Cell host & microbe最新文献_第2页

XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against XBB subvariants and JN.1. XBB.1.5 单价 mRNA 疫苗增强剂可激发针对 XBB 亚变体和 JN.1 的强效中和抗体。

Cell host & microbe Pub Date : 2024-03-13 Epub Date: 2024-02-19 DOI: 10.1016/j.chom.2024.01.014

Qian Wang, Yicheng Guo, Anthony Bowen, Ian A Mellis, Riccardo Valdez, Carmen Gherasim, Aubree Gordon, Lihong Liu, David D Ho

{"title":"XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against XBB subvariants and JN.1.","authors":"Qian Wang, Yicheng Guo, Anthony Bowen, Ian A Mellis, Riccardo Valdez, Carmen Gherasim, Aubree Gordon, Lihong Liu, David D Ho","doi":"10.1016/j.chom.2024.01.014","DOIUrl":"10.1016/j.chom.2024.01.014","url":null,"abstract":"COVID-19 vaccines have recently been updated to specifically encode or contain the spike protein of the SARS-CoV-2 XBB.1.5 subvariant, but their immunogenicity in humans has yet to be fully evaluated and reported, particularly against emergent viruses that are rapidly expanding. We now report that administration of an updated monovalent mRNA vaccine booster (XBB.1.5 MV) to previously uninfected individuals boosted serum virus-neutralizing antibodies significantly against not only XBB.1.5 (27.0-fold increase) and EG.5.1 (27.6-fold increase) but also key emerging viruses such as HV.1, HK.3, JD.1.1, and JN.1 (13.3- to 27.4-fold increase). Individuals previously infected by an Omicron subvariant had the highest overall serum neutralizing titers (ID50 1,504-22,978) against all viral variants tested. While immunological imprinting was still evident with the updated vaccines, it was not nearly as severe as observed with the previously authorized bivalent BA.5 vaccine. Our findings strongly support the official recommendation to widely apply the updated COVID-19 vaccines.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"315-321.e3"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139914254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donor-recipient intermicrobial interactions impact transfer of subspecies and fecal microbiota transplantation outcome. 供体-受体微生物间的相互作用影响亚种转移和粪便微生物群移植的结果。

Cell host & microbe Pub Date : 2024-03-13 Epub Date: 2024-02-16 DOI: 10.1016/j.chom.2024.01.013

Qiyi Chen, Chunyan Wu, Jinfeng Xu, Chen Ye, Xiang Chen, Hongliang Tian, Naixin Zong, Shaoyi Zhang, Long Li, Yuan Gao, Di Zhao, Xiaoqiong Lv, Qilin Yang, Le Wang, Jiaqu Cui, Zhiliang Lin, Jubao Lu, Rong Yang, Fang Yin, Nan Qin, Ning Li, Qian Xu, Huanlong Qin

{"title":"Donor-recipient intermicrobial interactions impact transfer of subspecies and fecal microbiota transplantation outcome.","authors":"Qiyi Chen, Chunyan Wu, Jinfeng Xu, Chen Ye, Xiang Chen, Hongliang Tian, Naixin Zong, Shaoyi Zhang, Long Li, Yuan Gao, Di Zhao, Xiaoqiong Lv, Qilin Yang, Le Wang, Jiaqu Cui, Zhiliang Lin, Jubao Lu, Rong Yang, Fang Yin, Nan Qin, Ning Li, Qian Xu, Huanlong Qin","doi":"10.1016/j.chom.2024.01.013","DOIUrl":"10.1016/j.chom.2024.01.013","url":null,"abstract":"Studies on fecal microbiota transplantation (FMT) have reported inconsistent connections between clinical outcomes and donor strain engraftment. Analyses of subspecies-level crosstalk and its influences on lineage transfer in metagenomic FMT datasets have proved challenging, as single-nucleotide polymorphisms (SNPs) are generally not linked and are often absent. Here, we utilized species genome bin (SGB), which employs co-abundance binning, to investigate subspecies-level microbiome dynamics in patients with autism spectrum disorder (ASD) who had gastrointestinal comorbidities and underwent encapsulated FMT (Chinese Clinical Trial: 2100043906). We found that interactions between donor and recipient microbes, which were overwhelmingly phylogenetically divergent, were important for subspecies transfer and positive clinical outcomes. Additionally, a donor-recipient SGB match was indicative of a high likelihood of strain transfer. Importantly, these ecodynamics were shared across FMT datasets encompassing multiple diseases. Collectively, these findings provide detailed insight into specific microbial interactions and dynamics that determine FMT success.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"349-365.e4"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139898375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Invade to evade: E. coli's gutsy survival strategies. 入侵以逃避：大肠杆菌狡猾的生存策略

