Cureus最新文献

{"title":"The Integration of Artificial Intelligence Into Precision Medicine for Neuro-Oncology: Ethical, Clinical, and Nursing Implications in Immunotherapy Care.","authors":"Victoria M Ajibade, Chidinma S Madu","doi":"10.7759/cureus.85024","DOIUrl":"10.7759/cureus.85024","url":null,"abstract":"<p><p>This paper explores how artificial intelligence (AI) is being woven into precision medicine for neuro-oncology, highlighting its ethical, clinical, and nursing implications in the realm of immunotherapy. With AI-powered diagnostics and predictive analytics, we're seeing a boost in treatment accuracy, which paves the way for more personalized and effective care. On the clinical side, AI is fine-tuning targeted therapies, leading to better patient outcomes and less treatment-related toxicity. However, ethical concerns pop up around data privacy, algorithmic bias, and fair access to these AI-driven treatments. Nurses are at the forefront of tackling these issues, ensuring that care remains patient-centered, monitoring AI-assisted interventions, and grappling with ethical challenges. Their role in education and advocacy is crucial in connecting the dots between AI innovations and compassionate care. As AI continues to advance, it's vital for different disciplines to work together to tap into its potential while maintaining ethical standards and enhancing care in neuro-oncology.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 5","pages":"e85024"},"PeriodicalIF":1.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Congenital Hydronephrosis Due to Pyeloureteral Atresia: A Case Report.","authors":"Zainab H Alowainati, Zainab H Salman, Hibah A Alhamad, Njood Alsudairy","doi":"10.7759/cureus.r182","DOIUrl":"10.7759/cureus.r182","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.7759/cureus.76664.].</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 5","pages":"r182"},"PeriodicalIF":1.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: The Patterns of Non-adherence to Medication in the Management of Cardiovascular Disease: A Descriptive Study.","authors":"Anurag Agarwal, Shilpa Mannagudda Sandip, Amey Joshi, Arshitha Ashok","doi":"10.7759/cureus.r184","DOIUrl":"https://doi.org/10.7759/cureus.r184","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.7759/cureus.69810.].</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 5","pages":"r184"},"PeriodicalIF":1.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Applicability of Moorrees, Fanning, and Hunt Method for Age Estimation in Gandhinagar, India: An Orthopantomogram (OPG)-Based Retrospective Study.","authors":"Megha C Patel, Foram Patel, Shubham S Srivastav, Disha Makwani, Chhaya Patel, Miral Mehta, Chandni J Adalja, Khushi Rathod","doi":"10.7759/cureus.r183","DOIUrl":"https://doi.org/10.7759/cureus.r183","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.7759/cureus.83743.].</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 5","pages":"r183"},"PeriodicalIF":1.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Waves of Endurance: A Pilot Study of Beta Brain Wave Signatures Linked to Immune Adaptation in Transatlantic Rowers.","authors":"Merin Chandanathil, Daniel P Longman, Tomasz Nowak, Jonathan C K Wells, Jay T Stock, Michael P Muehlenbein, Hannah Schneiders, Nicola L Kelly, Vasavi R Gorantla, Courtney C Lewis, Richard M Millis","doi":"10.7759/cureus.c226","DOIUrl":"https://doi.org/10.7759/cureus.c226","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.7759/cureus.84059.].</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 5","pages":"c226"},"PeriodicalIF":1.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathomics in Gastrointestinal Tumors: Research Progress and Clinical Applications.","authors":"Changming Lv, Yulian Wu","doi":"10.7759/cureus.85060","DOIUrl":"10.7759/cureus.85060","url":null,"abstract":"<p><p>Gastrointestinal tumors are among the malignancies with the highest global incidence and mortality rates, and their diagnosis and treatment heavily rely on histopathological examination. However, traditional pathological assessment faces challenges such as strong subjectivity, heavy workload, and low diagnostic consistency. In recent years, with advancements in high-resolution digital slide scanning technology and the rapid development of deep learning algorithms, pathomics has emerged as a novel tool for the precise diagnosis and treatment of gastrointestinal tumors. By extracting high-throughput quantitative features from whole slide images and combining machine learning and deep learning techniques, pathomics enables automated tumor typing, prognosis prediction, and treatment response evaluation. This article reviews the research progress of pathomics in gastrointestinal tumors, focusing on its applications in gene mutation prediction, prognosis assessment, and treatment response prediction, while analyzing current challenges and future directions.