IF 1

Cureus Pub Date : 2024-12-25 eCollection Date: 2024-12-01 DOI: 10.7759/cureus.76359

Jean-François Catanzariti, Fabien Moretto, Quentin Hanot, Chloé Adam, Gemma Renaud, Anthony Brouillard

{"title":"Benefits of Intensive Rehabilitation Programs Using Physiotherapeutic Scoliosis-Specific Exercises in Adolescent Idiopathic Scoliosis.","authors":"Jean-François Catanzariti, Fabien Moretto, Quentin Hanot, Chloé Adam, Gemma Renaud, Anthony Brouillard","doi":"10.7759/cureus.76359","DOIUrl":"10.7759/cureus.76359","url":null,"abstract":"Purpose Adolescent Idiopathic Scoliosis (AIS) affects 3% of adolescents. Physiotherapeutic Scoliosis Specific Exercises (PSSE) are recommended to limit AIS progression, especially within intensive multidisciplinary programs. Our study evaluated the efficiency of these programs in AIS cases with a high progression risk. Methods We conducted a controlled retrospective observational study using data collected from a multicenter cohort that was prospectively collected. One hundred and forty-three major AIS cases with a high progression risk, treated with a corrective brace, were included and divided into two matched groups. In the PSSE group, 72 adolescents followed an intensive 4-week PSSE rehabilitation program; in the control group, 71 adolescents did not follow this program. Patient files were assessed at V0 (inclusion), V1 (6 to 12 months after V0) and V2 (≥ 6 months after V1). The evaluation criteria were: change in Cobb angle and percentage of patients reaching surgical stage at V2. Results At V1, 54.2% of patients in the PSSE group showed improvement compared to 16.9% in the control group (p < 0.001). In contrast, 38.9% of patients in the PSSE group were stabilized, compared to 53.3% in the control group (p = 0.2). At V2, 34.7% of patients in the PSSE group improved compared to 15.5.% in the control group (p <0.006). At V2, 55.6% of patients in the PSSE group were stabilised versus 40.8% in the control group (p < 0.05). At V2, 8.3% of patients in the PSSE group reached the surgical stage versus 21.1% in the control group (p = 0.005). Conclusion Our study is an additional argument in favor of using PSSE rehabilitation in AIS.","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"16 12","pages":"e76359"},"PeriodicalIF":1.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Silver Nanoparticles and Evaluation of Antimicrobial Activity Using the Aqueous Extract of Pterodon emarginatus Seeds.

IF 1

Cureus Pub Date : 2024-12-25 eCollection Date: 2024-12-01 DOI: 10.7759/cureus.76382

Maria Clara Leal Pereira, Anderson M Pereira da Silva, Léo C Magalhaes, Maria L Magalhaes, Taissa Magalhães, Eryvelton de Souza Franco, Deuzuita Dos Santos Freitas Viana

{"title":"Synthesis of Silver Nanoparticles and Evaluation of Antimicrobial Activity Using the Aqueous Extract of Pterodon emarginatus Seeds.","authors":"Maria Clara Leal Pereira, Anderson M Pereira da Silva, Léo C Magalhaes, Maria L Magalhaes, Taissa Magalhães, Eryvelton de Souza Franco, Deuzuita Dos Santos Freitas Viana","doi":"10.7759/cureus.76382","DOIUrl":"10.7759/cureus.76382","url":null,"abstract":"The decline in research for new antimicrobials, combined with the rise in bacterial resistance, has become a critical issue that is expected to worsen over time. As an alternative, health sciences have integrated materials engineering to develop new bioactive compounds through the interaction of nanoparticles with plant-derived compounds. These compounds offer advantages such as high bioavailability and low cost, exemplified by Pterodon emarginatus, a plant native to the Brazilian Cerrado. This study aimed to synthesize and stabilize silver nanoparticles (AgNPs) using the aqueous extract of Pterodon emarginatus seeds and evaluate their antimicrobial activity against fungal (Candida albicans) and bacterial (Escherichia coli) strains. The synthesis of AgNPs was performed using the aqueous plant extract as a stabilizing agent, with formation confirmed through UV-Vis spectroscopy, showing a characteristic absorbance peak at 400 nm. The resulting AgNPs were then tested for antimicrobial activity. While the aqueous extract of P. emarginatus alone showed no significant antimicrobial activity, the synthesized AgNPs demonstrated remarkable antifungal and antibacterial effects. These results highlight the synergistic interaction between the bactericidal properties of AgNPs and the bioactive compounds present in the plant extract. This approach offers a promising and sustainable alternative for the development of new antimicrobial agents, addressing the urgent need for effective solutions to combat microbial resistance.","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"16 12","pages":"e76382"},"PeriodicalIF":1.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superficial Serrated Adenoma: A Rare Case of Sigmoid Polyp With Malignant Potential.