Cell host & microbe Pub Date : 2024-03-13 DOI: 10.1016/j.chom.2024.02.006

Yuval Mulla, Tobias Bollenbach

引用次数: 0

A new piece of the microbiota pie: Mining 'omics for DNA inversion states. 微生物群的一块新蛋糕：挖掘DNA反转状态的'omics'。

Cell host & microbe Pub Date : 2024-03-13 DOI: 10.1016/j.chom.2024.02.009

Danielle E Campbell, Megan T Baldridge

引用次数: 0

A tough act to swallow: Streptococcusanginosus and gastric cancer. 难以下咽链球菌与胃癌

Cell host & microbe Pub Date : 2024-03-13 DOI: 10.1016/j.chom.2024.02.004

Sunny Wong, Patrick Tan

引用次数: 0

Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota. 炎症和噬菌体影响 DNA 反转状态和肠道微生物群的功能。

Cell host & microbe Pub Date : 2024-03-13 Epub Date: 2024-02-28 DOI: 10.1016/j.chom.2024.02.003

Shaqed Carasso, Rawan Zaatry, Haitham Hajjo, Dana Kadosh-Kariti, Nadav Ben-Assa, Rawi Naddaf, Noa Mandelbaum, Sigal Pressman, Yehuda Chowers, Tal Gefen, Kate L Jeffrey, Juan Jofre, Michael J Coyne, Laurie E Comstock, Itai Sharon, Naama Geva-Zatorsky

{"title":"Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota.","authors":"Shaqed Carasso, Rawan Zaatry, Haitham Hajjo, Dana Kadosh-Kariti, Nadav Ben-Assa, Rawi Naddaf, Noa Mandelbaum, Sigal Pressman, Yehuda Chowers, Tal Gefen, Kate L Jeffrey, Juan Jofre, Michael J Coyne, Laurie E Comstock, Itai Sharon, Naama Geva-Zatorsky","doi":"10.1016/j.chom.2024.02.003","DOIUrl":"10.1016/j.chom.2024.02.003","url":null,"abstract":"Reversible genomic DNA inversions control the expression of numerous gut bacterial molecules, but how this impacts disease remains uncertain. By analyzing metagenomic samples from inflammatory bowel disease (IBD) cohorts, we identified multiple invertible regions where a particular orientation correlated with disease. These include the promoter of polysaccharide A (PSA) of Bacteroides fragilis, which induces regulatory T cells (Tregs) and ameliorates experimental colitis. The PSA promoter was mostly oriented \"OFF\" in IBD patients, which correlated with increased B. fragilis-associated bacteriophages. Similarly, in mice colonized with a healthy human microbiota and B. fragilis, induction of colitis caused a decline of PSA in the \"ON\" orientation that reversed as inflammation resolved. Monocolonization of mice with B. fragilis revealed that bacteriophage infection increased the frequency of PSA in the \"OFF\" orientation, causing reduced PSA expression and decreased Treg cells. Altogether, we reveal dynamic bacterial phase variations driven by bacteriophages and host inflammation, signifying bacterial functional plasticity during disease.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"322-334.e9"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10939037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbe guides alveolar macrophages to fight flu. 肠道微生物引导肺泡巨噬细胞对抗流感

Cell host & microbe Pub Date : 2024-03-13 DOI: 10.1016/j.chom.2024.02.007

Tao Wang, Yanling Wang, Yushi Yao

引用次数: 0

Susceptible bacteria can survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance. 易感细菌 "可以 "在哺乳动物胃肠道中经受抗生素治疗而不产生抗药性。

Cell host & microbe Pub Date : 2024-03-13 Epub Date: 2024-02-14 DOI: 10.1016/j.chom.2024.01.012

Marinelle Rodrigues, Parastoo Sabaeifard, Muhammed Sadik Yildiz, Adam Lyon, Laura Coughlin, Sara Ahmed, Nicole Poulides, Ahmet C Toprak, Cassie Behrendt, Xiaoyu Wang, Marguerite Monogue, Jiwoong Kim, Shuheng Gan, Xiaowei Zhan, Laura Filkins, Noelle S Williams, Lora V Hooper, Andrew Y Koh, Erdal Toprak

