Cell host & microbe

Akkermansia muciniphila attenuates macrophage efferocytosis to enhance anti-PD-1 efficacy in microsatellite-stable colorectal cancer.

Pub Date : 2026-11-11 DOI: 10.1016/j.chom.2026.09.014 Yu-Ting Jiang, Guang-Qi Li, Yu-Wen Zhou, Ze-Dong Jiang, Yu-Nuo Zhao, Yu Zhang, Xiao-Meng Yin, Shen Li, Huan Tong, Lu-Si Feng, Shi-Yu Wen, Xue-Yan Zhou, Ren-Wei Li, Jing-Wen Wei, Jie-Ping Qiu, Yu-Hao Wei, Ke-Qin Tan, Sheng-Xin Zhang, Hao-Rui Zhou, Jia-Qing Yang, Jing Bai, Qin Deng, Xing-Gang Yang, Xiao-Qian Yang, Yu-Sha Wang, Xia-Wei Wei, Meng Qiu, Juan Huang, Xue-Lei Ma

Microbial metabolism of methotrexate produces a STAT3 signaling molecule that alleviates gut inflammation.

Pub Date : 2026-11-05 DOI: 10.1016/j.chom.2026.10.005 Juyeong Cho, Rebecca Danner, Woo Sung Kim, Luiz Lopez, Jonathan Williams, Anshit Singh, Jiyoung A Han, Jonathan G Van Vranken, Allison S Walker, Timothy W Rhoads, Snehal N Chaudhari

Secretory bile salt hydrolases regulate niche displacement and gut colonization of vancomycin-resistant Enterococcus.

Pub Date : 2026-10-23 DOI: 10.1016/j.chom.2026.09.020 Mizuho Hasegawa, Yukiko Koizumi, Nupur K Das, Li Zhang, Costas A Lyssiotis, Yatrik M Shah, Shinji Fukuda, Gabriel Núñez, Naohiro Inohara