Cell host & microbePub Date : 2026-08-12Epub Date: 2026-06-23DOI: 10.1016/j.chom.2026.05.029
Christine M Tin, Bianca Cordazzo Vargas, Darryl A Abbott, Aditi R Lohar, Tiffany C Taylor, Ivan A Valishev, Sarah N Weinshel, Vung Lian, Kacey J Sullinger, Matthew Butoryak, Michael A Silverman, Liat Shenhav, William H DePas, Timothy W Hand
{"title":"Single-cell detection and quantification of the microbiota by MicFLY.","authors":"Christine M Tin, Bianca Cordazzo Vargas, Darryl A Abbott, Aditi R Lohar, Tiffany C Taylor, Ivan A Valishev, Sarah N Weinshel, Vung Lian, Kacey J Sullinger, Matthew Butoryak, Michael A Silverman, Liat Shenhav, William H DePas, Timothy W Hand","doi":"10.1016/j.chom.2026.05.029","DOIUrl":"10.1016/j.chom.2026.05.029","url":null,"abstract":"<p><p>The intestinal microbiota regulates multiple host functions, including digestion and immune development. Our knowledge of the microbiota has been shaped by available technology, which primarily measures relative abundance. Quantitative, single-cell bacterial measurements would improve our understanding of microbiome biology, including the dynamics behind shifts in microbiota composition. We present microbiota flow cytometry (MicFLY), a single-cell technology that quantifies absolute bacterial abundance with species-level resolution. Using MicFLY, we can identify the major intestinal taxa, discriminate live from dead bacteria, measure heterogeneous mRNA expression, and concurrently quantify immunoglobulin A (IgA) and IgG binding to intestinal bacteria. Using longitudinal, quantitative microbiota analyses on a small cohort of preterm infants, we find that increases in IgA- and IgG-unbound bacteria from various Enterobacteriaceae species associate with the development of necrotizing enterocolitis (NEC). MicFLY single-cell technology thus enables fine-scale quantitative microbiota measurements for a deeper mechanistic understanding of compositional changes.</p>","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1663-1679.e10"},"PeriodicalIF":18.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13361012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hadal topography incubates hidden microbial hotspots in the deepest ocean.","authors":"Weishu Zhao, Jing Wang, Chuanxu Chen, Aijun Jiang, Yinzhao Wang, Aoran Hu, Qi Qi, Yunru Chen, Weikang Sui, Liang Dong, Yao Zhang, Xiang Xiao","doi":"10.1016/j.chom.2026.06.015","DOIUrl":"10.1016/j.chom.2026.06.015","url":null,"abstract":"<p><p>Plate subduction creates unique topographic features in hadal trenches, yet their influence on microbial ecosystems and the global ocean remains unclear. Here, we conducted a topography-targeted investigation across 6-11 km of water depth within the Mariana Trench, integrating metagenomic, metaproteomic, and geochemical analyses. Coupled with high-resolution topographic mapping, our analyses reveal topography as an overlooked determinant of hadal geochemical and microbial heterogeneity. Convex areas exhibit classical sediment-depth-decay patterns with sparse, cooperative microbial communities. Conversely, concave features maintain higher biomass and activity as well as dense microbial interactions. Critically, slope concave sites incubate previously unrecognized microbial hotspots and may serve as interchange hubs, potentially facilitating genetic exchange and upward dispersal of microorganisms from Earth's deepest regions to the broader ocean. Our findings demonstrate that topographic features, rather than water depth, significantly correlate with organic carbon influx and its microbial turnover rates, enabling predictive modeling of hadal carbon cycling with global implications.</p>","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1523-1539.e7"},"PeriodicalIF":18.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148537804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Uric acid promotes dietary lipid absorption through microbiome and metabolomic remodeling via a liver-gut endocrine axis.","authors":"Cheng Tian, Xiaozhen Guo, Dongmei Wang, Qiubing Chen, Haokun Shen, Xin Li, Chenyu Liu, Yunfei Qi, Yanhao Chen, Linwei Wang, Yangyang Wang, Yutang Cao, Yan Liu, Hao Yin, Yan Chen, Xiaosong Gu, Chunping Jiang, Liming Tang, Cen Xie, Qiurong Ding","doi":"10.1016/j.chom.2026.05.005","DOIUrl":"10.1016/j.chom.2026.05.005","url":null,"abstract":"<p><p>Hyperuricemia closely correlates with obesity, yet high uric acid (UA) is largely viewed as a consequence or biomarker of obesity rather than a causal driver. Integrating human clinical analyses with animal studies, we redefine UA as a liver-derived endocrine regulator that drives obesity by modulating gut ecology. UA remodels the gut microbiota, selectively