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Factors influencing Systemic Coronary Risk Estimation 2 (SCORE2).
Cardiology journal Pub Date : 2025-02-12 DOI: 10.5603/cj.95922
Katarzyna Gryglewska-Wawrzak, Maciej Banach, Agata Sakowicz, Bozena Sosnowska, Weronika Adach, Agata Bielecka-Dabrowa
{"title":"Factors influencing Systemic Coronary Risk Estimation 2 (SCORE2).","authors":"Katarzyna Gryglewska-Wawrzak, Maciej Banach, Agata Sakowicz, Bozena Sosnowska, Weronika Adach, Agata Bielecka-Dabrowa","doi":"10.5603/cj.95922","DOIUrl":"https://doi.org/10.5603/cj.95922","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to identify factors associated with the 10-year risk of fatal and non-fatal cardiovascular disease (CVD) events in apparently healthy individuals aged 40-69 years.</p><p><strong>Methods: </strong>148 patients without established CVD were divided into low-risk (70 patients) and high-risk (78 patients) groups based on their CVD risk in SCORE2.</p><p><strong>Results: </strong>High-risk patients presented with higher left atrial volume index (LAVI) (p = 0.003), left ventricular mass index (LVMI) (p < 0.001), and ratio of peak velocity of early diastolic transmitral flow to peak velocity of early diastolic mitral annular motion (E/E') (p < 0.001) but lower oxygen uptake at anaerobic threshold (VO₂AT) (p = 0.02) and maximal oxygen uptake (VO2max) (p = 0.008), compared to their counterparts. High-risk patients also had higher values of high-sensitivity cardiac troponin T (hs-cTnT) (p < 0.001) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) (p<0.001), and lower level of glomerular filtration rate (GFR) (p < 0.001). In a multiple logistic regression model, E/E' > 6.75 cm/s (OR 3.9, 95% CI: 1.5-10.3; p = 0.004) andhs-cTnT > 4.8 pg/ml (OR 6.02, 95% CI: 2.3-15.8; p < 0.001) were independently associated with high and very high CVD risk. SCORE2 (%) correlated positively with metabolic age (R Spearman = 0.79; p < 0.001), hs-cTnT (R = 0.6; p < 0.001), and NT-proBNP (R = 0.5; p < 0.001) and negatively with GFR (R = -0.5; p < 0.001) and VO2max (ml/min/kg) (R = -0.3; p < 0.001).</p><p><strong>Conclusions: </strong>Elevated E/E' and higher hs-cTnT level independently predict high and very high risk in SCORE2. The increasing 10-year cardiovascular disease risk correlates with higher metabolic age, higher levels of NT-proBNP and hs-cTnT, and lower level of GFR.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Silent cerebral ischemic lesions in ablation-naïve patients with non-valvular atrial fibrillation: Does the pulmonary vein anatomy matter? 未经消融治疗的非瓣膜性心房颤动患者的无声脑缺血病变:肺静脉解剖结构是否重要?
