Cell host & microbe最新文献_第5页

Intricate guard-guardee interplay in plant immune signaling. 植物免疫信号传导中复杂的guard-guardee相互作用。

Cell host & microbe Pub Date : 2023-11-08 DOI: 10.1016/j.chom.2023.10.010

Takaki Maekawa

引用次数: 0

Meet the extended Segatella copri complex. 满足扩展Segatella椰油复合体。

Cell host & microbe Pub Date : 2023-11-08 DOI: 10.1016/j.chom.2023.10.009

Ye Peng, Hein M Tun

引用次数: 0

One receptor, two worlds: MXRA8's alphavirus tango. 一个受体，两个世界：MXRA8的阿尔法病毒探戈。

Cell host & microbe Pub Date : 2023-11-08 DOI: 10.1016/j.chom.2023.10.008

James Weger-Lucarelli

引用次数: 0

Extension of the Segatella copri complex to 13 species with distinct large extrachromosomal elements and associations with host conditions. Segatella粪菌复合体扩展到13个物种，具有明显的大型染色体外元件并与宿主条件相关。

Cell host & microbe Pub Date : 2023-11-08 Epub Date: 2023-10-25 DOI: 10.1016/j.chom.2023.09.013

Aitor Blanco-Míguez, Eric J C Gálvez, Edoardo Pasolli, Francesca De Filippis, Lena Amend, Kun D Huang, Paolo Manghi, Till-Robin Lesker, Thomas Riedel, Linda Cova, Michal Punčochář, Andrew Maltez Thomas, Mireia Valles-Colomer, Isabel Schober, Thomas C A Hitch, Thomas Clavel, Sarah E Berry, Richard Davies, Jonathan Wolf, Tim D Spector, Jörg Overmann, Adrian Tett, Danilo Ercolini, Nicola Segata, Till Strowig

{"title":"Extension of the Segatella copri complex to 13 species with distinct large extrachromosomal elements and associations with host conditions.","authors":"Aitor Blanco-Míguez, Eric J C Gálvez, Edoardo Pasolli, Francesca De Filippis, Lena Amend, Kun D Huang, Paolo Manghi, Till-Robin Lesker, Thomas Riedel, Linda Cova, Michal Punčochář, Andrew Maltez Thomas, Mireia Valles-Colomer, Isabel Schober, Thomas C A Hitch, Thomas Clavel, Sarah E Berry, Richard Davies, Jonathan Wolf, Tim D Spector, Jörg Overmann, Adrian Tett, Danilo Ercolini, Nicola Segata, Till Strowig","doi":"10.1016/j.chom.2023.09.013","DOIUrl":"10.1016/j.chom.2023.09.013","url":null,"abstract":"The Segatella copri (formerly Prevotella copri) complex (ScC) comprises taxa that are key members of the human gut microbiome. It was previously described to contain four distinct phylogenetic clades. Combining targeted isolation with large-scale metagenomic analysis, we defined 13 distinct Segatella copri-related species, expanding the ScC complex beyond four clades. Complete genome reconstruction of thirteen strains from seven species unveiled the presence of genetically diverse large circular extrachromosomal elements. These elements are consistently present in most ScC species, contributing to intra- and inter-species diversities. The nine species-level clades present in humans display striking differences in prevalence and intra-species genetic makeup across human populations. Based on a meta-analysis, we found reproducible associations between members of ScC and the male sex and positive correlations with lower visceral fat and favorable markers of cardiometabolic health. Our work uncovers genomic diversity within ScC, facilitating a better characterization of the human microbiome.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1804-1819.e9"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54232784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Homotypic antibodies target novel E glycoprotein domains after natural DENV 3 infection/vaccination. 自然DENV 3感染/疫苗接种后，同种型抗体靶向新的E糖蛋白结构域。

Cell host & microbe Pub Date : 2023-11-08 Epub Date: 2023-10-30 DOI: 10.1016/j.chom.2023.10.004

Jennifer E Munt, Sandra Henein, Cameron Adams, Ellen Young, Yixuan J Hou, Helen Conrad, Deanna Zhu, Stephanie Dong, Nurgun Kose, Boyd Yount, Rita M Meganck, Long Ping V Tse, Guillermina Kuan, Angel Balmaseda, Michael J Ricciardi, David I Watkins, James E Crowe, Eva Harris, Aravinda M DeSilva, Ralph S Baric

