Cell host & microbe最新文献_第3页

Arming up against Omicron subvariants. 武装起来，对抗 Omicron 子变种。

Cell host & microbe Pub Date : 2024-02-14 DOI: 10.1016/j.chom.2024.01.010

Daniel M Altmann, Rosemary J Boyton

引用次数: 0

Milk to mucus: How B. fragilis colonizes the gut. 从牛奶到粘液脆弱拟杆菌如何在肠道内定植。

Cell host & microbe Pub Date : 2024-02-14 DOI: 10.1016/j.chom.2024.01.007

Matthew R Olm, Noel T Mueller

引用次数: 0

"Indole-gence" for the mind. 心灵的 "吲哚-良药"。

Cell host & microbe Pub Date : 2024-02-14 DOI: 10.1016/j.chom.2024.01.006

Jordi Mayneris-Perxachs, Anna Castells-Nobau, José Manuel Fernández-Real

引用次数: 0

Designing microbial communities to starve out invading pathogens. 设计微生物群落，消灭入侵的病原体。

Cell host & microbe Pub Date : 2024-02-14 DOI: 10.1016/j.chom.2024.01.008

Melissa Ellermann

引用次数: 0

A Gpr35-tuned gut microbe-brain metabolic axis regulates depressive-like behavior. Gpr35调谐的肠道微生物-大脑代谢轴调节抑郁样行为。

Cell host & microbe Pub Date : 2024-02-14 Epub Date: 2024-01-09 DOI: 10.1016/j.chom.2023.12.009

Lingsha Cheng, Haoqian Wu, Xiaoying Cai, Youying Zhang, Siqi Yu, Yuanlong Hou, Zhe Yin, Qingyuan Yan, Qiong Wang, Taipeng Sun, Guangji Wang, Yonggui Yuan, Xueli Zhang, Haiping Hao, Xiao Zheng

{"title":"A Gpr35-tuned gut microbe-brain metabolic axis regulates depressive-like behavior.","authors":"Lingsha Cheng, Haoqian Wu, Xiaoying Cai, Youying Zhang, Siqi Yu, Yuanlong Hou, Zhe Yin, Qingyuan Yan, Qiong Wang, Taipeng Sun, Guangji Wang, Yonggui Yuan, Xueli Zhang, Haiping Hao, Xiao Zheng","doi":"10.1016/j.chom.2023.12.009","DOIUrl":"10.1016/j.chom.2023.12.009","url":null,"abstract":"Gene-environment interactions shape behavior and susceptibility to depression. However, little is known about the signaling pathways integrating genetic and environmental inputs to impact neurobehavioral outcomes. We report that gut G-protein-coupled receptor, Gpr35, engages a microbe-to-brain metabolic pathway to modulate neuronal plasticity and depressive behavior in mice. Psychological stress decreases intestinal epithelial Gpr35, genetic deletion of which induces depressive-like behavior in a microbiome-dependent manner. Gpr35-/- mice and individuals with depression have increased Parabacteroides distasonis, and its colonization to wild-type mice induces depression. Gpr35-/- and Parabacteroides distasonis-colonized mice show reduced indole-3-carboxaldehyde (IAld) and increased indole-3-lactate (ILA), which are produced from opposing branches along the bacterial catabolic pathway of tryptophan. IAld and ILA counteractively modulate neuroplasticity in the nucleus accumbens, a brain region linked to depression. IAld supplementation produces anti-depressant effects in mice with stress or gut epithelial Gpr35 deficiency. Together, these findings elucidate a gut microbe-brain signaling mechanism that underlies susceptibility to depression.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"227-243.e6"},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139418806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism. 口服镁通过调节微生物代谢来预防对乙酰氨基酚引起的急性肝损伤。

Cell host & microbe Pub Date : 2024-01-10 Epub Date: 2023-12-05 DOI: 10.1016/j.chom.2023.11.006

Dongping Li, Yu Chen, Meijuan Wan, Fengyi Mei, Fangzhao Wang, Peng Gu, Xianglong Zhang, Rongjuan Wei, Yunong Zeng, Hanzhao Zheng, Bangguo Chen, Qingquan Xiong, Tao Xue, Tianshan Guan, Jiayin Guo, Yuanxin Tian, Li-Yan Zeng, Zhanguo Liu, Hang Yuan, Ling Yang, Hongbin Liu, Lei Dai, Yao Yu, Yifeng Qiu, Peng Wu, Sanda Win, Tin Aung Than, Riqing Wei, Bernd Schnabl, Neil Kaplowitz, Yong Jiang, Qiang Ma, Peng Chen