IF 1

Cureus Pub Date : 2024-12-24 eCollection Date: 2024-12-01 DOI: 10.7759/cureus.76305

Yu-Cong Chen, Yung-Ning Huang, Yang-Bor Lu

{"title":"Superficial Serrated Adenoma: A Rare Case of Sigmoid Polyp With Malignant Potential.","authors":"Yu-Cong Chen, Yung-Ning Huang, Yang-Bor Lu","doi":"10.7759/cureus.76305","DOIUrl":"10.7759/cureus.76305","url":null,"abstract":"We present the case of a 68-year-old woman who underwent complete endoscopic resection of a superficial serrated adenoma (SuSA). Due to its rarity and limited case reports, SuSA is often misdiagnosed as a hyperplastic lesion without malignant potential, leading to missed diagnoses. A polypoid lesion was identified in the sigmoid colon during the initial endoscopic evaluation, where it was initially classified as a sessile serrated lesion (SSL). The subsequent endoscopic evaluation, using crystal violet staining, revealed a type IIIL pit pattern. Endoscopic mucosal resection (EMR) was performed, and histopathological analysis confirmed serrated glandular hyperplasia with mild atypia. Immunohistochemical staining showed cytokeratin 20 (CK20) expression predominantly in the upper layer, while Ki-67 and cellular myelocytomatosis oncogene (c-MYC) were distributed in the basal and intermediate layers. Beta-catenin positivity was observed in the cytoplasm of some nuclei, confirming the diagnosis of SuSA. This case underscores the importance of timely recognition and management of SuSA to prevent progression to more severe conditions.","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"16 12","pages":"e76305"},"PeriodicalIF":1.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors Associated With Lymph Node Metastasis and Recurrence in Surgical Cases of pT1 Colorectal Cancer.

IF 1

Cureus Pub Date : 2024-12-24 eCollection Date: 2024-12-01 DOI: 10.7759/cureus.76333

Ben Sasaki, Masahiro Yamada, Yusuke Mishima, Takahito Ohmine, Masaki Tani, Asahi Sato, Kosuke Toda, Takefumi Yazawa, Hidenori Ohe, Kenya Yamanaka

{"title":"Risk Factors Associated With Lymph Node Metastasis and Recurrence in Surgical Cases of pT1 Colorectal Cancer.","authors":"Ben Sasaki, Masahiro Yamada, Yusuke Mishima, Takahito Ohmine, Masaki Tani, Asahi Sato, Kosuke Toda, Takefumi Yazawa, Hidenori Ohe, Kenya Yamanaka","doi":"10.7759/cureus.76333","DOIUrl":"10.7759/cureus.76333","url":null,"abstract":"Objective This study aims to investigate the risk factors for lymph node metastasis (LNM) and postoperative recurrence in patients undergoing surgery for pT1 colorectal cancer (pT1-CRC). Materials and methods We retrospectively analyzed 150 patients who underwent bowel resection with lymph node dissection for pT1-CRC at our department between September 2011 and December 2021. Univariate and multivariate analyses were performed to examine the effects of sex, depth of tumor invasion, venous invasion, lymphatic invasion, tumor budding (BD), and histological type on LNM and recurrence. We analyzed recurrence-free survival (RFS) curves. Results LNM was observed in 21 (14.0%) patients. Univariate analysis identified female sex, undifferentiated histological type, positive lymphatic invasion, and tumor budding grade 2/3 (BD2/3) as significant risk factors for LNM, whereas multivariate analysis identified female sex, undifferentiated histological type, and BD2/3 as independent risk factors. No cancer-related deaths were observed during the median observation period of 60.7 months. The five-year RFS rate differed significantly between LNM- and LNM+ patients, at 97.3% and 66.4%, respectively (p=0.0005). BD2/3 was also the significant risk factor for recurrence in the univariate analysis (p<0.0001). In LNM- patients, the five-year RFS was 98.7% for BD1 and 88.2% for BD2/3 (p=0.0014), while in LNM+ patients, it was 100% for BD1 and 37.0% for BD2/3 (p=0.036), with significant differences observed. Conclusion In pT1-CRC patients, female sex, undifferentiated histological type, and BD2/3 were the risk factors for LNM. The recurrence rate was higher in patients with LNM than in those without LNM. Regardless of LNM, BD2/3 was the risk factor for the postoperative recurrence of pT1-CRC.","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"16 12","pages":"e76333"},"PeriodicalIF":1.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11682683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the COVID-19 Pandemic on the Implementation and Adoption of a Virtual Fracture Clinic Pathway: A Closed Loop Audit.