{"title":"Homotypic antibodies target novel E glycoprotein domains after natural DENV 3 infection/vaccination.","authors":"Jennifer E Munt, Sandra Henein, Cameron Adams, Ellen Young, Yixuan J Hou, Helen Conrad, Deanna Zhu, Stephanie Dong, Nurgun Kose, Boyd Yount, Rita M Meganck, Long Ping V Tse, Guillermina Kuan, Angel Balmaseda, Michael J Ricciardi, David I Watkins, James E Crowe, Eva Harris, Aravinda M DeSilva, Ralph S Baric","doi":"10.1016/j.chom.2023.10.004","DOIUrl":"10.1016/j.chom.2023.10.004","url":null,"abstract":"The envelope (E) glycoprotein is the primary target of type-specific (TS) neutralizing antibodies (nAbs) after infection with any of the four distinct dengue virus serotypes (DENV1-4). nAbs can be elicited to distinct structural E domains (EDs) I, II, or III. However, the relative contribution of these domain-specific antibodies is unclear. To identify the primary DENV3 nAb targets in sera after natural infection or vaccination, chimeric DENV1 recombinant encoding DENV3 EDI, EDII, or EDIII were generated. DENV3 EDII is the principal target of TS polyclonal nAb responses and encodes two or more neutralizing epitopes. In contrast, some were individuals vaccinated with a DENV3 monovalent vaccine-elicited serum TS nAbs targeting each ED in a subject-dependent fashion, with an emphasis on EDI and EDIII. Vaccine responses were also sensitive to DENV3 genotypic variation. This DENV1/3 panel allows the measurement of serum ED TS nAbs, revealing differences in TS nAb immunity after natural infection or vaccination.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1850-1865.e5"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71430174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Build-a-bug workshop: Using microbial-host interactions and synthetic biology tools to create cancer therapies. 构建bug研讨会：使用微生物与宿主的相互作用和合成生物学工具来创建癌症疗法。

Cell host & microbe Pub Date : 2023-10-11 DOI: 10.1016/j.chom.2023.09.006

Vishnu Raman, Chinmay P Deshpande, Shradha Khanduja, Lars M Howell, Nele Van Dessel, Neil S Forbes

{"title":"Build-a-bug workshop: Using microbial-host interactions and synthetic biology tools to create cancer therapies.","authors":"Vishnu Raman, Chinmay P Deshpande, Shradha Khanduja, Lars M Howell, Nele Van Dessel, Neil S Forbes","doi":"10.1016/j.chom.2023.09.006","DOIUrl":"10.1016/j.chom.2023.09.006","url":null,"abstract":"Many systemically administered cancer therapies exhibit dose-limiting toxicities that reduce their effectiveness. To increase efficacy, bacterial delivery platforms have been developed that improve safety and prolong treatment. Bacteria are a unique class of therapy that selectively colonizes most solid tumors. As delivery vehicles, bacteria have been genetically modified to express a range of therapies that match multiple cancer indications. In this review, we describe a modular \"build-a-bug\" method that focuses on five design characteristics: bacterial strain (chassis), therapeutic compound, delivery method, immune-modulating features, and genetic control circuits. We emphasize how fundamental research into gut microbe pathogenesis has created safe bacterial therapies, some of which have entered clinical trials. The genomes of gut microbes are fertile grounds for discovery of components to improve delivery and modulate host immune responses. Future work coupling these delivery vehicles with insights from gut microbes could lead to the next generation of microbial cancer therapy.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":"31 10","pages":"1574-1592"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41223568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Divide and conquer: Spatiotemporal plant innate immunity at single-cell resolution. 分而治之：单细胞分辨率的时空植物先天免疫。

Cell host & microbe Pub Date : 2023-10-11 DOI: 10.1016/j.chom.2023.09.005

Xiaowei Han, Kenichi Tsuda

引用次数: 0

Lymph node dendritic cells harbor inducible replication-competent HIV despite years of suppressive ART. 淋巴结树突状细胞携带可诱导复制的HIV，尽管有多年的抑制性ART。

Cell host & microbe Pub Date : 2023-10-11 Epub Date: 2023-09-25 DOI: 10.1016/j.chom.2023.08.020

