CureusPub Date : 2026-04-10eCollection Date: 2026-04-01DOI: 10.7759/cureus.106782
Guillermo Roa Alvarez, Mario Shuchleib Cukiert, Evelyn I Figueroa Saavedra, Maria F Molina Hernandez, Luisa M Guerrero Escudero, Cristina Berumen-Glinz, Maria E Vega Memije
{"title":"Multiple Periocular Eccrine Hidrocystomas Mimicking Malignancy: A Clinicopathologic Diagnostic Challenge.","authors":"Guillermo Roa Alvarez, Mario Shuchleib Cukiert, Evelyn I Figueroa Saavedra, Maria F Molina Hernandez, Luisa M Guerrero Escudero, Cristina Berumen-Glinz, Maria E Vega Memije","doi":"10.7759/cureus.106782","DOIUrl":"https://doi.org/10.7759/cureus.106782","url":null,"abstract":"<p><p>Hidrocystomas are benign cystic tumors of sweat gland origin that may arise from eccrine or apocrine structures and frequently involve the periocular region. Their clinical resemblance to both benign and malignant adnexal lesions represents a diagnostic challenge. We report a case of multiple periocular eccrine hidrocystomas in a man in his 50s presenting with bilateral translucent cystic papules along the eyelid margins. Histopathologic evaluation revealed a well-circumscribed dermal cyst lined by a double layer of cuboidal epithelial cells without decapitation secretion, confirming eccrine differentiation. Given the potential for misdiagnosis as basal cell carcinoma or other adnexal neoplasms, accurate clinicopathologic correlation is essential to prevent unnecessary aggressive interventions. This case highlights distinguishing features, expands the differential diagnosis, and underscores the importance of histopathology in periocular cystic lesions.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"18 4","pages":"e106782"},"PeriodicalIF":1.3,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13081194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Visual Epilepsy Mimicking Migraine Aura Leading to Delayed Diagnosis of an Occipital Cavernoma: A Case Report.","authors":"Manal Touilite, Yasmina Zakaria, Mohamed Chraa, Najib Kissani, Nissrine Louhab","doi":"10.7759/cureus.106768","DOIUrl":"https://doi.org/10.7759/cureus.106768","url":null,"abstract":"<p><p>Cerebral cavernous malformations, also known as cavernomas, are uncommon vascular malformations that may present with seizures, headache, or focal neurologic deficits depending on lesion location. Occipital cavernomas are rare and may manifest with positive visual phenomena, thereby mimicking migraine aura and delaying diagnosis. We report the case of a 54-year-old woman who presented in March 2018 with recurrent brief visual episodes described as flashing lights, colored shapes, scotomas, and distortion of object contours, associated with a persistent headache. She was initially treated for migraine with aura for approximately two years without clinical improvement. Repeated electroencephalography (EEG) later demonstrated rare focal epileptiform discharges in the left temporo-occipital region. Brain magnetic resonance imaging (MRI) revealed a rounded left occipital cortico-subcortical lesion measuring 17 x 16.5 x 16 mm, with imaging features suggestive of a cavernoma and without significant mass effect or perilesional edema. Carbamazepine was gradually titrated to 800 mg/day orally in two divided doses, with complete resolution of visual seizures. No surgical treatment was required, and the patient remained seizure-free during long-term follow-up. This case highlights the diagnostic overlap between visual epilepsy and migraine aura in patients with occipital cavernoma. It also underscores the importance of early MRI and EEG in patients with atypical or treatment-resistant visual symptoms, as timely recognition may permit effective medical management and avoid prolonged diagnostic delay.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"18 4","pages":"e106768"},"PeriodicalIF":1.3,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13067294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CureusPub Date : 2026-04-10eCollection Date: 2026-04-01DOI: 10.7759/cureus.106827
Vikas Chauhan, Andrew Sexton
