CureusPub Date : 2025-01-21eCollection Date: 2025-01-01DOI: 10.7759/cureus.77768
Abdullah M Althunayyan, Abdulaziz H Alsadun, Fahad Alrumayh, Lamees Alsulaim
{"title":"Assessment of Knowledge and Attitudes Toward Organ Donation in the Qassim Region, Saudi Arabia.","authors":"Abdullah M Althunayyan, Abdulaziz H Alsadun, Fahad Alrumayh, Lamees Alsulaim","doi":"10.7759/cureus.77768","DOIUrl":"10.7759/cureus.77768","url":null,"abstract":"<p><strong>Introduction: </strong>Organ donation is the transplantation of tissues or organs from one person to another, and it is considered a method to save lives when a patient has end-stage organ failure. Community willingness to engage in organ donation programs is imperative in promoting successful organ transplantation.</p><p><strong>Methods: </strong>This research employed a cross-sectional study design involving 420 adult participants from the Qassim Region, Saudi Arabia. An online questionnaire was used to collect data and later analyzed using IBM SPSS Statistics for Windows, Version 27 (Released 2020; IBM Corp., Armonk, New York, United States).</p><p><strong>Results: </strong>The results reveal that only six (1.4%) participants had donated an organ before. One hundred sixty-eight (40.0%) participants believed that a person could donate their organ during their lifetime, with 225 (53.6%) aware that kidneys could be donated. A total of 198 (47.1%) participants supported the practice of organ donation. Religious motivation was the primary reason for the majority of participants willing to donate their organs (128, 64.7%). Conversely, among those unwilling to donate, 86 individuals (38.7%) cited a lack of knowledge about the practice as their reason. Two hundred sixty-six (63.3%) respondents expressed willingness to donate organs if laws and religion encouraged the practice. One hundred fifteen (27.4%) had a low knowledge level, 203 (48.3%) had a moderate knowledge level, and 102 (24.3%) had a high knowledge level. Age, education level, and occupation showed a statistically significant relationship with the knowledge score on organ donation (p < 0.05).</p><p><strong>Conclusion: </strong>The study revealed that the general population exhibited a moderate understanding of and favorable attitude toward organ donation. Age, education level, and occupation significantly influenced knowledge scores related to organ donation. Additionally, religious beliefs emerged as the primary driver for organ donation. There is a need to raise public knowledge about the importance of organ donation in saving lives, improving quality of life, and establishing sustainable and ethical organ transplantation systems in Saudi Arabia.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 1","pages":"e77768"},"PeriodicalIF":1.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CureusPub Date : 2025-01-21eCollection Date: 2025-01-01DOI: 10.7759/cureus.77774
Santiago Garfias-Arjona, Monica Lara-Almunia, Ester Antón-Valentí, Javier Pierola-Lopetegui, Joan Bestard-Escalas, Albert Maimó-Barceló, Diego M Marzese-Parrilli, Sandra Íñiguez-Muñoz, Miquel Ensenyat-Mendez, Marta Brell
{"title":"Molecular Characteristics of High-Grade Glioma in Relation to 5-Aminolevulinic Acid (5-ALA) Fluorescence Intensity.","authors":"Santiago Garfias-Arjona, Monica Lara-Almunia, Ester Antón-Valentí, Javier Pierola-Lopetegui, Joan Bestard-Escalas, Albert Maimó-Barceló, Diego M Marzese-Parrilli, Sandra Íñiguez-Muñoz, Miquel Ensenyat-Mendez, Marta Brell","doi":"10.7759/cureus.77774","DOIUrl":"10.7759/cureus.77774","url":null,"abstract":"<p><strong>Introduction: </strong>5-aminolevulinic acid (5-ALA) fluorescence used in glioma surgery has different intensities within tumors and among different patients, some molecular and external factors have been implicated, but there is no clear evidence analyzing the difference of fluorescence according to glioma molecular characteristics. This study aimed to compare molecular factors of glioma samples with fluorescence intensity to identify potential cofounders and associations with clinically relevant tumor features.