Cell host & microbe最新文献_第3页

Microbiota-derived short-chain fatty acids mediate Candida albicans gastrointestinal colonization resistance. 微生物源性短链脂肪酸介导白色念珠菌胃肠道定植抗性。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 Epub Date: 2026-06-04 DOI: 10.1016/j.chom.2026.05.007

Animesh A Mishra, Suzette N Palmer, Christina M Zarek, Laura A Coughlin, Nicole Poulides, Jana Dakour, Rebecca S Chiu, Parastoo Sabaeifard, Wenling Li, Aidan C Morrill, Jiwoong Kim, Shuheng Gan, Cassie L Behrendt, Monika I Antczak, Xiaowei Zhan, Sebastian E Winter, Joseph M Ready, Lora V Hooper, Andrew Y Koh

{"title":"Microbiota-derived short-chain fatty acids mediate Candida albicans gastrointestinal colonization resistance.","authors":"Animesh A Mishra, Suzette N Palmer, Christina M Zarek, Laura A Coughlin, Nicole Poulides, Jana Dakour, Rebecca S Chiu, Parastoo Sabaeifard, Wenling Li, Aidan C Morrill, Jiwoong Kim, Shuheng Gan, Cassie L Behrendt, Monika I Antczak, Xiaowei Zhan, Sebastian E Winter, Joseph M Ready, Lora V Hooper, Andrew Y Koh","doi":"10.1016/j.chom.2026.05.007","DOIUrl":"10.1016/j.chom.2026.05.007","url":null,"abstract":"The gut microbiota plays critical roles in constraining Candida albicans colonization of the gastrointestinal (GI) tract, which is a key precursor to disseminated fungal infection in immunocompromised hosts. Depletion of commensal microbiota, such as by antibiotic treatment, increases C. albicans burden and promotes dissemination, yet the mechanisms of colonization resistance remain unclear. Here, we show that microbiota-derived short-chain fatty acids (SCFAs) directly inhibit C. albicans growth by inducing fungal metabolic reprogramming, impairing hexose uptake, and inducing intracellular acidification. In vivo, SCFAs enhance Candida colonization resistance only in the presence of an intact gut microbiome, which drives SCFA-induced taxonomic shifts that augment resistance. A Bacteroides thetaiotaomicron mutant unable to produce SCFAs exhibits diminished capacity to restrict C. albicans colonization, while prebiotic therapy that increases luminal SCFAs enhances C. albicans clearance. These findings define a critical microbiota-metabolite mechanism underlying Candida colonization resistance and suggest strategies to modulate GI fungal burden and prevent invasive disease.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1302-1319.e11"},"PeriodicalIF":18.7,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

YprA-family helicases provide the missing link between diverse prokaryotic immune systems. ypra家族解旋酶提供了多种原核免疫系统之间缺失的联系。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 Epub Date: 2026-06-11 DOI: 10.1016/j.chom.2026.05.015

Ryan T Bell, Thomas Gaudin, Yi Wu, Sofya K Garushyants, Harutyun Sahakyan, Kira S Makarova, Yuri I Wolf, Simon A Jackson, Franklin L Nobrega, Chase L Beisel, Eugene V Koonin

{"title":"YprA-family helicases provide the missing link between diverse prokaryotic immune systems.","authors":"Ryan T Bell, Thomas Gaudin, Yi Wu, Sofya K Garushyants, Harutyun Sahakyan, Kira S Makarova, Yuri I Wolf, Simon A Jackson, Franklin L Nobrega, Chase L Beisel, Eugene V Koonin","doi":"10.1016/j.chom.2026.05.015","DOIUrl":"10.1016/j.chom.2026.05.015","url":null,"abstract":"Bacteria and archaea possess an enormous variety of antiviral immune systems that often share homologous proteins and domains. YprA-family helicases are central to widespread defense systems, which include defense island system associated with restriction-modification (DISARM), 7-deazapurine in DNA (Dpd), and Druantia. Through comprehensive phylogenetic and structural analyses of YprA-like helicases, we identify several major clades, which define distinct defense systems including a broad class we call ARMADA (disARM-related antiviral defense array). Apart from the YprA-like helicase, ARMADAs share two more proteins with DISARM, but their YprA homologs are most similar to those of Druantia, which suggests that ARMADA is a missing link connecting DISARM and Druantia. We show experimentally that ARMADA protects bacteria against a broad range of phages via a direct, non-abortive mechanism. We further demonstrate that ARMADA and Druantia Type III systems often co-occur within distinct satellite phage-like mobile elements, which we call SPIDERs (satellite phage integrated defensive and ecotypic replicons) and which provide synergistic resistance against diverse phages.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1430-1444.e3"},"PeriodicalIF":18.7,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare twin cysteine residues in the HIV-1 envelope variable region 1 link to neutralization escape and breadth development. HIV-1包膜可变区1中罕见的双半胱氨酸残基与中和逃逸和宽度发育有关。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 Epub Date: 2026-06-02 DOI: 10.1016/j.chom.2026.05.021