{"title":"Anesthetic Management of a Patient With Factor XIII Deficiency Undergoing Encephaloduroarteriosynangiosis (EDAS): A Case Report and Literature Review.","authors":"Vikas Chauhan, Andrew Sexton","doi":"10.7759/cureus.106827","DOIUrl":"https://doi.org/10.7759/cureus.106827","url":null,"abstract":"<p><p>Factor XIII (FXIII) deficiency is an extremely rare inherited coagulopathy that poses significant perioperative risks of delayed bleeding despite normal routine coagulation tests. Due to the routine normality of the standard coagulation screening tests in the affected patients, the diagnosis needs a high index of clinical suspicion. The implications for the perioperative environment are especially critical in neurosurgical procedures, in which uncontrolled hemorrhage can lead to either stroke, irreversible neurological damage, or death. We discuss the case of a 48-year-old woman with FXIII deficiency and Moyamoya disease who has undergone left-sided encephaloduroarteriosynangiosis (EDAS) surgery after receiving 40 units/kg of plasma-derived FXIII concentrate (Corifact®). Normotension and normocapnia were ensured intraoperatively, and estimated blood loss was 300 milliliters. The hemoglobin levels were stable. The patient was discharged on day 3 after the surgery without any hemorrhagic incidents. We also surveyed the literature on FXIII deficiency in the perioperative environment that has been published so far, especially on diagnostic methods, replacement, and the findings in the neurosurgical patients. Given the limited literature on FXIII deficiency in the context of EDAS and Moyamoya disease, this report contributes valuable clinical insight and supports the need for individualized, evidence-based perioperative strategies.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"18 4","pages":"e106827"},"PeriodicalIF":1.3,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13081199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CureusPub Date : 2026-04-10eCollection Date: 2026-04-01DOI: 10.7759/cureus.106822
Oscar F Vargas, Juliana Salcedo-Mesa
{"title":"Giant Infrarenal Abdominal Aortic Aneurysm Treated With Elective Endovascular Repair Using an Anaconda Bifurcated Device: A Case Report.","authors":"Oscar F Vargas, Juliana Salcedo-Mesa","doi":"10.7759/cureus.106822","DOIUrl":"https://doi.org/10.7759/cureus.106822","url":null,"abstract":"<p><p>Giant abdominal aortic aneurysms (GAAAs) are extremely uncommon and carry a markedly increased risk of rupture. Their complex anatomy presents significant challenges for surgical management. Endovascular aneurysm repair (EVAR) has emerged as an increasingly utilized alternative in appropriately selected patients with favorable anatomy. We present the case of a 72-year-old male presenting with a non-ruptured, 12.8 cm infrarenal fusiform GAAA, successfully managed with elective EVAR using an Anaconda LoPro90 trimodular bifurcated endograft system (Terumo Aortic, Inchinnan, Scotland). We describe the clinical and radiologic features, technical approach, intraoperative challenges, and 10-month follow-up. EVAR using a bifurcated Anaconda endograft is a feasible and safe option for anatomically suitable GAAA patients, even in the presence of complex features such as angulated necks and iliac involvement. Further studies are warranted to establish long-term durability and optimal management protocols for GAAA.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"18 4","pages":"e106822"},"PeriodicalIF":1.3,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13081221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CureusPub Date : 2026-04-10eCollection Date: 2026-04-01DOI: 10.7759/cureus.106769
Abdullah Bousamri, Mohammad Al-Shehri, Mohammad Mestarihi, Talal B Almutairi, Mateb Alaredhi, Bader Mahanna, Faisal Alharbi
{"title":"Clinical Outcomes of High-Dose Aflibercept 8 mg in Polypoidal Choroidal Vasculopathy: A Systematic Review and Meta-Analysis.","authors":"Abdullah Bousamri, Mohammad Al-Shehri, Mohammad Mestarihi, Talal B Almutairi, Mateb Alaredhi, Bader Mahanna, Faisal Alharbi","doi":"10.7759/cureus.106769","DOIUrl":"https://doi.org/10.7759/cureus.106769","url":null,"abstract":"<p><p>Polypoidal choroidal vasculopathy (PCV) is a distinct subtype of neovascular macular disease with variable responses to anti-vascular endothelial growth factor (anti-VEGF) therapy. This systematic review and meta-analysis evaluated the visual, anatomical, and lesion-regression outcomes of intravitreal aflibercept 8 mg, a formulation developed to extend dosing intervals while maintaining efficacy, in patients with PCV. PubMed, Embase, Scopus, Web of Science, and Google Scholar were searched from inception to March 12, 2026 (PROSPERO: CRD420261339679). Eligible studies enrolled adults with indocyanine green angiography (ICGA)-confirmed PCV treated with aflibercept 8 mg and reported at least one co-primary outcome: change in best-corrected visual acuity (BCVA), central retinal or subfield thickness (CRT/CST), or complete polyp regression. Risk of bias was assessed using the Cochrane Risk of Bias 2 (RoB 2), Risk Of Bias In Non-randomized Studies - of Interventions (ROBINS-I), and Joanna Briggs Institute (JBI) appraisal tools. Complete polyp regression was analyzed using a generalized linear mixed model with a logit link; continuous outcomes were pooled