</p><p><strong>Methods: </strong>Tumor samples of high-grade glioma patients operated using 5-ALA for guided resection were included for comparative analysis of fluorescence intensity and molecular features. All the samples were processed under the same conditions. The power for fluorescent stimulation and acquisition time was the same between samples. An inverted fluorescence microscope compared the mean fluorescence for each molecular variation. p53, ATRX and Ki67 expression and IDH1 mutation were assessed by immunohistochemistry. Follow-up of the patients for progression-free survival and overall survival was made.</p><p><strong>Results: </strong>We found that the fluorescence intensity for each specific tumor was independent of the methylation of the methylguanine-DNA-methyltransferase (MGMT) promoter region assessed by pyrosequencing, there was no association of fluorescence with p53, ATRX, IDH1 mutation as assessed by immunochemistry. Also, fluorescence intensity has no relation with time of tumor recurrence or overall survival.</p><p><strong>Conclusion: </strong>With the results, we argue that many factors are involved in fluorescence intensity that may be related to the specific metabolic status of the glioma cells analyzed, which is more likely to be responsible for the variation of fluorescence.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 1","pages":"e77774"},"PeriodicalIF":1.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CureusPub Date : 2025-01-20eCollection Date: 2025-01-01DOI: 10.7759/cureus.77722
Borna A Assarian, Muhammed Shahid, Melika Z Assarian, Erisa Ito
{"title":"Improving Communication and Teamwork Between Resident Doctor Teams Using a Group Messaging Application: A Quality Improvement Project.","authors":"Borna A Assarian, Muhammed Shahid, Melika Z Assarian, Erisa Ito","doi":"10.7759/cureus.77722","DOIUrl":"10.7759/cureus.77722","url":null,"abstract":"<p><p>Background Communication and teamwork are essential in medicine. Established standards emphasise the importance of collaboration and access to support. Some departments divide doctors into teams; however, inter-team communication is not always efficient. This quality improvement project aimed to improve teamwork and communication between resident-doctor teams at the Medicine for Older People (MOP) department at University Hospital Southampton using a messaging application. Secondary objectives were to assess the management of workload, resident doctor well-being, and patient safety. Materials and methods A WhatsApp (Meta Platforms, Inc., Menlo Park, California, United States) communication group was created to involve all eight MOP teams (no patient information was discussed). Anonymous questionnaires were used pre-implementation and two months post-implementation to assess the impact on communication, teamwork, overtime hours, doctor well-being, and patient safety. Data analysis was carried out using the IBM SPSS Statistics for Windows, Version 30 (Released 2024; IBM Corp., Armonk, New York, United States). We calculated 95% confidence intervals (CIs) and p-values using the Wilcoxon signed-rank test. Results All 24 resident doctors (Foundation/Senior House Officers) participated, and 19 completed both questionnaires. Significant improvements were seen in communication (very good/good ratings: pre-implementation 5%; post-implementation 100%, 95% CI 1.62-2.58, p<0.001), teamwork (pre-implementation 26%; post-intervention 84%, 95% CI 1.12-2.15, p<0.001), and workplace well-being (pre-intervention 47%; post-intervention 84%, 95% CI 0.47-1.21, p=0.001). Mean days worked overtime per week were reduced from 1.89 to 1.31 (95% CI (-0.91) - (-0.25), p=0.005) and the mean time worked overtime was reduced from 29.7 minutes/week to 19.9 minutes/week (95% CI (-14.61) - (-4.92), p=0.003). All the doctors (100%) strongly agreed/agreed the intervention helped distribute tasks more evenly and facilitated the timely completion of work. Around 90% felt this very positively/positively impacted patient safety. All doctors recommended this intervention for future residents. Conclusion Group messaging applications, such as WhatsApp, can enhance communication between resident-doctor teams, leading to improvements in supportive teamwork, patient care, and doctor well-being.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 1","pages":"e77722"},"PeriodicalIF":1.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CureusPub Date : 2025-01-20eCollection Date: 2025-01-01DOI: 10.7759/cureus.77694
Basant K Puri, Cecilia Catuogno-Cal, Ivan Verduci
