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Impact of obesity on palpation-guided distal radial access for coronary procedures: subgroup analysis of the multicenter, prospective KODRA registry. 肥胖对触诊引导的冠状动脉远端桡动脉通路的影响:多中心前瞻性KODRA登记的亚组分析。
Cardiology journal Pub Date : 2025-09-04 DOI: 10.5603/cj.106255
Ji Woong Roh, Seok-Jae Heo, Oh-Hyun Lee, Eui Im, Deok-Kyu Cho, Jun-Won Lee, Bong-Ki Lee, Sang-Yong Yoo, Sang Yeub Lee, Chan Joon Kim, Han-Young Jin, Jin Sup Park, Jung Ho Heo, Do Hoi Kim, Jin Bae Lee, Dong-Kie Kim, Jun Ho Bae, Sung-Yun Lee, Seung-Hwan Lee, Yongcheol Kim
{"title":"Impact of obesity on palpation-guided distal radial access for coronary procedures: subgroup analysis of the multicenter, prospective KODRA registry.","authors":"Ji Woong Roh, Seok-Jae Heo, Oh-Hyun Lee, Eui Im, Deok-Kyu Cho, Jun-Won Lee, Bong-Ki Lee, Sang-Yong Yoo, Sang Yeub Lee, Chan Joon Kim, Han-Young Jin, Jin Sup Park, Jung Ho Heo, Do Hoi Kim, Jin Bae Lee, Dong-Kie Kim, Jun Ho Bae, Sung-Yun Lee, Seung-Hwan Lee, Yongcheol Kim","doi":"10.5603/cj.106255","DOIUrl":"https://doi.org/10.5603/cj.106255","url":null,"abstract":"<p><strong>Background: </strong>There is limited data on the impact of body mass index (BMI) on distal radial access (DRA). Using a large-scale prospective registry, the influence of obesity on DRA outcomes was evaluated, including cannulation and complications.</p><p><strong>Methods: </strong>Using data from the prospective, multicenter KODRA (Korean Prospective Registry for Evaluation the Safety and Efficacy of Distal Radial Approach) registry data, 4,638 patients who planned palpation-guided distal radial artery puncture were enrolled into two groups, both with body mass index (BMI) information available: obese (n = 2,205; BMI ≥ 25 kg/m²) and non-obese (n = 2,433). The primary endpoint was the success rate of distal radial artery cannulation. Secondary endpoints included cannulation time, crossover rate, and DRA-related complications.</p><p><strong>Results: </strong>The mean age was 66.6 ± 11.7 years and 67.2% were men. No significant difference existed in the success rate of distal radial artery cannulation between the two groups (94.5% in the obese group vs. 94.3% in the non-obese group, p = 0.787). This tendency in cannulation success rate and cannulation time was consistently observed in multiple sensitivity analyses, including multivariable and propensity score-matched analyses. Crossover rate (6.6% vs. 6.7%, p = 0.962) and DRA-related complications (4.3% vs. 4.6%, p = 0.630) were not significantly different between groups. However, cannulation time was significantly longer in the obese group compared to the non-obese group [105 (64-180) sec vs. 100 (60-155) sec, p = 0.002].</p><p><strong>Conclusions: </strong>In this subgroup analysis of the KODRA trial, obesity was not associated with the success rate for palpation-guided distal radial artery cannulation, crossover rate, and DRA-related complications.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Importance of an online educational platform for heart failure nurses in Poland: the results of the survey. 波兰心力衰竭护士在线教育平台的重要性:调查结果。
Cardiology journal Pub Date : 2025-09-04 DOI: 10.5603/cj.105494
Michał Bohdan, Anna Furman-Niedziejko, Marta Kałużna-Oleksy, Agnieszka Młynarska, Krystyna Czapla, Jadwiga Nessler, Marcin Gruchała, Małgorzata Lelonek
{"title":"Importance of an online educational platform for heart failure nurses in Poland: the results of the survey.","authors":"Michał Bohdan, Anna Furman-Niedziejko, Marta Kałużna-Oleksy, Agnieszka Młynarska, Krystyna Czapla, Jadwiga Nessler, Marcin Gruchała, Małgorzata Lelonek","doi":"10.5603/cj.105494","DOIUrl":"https://doi.org/10.5603/cj.105494","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) nurses play an important role in heart failure management. This study aimed to assess the knowledge of HF nurses in Poland regarding HF management.