 points) in non-ventilated patients, arguing against sedation as the sole explanation. Higher inflammatory markers accompanied the ABD proxy, and the association between admission acute brain dys-function and mortality was consistent across analyses.</p><p><strong>Conclusions: </strong>Admission acute brain dysfunction was strongly associated with in-ICU mortality, and this association persisted in non-ventilated patients. The findings are descriptive associations within an extreme, single-center pre-vaccination cohort under surge conditions; they are not causal, and should not be generalised to vaccinated or contemporary critical care.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 2","pages":"185-205"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Assessment of T-Lymphocytes In Gastric Adenocarcinomas.","authors":"Roxana-Andreea Pisică-Ilinca, Liliana Stanca, Marian Valentin Zorilă, Alex Emilian Stepan","doi":"10.12865/CHSJ.52.02.224","DOIUrl":"10.12865/CHSJ.52.02.224","url":null,"abstract":"<p><p>Gastric adenocarcinomas (GAC) are common cancers in pathology, which pose real problems in practice due to heterogeneity, response to treatment and prognosis. New therapeutic approaches in GAC are aimed at activating the immune system by unblocking or modulating it. In this study, we analyzed the density and distribution of intra- and peritumoral CD4 and CD8 lymphocytes, by immunohistochemistry, in relation to the main prognostic parameters of GAC. CD4 and CD8 lymphocytes were superior in the tumor compartments in the case of discohesive and mixed GAC. They also predominated in discohesive GAC with signet ring cells at the intratumoral level and in those without other specifications at the peritumoral level. CD4 and CD8 were superior in high-grade GAC, in stages II/III and with lymphovascular invasion, more frequently peritumoral. The study indicated differences in the distribution of CD4 and CD8 T lymphocytes that may be useful for improving patient stratification for personalized targeted therapy of GAC.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 2","pages":"224-233"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Performance of Diffusion-Weighted MRI and ADC Values in Differentiating Atypical Leiomyomas from Uterine Sarcomas.","authors":"Ramona-Andreea Rizescu, Iulia Alecsandra Salcianu, Alexandre Ionescu, Gheorghe Iana, Ana Magdalena Bratu, Ioana-Andreea Gheonea","doi":"10.12865/CHSJ.52.02.241","DOIUrl":"10.12865/CHSJ.52.02.241","url":null,"abstract":"<p><strong>Background: </strong>Leiomyomas are the most common benign uterine tumors, whereas uterine sarcomas are rare malignant neoplasms associated with high morbidity and mortality. Differentiation using imaging remains challenging because of overlapping radiologic features.</p><p><strong>Purpose: </strong>To evaluate magnetic resonance imaging (MRI) characteristics of atypical leiomyomas and uterine sarcomas, with emphasis on diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) values.</p><p><strong>Materials and methods: </strong>In this retrospective study, 22 patients with histopathologically confirmed uterine leiomyoma or sarcoma underwent MRI for atypical or suspicious uterine lesions. MRI assessment included T2-weighted imaging, DWI with ADC maps, and fat-suppressed T1-weighted sequences before and after gadolinium administration.</p><p><strong>Results: </strong>Thirteen atypical leiomyomas (59%) and nine sarcomas (41%) were analyzed. Mean patient age was similar between groups. Abnormal vaginal bleeding was more frequent in sarcomas (89% vs. 38%). Sarcomas more commonly showed irregular margins (89% vs. 69%) and T2 hyperintensity (89% vs. 15%). Heterogeneous enhancement and cystic or hemorrhagic changes occurred in both tumor types, while extrauterine disease was observed only in sarcomas. All sarcomas demonstrated high DWI signal intensity exceeding that of the endometrium, whereas most leiomyomas showed intermediate signal intensity. Mean ADC values were significantly lower in sarcomas (0.813 × 10⁻³mm²/s) than in leiomyomas (1.050 × 10⁻³ mm²/s), with an optimal cutoff of 0.892 × 10⁻³mm²/s.</p><p><strong>Conclusion: </strong>MRI, particularly DWI and ADC analysis, provides valuable differentiation between atypical leiomyomas and uterine sarcomas, with sarcomas demonstrating higher DWI signal intensity and significantly lower ADC values.