depleting Lactobacillus johnsonii by disrupting peptidoglycan synthesis. This depletion reduces microbial phenyllactic acid (PLA)-a metabolite produced by L. johnsonii lactate dehydrogenase that we identify as an endogenous suppressor of intestinal peroxisome proliferator-activated receptor alpha (PPARα) signaling. Consequently, PPARα disinhibition upregulates fatty acid transporters, accelerating lipid absorption and promoting obesity. Leveraging human genetic data, we pinpoint lysine acetyltransferase 5 (TIP60) as a master regulator of hepatic UA production. Hepatic TIP60 ablation lowers UA, restoring the L. johnsonii-PLA axis and conferring obesity resistance. These findings establish a UA-driven liver-gut axis and nominate TIP60 inhibition as a dual-target therapy for obesity and hyperuricemia.</p>","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1646-1662.e11"},"PeriodicalIF":18.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell host & microbePub Date : 2026-08-12Epub Date: 2026-06-19DOI: 10.1016/j.chom.2026.05.024
Erin Huiting, Esther Shmidov, Bruce Wang, Sriharshita Musunuri, Zemer Gitai, Joseph Bondy-Denomy
{"title":"CBASS limits bacteriophage production while maintaining cell viability in Pseudomonas aeruginosa.","authors":"Erin Huiting, Esther Shmidov, Bruce Wang, Sriharshita Musunuri, Zemer Gitai, Joseph Bondy-Denomy","doi":"10.1016/j.chom.2026.05.024","DOIUrl":"10.1016/j.chom.2026.05.024","url":null,"abstract":"<p><p>Cyclic-oligonucleotide-based anti-phage signaling system (CBASS) is an immune pathway that recognizes phage infection and generates cyclic nucleotide signals, which activate effectors to limit phage replication. Membrane-acting effectors are proposed to induce cell death; however, this mechanism has not been assessed at endogenous effector expression levels. Here, we examine cell viability outcomes of the CBASS phospholipase effector (CapV) upon activation with 3',3'-cGAMP in Pseudomonas aeruginosa. Surprisingly, exogenous 3',3'-cGAMP or constitutive 3',3'-cGAMP signaling from the synthase (CdnA) enables robust cell growth and viability while abolishing phage production. Constitutive activation of the CapV effector induces no cell fitness cost and selectively blocks many phages. During CBASS activation, phage transcription and initial DNA replication proceed normally, but phages do not reach maximum DNA levels and exhibit impaired DNA packaging. We propose that CapV disrupts capsid assembly at the inner membrane, preventing stable phage DNA packaging, thereby allowing effective CBASS anti-viral activity while preserving host viability.</p>","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1603-1613.e6"},"PeriodicalIF":18.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148285043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell host & microbePub Date : 2026-08-12Epub Date: 2026-06-10DOI: 10.1016/j.chom.2026.05.016
Dominic Eriksson, Jonas Schiller, Alexandre Schickele, Taylor Priest, Anna Mankowski, Enzo Faucher, Lucas J Ustick, Michael Kuhn, Samuel Miravet-Verde, Hans-Joachim Ruscheweyh, Corentin Clerc, Nicolas Gruber, Shinichi Sunagawa, Peer Bork, Meike Vogt
{"title":"Variations in the latitudinal diversity gradients of the ocean microbiome.","authors":"Dominic Eriksson, Jonas Schiller, Alexandre Schickele, Taylor Priest, Anna Mankowski, Enzo Faucher, Lucas J Ustick, Michael Kuhn, Samuel Miravet-Verde, Hans-Joachim Ruscheweyh, Corentin Clerc, Nicolas Gruber, Shinichi Sunagawa, Peer Bork, Meike Vogt","doi":"10.1016/j.chom.2026.05.016","DOIUrl":"10.1016/j.chom.2026.05.016","url":null,"abstract":"<p><p>Latitudinal diversity gradients (LDGs), which typically decline from the equator to the poles, are a pervasive macroecological pattern. However, their generality and drivers in the ocean microbiome remain widely unresolved. We integrated global-scale metagenomic data with habitat modeling to study marine microbial LDGs across seasons and depths. Surface mixed-layer microbiomes exhibit diversity peaks at (sub)tropical latitudes and a poleward decline, whereas mesopelagic communities (200-1,000 m) show no latitudinal diversity structuring. Taxonomic resolution reveals that the mixed-layer LDG is underpinned by Alphaproteobacteria and Cyanobacteriia, while other taxa exhibit distinct or contrasting LDGs. Diversity structuring also varies by seasons and regions and is governed by temperature and nutrient availability. Together, these findings highlight that, within the ocean microbiome, LDGs are not universal but reflect lineage-specific ecological strategies and responses to environmental gradients. Our study provides fundamental insights into the structuring of ocean microbiome diversity and lays the foundation for predicting responses to environmental change.</p>","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1560-1574.e5"},"PeriodicalIF":18.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell host & microbePub Date : 2026-08-12Epub Date: 2026-07-22DOI: 10.1016/j.chom.2026.06.019
