Cureus最新文献

{"title":"Periodontal Health Changes During Lower Anterior Crowding Treatment With a Modified Inman Appliance: A Prospective Cohort Study.","authors":"Ziad Mohamad Alhafi, Mohammad Y Hajeer, Ahmad S Burhan, Mowaffak A Ajaj, Samer T Jaber, Alaa Oudah Ali Almusawi","doi":"10.7759/cureus.78909","DOIUrl":"https://doi.org/10.7759/cureus.78909","url":null,"abstract":"<p><p>Objective This study investigated periodontal health changes in adult patients with mild crowding, undergoing treatment with a modified Inman appliance. Materials and methods This prospective cohort study involved 16 malocclusion patients (4 males and 12 females; mean age 21.94 ± 2.26 years) with mild crowding. Participants were treated using a modified Inman appliance. Plaque Index (PI), Gingival Index (GI), and Papillary Bleeding Index (PBI) were measured at four assessment times: before treatment (T0), two weeks (T1), one month (T2), and two months (T3) after appliance placement. Results All three indices (PI, GI, and PBI) exhibited significant differences across the assessment times (p < 0.001). Pairwise comparisons revealed significant differences in most cases (p ≤ 0.0125), with exceptions primarily observed in comparisons involving T2-T3. Conclusions Periodontal health can be negatively affected during orthodontic treatment due to the difficulty of maintaining optimal oral hygiene with the modified Inman appliance. This can lead to increased plaque accumulation and a subsequent rise in periodontal indices. However, these changes typically remain within acceptable limits. Patient-specific factors, such as oral hygiene practices, significantly influence the extent of these changes, emphasizing the importance of diligent oral care throughout treatment.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 2","pages":"e78909"},"PeriodicalIF":1.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11820922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Adolescent Abdominal Tumors Presenting With Neuropsychiatric and Massive Abdominopelvic Manifestations: A Report of Two Cases.","authors":"Avinash Hiremath, Mohammed Alblooshi, Mamoun AlMarzouqi, Diary Mohammed, Pawan Kashyape","doi":"10.7759/cureus.78899","DOIUrl":"https://doi.org/10.7759/cureus.78899","url":null,"abstract":"<p><p>Abdominal tumors in adolescence represent a diverse group of pathologies that can present atypically, ranging from neuropsychiatric disturbances to significant abdominal distension. The objective of this study is to report two rare cases that highlight the diagnostic and therapeutic challenges of abdominal tumors in this age group. In the first case, a 12-year-old girl presented with a 10-day history of acute-onset neuropsychiatric symptoms, including hallucinations and cognitive decline, leading to a diagnosis of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Although the initial ultrasound was non-diagnostic, subsequent magnetic resonance imaging (MRI) revealed a 3-cm ovarian dermoid cyst. Prompt surgical resection combined with immunotherapy resulted in rapid neurological improvement, with complete recovery observed within days and sustained at a one-year follow-up. In the second case, a 14-year-old girl exhibited progressive abdominal distension over one month and was found to have a large, predominantly solid pelvic mass. Detailed imaging studies, including computed tomography (CT), delineated a bilobed mass measuring up to 30 cm in maximum dimension. Intraoperative findings confirmed the mass to be an intramural uterine leiomyoma; surgical excision led to the resolution of symptoms and normalization of laboratory parameters (hemoglobin improved from 8.6 g/dL), with no recurrence noted during follow-up. These cases quantitatively underscore that even benign tumors measuring 3 cm and 30 cm, respectively, lead to significant morbidity. Ultimately, our findings emphasize the importance of a high index of suspicion, repeated high-resolution imaging, and a multidisciplinary approach to ensure timely diagnosis and optimal management, thereby contributing to improved clinical strategies in the management of atypical abdominal tumors in adolescents.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 2","pages":"e78899"},"PeriodicalIF":1.