using restricted maximum likelihood estimation with the Hartung-Knapp-Sidik-Jonkman correction. Certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework. Five studies encompassing 362 eyes (245 treated with aflibercept 8 mg) were included. The pooled complete polyp regression rate was 57% (95% confidence interval (CI), 39%-73%; I<sup>2</sup>=55.9%; k=3). The pooled mean CRT/CST change was -157.8 µm (95% CI, -176.9 to -138.7 µm; I<sup>2</sup>=0%; k=2), though the estimate was predominantly driven by a single study contributing 95.5% of the inverse-variance weight. BCVA outcomes were not pooled due to metric incompatibility and clinical heterogeneity; however, individual study results were directionally favorable, with Early Treatment Diabetic Retinopathy Study (ETDRS) gains of +8.4 to +9.5 letters at 48 weeks in the largest contributing study. Extended dosing intervals were maintained in 80.5% (q12) and 86.5% (q16) of treated eyes at 48 weeks. One study reported intraocular inflammation in 10.8% of the overall neovascular age-related macular degeneration (AMD) cohort in that study, a safety signal not observed in the remaining studies. The certainty of evidence was low for CRT/CST change and very low for polyp regression and BCVA. Available evidence suggests that aflibercept 8 mg may produce clinically relevant polyp regression and substantial anatomical improvement in PCV, with a potential reduction in injection frequency. However, given the low to very low certainty of the current evidence base across all co-primary outcomes, definitive efficacy and safety conclusions cannot yet be drawn. Prospective, PCV-specific trials with standardized outcome reporting are needed.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"18 4","pages":"e106769"},"PeriodicalIF":1.3,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13081196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CureusPub Date : 2026-04-09eCollection Date: 2026-04-01DOI: 10.7759/cureus.106719
Noor Albusta, Ahmed Ali, Ali Yusuf, Hussain Alrahma
{"title":"Herbal and Dietary Supplement-Induced Liver Injury Compared With Conventional Drug-Induced Liver Injury: A Retrospective Cohort Study.","authors":"Noor Albusta, Ahmed Ali, Ali Yusuf, Hussain Alrahma","doi":"10.7759/cureus.106719","DOIUrl":"https://doi.org/10.7759/cureus.106719","url":null,"abstract":"<p><strong>Introduction: </strong> Herbal and dietary supplements (HDS) are widely used globally and across the Middle East, yet their hepatotoxic potential remains underrecognized in this region. Comparable Bahrain-specific prevalence data are limited. This study aimed to quantify the proportion of drug-induced liver injury (DILI) attributable to HDS in a Bahraini cohort and to compare the clinical features and outcomes of HDS-related versus conventional medication-related liver injury, with severe liver injury as the primary outcome. We hypothesized that HDS-related DILI would be associated with more severe clinical outcomes than conventional medication-related DILI.</p><p><strong>Methods: </strong> We conducted a retrospective cohort study of adults admitted with suspected DILI to Bahrain Government Hospital in Manama, Bahrain, between January 2018 and December 2024. Cases underwent structured causality assessment using the updated Roussel Uclaf Causality Assessment Method (RUCAM), and patients with RUCAM scores ≥6 for at least one implicated agent were included. Patients were classified into HDS-related or conventional medication-related liver injury groups according to the agent with the highest RUCAM score; cases with equal scores or unresolved competing exposures were excluded. Alternative causes of liver injury, including viral hepatitis and autoimmune liver disease, were excluded through routine clinical evaluation and available laboratory and imaging data. The primary outcome was severe liver injury, defined as coagulopathy, hepatic encephalopathy, or liver transplantation. Multivariable logistic regression was performed to identify independent predictors of severe liver injury.</p><p><strong>Results: </strong> A total of 712 patients met the inclusion criteria, of whom 168 (23.6%) were attributed to HDS and 544 (76.4%) to conventional medications. Patients with HDS-related liver injury were younger (median age 34 vs. 52 years, p = 0.002) and more commonly female (63.2% vs. 41.1%, p < 0.001). Hepatocellular injury was more frequent in the HDS group (68.5% vs. 45.2%, p = 0.02). Severe liver injury occurred in 49/168 (29.2%) of HDS cases versus 79/544 (14.5%) of medication-related cases, corresponding to an absolute risk difference of 14.7% (95% CI 7.2-22.2). On multivariable analysis, HDS exposure remained independently associated with severe liver injury (adjusted OR 2.3, 95% CI 1.1-5.1, p = 0.03). Liver transplantation (7.7% vs. 1.7%, p = 0.08) and mortality (10.7% vs. 4.8%, p = 0.21) were numerically higher in the HDS group, although these differences did not reach statistical significance.