{"title":"揭开面纱：甲氨蝶呤毒性导致严重骨髓抑制的一例报告。","authors":"Dipesh Karki, Roshna Shrestha, Asmi Pandey, Prashant Neupane","doi":"10.7759/cureus.93828","DOIUrl":null,"url":null,"abstract":"<p><p>Methotrexate (MTX), a cornerstone in the management of rheumatic diseases, can induce severe adverse effects if not monitored meticulously. This report details a rare case of MTX-induced severe bone marrow suppression in a 65-year-old female, highlighting the critical importance of dosing accuracy, especially in the elderly. The patient, diagnosed with rheumatoid arthritis, experienced an acute episode of toxicity due to a dosing error. This case underscores the necessity for stringent monitoring and patient education to prevent similar incidents.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 10","pages":"e93828"},"PeriodicalIF":1.3000,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495944/pdf/","citationCount":"0","resultStr":"{\"title\":\"Unmasking the Masked: A Case Report of Atypical Methotrexate Toxicity Leading to Severe Bone Marrow Suppression.\",\"authors\":\"Dipesh Karki, Roshna Shrestha, Asmi Pandey, Prashant Neupane\",\"doi\":\"10.7759/cureus.93828\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Methotrexate (MTX), a cornerstone in the management of rheumatic diseases, can induce severe adverse effects if not monitored meticulously. This report details a rare case of MTX-induced severe bone marrow suppression in a 65-year-old female, highlighting the critical importance of dosing accuracy, especially in the elderly. The patient, diagnosed with rheumatoid arthritis, experienced an acute episode of toxicity due to a dosing error. This case underscores the necessity for stringent monitoring and patient education to prevent similar incidents.</p>\",\"PeriodicalId\":93960,\"journal\":{\"name\":\"Cureus\",\"volume\":\"17 10\",\"pages\":\"e93828\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-10-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495944/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cureus\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7759/cureus.93828\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/10/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cureus","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7759/cureus.93828","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/10/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Unmasking the Masked: A Case Report of Atypical Methotrexate Toxicity Leading to Severe Bone Marrow Suppression.
Methotrexate (MTX), a cornerstone in the management of rheumatic diseases, can induce severe adverse effects if not monitored meticulously. This report details a rare case of MTX-induced severe bone marrow suppression in a 65-year-old female, highlighting the critical importance of dosing accuracy, especially in the elderly. The patient, diagnosed with rheumatoid arthritis, experienced an acute episode of toxicity due to a dosing error. This case underscores the necessity for stringent monitoring and patient education to prevent similar incidents.
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