Cell host & microbe最新文献_第7页

Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection. 在沙门氏菌感染期间，共生细菌获取铁会改变宿主的营养免疫。

Cell host & microbe Pub Date : 2023-10-11 Epub Date: 2023-09-29 DOI: 10.1016/j.chom.2023.08.018

Luisella Spiga, Ryan T Fansler, Yasiru R Perera, Nicolas G Shealy, Matthew J Munneke, Holly E David, Teresa P Torres, Andrew Lemoff, Xinchun Ran, Katrina L Richardson, Nicholas Pudlo, Eric C Martens, Ewa Folta-Stogniew, Zhongyue J Yang, Eric P Skaar, Mariana X Byndloss, Walter J Chazin, Wenhan Zhu

{"title":"Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection.","authors":"Luisella Spiga, Ryan T Fansler, Yasiru R Perera, Nicolas G Shealy, Matthew J Munneke, Holly E David, Teresa P Torres, Andrew Lemoff, Xinchun Ran, Katrina L Richardson, Nicholas Pudlo, Eric C Martens, Ewa Folta-Stogniew, Zhongyue J Yang, Eric P Skaar, Mariana X Byndloss, Walter J Chazin, Wenhan Zhu","doi":"10.1016/j.chom.2023.08.018","DOIUrl":"10.1016/j.chom.2023.08.018","url":null,"abstract":"During intestinal inflammation, host nutritional immunity starves microbes of essential micronutrients, such as iron. Pathogens scavenge iron using siderophores, including enterobactin; however, this strategy is counteracted by host protein lipocalin-2, which sequesters iron-laden enterobactin. Although this iron competition occurs in the presence of gut bacteria, the roles of commensals in nutritional immunity involving iron remain unexplored. Here, we report that the gut commensal Bacteroides thetaiotaomicron acquires iron and sustains its resilience in the inflamed gut by utilizing siderophores produced by other bacteria, including Salmonella, via a secreted siderophore-binding lipoprotein XusB. Notably, XusB-bound enterobactin is less accessible to host sequestration by lipocalin-2 but can be \"re-acquired\" by Salmonella, allowing the pathogen to evade nutritional immunity. Because the host and pathogen have been the focus of studies of nutritional immunity, this work adds commensal iron metabolism as a previously unrecognized mechanism modulating the host-pathogen interactions and nutritional immunity.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1639-1654.e10"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41170303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prevotella copri Complex Comprises Four Distinct Clades Underrepresented in Westernized Populations. Prevotella粪菌复合体由四个不同的分支组成，在西方化人群中代表性不足。

Cell host & microbe Pub Date : 2019-11-13 Epub Date: 2019-10-10 DOI: 10.1016/j.chom.2019.08.018

Adrian Tett, Kun D Huang, Francesco Asnicar, Hannah Fehlner-Peach, Edoardo Pasolli, Nicolai Karcher, Federica Armanini, Paolo Manghi, Kevin Bonham, Moreno Zolfo, Francesca De Filippis, Cara Magnabosco, Richard Bonneau, John Lusingu, John Amuasi, Karl Reinhard, Thomas Rattei, Fredrik Boulund, Lars Engstrand, Albert Zink, Maria Carmen Collado, Dan R Littman, Daniel Eibach, Danilo Ercolini, Omar Rota-Stabelli, Curtis Huttenhower, Frank Maixner, Nicola Segata

{"title":"The Prevotella copri Complex Comprises Four Distinct Clades Underrepresented in Westernized Populations.","authors":"Adrian Tett, Kun D Huang, Francesco Asnicar, Hannah Fehlner-Peach, Edoardo Pasolli, Nicolai Karcher, Federica Armanini, Paolo Manghi, Kevin Bonham, Moreno Zolfo, Francesca De Filippis, Cara Magnabosco, Richard Bonneau, John Lusingu, John Amuasi, Karl Reinhard, Thomas Rattei, Fredrik Boulund, Lars Engstrand, Albert Zink, Maria Carmen Collado, Dan R Littman, Daniel Eibach, Danilo Ercolini, Omar Rota-Stabelli, Curtis Huttenhower, Frank Maixner, Nicola Segata","doi":"10.1016/j.chom.2019.08.018","DOIUrl":"10.1016/j.chom.2019.08.018","url":null,"abstract":"Prevotella copri is a common human gut microbe that has been both positively and negatively associated with host health. In a cross-continent meta-analysis exploiting >6,500 metagenomes, we obtained >1,000 genomes and explored the genetic and population structure of P. copri. P. copri encompasses four distinct clades (>10% inter-clade genetic divergence) that we propose constitute the P. copri complex, and all clades were confirmed by isolate sequencing. These clades are nearly ubiquitous and co-present in non-Westernized populations. Genomic analysis showed substantial functional diversity in the complex with notable differences in carbohydrate metabolism, suggesting that multi-generational dietary modifications may be driving reduced prevalence in Westernized populations. Analysis of ancient metagenomes highlighted patterns of P. copri presence consistent with modern non-Westernized populations and a clade delineation time pre-dating human migratory waves out of Africa. These findings reveal that P. copri exhibits a high diversity that is underrepresented in Western-lifestyle populations.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":"26 5","pages":"666-679.e7"},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viral Satellites Exploit Phage Proteins to Escape Degradation of the Bacterial Host Chromosome. 病毒卫星利用噬菌体蛋白质逃避细菌宿主染色体的降解。