Andrew T Nishimoto, Juan C Ortiz-Marquez, Michelle R Scribner, Yanying Yu, Qidong Jia, Haley Echlin, Amy R Iverson, Abigail E McKnight, Nadia Olivero, Aaron Poole, Enolia Marr, Jordan Coggins, Adam Rosenthal, Chrispin Chaguza, Randolph K Larsen, Mark E Hatley, Ralph R Isberg, Vaughn S Cooper, Tim van Opijnen, Jason W Rosch
{"title":"RNA quality control enables antibiotic tolerance.","authors":"Andrew T Nishimoto, Juan C Ortiz-Marquez, Michelle R Scribner, Yanying Yu, Qidong Jia, Haley Echlin, Amy R Iverson, Abigail E McKnight, Nadia Olivero, Aaron Poole, Enolia Marr, Jordan Coggins, Adam Rosenthal, Chrispin Chaguza, Randolph K Larsen, Mark E Hatley, Ralph R Isberg, Vaughn S Cooper, Tim van Opijnen, Jason W Rosch","doi":"10.1016/j.chom.2026.06.019","DOIUrl":"10.1016/j.chom.2026.06.019","url":null,"abstract":"<p><p>Antibiotic resistance poses significant challenges, yet pathogen adaptation pathways vary. To determine how host environments affect adaptation, we experimentally evolved Streptococcus pneumoniae in mice subjected to antibiotics in the context of distinct immune states. High fitness costs of canonical resistance restrict its emergence. Instead, populations adopt context-specific adaptive strategies. While neutrophil-replete environments select for immune-evasive mutations in nicotinamidase, general antibiotic stress drives convergent mutations in rny, encoding the RNA degradosome scaffold RNase Y. In contrast, antibiotic-induced death in wild-type bacteria is driven by transcriptional collapse; rny mutants avert this fate via a bet-hedging strategy, in which a resilient minority maintains a near-baseline transcriptional profile while a majority undergoes selective RNA degradation to preserve transcript fidelity. Upon stress removal, these populations execute a prioritized transcriptional ribosomal reboot, facilitating recovery. Thus, RNA turnover is a tunable master regulator of stress tolerance that pathogens exploit to survive the combined pressures of antibiotics and immunity.</p>","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1614-1629.e8"},"PeriodicalIF":18.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell host & microbePub Date : 2026-08-12Epub Date: 2026-07-20DOI: 10.1016/j.chom.2026.06.017
Helena Shomar, Marie Guillaume, Florian Tesson, Valentin Conte, Le Zhang, Chao Du, Véronique Ongenae, Arthur Loubat, Margot Le Bot, Héloïse Georjon, Ernest Mordret, Daniel Rozen, Ariane Briegel, Vincent Libis, Dennis Claessen, Yanyan Li, Gilles P van Wezel, Aude Bernheim
{"title":"A family of lanthipeptides with anti-phage function.","authors":"Helena Shomar, Marie Guillaume, Florian Tesson, Valentin Conte, Le Zhang, Chao Du, Véronique Ongenae, Arthur Loubat, Margot Le Bot, Héloïse Georjon, Ernest Mordret, Daniel Rozen, Ariane Briegel, Vincent Libis, Dennis Claessen, Yanyan Li, Gilles P van Wezel, Aude Bernheim","doi":"10.1016/j.chom.2026.06.017","DOIUrl":"10.1016/j.chom.2026.06.017","url":null,"abstract":"<p><p>Bacteria produce natural products to adapt to their environments, with phage interactions as major ecological and evolutionary drivers. While some natural products protect bacteria from phages, the prevalence and diversity of chemical anti-phage defenses remain largely unexplored. Here, we identify a widespread family of lanthipeptide biosynthetic gene clusters (BGCs) in Actinobacteria, which we term lanthivirin BGCs, that confer anti-phage activity. Lanthivirin BGCs often colocalize with other defense systems in genomic defense islands. We demonstrate anti-phage activity both in a native Streptomyces context and through heterologous expression of six distinct lanthivirin systems. Mutational analyses of the biosynthetic machinery and core peptide show that lanthivirin maturation is required for anti-phage activity. Genetic and biochemical analyses during infection support a phage-protein-dependent inhibition of phage DNA replication, with no host toxicity. Our findings highlight the untapped potential of BGCs as sources of anti-phage natural products, offering a new avenue for discovering antiviral compounds.</p>","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1591-1602.e9"},"PeriodicalIF":18.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148537789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell host & microbePub Date : 2026-08-12Epub Date: 2026-06-17DOI: 10.1016/j.chom.2026.05.019