Maria C Hesselman, Marius Zeeb, Peter Rusert, Chloé Pasin, Jennifer Mamrosh, Samuel Kariuki, Ian Pichler, Michèle Sickmann, Masako M Kaufmann, Daniel Schmidt, Nikolas Friedrich, Karin J Metzner, Audrey Rindler, Herbert Kuster, Craig Adams, Ruwayhida Thebus, Michael Huber, Sabine Yerly, Karoline Leuzinger, Matthieu Perreau, Roger Koller, Günter Dollenmaier, Simona Frigerio, Dylan H Westfall, Wenjie Deng, Allan C deCamp, Michal Juraska, Srilatha Edupuganti, Nyaradzo Mgodi, Hugh Murrell, Nigel Garrett, Kshitij Wagh, James I Mullins, Carolyn Williamson, Penny L Moore, Huldrych F Günthard, Roger D Kouyos, Alexandra Trkola

引用次数: 0

Evolution of antifungal drug resistance: Challenges and mitigations. 抗真菌药物耐药性的演变：挑战和缓解措施。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 DOI: 10.1016/j.chom.2026.05.018

Yunjin Lee, Nicole Robbins, Leah E Cowen

引用次数: 0

Cell-to-cell spread primes the nuclear pore for HIV-1. 细胞间的扩散为HIV-1的核孔提供了条件。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 DOI: 10.1016/j.chom.2026.05.028

Francesca Di Nunzio

引用次数: 0

Decoding the microbiome: Insights into FMT for depression. 解读微生物群：FMT治疗抑郁症的见解。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 DOI: 10.1016/j.chom.2026.06.004

Mireia Valles-Colomer, Jane A Foster

引用次数: 0

A repair helicase unravels the tangled web of bacterial immunity. 一种修复解旋酶解开了细菌免疫的纠结网。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 DOI: 10.1016/j.chom.2026.06.010

Oksana Kotovskaya, Artem Isaev

引用次数: 0

Oat-β-glucan potentiates anti-PD-1 efficacy through Faecalibacterium prausnitzii-derived butyrate and indole-3-propionic acid. 燕麦-β-葡聚糖通过prausnitzifaecalibacterium衍生的丁酸盐和吲哚-3-丙酸增强抗pd -1的功效。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 Epub Date: 2026-05-29 DOI: 10.1016/j.chom.2026.05.002

Shuaishuai Yang, Haojie Lu, Min Jin, Wei Pei, Zhen Wang, Jingjing Ni, Yuting Shi, Shuo Zhang, Yiting Li, Caiyu Li, Haoxin Sun, Xing Jia, Haizhi Deng, Hongli Liu, Li Liu