IF 1

Cureus Pub Date : 2024-12-24 eCollection Date: 2024-12-01 DOI: 10.7759/cureus.76317

Daire-Sean Gibbons, Aaron A Glynn

{"title":"Impact of the COVID-19 Pandemic on the Implementation and Adoption of a Virtual Fracture Clinic Pathway: A Closed Loop Audit.","authors":"Daire-Sean Gibbons, Aaron A Glynn","doi":"10.7759/cureus.76317","DOIUrl":"10.7759/cureus.76317","url":null,"abstract":"Introduction: Trauma and orthopedics departments have traditionally used face-to-face (FTF) fracture clinics for non-operative fractures. Developed in 2011, the virtual fracture clinic (VFC) was fully implemented at an institution during the COVID-19 pandemic to reduce in-person interactions.Aims: First, the study aims to measure the percentage of non-operative patients triaged through the VFC when this was optional and re-audit after implementing a COVID-19-related policy change mandating VFC triage. Second, the study aims to measure the number of FTF fracture clinic interactions and re-audit after implementing three policies: national COVID-19 lockdowns, mandated VFC triage, and early appropriate discharge.Methods: Data from two periods were examined, pre-pandemic (2018-2020) and pandemic (2020-2022), at a university teaching hospital. We measured compliance with modified British Orthopaedic Association Standards for timely senior review, minimizing outpatient visits, and patient-initiated follow-up.Results: The percentage of cases triaged to the VFC rose from 39% to 100%. FTF fracture clinic interactions dropped by 50.2% from 35,399 to 17,639. All three policy changes reduced FTF numbers: 3.7% due to national lockdowns, 14.7% due to VFC triage, and 35.5% due to early appropriate discharge.Conclusions: The COVID-19 pandemic provided a window in which healthcare working partners were more receptive to change. Our institution successfully used this opportunity to implement policy changes that improved patient care and maximized resources.","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"16 12","pages":"e76317"},"PeriodicalIF":1.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Principles of Fracture Healing and Fixation: A Literature Review.

IF 1

Cureus Pub Date : 2024-12-23 eCollection Date: 2024-12-01 DOI: 10.7759/cureus.76250

Mohammad Waseem Beeharry, Belal Ahmad

{"title":"Principles of Fracture Healing and Fixation: A Literature Review.","authors":"Mohammad Waseem Beeharry, Belal Ahmad","doi":"10.7759/cureus.76250","DOIUrl":"10.7759/cureus.76250","url":null,"abstract":"Bone healing is a complex, dynamic process involving a series of well-coordinated stages, influenced by both mechanical and biological factors. The skeletal system, composed of inorganic (36%), organic (36%), and water (28%) components by volume, plays a crucial role in maintaining structural integrity and mineral homeostasis. Bone is classified into two main types based on microstructure: lamellar and woven bone, with lamellar bone being stronger and more durable. Factors such as inflammation, the periosteum, vascularity, and infection significantly impact healing outcomes. Moreover, fracture fixation is fundamental to optimal healing, guided by principles of anatomical reduction, stable fixation, blood supply preservation, and early mobilisation. Perren's strain theory emphasises the importance of strain at the fracture site, which can determine whether primary or secondary healing occurs. Rigid fixation provides an environment which promotes primary bone healing, while flexible fixation promotes secondary healing through controlled motion. Internal and external fixation methods, including plates, screws, and intramedullary nails, offer varying degrees of stability, supporting bone healing. Overall, optimal fracture fixation, combined with an understanding of bone biology, enhances healing and functional recovery.","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"16 12","pages":"e76250"},"PeriodicalIF":1.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bentall Procedure in a Marfan Syndrome Patient With Reduced Ejection Fraction: A Case Report.

IF 1

Cureus Pub Date : 2024-12-23 eCollection Date: 2024-12-01 DOI: 10.7759/cureus.76238

Ghadeer F Bu Saeed, Manal F Alshammari, Dana S Abalkhail, Yasser A Elghoneimy

引用次数: 0

Recovery From Long COVID: The Role of Bioelectric Meridian Therapy in Restoring Health and Well-Being.