{"title":"Susceptible bacteria can survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance.","authors":"Marinelle Rodrigues, Parastoo Sabaeifard, Muhammed Sadik Yildiz, Adam Lyon, Laura Coughlin, Sara Ahmed, Nicole Poulides, Ahmet C Toprak, Cassie Behrendt, Xiaoyu Wang, Marguerite Monogue, Jiwoong Kim, Shuheng Gan, Xiaowei Zhan, Laura Filkins, Noelle S Williams, Lora V Hooper, Andrew Y Koh, Erdal Toprak","doi":"10.1016/j.chom.2024.01.012","DOIUrl":"10.1016/j.chom.2024.01.012","url":null,"abstract":"Antibiotic resistance and evasion are incompletely understood and complicated by the fact that murine interval dosing models do not fully recapitulate antibiotic pharmacokinetics in humans. To better understand how gastrointestinal bacteria respond to antibiotics, we colonized germ-free mice with a pan-susceptible genetically barcoded Escherichia coli clinical isolate and administered the antibiotic cefepime via programmable subcutaneous pumps, allowing closer emulation of human parenteral antibiotic dynamics. E. coli was only recovered from intestinal tissue, where cefepime concentrations were still inhibitory. Strikingly, \"some\" E. coli isolates were not cefepime resistant but acquired mutations in genes involved in polysaccharide capsular synthesis increasing their invasion and survival within human intestinal cells. Deleting wbaP involved in capsular polysaccharide synthesis mimicked this phenotype, allowing increased invasion of colonocytes where cefepime concentrations were reduced. Additionally, \"some\" mutant strains exhibited a persister phenotype upon further cefepime exposure. This work uncovers a mechanism allowing \"select\" gastrointestinal bacteria to evade antibiotic treatment.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"396-410.e6"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10942764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin microbe-dependent TSLP-ILC2 priming axis in early life is co-opted in allergic inflammation. 生命早期依赖皮肤微生物的 TSLP-ILC2 启动轴在过敏性炎症中被共同利用。

Cell host & microbe Pub Date : 2024-02-14 Epub Date: 2024-01-09 DOI: 10.1016/j.chom.2023.12.006

Jimin Cha, Tae-Gyun Kim, Euihyun Bhae, Ho-Jin Gwak, Yeajin Ju, Young Ho Choe, In-Hwan Jang, Youngae Jung, Sungmin Moon, Taehyun Kim, Wuseong Lee, Jung Sun Park, Youn Wook Chung, Siyoung Yang, Yong-Kook Kang, Young-Min Hyun, Geum-Sook Hwang, Won-Jae Lee, Mina Rho, Ji-Hwan Ryu

{"title":"Skin microbe-dependent TSLP-ILC2 priming axis in early life is co-opted in allergic inflammation.","authors":"Jimin Cha, Tae-Gyun Kim, Euihyun Bhae, Ho-Jin Gwak, Yeajin Ju, Young Ho Choe, In-Hwan Jang, Youngae Jung, Sungmin Moon, Taehyun Kim, Wuseong Lee, Jung Sun Park, Youn Wook Chung, Siyoung Yang, Yong-Kook Kang, Young-Min Hyun, Geum-Sook Hwang, Won-Jae Lee, Mina Rho, Ji-Hwan Ryu","doi":"10.1016/j.chom.2023.12.006","DOIUrl":"10.1016/j.chom.2023.12.006","url":null,"abstract":"Although early life colonization of commensal microbes contributes to long-lasting immune imprinting in host tissues, little is known regarding the pathophysiological consequences of postnatal microbial tuning of cutaneous immunity. Here, we show that postnatal exposure to specific skin commensal Staphylococcus lentus (S. lentus) promotes the extent of atopic dermatitis (AD)-like inflammation in adults through priming of group 2 innate lymphoid cells (ILC2s). Early postnatal skin is dynamically populated by discrete subset of primed ILC2s driven by microbiota-dependent induction of thymic stromal lymphopoietin (TSLP) in keratinocytes. Specifically, the indole-3-aldehyde-producing tryptophan metabolic pathway, shared across Staphylococcus species, is involved in TSLP-mediated ILC2 priming. Furthermore, we demonstrate a critical contribution of the early postnatal S. lentus-TSLP-ILC2 priming axis in facilitating AD-like inflammation that is not replicated by later microbial exposure. Thus, our findings highlight the fundamental role of time-dependent neonatal microbial-skin crosstalk in shaping the threshold of innate type 2 immunity co-opted in adulthood.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"244-260.e11"},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139418807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pathway linking atopic dermatitis to skin microbes. 特应性皮炎与皮肤微生物的联系途径。

Cell host & microbe Pub Date : 2024-02-14 DOI: 10.1016/j.chom.2024.01.009

Jinfang Zhu

引用次数: 0