{"title":"Modulation of Glutamatergic Burst Activity by Hydrolysed Arabinoxylan Rice Bran: A Multielectrode Array Study in Human-Induced Pluripotent Stem Cell-Derived Neurones and Astrocytes.","authors":"Basant K Puri, Cecilia Catuogno-Cal, Ivan Verduci","doi":"10.7759/cureus.77694","DOIUrl":"10.7759/cureus.77694","url":null,"abstract":"<p><p>The natural product MGN-3 (Biobran) is a defatted, partially hydrolysed rice bran-derived hemicellulose enzymatically modified with an extract of <i>Lentinus edodes</i>. It has a high proportion of arabinoxylan. It has a protective action against intracerebroventricular streptozotocin-induced murine sporadic Alzheimer's disease and reverses spatial memory deficit in this disease model. The aim was to test the hypothesis that MGN-3 increases glutamatergic burst activity in human neuronal and glial cells by conducting an in vitro multielectrode array-based micro-electrophysiological study in a cultured mixture of human glutamatergic neurones, GABAergic neurones and astrocytes. The effects of MGN-3 at two concentrations, 0.750 g L<sup>-1</sup> and 0.375 g L<sup>-1</sup>, and vehicle (control), on glutamatergic burst activity in a triculture of human-induced pluripotent stem cell (hiPSC)-derived GABAergic neurones, glutamatergic neurones and astrocytes were studied. The change in the number of glutamatergic bursts normalised to the vehicle control was analysed using a normal or Gaussian generalised linear model. This statistical model was highly significant (<i>p</i> = 1.468 × 10<sup>-17</sup>). Both MGN-3 concentrations were associated with highly significant main effects. These results provide strong evidence to reject the null hypothesis that MGN-3 does not affect glutamatergic burst activity in human neuronal and astrocytic cells. The study's strengths include the novel use of hiPSC-derived neurones and astrocytes and the robust statistical significance of the findings. Limitations include in vitro conditions that may not fully replicate in vivo conditions, potential variability in hiPSC-derived cell preparations, and the need to test other neuronal subtypes or additional doses to assess dose-dependent effects. These should be addressed in future studies.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 1","pages":"e77694"},"PeriodicalIF":1.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CureusPub Date : 2025-01-20eCollection Date: 2025-01-01DOI: 10.7759/cureus.77699
Abdulaziz A Alzahrani, Abdulrahman M Zawawi, Suhail H Alrudaini, Nader A Hassan, Adel A Alsulami, Abdulaziz M Alkhoshi, Mohammed Alyousef
{"title":"Incidence of Communicating Hydrocephalus Following Intraventricular Hemorrhage Among Adult Patients Treated at a Hospital in Jeddah, Saudi Arabia: A Retrospective Study.","authors":"Abdulaziz A Alzahrani, Abdulrahman M Zawawi, Suhail H Alrudaini, Nader A Hassan, Adel A Alsulami, Abdulaziz M Alkhoshi, Mohammed Alyousef","doi":"10.7759/cureus.77699","DOIUrl":"10.7759/cureus.77699","url":null,"abstract":"<p><p>Introduction Intraventricular hemorrhage is a severe condition caused by bleeding within the brain ventricles. It is often due to trauma, tumors, vascular malformation, aneurysm, oxygen deprivation, or idiopathic. A common complication associated with intraventricular hemorrhage is hydrocephalus, which is the accumulation of cerebrospinal fluid in the ventricles. Hydrocephalus can be classified as communicating or non-communicating. This study aimed to evaluate the incidence of communicating hydrocephalus after intraventricular hemorrhage. Methods This retrospective study was conducted at King Abdulaziz University Hospital in Jeddah, Saudi Arabia, and included 52 adult patients treated between 2012-2022 who met the eligibility criteria. We examined the relationships among age, sex, length of hospitalization, presenting symptoms, co-morbidities, Evans index, Graeb score, Glasgow Coma Score, survival, and ventriculoperitoneal shunt complications through univariate and bivariate analyses. The Shapiro-Wilk test was used to evaluate data distribution. Differences between groups were analyzed using the chi-square test for categorical variables and the Mann-Whitney U test for non-parametric variables. Results The median age of the participants was 54 years, with a male predominance (57.7%). Motor dysfunction was the most frequently reported symptom at presentation (48.1%). Among the 30 patients who developed hydrocephalus after intraventricular hemorrhage, 70% had communicating hydrocephalus. There was a substantial correlation between mortality and hydrocephalus type (P =0.020). Conclusion Intraventricular bleeding is associated with an increased risk of communicating hydrocephalus, with an incidence rate of 3% per person-year.