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 2","pages":"241-249"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Role of Exosome Therapy in Reproductive Aging:A Narrative Review of Recent Advancements.","authors":"Elham Sadat Alavi Moghaddam, Hooman Mohammad Talebi","doi":"10.12865/CHSJ.51.02.160","DOIUrl":"10.12865/CHSJ.51.02.160","url":null,"abstract":"<p><strong>Introduction: </strong>Exosome therapy shows promise as a non-hormonal treatment to restore ovarian function and combat reproductive aging. This review aims to explore recent advances, mechanisms, and clinical potential of exosome therapy in reproductive aging.</p><p><strong>Methods: </strong>This narrative review explored advancements in exosome therapy for reproductive aging through a comprehensive literature search of PubMed, Embase, Google Scholar, and ClinicalKey, covering studies from 2015 to 2025. Using a structured search strategy with relevant MeSH terms and keywords. After applying inclusion and exclusion criteria focused on human studies with therapeutic relevance, 13 articles were selected. Key data were extracted and synthesized to highlight mechanisms, clinical potential, and future directions of exosome-based interventions in ovarian aging.</p><p><strong>Results: </strong>Thirteen human-focused studies were categorized into four themes: ovarian function restoration, exosomal biomarkers, therapeutic roles in reproductive diseases, and clinical applications. Exosomes especially MSC-derived enhanced ovarian regeneration through anti-apoptotic, anti-inflammatory, and metabolic pathways. Age-related changes in exosomal cargo showed strong diagnostic potential. Exosomes also demonstrated therapeutic effects in POI and PCOS and showed promise as low-immunogenic, cell-free nanocarriers for targeted reproductive-aging interventions.</p><p><strong>Conclusion: </strong>Exosome therapy is a promising, non-hormonal option for addressing reproductive aging, with potential for safe and effective clinical use.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 2","pages":"160-168"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbicide Mixture-Driven Neurotoxicity in the Maternal Brain: Combined Exposure Produces Greater-Than-Individual Effects at Regulatory Relevant Doses.","authors":"Adriana Maria Constantinescu, Liliana Cercelaru, Radu Mitrut, Antonia Blendea, Robin Mesnage, Michael Nicolas Antoniou, Daniela Calina, Anca Oana Docea, Bodgan Catalin","doi":"10.12865/CHSJ.52.01.08","DOIUrl":"10.12865/CHSJ.52.01.08","url":null,"abstract":"<p><strong>Background: </strong>Glyphosate is the most widely used herbicide worldwide and is frequently applied with auxinic herbicides such as dicamba and 2,4-dichlorophenoxyacetic acid (2,4-D). Regulatory limits are largely based on single-compound toxicity but real-life exposure occurs as mixtures.</p><p><strong>Objective: </strong>To evaluate whether chronic exposure to regulatory-relevant doses of glyphosate alone or combined with dicamba and 2,4-D during pregnancy and lactation induces neurobehavioral and histopathological alterations in maternal brain tissue.</p><p><strong>Methods: </strong>Pregnant Wistar rat dams were exposed from gestational day-6 to postnatal day-21 to: 0mg/kg/day glyphosate (control group), 0.5mg/kg/day glyphosate (European Union ADI-Gly group), 50mg/kg/day glyphosate (European Union NOAEL-Gly group), or a mixture of glyphosate, dicamba, and 2,4-D at their respective European Union ADI levels (Combination group). Neurobehavioral assessment included open field, elevated plus maze, and forced swim tests. Brain tissues were examined using hematoxylin and eosin staining with semi-quantitative scoring. Statistical analysis employed one-way ANOVA with Dunnett post-hoc comparisons.</p><p><strong>Results: </strong>Grooming behavior increased significantly in the NOAEL-Gly group and more markedly in the Combination group, consistent with anxiety-like alterations, while locomotor and depressive-like behaviors were unchanged. Histopathology revealed neuronal degeneration, perineuronal edema, and vascular congestion, most pronounced in the hippocampus of mixture-exposed dams. Structural alterations paralleled behavioural findings.</p><p><strong>Conclusions: </strong>Chronic exposure to regulatory relevant doses of glyphosate induces maternal neurotoxicity that is amplified by co-exposure to dicamba and 2,4-D, suggesting additive effects and underscoring the need to incorporate mixture toxicity into pesticide risk assessment.