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11820923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Phase Ib Investigator-Initiated Trial of Filgotinib in Patients With Idiopathic Multicentric Castleman Disease.","authors":"Shoichi Fukui, Remi Sumiyoshi, Tomohiro Koga, Naoki Hosogaya, Sawana Narita, Shimpei Morimoto, Hiroshi Yano, Atsushi Katsube, Shingo Yano, Yasufumi Masaki, Shinichiro Tsunoda, Shuzo Sato, Kiyoshi Migita, Kazuko Matsuyama, Naoki Kato, Atsuhiko Kawamoto, Atsushi Kawakami","doi":"10.7759/cureus.78865","DOIUrl":"https://doi.org/10.7759/cureus.78865","url":null,"abstract":"<p><p>Background Idiopathic multicentric Castleman disease (iMCD) is a chronic systemic inflammatory disease characterized by the production of interleukin (IL)-6. The contribution of Janus kinase, downstream of IL-6 signaling, to the pathophysiology of iMCD has been suggested by several studies. Patients and methods This phase Ib single-arm trial evaluated the safety profile and efficacy of filgotinib, a JAK1 preferential inhibitor, in patients with iMCD. We recruited patients with disease activity evaluated based on their values of C-reactive protein (CRP), hemoglobin, albumin, and Eastern Cooperative Oncology Group performance status (ECOG-PS). Filgotinib (200 mg daily) was administered for eight weeks. Results Five patients who were newly diagnosed with or under treatment for iMCD were recruited. The lymph node histology of all five patients was the plasma-cell type. Filgotinib demonstrated a favorable safety profile with manageable adverse events. At eight weeks, improvements in the ECOG-PS were observed in two patients, but no improvements in CRP, hemoglobin, or albumin levels were observed. Conclusion The safety profile of filgotinib against iMCD was comparable to those against rheumatoid arthritis and ulcerative colitis over a short duration, but the efficacy of filgotinib against iMCD was not evident after eight weeks. Long-term evaluations of the safety profile and efficacy of filgotinib in the treatment of iMCD are necessary.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 2","pages":"e78865"},"PeriodicalIF":1.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncommon Systemic Manifestation of Group A Beta-Hemolytic Streptococcus in a Middle-Aged Woman: A Case Report.","authors":"Tetsuya Akaishi","doi":"10.7759/cureus.78863","DOIUrl":"10.7759/cureus.78863","url":null,"abstract":"<p><p>Group A beta-hemolytic <i>Streptococcus</i> (GABHS) is a gram-positive type of bacteria, typically causing high fever and painful pharyngitis. The bacteria may sometimes trigger widespread skin rash in children, but systemic conditions other than sore throat are rare in adult patients with the infection. A 57-year-old woman visited our hospital with a sore throat, pruritic skin rash in the body trunk, painful oral ulcer, swollen lips, arthralgia, and swollen left wrist joint with pain. She had a recent similar clinical episode approximately four weeks before the hospital visit, which was alleviated with oral loxoprofen. The swelling of the left wrist had migrated from the left elbow area in the preceding four weeks. The patient had similar symptoms about 30 years ago, which were diagnosed with GABHS infection and successfully treated with oral antibiotics. Based on this past similar clinical episode, the patient was evaluated by the GABHS rapid antigen detection tests, which revealed a positive result. The blood test data showed normal white blood cell (WBC) count and C-reactive protein (CRP) level. She was free of any serum antibodies associated with autoimmune connective tissue diseases or syphilis. Deciding the diagnosis was difficult, but based on her past similar clinical episode in her 20s and systemic conditions resembling rheumatic fever, a diagnosis of GABHS-related uncommon systemic response was made. The patient was treated with clarithromycin (200 mg, twice a day) for 10 days and amoxicillin (250 mg, three times a day) for an additional seven days, and all symptoms resolved. Four weeks after the first hospital visit, the serum anti-streptolysin-O (ASO) level was normal at 135 IU/ml. An echocardiogram revealed an anterior mitral leaflet calcification with a mild level of mitral regurgitation. The present case indicated the importance of considering GABHS infection in adults with strong sore throat, widespread skin rash, arthralgia, and swollen joints with uncertain causes, even when the patient is afebrile with normal WBC count, CRP level, and ASO titer.