</p><p><strong>Methods: </strong>97 nurses from Poland provided their consent and completed an online questionnaire comprised of 20 questions. The study was conducted from January 2023 to May 2023. The questionnaire was divided into three parts: general information, practical issues, and the impact of the Polish online educational platform on clinical practice. The inclusion criteria were: a registered nursing license, age under 60, and participation in the Association of Heart Failure of Polish Cardiac Society's online learning platform course for HF nurses. The study group was divided into two subgroups: cardiovascular (CV) nurses (n = 37) and non-CV nurses (n = 60). Statistical analysis was performed using STATISTICA software, with p < 0.05 considered statistically significant.</p><p><strong>Results: </strong>CV nurses showed a higher initial level of education and greater involvement in hospital settings and patient education in comparison to non-CV nurses. Knowledge levels regarding HF management were similar in both groups. Significant differences were found in the work settings and engagement in patient education between CV and non-CV nurses.</p><p><strong>Conclusions: </strong>The study highlights the importance of the HF nurse educational program in Poland, emphasizing the role of CV nurses and the impact of an online educational platform. Findings contribute to ongoing efforts to enhance HF management and improve the quality of care for patients with heart failure.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence based fractional flow reserve. 基于人工智能的分流储备。
Cardiology journal Pub Date : 2025-08-14 DOI: 10.5603/cj.102635
Adrian Bednarek, Paweł Gąsior, Miłosz Jaguszewski, Piotr P Buszman, Krzysztof Milewski, Michał Hawranek, Robert Gil, Wojciech Wojakowski, Janusz Kochman, Mariusz Tomaniak
{"title":"Artificial Intelligence based fractional flow reserve.","authors":"Adrian Bednarek, Paweł Gąsior, Miłosz Jaguszewski, Piotr P Buszman, Krzysztof Milewski, Michał Hawranek, Robert Gil, Wojciech Wojakowski, Janusz Kochman, Mariusz Tomaniak","doi":"10.5603/cj.102635","DOIUrl":"https://doi.org/10.5603/cj.102635","url":null,"abstract":"<p><p>Fractional flow reserve (FFR) - a physiological indicator of coronary stenosis significance - has now become a widely used parameter also in the guidance of percutaneous coronary intervention (PCI). Several studies have shown the superiority of FFR compared to visual assessment, contributing to the reduction in clinical endpoints. However, the current approach to FFR assessment requires coronary instrumentation with a dedicated pressure wire and thus increasing invasiveness, cost, and duration of the procedure. Alternative, noninvasive methods of FFR assessment based on computational fluid dynamics are being widely tested; these approaches are generally not fully automated and may sometimes require substantial computational power. Nowadays, one of the most rapidly expanding fields in medicine is the use of artificial intelligence (AI) in therapy optimization, diagnosis, treatment, and risk stratification. AI usage contributes to the development of more sophisticated methods of imaging analysis and allows for the derivation of clinically important parameters in a faster and more accurate way. Over the recent years, AI utility in deriving FFR in a noninvasive manner has been increasingly reported. In this review, we critically summarize current knowledge in the field of AI-derived FFR based on data from computed tomography angiography, invasive angiography, optical coherence tomography, and intravascular ultrasound. Available solutions, possible future directions in optimizing cathlab performance, including the use of mixed reality, as well as current limitations standing behind the wide adoption of these techniques, are overviewed.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A protocol of 'A post-market national POLish registry of biological prostheses with RESilia tissue (POLRES)'. “带有弹性组织的波兰生物假体上市后国家注册(POLRES)”的协议。
Cardiology journal Pub Date : 2025-08-07 DOI: 10.5603/cj.104560
Bartłomiej Perek, Radosław Wilimski, Radosław Gocoł, Wojciech Karolak, Mariusz Kuśmierczyk, Adam Kowalówka, Agnieszka Skoczyńska, Krzysztof Bartuś, Marek Jemielity, Polres Investigators