Riddhima Banga, Francesco Andrea Procopio, Erica Lana, Gregory T Gladkov, Isabelle Roseto, Elizabeth M Parsons, Xiaodong Lian, Marie Armani-Tourret, Maxime Bellefroid, Ce Gao, Annamaria Kauzlaric, Mathilde Foglierini, Oscar Alfageme-Abello, Susanna H M Sluka, Olivia Munoz, Andrea Mastrangelo, Craig Fenwick, Yannick Muller, Catherine Gerald Mkindi, Claudia Daubenberger, Matthias Cavassini, Rafael Trunfio, Sébastien Déglise, Jean-Marc Corpataux, Mauro Delorenzi, Mathias Lichterfeld, Giuseppe Pantaleo, Matthieu Perreau

{"title":"Lymph node dendritic cells harbor inducible replication-competent HIV despite years of suppressive ART.","authors":"Riddhima Banga, Francesco Andrea Procopio, Erica Lana, Gregory T Gladkov, Isabelle Roseto, Elizabeth M Parsons, Xiaodong Lian, Marie Armani-Tourret, Maxime Bellefroid, Ce Gao, Annamaria Kauzlaric, Mathilde Foglierini, Oscar Alfageme-Abello, Susanna H M Sluka, Olivia Munoz, Andrea Mastrangelo, Craig Fenwick, Yannick Muller, Catherine Gerald Mkindi, Claudia Daubenberger, Matthias Cavassini, Rafael Trunfio, Sébastien Déglise, Jean-Marc Corpataux, Mauro Delorenzi, Mathias Lichterfeld, Giuseppe Pantaleo, Matthieu Perreau","doi":"10.1016/j.chom.2023.08.020","DOIUrl":"10.1016/j.chom.2023.08.020","url":null,"abstract":"Although gut and lymph node (LN) memory CD4 T cells represent major HIV and simian immunodeficiency virus (SIV) tissue reservoirs, the study of the role of dendritic cells (DCs) in HIV persistence has long been limited to the blood due to difficulties to access lymphoid tissue samples. In this study, we show that LN migratory and resident DC subpopulations harbor distinct phenotypic and transcriptomic profiles. Interestingly, both LN DC subpopulations contain HIV intact provirus and inducible replication-competent HIV despite the expression of the antiviral restriction factor SAMHD1. Notably, LN DC subpopulations isolated from HIV-infected individuals treated for up to 14 years are transcriptionally silent but harbor replication-competent virus that can be induced upon TLR7/8 stimulation. Taken together, these results uncover a potential important contribution of LN DCs to HIV infection in the presence of ART.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1714-1731.e9"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11068440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41159567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subtle, persistent shaping of the gut microbiome by host genes: A critical determinant of host biology. 宿主基因对肠道微生物组的微妙而持久的塑造：宿主生物学的关键决定因素。

Cell host & microbe Pub Date : 2023-10-11 DOI: 10.1016/j.chom.2023.09.007

Lindsey Dzierozynski, Jessica Queen, Cynthia L Sears

引用次数: 0

Cell-type-specific responses to fungal infection in plants revealed by single-cell transcriptomics. 单细胞转录组学揭示了植物对真菌感染的细胞类型特异性反应。

Cell host & microbe Pub Date : 2023-10-11 Epub Date: 2023-09-22 DOI: 10.1016/j.chom.2023.08.019

Bozeng Tang, Li Feng, Michelle T Hulin, Pingtao Ding, Wenbo Ma

{"title":"Cell-type-specific responses to fungal infection in plants revealed by single-cell transcriptomics.","authors":"Bozeng Tang, Li Feng, Michelle T Hulin, Pingtao Ding, Wenbo Ma","doi":"10.1016/j.chom.2023.08.019","DOIUrl":"10.1016/j.chom.2023.08.019","url":null,"abstract":"Pathogen infection is a dynamic process. Here, we employ single-cell transcriptomics to investigate plant response heterogeneity. By generating an Arabidopsis thaliana leaf atlas encompassing 95,040 cells during infection by a fungal pathogen, Colletotrichum higginsianum, we unveil cell-type-specific gene expression, notably an enrichment of intracellular immune receptors in vasculature cells. Trajectory inference identifies cells that had different interactions with the invading fungus. This analysis divulges transcriptional reprogramming of abscisic acid signaling specifically occurring in guard cells, which is consistent with a stomatal closure dependent on direct contact with the fungus. Furthermore, we investigate the transcriptional plasticity of genes involved in glucosinolate biosynthesis in cells at the fungal infection sites, emphasizing the contribution of the epidermis-expressed MYB122 to disease resistance. This work underscores spatially dynamic, cell-type-specific plant responses to a fungal pathogen and provides a valuable resource that supports in-depth investigations of plant-pathogen interactions.","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":" ","pages":"1732-1747.e5"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41171143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0