Cell host & microbe最新文献_第4页

Ecological and dietary strategies to constrain Clostridioides difficile. 限制艰难梭菌的生态和饮食策略。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 DOI: 10.1016/j.chom.2026.05.023

Melinda A Engevik, Aaron L Hecht, Jessica R Allegretti, Purna C Kashyap

{"title":"Ecological and dietary strategies to constrain Clostridioides difficile.","authors":"Melinda A Engevik, Aaron L Hecht, Jessica R Allegretti, Purna C Kashyap","doi":"10.1016/j.chom.2026.05.023","DOIUrl":"10.1016/j.chom.2026.05.023","url":null,"abstract":"Clostridioides difficile exemplifies a pathogen that leverages its metabolic plasticity to exploit nutrients that become available during community disruption, including host and microbiota-derived metabolites and substrates enriched in modern diets. These ecological dynamics underpin the high and growing burden of C. difficile infection (CDI), including recurrent disease and the rising prevalence of community-associated CDI. Fecal microbiota transplantation and standardized stool-derived products consistently re-establish colonization resistance through convergent functions that include secondary bile acid restoration, nutrient niche exclusion, and suppression of opportunistic pathogens. These principles have provided a valuable roadmap for rational consortia design. In this review, we synthesize current ecological mechanisms governing C. difficile colonization, persistence, and recurrence, highlight missing dimensions in diet intervention studies and mucosal colonization by C. difficile, and propose an ecology-informed, artificial intelligence-enabled precision framework that integrates host susceptibility, exposures, diet, community function, and pathogen features to guide personalized prevention and treatment.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":"34 7","pages":"1220-1240"},"PeriodicalIF":18.7,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13353202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148414095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding ripple effects in the gut microbiome. 了解肠道微生物群的连锁反应。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 DOI: 10.1016/j.chom.2026.06.002

Wenlong Zuo, Yang-Yu Liu, Juntao Shen, Lei Dai

引用次数: 0

Following Ariadne's thread through microbiome-based biomarker discovery in CRC. 通过在结直肠癌中发现基于微生物组的生物标志物，遵循阿里阿德涅的思路。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 DOI: 10.1016/j.chom.2026.06.003

Jason Xing Kang, Sunny Hei Wong

引用次数: 0

Adjunctive fecal microbiota transplantation for major depressive disorder: A randomized, double-blind, placebo-controlled trial. 辅助粪便菌群移植治疗重度抑郁症：一项随机、双盲、安慰剂对照试验。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 Epub Date: 2026-06-17 DOI: 10.1016/j.chom.2026.05.017

Jing Li, Yaping Wang, Ruinan Li, Huanwei Huang, Xuequan Zhu, Xiaozheng Li, Zuoli Sun, Ling Zhang, Peng Zheng, Yi He, Jing Liu, Xueshan Zhang, Siyu Ren, Mingxia Liu, Haixia Wang, Yanting Luo, Fei Wang, Jingjing Zhou, Jian Yang, Gang Wang

{"title":"Adjunctive fecal microbiota transplantation for major depressive disorder: A randomized, double-blind, placebo-controlled trial.","authors":"Jing Li, Yaping Wang, Ruinan Li, Huanwei Huang, Xuequan Zhu, Xiaozheng Li, Zuoli Sun, Ling Zhang, Peng Zheng, Yi He, Jing Liu, Xueshan Zhang, Siyu Ren, Mingxia Liu, Haixia Wang, Yanting Luo, Fei Wang, Jingjing Zhou, Jian Yang, Gang Wang","doi":"10.1016/j.chom.2026.05.017","DOIUrl":"10.1016/j.chom.2026.05.017","url":null,"abstract":"Gut microbiota may influence antidepressant treatment outcomes, yet whether targeted modulation can enhance efficacy remains unclear. We conducted a randomized, double-blind, placebo-controlled trial in patients with major depressive disorder, administering a 2-week course of fecal microbiota transplantation (FMT) capsules or placebo as an adjunct to escitalopram (ChiCTR2300071421). Remission rates at week 8 did not differ significantly between groups, but FMT produced greater reductions in Hamilton Depression Rating Scale, 17-item version (HAMD-17) scores at weeks 2 and 8. FMT was well-tolerated with a safety profile comparable to placebo. Multi-omics analyses show durable donor microbial engraftment and enrichment of beneficial Lachnospiraceae and Oscillospiraceae taxa. Microbial remodeling is accompanied by an increase in serum bile acids that correlate with the alleviation of depressive symptoms. Mediation analysis supports a bile-acid-mediated suppression of inflammatory pathways linking microbial changes to antidepressant effects. Overall, FMT may provide a safe avenue to enhance escitalopram efficacy through microbiota-directed regulation of bile-acid metabolism and inflammation.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1367-1382.e7"},"PeriodicalIF":18.7,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148274198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Operationalizing microbiome ecology in cancer care. 微生物组生态学在癌症治疗中的应用。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 DOI: 10.1016/j.chom.2026.05.022

Joao B Xavier

引用次数: 0

Cross-kingdom metabolic interactions govern Candida albicans overgrowth and colitis progression. 跨界代谢相互作用控制白色念珠菌过度生长和结肠炎进展。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 Epub Date: 2026-05-28 DOI: 10.1016/j.chom.2026.04.020

Yilu Zhou, Jinmei Ding, Lijun Ning, Xi Xu, Lingyun Dou, Jing Shen, Baoqin Xuan, Zhenyu Wang, Yi Jiang, Ying Zhao, Yue Zhang, Xiaowen Huang, Muni Hu, Yuqi Shao, Lingxi Li, Changbin Chen, Min Li, Jing-Yuan Fang, Nan Shen, Ning-Ning Liu, Haoyan Chen, Chunquan Sheng, Jie Hong