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"65-77"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ABO Blood Group and Clinical Outcomes in Acute Pulmonary Embolism: A Retrospective Cohort Study.","authors":"Abdulkader Jamal Eddin, Stefan Iulian Stanciugelu, Arnaldo Dario Damian, Bogdan Petru Miutescu, Oana Elena Tunea, Ioana Monica Mozos","doi":"10.12865/CHSJ.52.01.05","DOIUrl":"10.12865/CHSJ.52.01.05","url":null,"abstract":"<p><strong>Background: </strong>ABO blood group is a well-established determinant of venous thromboembolism risk, largely attributed to differences in circulating von Willebrand factor and factor VIII levels. However, its influence on disease severity and short-term outcomes in acute pulmonary embolism (PE) remains uncertain.</p><p><strong>Methodology: </strong>In this retrospective single-center cohort study, 317 consecutive adult patients hospitalized with a first episode of acute PE were included. ABO blood group was categorized as O versus non-O for the primary analysis. The primary outcome was in-hospital mortality. Secondary outcomes included Pulmonary Embolism Severity Index (PESI) score, thrombus localization on computed tomographic pulmonary angiography (CTPA), systemic thrombolysis, respiratory support requirement, infectious complications, sepsis, and ischemic stroke. Multivariable logistic regression was used to evaluate the independent association between ABO blood group and mortality, adjusting for age, sex, cancer history, and heart failure history.</p><p><strong>Results: </strong>In-hospital mortality occurred in 35 patients (11.0%). Mortality was 14.5% in group O and 10.1% in non-O patients (crude OR 0.66, 95% CI 0.30-1.45; p=0.414). In adjusted analysis, non-O blood group was not independently associated with mortality (adjusted OR 0.67, 95% CI 0.30-1.49; p=0.324). Secondary analyses showed no consistent associations between ABO blood group and baseline severity markers, thrombus localization, or most in-hospital complications.</p><p><strong>Conclusions: </strong>In this cohort of patients with acute PE, ABO blood group was not independently associated with short-term mortality or clinically meaningful markers of disease severity, suggesting that ABO phenotype does not substantially influence prognostic stratification once pulmonary embolism is established.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"39-47"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Rectal Wings-Highlighting by Dissection, Contents and Clarifications Regarding the Terminology.","authors":"Iulian-Alexandru Dogaru, Daniela-Elena Gheoca Mutu, Iulian Slavu, Cosmin-Marian Panțu, Zoran-Florin Filipoiu","doi":"10.12865/CHSJ.52.01.11","DOIUrl":"10.12865/CHSJ.52.01.11","url":null,"abstract":"<p><strong>Background: </strong>The rectum is stabilized within the pelvis by connective condensations traditionally termed rectal wings or ligaments, classically divided into lateral and posterior components. Their anatomical definition, composition, and relationship with the mesorectum and pelvic fasciae remain controversial, despite their surgical significance during total mesorectal excision (TME). This study aims to clarify the structure, contents, and topographical relationships of the rectal wings through cadaveric dissection.</p><p><strong>Methodology: </strong>A descriptive anatomical dissection was conducted on four formalin-fixed adult cadavers at the Anatomy Laboratory of \"Carol Davila\" University of Medicine and Pharmacy, Bucharest. The rectum and mesorectum were mobilized according to the TME standard. Dissections were performed under direct vision, preserving the pelvic autonomic nerves. Macroscopic findings were photographed and analyzed to determine the composition and limits of the lateral and posterior rectal wings.</p><p><strong>Results: </strong>The lateral rectal wings were identified as subperitoneal condensations of pelvic connective tissue connecting the mesorectal fascia with the presacral fascia. They enclosed branches of the inferior hypogastric plexus and, occasionally, the middle rectal vessels (absent in all four cases). The posterior rectal wings appeared as sagittal condensations surrounding branches of the middle sacral vessels. Both types of wings merged with the mesorectal fascia at sites where neurovascular elements traversed toward the rectal wall, representing extensions of the sacro-recto-genito-pubic laminae.</p><p><strong>Conclusions: </strong>Both lateral and posterior rectal wings represent regional specializations of the pelvic subperitoneal connective tissue. Their recognition harmonizes anatomical terminology with surgical reality, refining the understanding of pelvic fascial planes critical for nerve-sparing TME.