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 5","pages":"e85060"},"PeriodicalIF":1.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent Diagnosis and Management of Primary Mediastinal Germ Cell Tumor and Klinefelter Syndrome.","authors":"David D Kim, Juan M Alcantar, Fukai L Chuang","doi":"10.7759/cureus.85003","DOIUrl":"10.7759/cureus.85003","url":null,"abstract":"<p><p>Primary mediastinal nonseminomatous germ cell tumor (PMNSGCT) stands out among other germ cell tumors not only because of its mediastinal site of origin, but by its aggressive behavior, need for maximal multidisciplinary therapy, and relatively poor prognosis. We present a case of a 22-year-old man who was evaluated for chest-related and systemic symptoms and found to have a large mediastinal mass compressing the pulmonary artery with no apparent disease outside the mediastinum. Physical exam at presentation to medical oncology revealed gynecomastia and small testicles, suspicious for sex hormone dysregulation. Workup revealed the diagnosis of PMNSGCT as well as Klinefelter syndrome (KS), a sex chromosome abnormality condition in males caused by an extra copy of the X chromosome. The association between these two conditions is reported but not well known, given the uncommon incidence of both and the lack of an obvious connection. Pre-treatment management included referral to multidisciplinary specialties and assessment for fertility preservation. The patient was treated with a curative intent with etoposide, ifosfamide, and cisplatin (VIP) chemotherapy for four cycles at full doses despite various side effects. He underwent surgical resection of his residual mediastinal mass, with pathology revealing a complete pathologic response, which is considered a good prognostic indicator for survival. Therefore, he did not require adjuvant chemotherapy. He was started on testosterone replacement therapy for KS-related hypogonadism with improvement in his testosterone level and quality of life. To date, he has not had evidence of recurrence. We discuss the evaluation and management of PMNSGCT and KS, as well as the evidence for their association reported in the literature.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 5","pages":"e85003"},"PeriodicalIF":1.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Amyloid Angiopathy: A Case Report.","authors":"Fatima Alam, Anup Banerjee, Chaminda Jayawarna","doi":"10.7759/cureus.84989","DOIUrl":"10.7759/cureus.84989","url":null,"abstract":"<p><p>Cerebral amyloid angiopathy (CAA) is a cerebrovascular condition characterized by the buildup of beta-amyloid protein within the walls of small and medium-sized blood vessels in the brain's cortex and leptomeninges. Clinically, it can present with a range of neurological symptoms, including recurrent headaches, cognitive disturbances, seizures, and focal deficits. A key feature of CAA is the tendency for lobar brain hemorrhages, though its clinical and radiological profile can overlap with other neurological disorders such as Alzheimer's disease, demyelinating conditions, vascular syndromes, and neoplasms. CAA pathology is frequently observed in individuals with Alzheimer's disease, with a subset showing significant vascular involvement. Although histopathological confirmation remains definitive, advanced imaging, particularly MRI, has become central to diagnosis, often identifying features such as cortical microbleeds, superficial siderosis, and non-deep (lobar) hemorrhages. In some presentations, especially inflammatory variants, patients may benefit from immunosuppressive treatment such as corticosteroids, making early diagnosis critical. Recognizing the distinction between CAA-related hemorrhages and other causes of cerebral bleeding is vital for timely and appropriate management. We present a case of an elderly male who had multiple hospital presentations with unexplained self-resolving expressive dysphasia, seizure, and gradually increasing confusion with the possibility of underlying dementia that responded well to high-dose steroids. This case underscores the need to consider inflammatory cerebral amyloid angiopathy (iCAA) as a differential in patients with recurrent, unexplained neurological symptoms with CT evidence of micro- and macro-hemorrhages and a dramatic response to steroids for symptomatic improvement. Improved awareness of atypical presentations and the utility of MRI can support earlier intervention. Further investigation is needed to refine diagnostic tools, identify reliable biomarkers, and explore therapeutic strategies targeting the underlying vascular and inflammatory mechanisms of the disease.