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 1","pages":"e77699"},"PeriodicalIF":1.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Persistent Gingival Bleeding Related to Periodontal Disease.","authors":"Yosuke Iijima, Miki Yamada, Takumi Takahashi, Shunsuke Hino, Motohiko Sano, Hiroshi Sakagami, Norio Horie, Takahiro Kaneko","doi":"10.7759/cureus.77693","DOIUrl":"10.7759/cureus.77693","url":null,"abstract":"<p><p>Objective More patients visit oral surgery outpatient clinics from evening to night to treat persistent gingival bleeding (PGB) related to periodontal disease (PD) (PD-PGB). Since there are few reports on PD-PGB, the present study performed a detailed characterisation of this disease. Materials and methods Patients who visited our oral surgery clinic between 1 January 2014 and 31 December 2022 to treat PD-PGB without trauma. Demographic data, systemic diseases and bleeding tooth characteristics were retrieved. The occurrence of systemic diseases was compared with that of the control group (patients consisting of temporomandibular joint dislocation and minor trauma). Results Among 295 patients with gingival bleeding (GB) unrelated to trauma, 193 patients (65.4%) showed postoperative bleeding, and 91 patients (30.1%) showed PD-PGB; 93.4% of patients over 60 years old showed PD-PGB. Patients in the PGB-RPD group showed a significantly higher percentage (57.1%) of taking anticoagulants and/or antiplatelets than the control group (24.2%) (P < 0.001) Significantly higher percentage of patients in the PGB-RPD group showed a significantly higher incidence of hypertension (68.1%) than the control group (34.1%) (P < 0.001). Bleeding is the most frequently observed in molars, with a depth of the pockets exceeding 4 mm. Conclusion PD-PGB accompanied by deep pockets was more common in older patients and aggravated by taking anticoagulants and/or antiplatelets and antihypertensives. PD-PGB is not rare, and periodontal maintenance, such as regular dental checks, is an important preventive measure.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 1","pages":"e77693"},"PeriodicalIF":1.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CureusPub Date : 2025-01-19eCollection Date: 2025-01-01DOI: 10.7759/cureus.77681
David A Jernigan, Roman D Hentish
{"title":"Successful Treatment of a Patient With Chronic Bronchiectasis Using an Induced Native Phage Cocktail: A Case Report.","authors":"David A Jernigan, Roman D Hentish","doi":"10.7759/cureus.77681","DOIUrl":"10.7759/cureus.77681","url":null,"abstract":"<p><p>Bronchiectasis is a well-recognized chronic respiratory disease characterized by a productive cough and multi-microbial activation syndrome (MMAS) of various respiratory infections due to what can be the permanent dilatation of the bronchi. Bronchiectasis represents an ongoing challenge to conventional antibiotic treatment as the damaged bronchial environment remains conducive to ongoing opportunistic infections and microbial mutations, leading to multi-drug resistance. Standard treatment guidelines are designed to promptly identify and address the primary infection. Despite the strong focus on identification of the primary infection in each new episode, by combining clinical history, and high-resolution computed tomography (HRCT), a high proportion of patients remain classified as \"idiopathic\". Important underlying infections, such as <i>Aspergillus</i> and other mold infections, <i>Pseudomonas aeruginosa</i>, <i>Mycobacterium</i>, <i>Mycoplasma</i>, and various viruses, are frequently not identified for prolonged periods of time, and selected broad-spectrum antibiotics are often ineffective. The introduction of Induced Native Phage Therapy in 2021 and Induced Native Phage cocktails in 2024 provides a new treatment alternative that induces naturally occurring phages to eliminate specifically targeted acute and chronic mixed infections even in cases of multi-drug resistant infections as seen in chronic bronchiectasis. This article will present the successful long-term results in a case study demonstrating the speed, gentleness, and effectiveness of induced native phage cocktails in a 45-year-old male with life-long asthma resulting in multi-microbial activation syndrome in severe non-cystic fibrosis bronchiectasis for the last 20 years.