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"95-103"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metrological Analysis of the Trueness of Prosthetic Metal Structures Obtained with Digital Methods.","authors":"Miruna Anghel, Catalin Popa, Alexandra Roiban, Alexandru Andrei Iliescu, Ioana Mitrut, Petre Mărășescu, Iuliana Stan, Daniela Micu, Horia Octavian Manolea","doi":"10.12865/CHSJ.52.01.12","DOIUrl":"10.12865/CHSJ.52.01.12","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the study was to evaluate of the accuracy and trueness of 24 Co-Cr alloy copings obtained through four digital methods in order to obtain the validation and compare the results of two dental dedicated measurement software.</p><p><strong>Material and methods: </strong>In this study, we analyzed 24 crowns made of Cobalt-Chrome using 4 different techniques to obtain the finished piece. The prosthetic pieces had the same design and were divided into 4 study groups (6 per group) depending on the method of obtaining as follows: R- resin, W- wax, M- milling, S- sintering. Each STL file of each crown was superimposed using the alignment functions of both the Medit Crown Fit program and the Meshmixer alignment functions in order to quantify the accuracy by analyzing the deviation from the design.</p><p><strong>Results: </strong>In total, over 6,720 references were generated, with approximately 280 images per layer. The results suggest that both software are capable of producing similar results in terms of deviation from design. The differences are below 0.01 mm, so they can be considered insignificant from a practical point of view. This confirms that both methods are eloquent in evaluating thicknesses regardless of the material.</p><p><strong>Conclusions: </strong>The measurement module integrated into 3D dental data allows for the precise quantification of various dental parameters, including interdental distances, angles, lengths and surfaces. This functionality is extremely valuable for prosthetic restorations, dental sizing and occlusion analysis, providing essential information for dental treatment planning.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"104-117"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Acute Biliary Pancreatitis in Practice Setting of a Multidisciplinary Hospital.","authors":"Ana-Laura Dima, Daniel Iulian Voiculescu, Ana-Laura Manda, Dragos Virgil Davitoiu","doi":"10.12865/CHSJ.52.01.10","DOIUrl":"10.12865/CHSJ.52.01.10","url":null,"abstract":"<p><p>Management of acute biliary pancreatitis involves collaboration between medical specialties-surgery, gastroenterology, interventional endoscopy, intensive care in different algorithms. We conducted an analytical retrospective study of 139 subjects diagnosed with acute biliary pancreatitis admitted in the time interval between January 2017 and September 2025. Pancreatitis form was mild or moderate in 128 cases and severe from the onset in 11 cases. All patients benefited from early conservative treatment and most (109) from ERCP and/or cholecystectomy during hospitalization, with favorable outcome in all cases of mild and moderate pancreatitis. Statistical analysis showed that for predictors of severe disease, prolonged evolution and poor outcome at admission, only glycemia was significantly higher in patients with unfavorable evolution (p=0.031). At 48 hours, statistically significant differences were identified for urea (p=0.0047), fibrinogen (p=0.041), lipase (p=0.049), and glycemia (p=0.01). At 72 hours, significant differences persisted for urea (p=0.0024), fibrinogen (p=0.018), and lipase (p=0.016). Exploratory predictive analysis performed showed urea at 72 hours with the strongest positive association with unfavorable clinical outcome (OR 1.06) in the logistic regression model, while Random Forest analysis identified urea at 72 hours, lipase at 72 hours, and admission laboratory parameters as the most relevant contributors to unfavorable clinical evolution. Both tested models have limited predictive performance, and the findings should be interpreted as exploratory. The results emphasize the value of a stepwise, multidisciplinary management strategy combined with dynamic biological assessment for optimizing therapeutic decisions and prognostic evaluation in acute biliary pancreatitis.</p>","PeriodicalId":93963,"journal":{"name":"Current health sciences journal","volume":"52 1","pages":"86-94"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}