{"title":"Oat-β-glucan potentiates anti-PD-1 efficacy through Faecalibacterium prausnitzii-derived butyrate and indole-3-propionic acid.","authors":"Shuaishuai Yang, Haojie Lu, Min Jin, Wei Pei, Zhen Wang, Jingjing Ni, Yuting Shi, Shuo Zhang, Yiting Li, Caiyu Li, Haoxin Sun, Xing Jia, Haizhi Deng, Hongli Liu, Li Liu","doi":"10.1016/j.chom.2026.05.002","DOIUrl":"10.1016/j.chom.2026.05.002","url":null,"abstract":"The gut microbiota governs immune checkpoint blockade responses, yet actionable strategies remain scarce. Here, we report that oat-β-glucan enhances anti-PD-1 (programmed cell death protein 1) efficacy in murine models by selectively expanding Faecalibacterium prausnitzii (F. prausnitzii). Combining anti-PD-1 with either oat-β-glucan or F. prausnitzii boosts intratumoral dendritic cell and CD8+ T cell infiltration and cytotoxic activation compared with anti-PD-1 monotherapy. Metabolomics identifies F. prausnitzii-derived butyrate and indole-3-propionic acid (IPA) as key mediators. Mechanistically, butyrate activates dendritic cells via the histone deacetylase (HDAC)8/H3K27ac/nuclear factor κB (NF-κB) p65 pathway, while both butyrate and IPA potentiate CD8+ T cell effector responses. In our colorectal cancer cohort undergoing anti-PD-1 treatment, higher baseline F. prausnitzii abundance and elevated plasma butyrate and IPA correlate with improved responses, a signature corroborated in independent external cohorts. A human intervention study confirms oat-β-glucan's safety, its ability to increase butyrate and IPA, and its capacity to modulate F. prausnitzii. Collectively, our work uncovers a microbiota-metabolite-immune axis whereby oat-β-glucan primes tumors for immunotherapy sensitization.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1333-1349.e10"},"PeriodicalIF":18.7,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148058838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering plant-associated microbiome for agriculture. 农业工程植物相关微生物组。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 DOI: 10.1016/j.chom.2026.05.027

Jingying Zhang, Qianhang Zhai, Yang Bai

引用次数: 0

Gut bacteria that produce fatty acid ethanolamides alleviate diarrhea-predominant IBS with insulin resistance. 产生脂肪酸乙醇酰胺的肠道细菌可缓解腹泻为主的肠易激综合征伴胰岛素抵抗。

IF 18.7

Cell host & microbe Pub Date : 2026-07-08 Epub Date: 2026-06-19 DOI: 10.1016/j.chom.2026.05.020

Shujun Xu, Junfang Lyu, Gengyu Bao, Ping Zheng, Yaqi Li, Ziwan Ning, Baohua Li, Min Zhuang, Hoi Ki Wong, Mingchun Wang, Yufei Zeng, Ya Zheng, Jingyuan Luo, Qin Liu, Lu Zhang, Chengyuan Lin, Haitao Xiao, Chun-Su Yuan, Hoi Leong Xavier Wong, Zhaoxiang Bian, Lixiang Zhai

{"title":"Gut bacteria that produce fatty acid ethanolamides alleviate diarrhea-predominant IBS with insulin resistance.","authors":"Shujun Xu, Junfang Lyu, Gengyu Bao, Ping Zheng, Yaqi Li, Ziwan Ning, Baohua Li, Min Zhuang, Hoi Ki Wong, Mingchun Wang, Yufei Zeng, Ya Zheng, Jingyuan Luo, Qin Liu, Lu Zhang, Chengyuan Lin, Haitao Xiao, Chun-Su Yuan, Hoi Leong Xavier Wong, Zhaoxiang Bian, Lixiang Zhai","doi":"10.1016/j.chom.2026.05.020","DOIUrl":"10.1016/j.chom.2026.05.020","url":null,"abstract":"Individuals with diarrhea-predominant irritable bowel syndrome (IBS-D) are at an increased risk of insulin resistance. Here, we identify a critical role for gut-microbe-derived fatty acid ethanolamides (FAEs) in the treatment of IBS-D with insulin resistance. In IBS-D patients with insulin resistance, serum levels of FAE are significantly reduced compared with healthy controls, and lower FAE levels negatively correlate with the severity of GI symptoms. Oral administration of FAE, specifically oleoylethanolamide (OEA), alleviates diarrhea and visceral hypersensitivity in murine IBS-D-like models. Mechanistically, OEA acts as a PPARα agonist to upregulate the serotonin transporter (SERT), limiting peripheral serotonin availability. Furthermore, fecal microbiota transplantation from high-FAE donors or treatment with FAE-producing bacteria (Escherichia coliereT+ or Eubacterium rectale) elevates fecal FAE and alleviates symptoms via the PPARα-SERT axis. Our findings reveal a microbial FAE-driven pathway linking IBS-D and insulin resistance, presenting a therapeutic target for this comorbidity. This study was registered at ClinicalTrials.gov (NCT02822677 and NCT03457324) and Chinese Clinical Trial Registry (ChiCTR2300069830 and ChiCTR2300067254).","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1350-1366.e8"},"PeriodicalIF":18.7,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148285021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0