Tarun Srinivasan, Chaitanya Dende, Kelly A Ruhn, Stefanie L Moye, Ann Johnson, Cassie L Behrendt, Brian Hassell, Gonçalo Vale, Jiwoong Kim, Jake N Lichterman, Chaoying Liang, Carlos Arana, Prithvi Raj, Xiaowei Zhan, Jeffrey G McDonald, Andrew Y Koh, Lora V Hooper
{"title":"The gut microbiota directs vitamin A flux to regulate intestinal T cell development.","authors":"Tarun Srinivasan, Chaitanya Dende, Kelly A Ruhn, Stefanie L Moye, Ann Johnson, Cassie L Behrendt, Brian Hassell, Gonçalo Vale, Jiwoong Kim, Jake N Lichterman, Chaoying Liang, Carlos Arana, Prithvi Raj, Xiaowei Zhan, Jeffrey G McDonald, Andrew Y Koh, Lora V Hooper","doi":"10.1016/j.chom.2026.05.019","DOIUrl":"10.1016/j.chom.2026.05.019","url":null,"abstract":"<p><p>The intestinal microbiota shapes adaptive immunity, but the mechanisms remain incompletely defined. Here, we show that the microbiota initiates movement of retinoids-dietary vitamin A derivatives including retinol and retinoic acid-through a sequential pathway from epithelial cells to myeloid cells and ultimately to T cells in the mesenteric lymph nodes (mLNs). This cellular axis is traversed over three days. Microbe-associated molecular patterns initiate retinoid flux by inducing expression of serum amyloid A proteins. These epithelial retinol-binding proteins are necessary and sufficient for epithelial-to-myeloid retinoid transfer and myeloid cell migration to the mLNs. In the mLNs, microbial antigen drives retinoid transfer from myeloid cells to developing T cells, culminating in T cell retinoid uptake and transcriptional programming. This pathway is activated during postnatal development, when gut adaptive immunity is established. These findings reveal that the microbiota programs intestinal adaptive immunity by regulating immune cell access to a nutrient-derived developmental signal.</p>","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1630-1645.e9"},"PeriodicalIF":18.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13371082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148274186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Feeding microbial allies to fight cancer.","authors":"Lan Zhang, Xianbin Tian, Meng Wu","doi":"10.1016/j.chom.2026.06.008","DOIUrl":"https://doi.org/10.1016/j.chom.2026.06.008","url":null,"abstract":"<p><p>In a recent Immunity paper, Lobel and colleagues integrate cross-cohort human microbiome meta-analyses with mechanistic studies in mice to uncover a dietary sulfur amino acid-microbiota-immune axis that enhances anti-tumor immunity. Sulfur amino acids expand the mucus-associated bacterium Mucispirillum schaedleri and trigger an NKT-cDC1 immune circuit.</p>","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":"34 7","pages":"1386-1388"},"PeriodicalIF":18.7,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148414230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paromita Sen, David Kaulmann, Ilan Youngster, Suhaib K Abdeen, Eran Elinav
{"title":"Advances and challenges in microbiome transplantation.","authors":"Paromita Sen, David Kaulmann, Ilan Youngster, Suhaib K Abdeen, Eran Elinav","doi":"10.1016/j.chom.2026.06.006","DOIUrl":"https://doi.org/10.1016/j.chom.2026.06.006","url":null,"abstract":"<p><p>Over the past two decades, the microbiome has emerged as a central modifier of host health, whose manipulation may prevent or treat disease. Fecal microbiome transplantation (FMT) transfers stool from healthy donors to recipients to restore microbial structure and function. It is universally accepted as therapy for recurrent Clostridioides difficile infection (rCDI) and is studied across metabolic, neurological, oncological, and autoimmune disorders. However, challenges remain, including donor selection, possible transmission of infectious or non-communicable risks, and limited understanding of mechanisms driving benefits. This review summarizes FMT designs, mechanisms, indications, and obstacles. It discusses emerging strategies such as the use of microbial consortia and extra-intestinal microbiome transplantation and suggests that a better understanding of FMT functions, limitations, and off-target effects may enable safer, more generalizable modulation of microbiome-regulated diseases. Such a mechanistic understanding may manifest as refined donor screening, standardized protocols, tracked outcomes, and identified microbes and metabolites inducing durable clinical benefits.</p>","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":"34 7","pages":"1202-1219"},"PeriodicalIF":18.7,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148414403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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