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 1","pages":"e77681"},"PeriodicalIF":1.0,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful Treatment of Refractory Ulcerative Colitis With 5-Aminosalicylic Acid Intolerance and Biologic Therapy Resistance Using Combined Granulocyte and Monocyte Adsorptive Apheresis.","authors":"Tomotaka Tanaka, Daiki Hirano, Syohei Ishimaru, Keiko Arataki","doi":"10.7759/cureus.77641","DOIUrl":"https://doi.org/10.7759/cureus.77641","url":null,"abstract":"<p><p>We report the case of a 37-year-old male patient diagnosed with moderate left-sided ulcerative colitis (UC). Initial therapy with 5-aminosalicylic acid (5-ASA) was terminated within days due to exacerbation of symptoms, leading to a diagnosis of 5-ASA intolerance. Although induction of remission was achieved with prednisolone, the patient developed steroid dependency. Treatment with vedolizumab and ustekinumab subsequently failed to achieve clinical or endoscopic improvement. Intensive granulocyte and monocyte apheresis (GMA) was introduced, successfully inducing remission. However, during maintenance therapy with GMA, the patient experienced a relapse. Initiation of golimumab yielded suboptimal results, necessitating a combination therapy involving prednisolone and reintensified intensive GMA. This multimodal approach successfully achieved remission induction and maintenance. This case highlights the potential utility of intensive GMA in combination with golimumab and prednisolone for the management of refractory UC, particularly in patients with 5-ASA intolerance and failure of multiple biologic agents. A brief review of the relevant literature is included.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 1","pages":"e77641"},"PeriodicalIF":1.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CureusPub Date : 2025-01-18eCollection Date: 2025-01-01DOI: 10.7759/cureus.77625
Kathryn A Brieck, Zachary J Brieck, John A Ashby, Owen C Phelps, Ibolja Cernak
{"title":"A Narrative Review of the Effects of Internal Jugular Vein Compression on Brain Structure and Function During Periods of Head Impact.","authors":"Kathryn A Brieck, Zachary J Brieck, John A Ashby, Owen C Phelps, Ibolja Cernak","doi":"10.7759/cureus.77625","DOIUrl":"10.7759/cureus.77625","url":null,"abstract":"<p><p>Subconcussive impacts are very common in the sports world and can have many negative impacts on human function, including increased risk for cognitive decline and behavioral impairments such as chronic traumatic encephalopathy (CTE). The purpose of this article is to analyze the available literature on the effects of jugular vein compression applied by a cervical collar on cerebral structure and function in the setting of chronic impact exposure. This narrative review analyzed 17 articles on brain structure and function, published between 1992 and 2022. Our review of the 17 studies shows an overall neuroprotective effect of the external jugular vein compression applied by the cervical collar during insult to the head as compared to groups who did not wear a collar. These findings suggest a potential role of the cervical collar, in addition to helmets, in reducing the incidence of concussion-induced microtraumas and cascading secondary injury mechanisms. Though positive results are consistent throughout the studies, future studies with increased sample sizes are necessary to create precise estimates of the effects of the cervical collar. In addition, the analyzed studies mainly looked at the effects of the cervical collar on football players, soccer players, and Special Weapons and Tactics (SWAT) team members; thus, additional rigorous studies are needed to assess the impact of the cervical collar on other high-risk populations such as military and law-enforcement personnel, among others.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"17 1","pages":"e77625"},"PeriodicalIF":1.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}