{"title":"A protocol of 'A post-market national POLish registry of biological prostheses with RESilia tissue (POLRES)'.","authors":"Bartłomiej Perek, Radosław Wilimski, Radosław Gocoł, Wojciech Karolak, Mariusz Kuśmierczyk, Adam Kowalówka, Agnieszka Skoczyńska, Krzysztof Bartuś, Marek Jemielity, Polres Investigators","doi":"10.5603/cj.104560","DOIUrl":"https://doi.org/10.5603/cj.104560","url":null,"abstract":"","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic trends in patients hospitalized with suspected myocarditis: 10-year data from the nationwide MYO-PL database. 疑似心肌炎住院患者的诊断趋势:来自全国MYO-PL数据库的10年数据
Cardiology journal Pub Date : 2025-08-07 DOI: 10.5603/cj.103407
Aleksandra Okrój, Emil Brociek, Krzysztof Ozierański, Marcin Kruk, Beata Koń, Marcin Grabowski, Agata Tymińska
{"title":"Diagnostic trends in patients hospitalized with suspected myocarditis: 10-year data from the nationwide MYO-PL database.","authors":"Aleksandra Okrój, Emil Brociek, Krzysztof Ozierański, Marcin Kruk, Beata Koń, Marcin Grabowski, Agata Tymińska","doi":"10.5603/cj.103407","DOIUrl":"https://doi.org/10.5603/cj.103407","url":null,"abstract":"<p><strong>Background: </strong>Myocarditis poses a great diagnostic challenge to clinicians, as the most sensitive diagnostic tools are not easily accessible in many hospitals. Clinical suspicion of myocarditis is based on clinical symptoms and additional tests' abnormalities. The diagnosis should be confirmed by endomyocardial biopsy (EMB) - the gold standard for the diagnosis of myocarditis. The study aimed to assess trends in the use of diagnostic procedures performed in all patients hospitalized with suspected myocarditis in Poland between 2011-2019.</p><p><strong>Methods: </strong>The nationwide MYO-PL database was derived from the database of the national healthcare insurer and created to identify hospitalization records with a primary diagnosis of myocarditis. We evaluated the use of recommended diagnostic procedures in this group of 19 978 patients within 6 months of the diagnosis of myocarditis.</p><p><strong>Results: </strong>Echocardiography was the most frequently used imaging technique among patients, and the number of patients who underwent this procedure between 2011-2019 rose every year (71.3-86.1%). Use of nuclear medicine procedures remained < 1% regardless of the year. Biomarkers measurements during primary hospitalization were performed in 13.8% (brain natriuretic peptides) and 41.3% (troponins) of patients. Interestingly, EMB was performed in less than 1% of patients. The most sensitive noninvasive test (cardiac magnetic resonance) was performed in 16.4% of patients (7.2-29.2% within 10 years). Most diagnostic tests were less frequently performed in females.</p><p><strong>Conclusions: </strong>The results highlight that the management of patients with myocarditis could be significantly improved if state-of-the-art diagnostic methods were followed according to guidelines.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic insights into SGLT2 inhibition and atrial fibrillation: exploring the mediating role of inflammatory proteins. SGLT2抑制和房颤的遗传学见解:探索炎症蛋白的介导作用。
Cardiology journal Pub Date : 2025-08-07 DOI: 10.5603/cj.100340
Chengcheng Yi, Wenyuan Zheng, Junqian Wang, Wenqiang Li, Yiming Zhang, Dan Zhou, Peng Lei, Yongxiang Wang, Ming Bai, Zheng Zhang
{"title":"Genetic insights into SGLT2 inhibition and atrial fibrillation: exploring the mediating role of inflammatory proteins.","authors":"Chengcheng Yi, Wenyuan Zheng, Junqian Wang, Wenqiang Li, Yiming Zhang, Dan Zhou, Peng Lei, Yongxiang Wang, Ming Bai, Zheng Zhang","doi":"10.5603/cj.100340","DOIUrl":"https://doi.org/10.5603/cj.100340","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to employ Mendelian randomization (MR) analysis to investigate the causal relationship between sodium-glucose cotransporter 2 (SGLT2) inhibition and atrial fibrillation (AF), as well as assess the potential mediating role of inflammatory proteins in this association.