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 2","pages":"e78863"},"PeriodicalIF":1.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete Esophageal Obstruction Due to Dysphagia Lusoria and Subclavian Artery Thrombosis: A Case Report.","authors":"Rim A Boutari, Moustafa W Diab, Fatmeh I Mallah","doi":"10.7759/cureus.78840","DOIUrl":"10.7759/cureus.78840","url":null,"abstract":"<p><p>Dysphagia lusoria is a rare condition caused by esophageal compression from an aberrant right subclavian artery (ARSA). Although often asymptomatic, complications such as aneurysmal dilation or thrombosis can result in severe presentations, including complete esophageal obstruction. Herein, we report the case of a 75-year-old woman with a five-year history of progressive dysphagia and significant weight loss. During her hospitalization for urosepsis and acute kidney injury, she developed complete esophageal obstruction, preventing oral intake. Imaging revealed an ARSA with significant parietal thrombosis, compressing the esophagus posteriorly. This confirmed the diagnosis of dysphagia lusoria complicated by ARSA thrombosis. Conservative measures failed, and she was referred for vascular surgical evaluation. This case highlights a rare but severe presentation of dysphagia lusoria with complete esophageal obstruction due to ARSA thrombosis. Early recognition and multidisciplinary management are critical for optimizing outcomes. Definitive treatment often requires surgical intervention, particularly in the setting of complications like thrombosis.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 2","pages":"e78840"},"PeriodicalIF":1.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of the Hematological Picture of Severe COVID-19 Infection.","authors":"Dominga Amoroso, Stefania Bongo, Anna Copponi, Vanessa Rossi, Roberta Di Giorgio, Sergio Bernardini, Lorenzo Ippoliti, Maria Morello","doi":"10.7759/cureus.78797","DOIUrl":"10.7759/cureus.78797","url":null,"abstract":"<p><p>Numerous hematological abnormalities have been documented in COVID-19 patients. We conducted an analysis of 82 articles from PubMed, focusing on the hematological characteristics observed in survivors (S) and non-survivors (NS) with moderate and severe COVID-19 symptoms, respectively. Our review underlines neutrophilia, lymphopenia, and thrombocytopenia as hallmark features of the disease. In severe cases, blood cell microscopy revealed the following abnormalities: i) an increased number of neutrophils, often displaying granularity, toxic granulation, and vacuolization; ii) lymphocytes with a notably blue cytoplasm; iii) several monocytes that contain vacuoles; iv) platelet aggregation; and v) basophilic stippling in red blood cells. Furthermore, scattergram analysis of COVID-19 patients revealed two common features: i) an increased neutrophil population and ii) the presence of a distinctive \"sandglass pattern\". This review underscores the critical role of hematochemical and cytomorphological blood cell analysis in COVID-19 patients, aiding clinicians in better recognizing and understanding the indicators of disease severity.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 2","pages":"e78797"},"PeriodicalIF":1.0,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous Feeding Insulin Injection (CFII): A New Simple Method to Stabilize Severe Glucose Variability and Nutrition Delivery in Critically Ill Patients.","authors":"Yuzuru Ohshiro","doi":"10.7759/cureus.78758","DOIUrl":"10.7759/cureus.78758","url":null,"abstract":"<p><p>This report describes a new, simple, and systematic approach, Continuous Feeding Insulin Injection (CFII), designed to stabilize severe glucose variability and optimize nutritional delivery in critically ill patients when intensive insulin therapy (IIT) alone proves insufficient. Septic patients frequently develop inflammation-induced insulin resistance, resulting in recurrent episodes of hyperglycemia and hypoglycemia. Fever, systemic inflammation, and appetite loss further disrupt glucose homeostasis, complicating nutritional management. CFII integrates two key components: continuous enteral nutrition (CEN) delivered at a fixed rate over 24 hours, based on the patient's metabolic needs, and continuous insulin infusion dynamically adjusted according to frequent or continuous blood glucose monitoring. This approach stabilizes both blood glucose levels and nutritional intake. We