IF 1

Cureus Pub Date : 2024-12-23 eCollection Date: 2024-12-01 DOI: 10.7759/cureus.76279

Praveen Mallari, Tracy Taulier, Mohammad A Kamal

{"title":"Recovery From Long COVID: The Role of Bioelectric Meridian Therapy in Restoring Health and Well-Being.","authors":"Praveen Mallari, Tracy Taulier, Mohammad A Kamal","doi":"10.7759/cureus.76279","DOIUrl":"10.7759/cureus.76279","url":null,"abstract":"This case report explores the journey to a healthier life of a 57-year-old man who stayed athletic after contracting COVID-19 during a trip to a foreign country. He had minimal symptoms in the beginning. He started with a dull cough, but the symptoms then progressed to loss of taste and smell, mental fatigue, and nerve problems. In this case study, traditional cures helped only to some extent. Out of frustration with these symptoms, the patient started bioelectric meridian therapy (BMT) in August 2021 and benefited from it. The patient described progressive sensation, cognition, and muscle power enhancement during six months of BMT sessions. The therapy relieved the muscles' stiffness and regulated the bio-energy circulation to improve the general quality of life and ease physical exertion operations. The case affirms how supportive modalities such as BMT help handle the after-effects of COVID-19. The patients' recovery involved precise mental concentration, return of appetite, and regained vigor, which improved the patient's life. This case report shows how integrative approaches may be helpful when it comes to the reactivation of health processes after virus infection.","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"16 12","pages":"e76279"},"PeriodicalIF":1.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-World Use and Outcomes of Hard-To-Heal Wounds Managed With Porcine Placental Extracellular Matrix.

IF 1

Cureus Pub Date : 2024-12-23 eCollection Date: 2024-12-01 DOI: 10.7759/cureus.76262

Caroline Fife, Ben LeBoutillier, Cristin Taylor, Brad T Marcinek

{"title":"Real-World Use and Outcomes of Hard-To-Heal Wounds Managed With Porcine Placental Extracellular Matrix.","authors":"Caroline Fife, Ben LeBoutillier, Cristin Taylor, Brad T Marcinek","doi":"10.7759/cureus.76262","DOIUrl":"10.7759/cureus.76262","url":null,"abstract":"Real-world data are a highly valuable resource in determining the efficacy of novel products in challenging populations, especially in wound care. This study retrospectively analyzed the real-world performance of porcine placental extracellular matrix (PPECM; InnovaMatrix® AC, Convatec Triad Life Sciences, LLC, Memphis, TN, USA), a novel cellular, acellular, and matrix-like product for the management of hard-to-heal wounds. The US Wound Registry (USWR), which comprises aggregated and structured electronic health records from 502 wound practices, provided a deidentified dataset collected from October 10, 2022 to March 25, 2024, containing 76,278 patients (248,278 wounds). Screening for PPECM usage identified 60 wounds in 41 patients. The median age was 74 (IQR: 66-80) years; 20 (49%) had impaired ambulation, five (12%) autoimmune diseases, and five (12%) peripheral arterial diseases. The most common wounds included 18 (30%) chronic ulcers, 12 (20%) diabetic ulcers, seven (12%) pressure ulcers or injuries, seven (12%) dehisced surgical wounds, and six (10%) venous leg ulcers. Median surface area was 1.50 (IQR: 0.42-4.69) cm²; 31 (52%) of the wounds were limb/life-threatening (L/LT); nine (17%) were present >1 year; 52 (87%) had bioburden/infection. Only two (3%) of the wounds had no necrotic tissue at the initial application. Following PPECM management, 32 (53%) of the wounds closed (of which 14 (44%) were L/LT) and five (8%) had major improvement (three (60%) L/LT). No adverse events were reported. This is the first clinical study of PPECM and demonstrates the real-world safety and efficacy of PPECM in the management of hard-to-heal wounds in a complex population.","PeriodicalId":93960,"journal":{"name":"Cureus","volume":"16 12","pages":"e76262"},"PeriodicalIF":1.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: The Impact of Microbiome Interventions on the Progression and Severity of Inflammatory Bowel Disease: A Systematic Review.

IF 1

Cureus Pub Date : 2024-12-23 eCollection Date: 2024-12-01 DOI: 10.7759/cureus.c205

Malik Kasapoglu, Rajesh Yadavalli, Sarosh Nawaz, Abdulaziz Althwanay, Esraa M AlEdani, Harleen Kaur, Samia Butt

引用次数: 0

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