{"title":"Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism.","authors":"Dongping Li, Yu Chen, Meijuan Wan, Fengyi Mei, Fangzhao Wang, Peng Gu, Xianglong Zhang, Rongjuan Wei, Yunong Zeng, Hanzhao Zheng, Bangguo Chen, Qingquan Xiong, Tao Xue, Tianshan Guan, Jiayin Guo, Yuanxin Tian, Li-Yan Zeng, Zhanguo Liu, Hang Yuan, Ling Yang, Hongbin Liu, Lei Dai, Yao Yu, Yifeng Qiu, Peng Wu, Sanda Win, Tin Aung Than, Riqing Wei, Bernd Schnabl, Neil Kaplowitz, Yong Jiang, Qiang Ma, Peng Chen","doi":"10.1016/j.chom.2023.11.006","DOIUrl":"10.1016/j.chom.2023.11.006","url":null,"abstract":"Acetaminophen overuse is a common cause of acute liver failure (ALF). During ALF, toxins are metabolized by enzymes such as CYP2E1 and transformed into reactive species, leading to oxidative damage and liver failure. Here, we found that oral magnesium (Mg) alleviated acetaminophen-induced ALF through metabolic changes in gut microbiota that inhibit CYP2E1. The gut microbiota from Mg-supplemented humans prevented acetaminophen-induced ALF in mice. Mg exposure modulated Bifidobacterium metabolism and enriched indole-3-carboxylic acid (I3C) levels. Formate C-acetyltransferase (pflB) was identified as a key Bifidobacterium enzyme involved in I3C generation. Accordingly, a Bifidobacterium pflB knockout showed diminished I3C generation and reduced the beneficial effects of Mg. Conversely, treatment with I3C or an engineered bacteria overexpressing Bifidobacterium pflB protected against ALF. Mechanistically, I3C bound and inactivated CYP2E1, thus suppressing formation of harmful reactive intermediates and diminishing hepatocyte oxidative damage. These findings highlight how interactions between Mg and gut microbiota may help combat ALF.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"48-62.e9"},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138500518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation. 控制阿拉伯糖在肠道微生物群中的利用的一个关键遗传因素可以缓解便秘。

Cell host & microbe Pub Date : 2023-12-13 Epub Date: 2023-11-21 DOI: 10.1016/j.chom.2023.10.011

Chengcheng Zhang, Leilei Yu, Chenchen Ma, Shuaiming Jiang, Yufeng Zhang, Shunhe Wang, Fengwei Tian, Yuzheng Xue, Jianxin Zhao, Hao Zhang, Liming Liu, Wei Chen, Shi Huang, Jiachao Zhang, Qixiao Zhai

{"title":"A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation.","authors":"Chengcheng Zhang, Leilei Yu, Chenchen Ma, Shuaiming Jiang, Yufeng Zhang, Shunhe Wang, Fengwei Tian, Yuzheng Xue, Jianxin Zhao, Hao Zhang, Liming Liu, Wei Chen, Shi Huang, Jiachao Zhang, Qixiao Zhai","doi":"10.1016/j.chom.2023.10.011","DOIUrl":"10.1016/j.chom.2023.10.011","url":null,"abstract":"Impaired gastrointestinal motility is associated with gut dysbiosis. Probiotics, such as Bifidobacteria, can improve this bowel disorder; however, efficacy is strain-dependent. We determine that a genetic factor, the abfA cluster governing arabinan utilization, in Bifidobacterium longum impacts treatment efficacy against functional constipation (FC). In mice with FC, B. longum, but not an abfA mutant, improved gastrointestinal transit time, an affect that was dependent upon dietary arabinan. abfA genes were identified in other commensal bacteria, whose effects in ameliorating murine FC were similarly abfA-dependent. In a double-blind, randomized, placebo-controlled clinical trial, supplementation with abfA-cluster-carrying B. longum, but not an abfA-deficient strain, enriched arabinan-utilization residents, increased beneficial metabolites, and improved FC symptoms. Across human cohorts, abfA-cluster abundance can predict FC, and transplantation of abfA cluster-enriched human microbiota to FC-induced germ-free mice improved gut motility. Collectively, these findings demonstrate a role for microbial abfA cluster in ameliorating FC, establishing principles for genomics-directed probiotic therapies.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1989-2006.e8"},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138296742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Reversible phosphorylation of a lectin-receptor-like kinase controls xylem immunity. 一种凝集素受体样激酶的可逆磷酸化控制木质部免疫。

Cell host & microbe Pub Date : 2023-12-13 Epub Date: 2023-11-16 DOI: 10.1016/j.chom.2023.10.017

Ran Wang, Chenying Li, Zhiyi Jia, Yaxing Su, Yingfei Ai, Qinghong Li, Xijie Guo, Zeng Tao, Fucheng Lin, Yan Liang