present a case of a 65-year-old woman with type 2 diabetes (BMI 21.2 kg/m²) who developed sepsis secondary to pyelonephritis. Despite receiving intensive insulin therapy (IIT), she experienced severe glycemic fluctuations (38-361 mg/dL; mean±SD: 218.6±110.0 mg/dL) and recurrent hypoglycemia, rendering oral intake nearly impossible. CFII was initiated with enteral feeding starting at 1000 kcal/day and gradually increased to 1400 kcal/day, while insulin infusion was dynamically adjusted every three hours. This strategy successfully stabilized severe glucose variability (164.5±35.9 mg/dL), eliminated hypoglycemic episodes, and achieved controlled nutrition delivery. Clinically, similar approaches are presumed to have been used in patients receiving CEN; however, this is the first report to the best of our knowledge to systematically describe CFII as a structured method for glucose and nutritional management in critically ill patients, to propose the term \"CFII\" and to demonstrate its effectiveness in a patient for whom IIT alone was insufficient. CFII enables nutritional delivery to be tailored to the course of treatment while maintaining stable glycemic control. Its simplicity, practicality, and compatibility with existing hospital systems make CFII an accessible method for broader clinical application. CFII has the potential to improve metabolic outcomes and enhance survival rates in this vulnerable patient population. Further research, including systematic evaluations and randomized controlled trials, is necessary to confirm its efficacy, safety, and applicability across diverse clinical settings.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 2","pages":"e78758"},"PeriodicalIF":1.0,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Uterine Broad Ligament Hernia Difficult to Distinguish From Adnexal Torsion.","authors":"Kazuaki Shima, Masakazu Nishida, Kentaro Kai, Kosuke Suzuki, Eiji Kobayashi","doi":"10.7759/cureus.78790","DOIUrl":"10.7759/cureus.78790","url":null,"abstract":"<p><p>Uterine broad ligament hernia is a rare type of internal hernia, with symptoms similar to those of adnexal torsion. Distinguishing these disorders is crucial. We treated a 49-year-old Japanese woman with a history of gravida (n=5), parity (n=3), and cesarean sections (n=2). After visiting a physician due to abdominal pain and vomiting, she was referred to our hospital based on suspicion of ovarian torsion. Emergency surgery at our hospital revealed that the patient's small intestine was contained within the defective hilar membrane, resulting in a uterine broad ligament hernia. With the cooperation of the intestinal surgeon, we performed a resection and anastomosis of the necrotic small intestine in the herniated area. The patient's postoperative course was uneventful, and she was discharged on the 9th postoperative day. A uterine broad ligament hernia causes necrosis of the small intestine and can be life-threatening. Women with a history of surgery or delivery might be at higher risk for this hernia. The swollen small intestine at the hernia site is often mistakenly diagnosed as adnexal torsion. In this patient's case, we diagnosed the uterine broad ligament hernia with necrotic small intestine during the surgery. The prompt surgery enabled a good patient prognosis.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 2","pages":"e78790"},"PeriodicalIF":1.0,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefits of Testosterone Hormone in the Human Body: A Systematic Review.","authors":"Julio G Rojas-Zambrano, Augusto R Rojas-Zambrano, Andres F Rojas-Zambrano, Gabriela E Barahona-Cueva","doi":"10.7759/cureus.78785","DOIUrl":"10.7759/cureus.78785","url":null,"abstract":"<p><p>Testosterone is a key hormone with a complex and essential role in the physiology of healthy individuals; it is crucial for developing and maintaining muscle mass and improved bone density. In addition to these physical features, testosterone is vital for reproductive health as libido, erectile function, and spermatogenesis, the process of sperm production; its impact extends across multiple bodily systems, highlighting its importance for physical traits and overall health and fertility. This study aims to explore the critical and multifaceted role of testosterone in the physiology of healthy individuals. The method was to search PubMed from the year 1993 until current data