</p><p><strong>Methods: </strong>A two-sample MR analysis was conducted using summary-level data from the genome-wide association study (GWAS) were used to evaluate the genetic prediction of SGLT2 inhibition and AF. Additionally, a two-step MR approach was applied to explore the causal mediation effects of inflammatory proteins in the SGLT2-AF pathway.</p><p><strong>Results: </strong>Genetically predicted SGLT2 inhibition was associated with a significantly lower risk of AF (odds ratio [OR] = 0.51; 95% confidence interval [CI]: 0.27-0.97; p = 0.039). Mendelian randomization analysis further identified FGF-23 (OR = 0.88; 95% CI: 0.79, 0.98; p = 0.024) and PD-L1 (OR = 0.90; 95% CI: 0.82, 0.96; p = 0.023) as significant mediators, accounting for 21.28% and 17.69% of the total effect, respectively.</p><p><strong>Conclusions: </strong>These findings provide potential protective role of SGLT2 inhibition against AF, mediated by inflammatory proteins. Further mechanistic and clinical investigations are warranted to elucidate the underlying pathways and therapeutic implications.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circulating microRNA-1 as a diagnostic biomarker for acute myocardial infarction: a meta-analysis. 循环microRNA-1作为急性心肌梗死的诊断生物标志物:一项荟萃分析
Cardiology journal Pub Date : 2025-08-07 DOI: 10.5603/cj.100348
Guangmei Li, Jiaye Zhao, Zeyu Zhou, Wenting Xu, Siming Wang, Qiyu Sun
{"title":"Circulating microRNA-1 as a diagnostic biomarker for acute myocardial infarction: a meta-analysis.","authors":"Guangmei Li, Jiaye Zhao, Zeyu Zhou, Wenting Xu, Siming Wang, Qiyu Sun","doi":"10.5603/cj.100348","DOIUrl":"https://doi.org/10.5603/cj.100348","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate the diagnostic performance of microRNA-1 in the diagnosis of acute myocardial infarction (AMI).</p><p><strong>Methods: </strong>PubMed, Embase, Cochrane, Web of science and CNKI databases were searched by computer to collect English literature evaluating the diagnostic value of microRNA-1 in AMI patients. The retrieval period is from the establishment of the database to September 2023. Two researchers independently screened the literature according to inclusion and exclusion criteria, extracted data, and evaluated the risk of bias in the included studies using QUADAS-2 tools. Stata15.0 software was used for meta-analysis. The combined sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the summary receiver operator characteristic (SROC) curve were calculated.</p><p><strong>Results: </strong>This study included 11 pieces of literature, which included 894 patients with AMI and 600 controls. The main results of meta-analysis were as follows: The pooled sensitivity and specificity of microRNA-1 for the diagnosis of AMI were 78% (95% CI: 0.69-0.85) and 85% (95% CI: 0.76-0.91), respectively, the positive likelihood ratio was 5.1 (95%CI: 3.0-8.6), the negative likelihood ratio was 0.26 (95% CI: 0.17-0.38), the diagnostic odds ratio was 20 (95% CI: 9-47), and the area under the SROC curve (AUC) was 88% (95% CI: 0.85-0.91).</p><p><strong>Conclusions: </strong>Plasma microRNA-1 has high sensitivity and specificity for early AMI, and has certain diagnostic value, which can help distinguish AMI from patients with other systemic diseases, and can be combined with other biomarkers to diagnose AMI.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of atrial fibrillation recurrence following a successful electrical cardioversion - narrative review. 电复律成功后房颤复发的预测因素——叙述性回顾。
Cardiology journal Pub Date : 2025-07-31 DOI: 10.5603/cj.103353
Paulina Skalska, Małgorzata Kurpaska, Paweł Krzesiński
{"title":"Predictors of atrial fibrillation recurrence following a successful electrical cardioversion - narrative review.","authors":"Paulina Skalska, Małgorzata Kurpaska, Paweł Krzesiński","doi":"10.5603/cj.103353","DOIUrl":"https://doi.org/10.5603/cj.103353","url":null,"abstract":"<p><p>Sinus rhythm (SR) maintenance strategies after electrical or pharmacological cardioversion in patients with atrial fibrillation (AF) may be only temporarily effective, leading to AF recurrence. Identifying predictors of AF recurrence after effective electrical cardioversion (ECV) may help personalize treatment, for instance, by affecting modifiable factors of unsuccessful long-term rhythm control. Disseminating information on this topic may benefit individual patients, lower the risk of subsequent procedures and the associated complications, and decrease health care costs. The purpose of this paper was to present the current state of knowledge on the predictors of failed ECV, with a particular focus on the most recent relevant research.