Cell host & microbe Pub Date : 2019-10-09 DOI: 10.1016/j.chom.2019.09.006

Amelia C McKitterick, Stephanie G Hays, Fatema-Tuz Johura, Munirul Alam, Kimberley D Seed

{"title":"Viral Satellites Exploit Phage Proteins to Escape Degradation of the Bacterial Host Chromosome.","authors":"Amelia C McKitterick, Stephanie G Hays, Fatema-Tuz Johura, Munirul Alam, Kimberley D Seed","doi":"10.1016/j.chom.2019.09.006","DOIUrl":"10.1016/j.chom.2019.09.006","url":null,"abstract":"Phage defense systems are often found on mobile genetic elements (MGEs), where they constitutively defend against invaders or are induced to respond to new assaults. Phage satellites, one type of MGE, are induced during phage infection to promote their own transmission, reducing phage production and protecting their hosts in the process. One such satellite in Vibrio cholerae, phage-inducible chromosomal island-like element (PLE), sabotages the lytic phage ICP1, which triggers PLE excision from the bacterial chromosome, replication, and transduction to neighboring cells. Analysis of patient stool samples from different geographic regions revealed that ICP1 has evolved to possess one of two syntenic loci encoding an SF1B-type helicase, either of which PLE exploits to drive replication. Further, loss of PLE mobilization limits anti-phage activity because of phage-mediated degradation of the bacterial genome. Our work provides insight into the unique challenges facing parasites of lytic phages and underscores the adaptions of satellites to their ever-evolving target phage.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":"26 4","pages":"504-514.e4"},"PeriodicalIF":0.0,"publicationDate":"2019-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910227/pdf/nihms-1544129.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Landscape of Genetic Content in the Gut and Oral Human Microbiome. 肠道和口腔人类微生物组中基因含量的景观。

Cell host & microbe Pub Date : 2019-08-14 DOI: 10.1016/j.chom.2019.07.008

Braden T Tierney, Zhen Yang, Jacob M Luber, Marc Beaudin, Marsha C Wibowo, Christina Baek, Eleanor Mehlenbacher, Chirag J Patel, Aleksandar D Kostic

{"title":"The Landscape of Genetic Content in the Gut and Oral Human Microbiome.","authors":"Braden T Tierney, Zhen Yang, Jacob M Luber, Marc Beaudin, Marsha C Wibowo, Christina Baek, Eleanor Mehlenbacher, Chirag J Patel, Aleksandar D Kostic","doi":"10.1016/j.chom.2019.07.008","DOIUrl":"10.1016/j.chom.2019.07.008","url":null,"abstract":"Despite substantial interest in the species diversity of the human microbiome and its role in disease, the scale of its genetic diversity, which is fundamental to deciphering human-microbe interactions, has not been quantified. Here, we conducted a cross-study meta-analysis of metagenomes from two human body niches, the mouth and gut, covering 3,655 samples from 13 studies. We found staggering genetic heterogeneity in the dataset, identifying a total of 45,666,334 non-redundant genes (23,961,508 oral and 22,254,436 gut) at the 95% identity level. Fifty percent of all genes were \"singletons,\" or unique to a single metagenomic sample. Singletons were enriched for different functions (compared with non-singletons) and arose from sub-population-specific microbial strains. Overall, these results provide potential bases for the unexplained heterogeneity observed in microbiome-derived human phenotypes. One the basis of these data, we built a resource, which can be accessed at https://microbial-genes.bio.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":"26 2","pages":"283-295.e8"},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716383/pdf/nihms-1536011.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41223567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0