using MESH terms: ((((testosterone) OR (androgens)) OR (testosterone insufficiency)) AND (healthy patients)) AND (testosterone replacement))). The inclusion criteria are studies with descriptive, observational, and experimental approaches on healthy patients that evaluated the action of testosterone. The updated review indicates that testosterone hormone supplementation positively influences several aspects, including sexual function, bone health, muscle strength, mood (particularly in reducing depression), and vascular endothelial function. However, these findings are limited by the small sample sizes and the relatively few studies available on this topic, warranting further research to better understand the full scope of testosterone's effects. Recent landmark trials have demonstrated that testosterone therapy offers modest benefits, particularly for older men with low testosterone levels and symptoms of hypogonadism. These benefits include improvements in sexual function, bone health, muscle strength, mood, and vascular endothelial function in healthy individuals. Given the potential benefits of testosterone therapy, ongoing research and clinical exploration are highly recommended to deepen our understanding of its full range of effects and to refine therapeutic strategies. Doing more studies will help clarify the role of testosterone in both healthy individuals and those with testosterone deficiency, leading to better-informed treatment approaches for the future.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 2","pages":"e78785"},"PeriodicalIF":1.0,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the Quality of Pediatric Basic Life Support Cardiopulmonary Resuscitation With a Novel Method: The Maryland Hiccup.","authors":"Jennifer F Anders, Camille Anderson, Cynthia Wright-Johnson, Karen J O'Connell","doi":"10.7759/cureus.78783","DOIUrl":"10.7759/cureus.78783","url":null,"abstract":"<p><p>Prehospital high-performance cardiopulmonary resuscitation (CPR) has demonstrated remarkable improvements in the survival of adult patients after out-of-hospital cardiac arrest (OHCA). With a goal to improve pediatric survival rates, Maryland Emergency Medical Services (EMS) for Children created a pediatric-specific high-performance CPR protocol to align with the existing state protocol for adult CPR. While prehospital CPR for adults has moved toward continuous compressions, prehospital CPR for children without an advanced airway continues to adhere to American Heart Association (AHA)/International Liaison Committee on Resuscitation (ILCOR) guidance for two ventilations for every 15 compressions. The Maryland Hiccup (MH) is a novel approach to pediatric CPR. The method combines the goal of continuous compressions with AHA/ILCOR guidance for a 15:2 compression-to-ventilation ratio. In contrast to the two- to four-second pause after compression 15 of the AHA/ILCOR style, the \"hiccup\" of the MH method describes two brief pauses for ventilation during the upstrokes of compressions 14 and 15. We compare basic CPR quality metrics for two-rescuer high-performance CPR using the standard AHA/ILCOR 15:2 style compared to the MH style. We enrolled 38 Maryland EMS clinicians in two-person teams to perform simulated CPR on a pediatric manikin. We recorded compression and ventilation data for 76 two-minute cycles of high-performance CPR. Compression fraction was significantly improved using the MH when compared to the standard AHA style for high-performance CPR (median 98% vs 80%, p<0.001). When compressions per minute (CPM) were compared by 30-second epochs, 80% of epochs were out of range (<100 CPM or >120 CPM) using the AHA/ILCOR style, while only 32% of epochs were out of range for MH style. No significant differences were found between the two CPR styles in ventilation volume or compression depth. The MH is a novel method for pediatric basic life support two-provider CPR which improves CPR quality metrics among EMS clinicians regardless of their prior experience. The use of this method in simulation allows near-continuous compressions without the placement of an advanced airway. Future research is needed to explore whether the CPR quality improvements translate to improved patient outcomes in real-world use.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 2","pages":"e78783"},"PeriodicalIF":1.0,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}