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-menopause women show age dependent increased levels in GRACE, PRECISE-DAPT and NCDR mortality risk prediction scores whereas the PARIS thrombotic score is reduced. 绝经后妇女GRACE、precision - dapt和NCDR死亡风险预测评分的水平随年龄增加,而PARIS血栓形成评分则降低。
Cardiology journal Pub Date : 2025-07-31 DOI: 10.5603/cj.98402
Jessica Weber, Julia Kielb, Süreyya Saffak, Silvana Glugla, Oscar Chávez-Talavera, Khatereh Shahjerdi, Leonard Baensch, Aylin Celik, Mirja Neizel-Wittke, Malte Kelm, Tobias Zeus, Amin Polzin, Lisa K Dannenberg
{"title":"Post-menopause women show age dependent increased levels in GRACE, PRECISE-DAPT and NCDR mortality risk prediction scores whereas the PARIS thrombotic score is reduced.","authors":"Jessica Weber, Julia Kielb, Süreyya Saffak, Silvana Glugla, Oscar Chávez-Talavera, Khatereh Shahjerdi, Leonard Baensch, Aylin Celik, Mirja Neizel-Wittke, Malte Kelm, Tobias Zeus, Amin Polzin, Lisa K Dannenberg","doi":"10.5603/cj.98402","DOIUrl":"https://doi.org/10.5603/cj.98402","url":null,"abstract":"","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophil-lymphocyte ratio (NLR) as an independent factor of 1-year mortality in patients with chronic heart failure with reduced ejection fraction. 中性粒细胞-淋巴细胞比率(NLR)作为射血分数降低的慢性心力衰竭患者1年死亡率的独立因素。
Cardiology journal Pub Date : 2025-07-30 DOI: 10.5603/cj.101332
Filip Sawczak, Helena Krysztofiak, Agata Kukfisz, Martyna Piszczek, Magdalena Szczechla, Katarzyna Przytarska, Magdalena Dudek, Izabella Uchmanowicz, Małgorzata Tomaszewska, Ewa Straburzyńska-Migaj, Marta Kałużna-Oleksy
{"title":"Neutrophil-lymphocyte ratio (NLR) as an independent factor of 1-year mortality in patients with chronic heart failure with reduced ejection fraction.","authors":"Filip Sawczak, Helena Krysztofiak, Agata Kukfisz, Martyna Piszczek, Magdalena Szczechla, Katarzyna Przytarska, Magdalena Dudek, Izabella Uchmanowicz, Małgorzata Tomaszewska, Ewa Straburzyńska-Migaj, Marta Kałużna-Oleksy","doi":"10.5603/cj.101332","DOIUrl":"https://doi.org/10.5603/cj.101332","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory components play a prominent role in the pathogenesis of heart failure (HF) and correlate with the progression and severity of the disease. The aim of the present study was to assess the association between the neutrophil-lymphocyte ratio (NLR) and mortality risk in patients with stable HF with reduced ejection fraction (HFrEF).</p><p><strong>Methods: </strong>A total of 140 patients hospitalized due to a scheduled routine examination without HF exacerbations were included. NLR was calculated as follows: NLR = neutrophil level [G/L]/lymphocyte level [G/L].</p><p><strong>Results: </strong>The average age in the study sample was 54.1 ± 11.3 years. NLR was significantly associated with co-existing atrial fibrillation and parameters related to nutrition: total cholesterol, triglycerides, low-density lipoproteins, and albumin. During a median follow-up (365 days; IQR 296.5-365), 17 (12.1%) patients died. The log-rank test showed the worst survival rate in the highest NLR tertile. A higher NLR value was an independent predictor of 1-year mortality (HR 1.326, 95% CI: 1.121-1.569, p = 0.0010) after adjustment for natriuretic peptides, comorbidities, and other clinical parameters. It retained its value even after the exclusion of patients with severe kidney dysfunction (eGFR < 30mL/min/1.73m²) and with chronic obstructive pulmonary disease (COPD).</p><p><strong>Conclusions: </strong>Neutrophil-lymphocyte ratio could be deployed as an auxiliary, no-cost marker of worse 1-year prognosis in stable HFrEF patients.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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