</p><p><strong>Conclusions: </strong> In this retrospective Bahraini cohort, HDS accounted for nearly one-quarter of RUCAM-confirmed DILI cases and was associated with a higher likelihood of severe liver injury than conventional medications. These findings support routine, structured inquiry about HDS exposure in patients presenting with liver injur","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"18 4","pages":"e106719"},"PeriodicalIF":1.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13064875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CureusPub Date : 2026-04-09eCollection Date: 2026-04-01DOI: 10.7759/cureus.106704
Mohammed F Alahmadi, Oweida Aldosary, Amer Bugnah, Hamad Alyami
{"title":"Delayed-Onset Autoimmune Hemolytic Anemia in Advanced HIV With Cerebral Toxoplasmosis.","authors":"Mohammed F Alahmadi, Oweida Aldosary, Amer Bugnah, Hamad Alyami","doi":"10.7759/cureus.106704","DOIUrl":"https://doi.org/10.7759/cureus.106704","url":null,"abstract":"<p><p>Autoimmune hemolytic anemia (AIHA) is an uncommon immune-mediated complication of human immunodeficiency virus (HIV) infection and represents a rare cause of anemia in this population. While anemia in HIV is typically multifactorial, AIHA has most often been reported early in the disease course or around the initiation of antiretroviral therapy. Delayed-onset AIHA developing during prolonged hospitalization is rarely described, particularly in patients with advanced immunosuppression. We report a case of delayed-onset warm AIHA occurring more than two months after admission in a patient with newly diagnosed advanced HIV infection complicated by cerebral toxoplasmosis. The patient developed acute hemolysis with laboratory evidence of immune-mediated destruction of erythrocytes after a period of clinical stability. Secondary causes of hemolysis were excluded, and the patient demonstrated a favorable response to corticosteroid therapy without relapse. This case highlights that AIHA may occur late during hospitalization, including during periods of partial immune recovery following antiretroviral therapy. Clinicians should maintain a high index of suspicion for immune-mediated hemolysis in patients with HIV who develop unexplained anemia. Further studies are needed to better understand the mechanisms underlying delayed-onset AIHA and its relationship to immune reconstitution.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"18 4","pages":"e106704"},"PeriodicalIF":1.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13081193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CureusPub Date : 2026-04-09eCollection Date: 2026-04-01DOI: 10.7759/cureus.106706
Zied Masmoudi, Sofiane Masmoudi, Mohamed Ali Khlif, Khaled Zitouna, Hend Riahi, Maher Barsaoui
{"title":"Clinical and Radiographic Factors Associated With Rotator Cuff Tears: A Case-Control Study.","authors":"Zied Masmoudi, Sofiane Masmoudi, Mohamed Ali Khlif, Khaled Zitouna, Hend Riahi, Maher Barsaoui","doi":"10.7759/cureus.106706","DOIUrl":"https://doi.org/10.7759/cureus.106706","url":null,"abstract":"<p><p>Background Rotator cuff tears (RCTs) are considered multifactorial, arising from both intrinsic and extrinsic mechanisms. The objective of this study was to evaluate the association between 12 clinical and radiographic factors, including smoking, alcohol consumption, occupational exposure, dominant side involvement, prior shoulder trauma, dyslipidemia, diabetes, thyroid dysfunction, obesity, arterial hypertension, critical shoulder angle (CSA), and acromial index (AI), with the occurrence of RCTs and to identify which factors independently predict their development. Methodology This retrospective, case-control study included patients with RCTs confirmed intraoperatively and age and sex matched controls with ultrasound-confirmed intact rotator cuffs. Clinical variables were recorded, and radiographic parameters (CSA and AI) were measured on standardized anteroposterior shoulder radiographs. Multivariable logistic regression analysis was performed to identify independent predictors, and receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic performance of radiographic parameters. Results In total, 80 participants were included: 40 cases (50%) and 40 matched controls (50%). RCTs were significantly associated with higher body mass index (BMI) (p = 0.003), dominant side involvement (p = 0.007), high-risk occupation (p = 0.001), higher AI (p = 0.003), and higher CSA (p = 0.005). Dyslipidemia, diabetes, dysthyroidism, arterial hypertension, alcohol consumption, smoking, and a history of shoulder trauma were not significantly associated with RCTs. ROC curve analysis showed CSA had superior predictive performance compared with AI. Multivariable logistic regression showed that CSA, BMI, dominant side involvement, and a high-risk occupation remained significantly and independently associated with the occurrence of an RCT. The AI was not an independent predictor. Conclusions RCTs are associated with both anatomical and clinical factors, particularly CSA, BMI, occupational exposure, and dominant side involvement. Among radiographic parameters, the CSA demonstrated the strongest predictive value. These findings may contribute to improved risk stratification and preventive strategies, particularly regarding weight management and workplace ergonomics, although prospective studies are required to confirm these associations.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"18 4","pages":"e106706"},"PeriodicalIF":1.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13063342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multidetector Computed Tomography Angiography for Preoperative Anatomical and Functional Assessment of Living Renal Donors: Correlation With Surgical Findings and Renal Scintigraphy.","authors":"Surya Kant, Anurag Singh, Poonam Verma, Hira Lal, Sunil Kumar, Narayan Prasad, Prasanta K Pradhan","doi":"10.7759/cureus.106703","DOIUrl":"https://doi.org/10.7759/cureus.106703","url":null,"abstract":"<p><p>Background Living donor renal transplantation is the most common treatment for end-stage renal disease, and correct donor evaluation is mandatory to ensure safety and improve outcomes. Multidetector computed tomography angiography offers high-resolution anatomical assessment and potential functional evaluation within a single imaging session. Aims and objectives The aim and objectives of the study were to analyse multidetector computed tomography accuracy in delineating renal vascular anatomy against surgical findings and compare multidetector computed tomography-derived differential renal function with technetium-99m DTPA (Tc-99m DTPA) scintigraphy. Material and methods Sixty-four living renal donors underwent multidetector computed tomography angiography using a triple-bolus contrast protocol, followed by Tc-99m DTPA renal scintigraphy. Renal arterial and venous anatomy, vascular variants, and collecting system abnormalities were evaluated on multidetector computed tomography. Surgical findings were used as the reference standard for vascular anatomy. Differential renal function calculated from computed tomography was compared with scintigraphy using Pearson correlation and Bland-Altman analysis. Results Multidetector computed tomography angiography correctly identified renal arteries in 98.44% (63/64) of donors and renal veins in 100% (64) of donors. Sensitivity and specificity for arterial variants were 98% and 100%, respectively, and 100% for venous variants. Multidetector computed tomography-derived differential renal function correlated significantly with scintigraphy-derived differential renal function (right kidney: r=0.59, p<0.01; left kidney: r=0.55, p<0.01) with a mean difference of 0.10% and 95% limits of agreement within ±6% for both kidneys. Conclusion Multidetector computed tomography angiography provides the best anatomical detail and shows a moderate agreement with scintigraphy for differential renal function. It is a reliable, comprehensive modality for living donor evaluation in appropriately selected candidates.</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"18 4","pages":"e106703"},"PeriodicalIF":1.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13063200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CureusPub Date : 2026-04-09eCollection Date: 2026-04-01DOI: 10.7759/cureus.c423
Haythum O Tayeb, Yousef Alsawwaf, Abeer A Khoja, Bashaer Batarfi, Abrar Baduwailan, Mawaddah Yousef, Reem Aldaheri, Suhailah E Alaklouk, Sarah A AlOthman, Yara Alqurashi
{"title":"Correction: Determinants of Health-Related Quality of Life of Epilepsy Patients in Jeddah, Saudi Arabia.","authors":"Haythum O Tayeb, Yousef Alsawwaf, Abeer A Khoja, Bashaer Batarfi, Abrar Baduwailan, Mawaddah Yousef, Reem Aldaheri, Suhailah E Alaklouk, Sarah A AlOthman, Yara Alqurashi","doi":"10.7759/cureus.c423","DOIUrl":"https://doi.org/10.7759/cureus.c423","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.7759/cureus.24118.].</p>","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"18 4","pages":"c423"},"PeriodicalIF":1.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}