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 5","pages":"e84989"},"PeriodicalIF":1.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary Management and Staged Surgical Treatment for Chronic Thromboembolic Pulmonary Hypertension and Subclavian Vein Thrombosis Caused by Venous Thoracic Outlet Syndrome.","authors":"Muhammad Zeeshan, Gregory J Pearl, Murali M Chakinala, Kunal D Kotkar, Morey A Blinder, Pavan K Kavali, Michael M Madani, Robert W Thompson","doi":"10.7759/cureus.84953","DOIUrl":"10.7759/cureus.84953","url":null,"abstract":"<p><p>Chronic thromboembolic pulmonary hypertension (CTEPH) is an uncommon complication of deep vein thrombosis (DVT) and pulmonary embolism (PE), occurring in 3-5% of patients despite therapeutic anticoagulation. Venous thoracic outlet syndrome (VTOS) causing subclavian vein (SCV) thrombosis is also an uncommon condition, not frequently associated with clinically significant PE. In this report, we present two patients with CTEPH and SCV thrombosis caused by VTOS who had successful multidisciplinary management and staged surgical treatment for both conditions. Each patient was young and otherwise healthy before presenting with progressively worsening shortness of breath. Both were found to have multiple peripheral PE and features of respiratory failure characteristic of CTEPH, along with axillary-SCV thrombosis and no other source of DVT. Each patient was treated with anticoagulation and riociguat but had ongoing pulmonary symptoms, and staged surgical treatment was recommended. The first stage was conducted by bilateral pulmonary thromboendarterectomy performed under deep hypothermic circulatory arrest. The second stage was conducted several months later after resolution of pulmonary hypertension, by paraclavicular thoracic outlet decompression that included complete first rib resection with a patent axillary-SCV on subsequent upper extremity imaging. Each patient recovered well with resolution of respiratory and upper extremity symptoms and a return to unrestricted activity by three months after the second operation. These patients are some of the first to have successful staged surgical treatment for CTEPH and SCV thrombosis caused by VTOS, illustrating the value of comprehensive multidisciplinary management for this unusual combination of rare conditions.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 5","pages":"e84953"},"PeriodicalIF":1.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Efficacy of Layered Moderate Tension Reduction Suturing in Facial Aesthetic Surgery.","authors":"Gui H Wang, Jin Y Gang, Yan Li","doi":"10.7759/cureus.85000","DOIUrl":"10.7759/cureus.85000","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the efficacy of the layer-by-layer moderate tension reduction suture technique in head and facial aesthetic plastic surgery.</p><p><strong>Methods: </strong>A retrospective analysis was performed on the clinical data of 80 patients who underwent head and facial cosmetic and plastic surgery in the outpatient department of our hospital from April 2022 to April 2024. Among these, the experimental group received the layer-by-layer moderate tension reduction suture technique, whereas the control group received the traditional suture technique. The incidence of surgical complications, scar width, and scar quality metrics derived from the Patient and Observer Scar Assessment Scale (POSAS) and Vancouver Scar Scale (VSS) scores were compared between the two groups.</p><p><strong>Results: </strong>The experimental group had a longer operation time but no complications (0%), compared to the control group's 17.5% complication rate. The χ² test confirmed the experimental group's significantly lower complication rate (P < 0.05). At one, three, six, and 12 months postoperatively, the experimental group had significantly smaller scar widths, lower POSAS scores, and lower VSS scores compared to the control group (all P < 0.05).</p><p><strong>Conclusion: </strong>The layer-by-layer moderate tension reduction suture technique demonstrated substantial advantages in head and facial aesthetic plastic surgery. It effectively minimized surgical complications, reduced scar width, and enhanced patients' scar appearance scores, making it highly worthy of clinical promotion.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 5","pages":"e85000"},"PeriodicalIF":1.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}