{"title":"Reversible phosphorylation of a lectin-receptor-like kinase controls xylem immunity.","authors":"Ran Wang, Chenying Li, Zhiyi Jia, Yaxing Su, Yingfei Ai, Qinghong Li, Xijie Guo, Zeng Tao, Fucheng Lin, Yan Liang","doi":"10.1016/j.chom.2023.10.017","DOIUrl":"10.1016/j.chom.2023.10.017","url":null,"abstract":"Pattern-recognition receptors (PRRs) mediate basal resistance to most phytopathogens. However, plant responses can be cell type specific, and the mechanisms governing xylem immunity remain largely unknown. We show that the lectin-receptor-like kinase LORE contributes to xylem basal resistance in Arabidopsis upon infection with Ralstonia solanacearum, a destructive plant pathogen that colonizes the xylem to cause bacterial wilt. Following R. solanacearum infection, LORE is activated by phosphorylation at residue S761, initiating a phosphorelay that activates reactive oxygen species production and cell wall lignification. To prevent prolonged activation of immune signaling, LORE recruits and phosphorylates type 2C protein phosphatase LOPP, which dephosphorylates LORE and attenuates LORE-mediated xylem immunity to maintain immune homeostasis. A LOPP knockout confers resistance against bacterial wilt disease in Arabidopsis and tomatoes without impacting plant growth. Thus, our study reveals a regulatory mechanism in xylem immunity involving the reversible phosphorylation of receptor-like kinases.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"2051-2066.e7"},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136400795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fiber-deficient diet inhibits colitis through the regulation of the niche and metabolism of a gut pathobiont. 纤维缺乏饮食通过调节肠道病原菌的生态位和代谢来抑制结肠炎。

Cell host & microbe Pub Date : 2023-12-13 Epub Date: 2023-11-14 DOI: 10.1016/j.chom.2023.10.016

Peter Kuffa, Joseph M Pickard, Austin Campbell, Misa Yamashita, Sadie R Schaus, Eric C Martens, Thomas M Schmidt, Naohiro Inohara, Gabriel Núñez, Roberta Caruso

{"title":"Fiber-deficient diet inhibits colitis through the regulation of the niche and metabolism of a gut pathobiont.","authors":"Peter Kuffa, Joseph M Pickard, Austin Campbell, Misa Yamashita, Sadie R Schaus, Eric C Martens, Thomas M Schmidt, Naohiro Inohara, Gabriel Núñez, Roberta Caruso","doi":"10.1016/j.chom.2023.10.016","DOIUrl":"10.1016/j.chom.2023.10.016","url":null,"abstract":"Exclusive enteral nutrition (EEN) with fiber-free diets is an effective steroid-sparing treatment to induce clinical remission in children with Crohn's disease (CD). However, the mechanism underlying the beneficial effects of EEN remains obscure. Using a model of microbiota-dependent colitis with the hallmarks of CD, we find that the administration of a fiber-free diet prevents the development of colitis and inhibits intestinal inflammation in colitic animals. Remarkably, fiber-free diet alters the intestinal localization of Mucispirillum schaedleri, a mucus-dwelling pathobiont, which is required for triggering disease. Mechanistically, the absence of dietary fiber reduces nutrient availability and impairs the dissimilatory nitrate reduction to ammonia (DNRA) metabolic pathway of Mucispirillum, leading to its exclusion from the mucus layer and disease remission. Thus, appropriate localization of the specific pathobiont in the mucus layer is critical for disease development, which is disrupted by fiber exclusion. These results suggest strategies to treat CD by targeting the intestinal niche and metabolism of disease-causing microbes.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"2007-2022.e12"},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10842462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infant gut microbiota contributes to cognitive performance in mice. 婴儿肠道微生物群有助于提高小鼠的认知能力

Cell host & microbe Pub Date : 2023-12-13 Epub Date: 2023-12-04 DOI: 10.1016/j.chom.2023.11.004

Tomás Cerdó, Alicia Ruiz-Rodríguez, Inmaculada Acuña, Francisco José Torres-Espínola, Sergio Menchén-Márquez, Fernando Gámiz, Milagros Gallo, Nico Jehmlich, Sven-Bastiaan Haange, Martin von Bergen, Cristina Campoy, Antonio Suárez

{"title":"Infant gut microbiota contributes to cognitive performance in mice.","authors":"Tomás Cerdó, Alicia Ruiz-Rodríguez, Inmaculada Acuña, Francisco José Torres-Espínola, Sergio Menchén-Márquez, Fernando Gámiz, Milagros Gallo, Nico Jehmlich, Sven-Bastiaan Haange, Martin von Bergen, Cristina Campoy, Antonio Suárez","doi":"10.1016/j.chom.2023.11.004","DOIUrl":"10.1016/j.chom.2023.11.004","url":null,"abstract":"Gut microbiota has been linked to infant neurodevelopment. Here, an association between infant composite cognition and gut microbiota composition is established as soon as 6 months. Higher diversity and evenness characterize microbial communities of infants with composite cognition above (Inf-aboveCC) versus below (Inf-belowCC) median values. Metaproteomic and metabolomic analyses establish an association between microbial histidine ammonia lyase and infant histidine metabolome with cognition. Fecal transplantation from Inf-aboveCC versus Inf-belowCC donors into germ-free mice shows that memory, assessed by a novel object recognition test, is a transmissible trait. Furthermore, Inf-aboveCC mice are enriched in species belonging to Phocaeicola, as well as Bacteroides and Bifidobacterium, previously linked to cognition. Finally, Inf-aboveCC mice show lower fecal histidine and urocanate:histidine and urocanate:glutamate ratios in the perirhinal cortex compared to Inf-belowCC mice. Overall, these findings reveal a causative role of gut microbiota on infant cognition, pointing at the modulation of histidine metabolite levels as a potential underlying mechanism.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1974-1988.e4"},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138489381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0