{"title":"Cross-kingdom metabolic interactions govern Candida albicans overgrowth and colitis progression.","authors":"Yilu Zhou, Jinmei Ding, Lijun Ning, Xi Xu, Lingyun Dou, Jing Shen, Baoqin Xuan, Zhenyu Wang, Yi Jiang, Ying Zhao, Yue Zhang, Xiaowen Huang, Muni Hu, Yuqi Shao, Lingxi Li, Changbin Chen, Min Li, Jing-Yuan Fang, Nan Shen, Ning-Ning Liu, Haoyan Chen, Chunquan Sheng, Jie Hong","doi":"10.1016/j.chom.2026.04.020","DOIUrl":"10.1016/j.chom.2026.04.020","url":null,"abstract":"Inflammatory bowel disease is shaped by complex microbial communities, yet the contribution of fungal-bacterial interactions to disease progression remains poorly defined. Here, we identify Cladosporium tenuissimum (C. tenuissimum) as a gut fungus with potent colitis-alleviating activity. Mechanistically, C. tenuissimum restrains Candida albicans (C. albicans) overgrowth through nutrient competition, particularly via the utilization and subsequent limitation of the amino acid ornithine. C. albicans can evade this suppression and potentiate intestinal inflammation through nutrient escape by preferentially exploiting specific amino acids, such as threonine. We further reveal a bacterial-fungal metabolic axis in which threonine-producing Bacteroides fragilis facilitates C. albicans escape from gut microbiome-mediated fungal control, thereby exacerbating colitis. Notably, dietary threonine restriction markedly attenuates C. albicans-driven colitis in mice. Together, our findings uncover a cross-kingdom metabolic network that determines C. albicans homeostasis and, in turn, governs intestinal inflammatory outcomes, offering new conceptual and therapeutic avenues for IBD.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1445-1461.e7"},"PeriodicalIF":18.7,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148058897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota alters drug metabolism and therapeutic outcomes. 肠道菌群改变药物代谢和治疗结果。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 DOI: 10.1016/j.chom.2026.06.001

Fusheng Guo, Yingjie Bai, Xiaoguang Lei

引用次数: 0

Breaking down barriers to improve phage therapy delivery. 打破障碍，改善噬菌体治疗的递送。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 DOI: 10.1016/j.chom.2026.06.013

Tiffany Luong, Izabela Rybicka, Patrick Blankenberg, Krystyna Dąbrowska, Paul L Bollyky

引用次数: 0

Improving the vaccine efficacy gap with microbial-derived therapies. 改善与微生物源性疗法的疫苗效力差距。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 DOI: 10.1016/j.chom.2026.06.009

Jongchan Kim, Godelieve de Bree, Vanessa Harris

引用次数: 0

Immune activation by a phloem-colonizing plant pathogen drives citrus Huanglongbing disease development. 韧皮部定殖植物病原体的免疫激活驱动柑橘黄龙冰病的发展。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 Epub Date: 2026-05-11 DOI: 10.1016/j.chom.2026.04.011

Xiaoen Huang, Wenxiu Ma, Wenting Wang, Yu Feng, Jinyun Li, Tirtha Lamichhane, Yuanchun Wang, Jin Xu, Sheo Shankar Pandey, Diann S Achor, Javier L Dalmendray, Zhuyuan Hu, Camila Ribeiro, Ning Zhang, Madhurababu Kunta, Allison K Hansen, Nian Wang

{"title":"Immune activation by a phloem-colonizing plant pathogen drives citrus Huanglongbing disease development.","authors":"Xiaoen Huang, Wenxiu Ma, Wenting Wang, Yu Feng, Jinyun Li, Tirtha Lamichhane, Yuanchun Wang, Jin Xu, Sheo Shankar Pandey, Diann S Achor, Javier L Dalmendray, Zhuyuan Hu, Camila Ribeiro, Ning Zhang, Madhurababu Kunta, Allison K Hansen, Nian Wang","doi":"10.1016/j.chom.2026.04.011","DOIUrl":"10.1016/j.chom.2026.04.011","url":null,"abstract":"Citrus Huanglongbing (HLB), caused by Candidatus Liberibacter asiaticus (CLas), was reported to be a pathogen-triggered immune disease. However, genetic evidence and mechanistic understanding for such a disease model are lacking. Here, we showed that mitigation of reactive oxygen species (ROS) accumulation by targeted overexpression of FLAVODOXIN in chloroplasts, but not mutation of respiratory burst oxidase protein D (RBOHD), reduces HLB symptoms. We explored the involvement of phloem callose deposition in HLB via treatment with a callose synthesis inhibitor, gene expression, mutation, and overexpression of CALS7 genes. Using tomato-Ca. L. psyllaurous as a surrogate, we demonstrated that Liberibacter causes immune diseases through the effector-triggered immunity (ETI) pathway mediated by two EDS1 modules (EDS1-NRG1 and EDS1-PAD4-ADR1) but not by NDR1. The eds1a/eds1b or eds1a mutant of citrus showed increased HLB resistance or reduced immune responses compared with the wild type after CLas inoculation. This study provides genetic evidence and mechanistic insights into Ca. Liberibacter-triggered immune-mediated diseases, highlighting parallels between immune dysregulation in humans and plants.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1398-1414.e9"},"PeriodicalIF":18.7,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0