Cardiology journal Pub Date : 2025-01-01 Epub Date: 2024-11-26 DOI: 10.5603/cj.99142
Andrzej Głowniak, Anna Drelich-Zbroja, Adam Tarkowski, Paweł Marzęda, Katarzyna Wojewoda, Katarzyna Wysokińska, Anna Wysocka, Monika Miazga, Anna Jaroszyńska, Krzysztof Kaczmarek, Andrzej Jaroszyński, Michał Orczykowski
{"title":"Silent cerebral ischemic lesions in ablation-naïve patients with non-valvular atrial fibrillation: Does the pulmonary vein anatomy matter?","authors":"Andrzej Głowniak, Anna Drelich-Zbroja, Adam Tarkowski, Paweł Marzęda, Katarzyna Wojewoda, Katarzyna Wysokińska, Anna Wysocka, Monika Miazga, Anna Jaroszyńska, Krzysztof Kaczmarek, Andrzej Jaroszyński, Michał Orczykowski","doi":"10.5603/cj.99142","DOIUrl":"10.5603/cj.99142","url":null,"abstract":"<p><strong>Background: </strong>Silent cerebral ischemic lesions (SCILs) detected by magnetic resonance imaging (MRI) can precede symptomatic stroke, the risk of which is increased five-fold in atrial fibrillation (AF) patients. In our study, we aimed to evaluate the initial incidence of SCILs in the population of patients referred for ablation due to symptomatic AF and to identify possible risk factors.</p><p><strong>Methods: </strong>A total of 110 patients, with a mean age (SD) of 59.9 (9.4) years, referred for ablation, were included in the study. In all patients, MRI was performed before the procedure to evaluate the incidence of SCILs in the ablation-naïve patients.</p><p><strong>Results: </strong>MRI revealed preexisting SCIL in 81/110 patients (73.6%). Notably, SCILs were found in all patients with CHA₂DS₂-VASc score ≥ 4. In univariable analysis, age (p < 0.001), CHA₂DS₂-VASc score (p = 0.001), hypertension (p = 0.01), and anticoagulation duration (p = 0.023) were identified as significant risk factors for SCILs, while the presence of anatomical variants of left-sided common pulmonary veins trunk (LCPV) had negative prognostic value (p = 0.026). Multivariable logistic regression analysis identified age (p < 0.001) as the risk factor of preexisting SCILs, whereas the presence of LCPV trunk was associated with significantly lower (p = 0.005) SCILs incidence.</p><p><strong>Conclusions: </strong>Silent cerebral ischemic lesions detected in MRI are frequent in the population of patients with non-valvular AF. The incidence of SCILs is higher in patients with long history of arrhythmia and higher CHA₂DS₂-VASc score. The relationship between the anatomy of pulmonary veins and the incidence of SCILs needs further investigation.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"35-42"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular sequelae in symptomatic SARS-CoV-2 infection survivors. 有症状的 SARS-CoV-2 感染幸存者的心血管后遗症。
Cardiology journal Pub Date : 2025-01-01 Epub Date: 2024-11-07 DOI: 10.5603/cj.99538
Grzegorz Skonieczny, Marta Skowrońska, Agnieszka Dolacińska, Beata Ratajczak, Patrycja Sulik, Oliwia Doroba, Alicja Kotula, Ewelina Błażejowska, Izabela Staniszewska, Olaf Domaszk, Piotr Pruszczyk
{"title":"Cardiovascular sequelae in symptomatic SARS-CoV-2 infection survivors.","authors":"Grzegorz Skonieczny, Marta Skowrońska, Agnieszka Dolacińska, Beata Ratajczak, Patrycja Sulik, Oliwia Doroba, Alicja Kotula, Ewelina Błażejowska, Izabela Staniszewska, Olaf Domaszk, Piotr Pruszczyk","doi":"10.5603/cj.99538","DOIUrl":"10.5603/cj.99538","url":null,"abstract":"<p><strong>Background: </strong>SARS-CoV-2 infection may lead to myocardial and endothelial damage. The present study sought to characterize the cardiovascular sequel in a large group of consecutive patients admitted for out-patient cardiovascular follow-up after a symptomatic COVID-19 infection.</p><p><strong>Methods: </strong>The aims of this study were as follows: to evaluate the presence of post-covid cardiovascular symptoms in an unselected population of outpatients referred to a post-COVID outpatient cardiology clinic and to characterize the long-term abnormalities associated with a more severe COVID-19 infection clinical course. A total of 914 patients were included in this single-center, observational, cross-sectional study, of which 163 were hospitalized and 149 required mechanical ventilation for COVID-19 pneumonia. Patients were analyzed at follow-up according to the care setting during the initial presentation.</p><p><strong>Results: </strong>The median time to follow-up was 126 days. At that time, only 3.5% of patients reported no persistent dyspnea, chest pain, or fatigue on exertion. In a follow-up echocardiographic assessment, patients who required hospitalization showed slight alterations in the pulmonary acceleration time and the tricuspid regurgitation pressure gradient, as well as reduced exercise tolerance during treadmill exercise testing when compared to patients with a benign clinical course. 24-hour Holter EKG monitoring or 24-hour blood pressure monitoring did not identify significant differences between the analyzed subgroups.</p><p><strong>Conclusions: </strong>The current study reports on an association between COVID-19 severity and the presence of cardiovascular alterations at follow-up. A simple diagnostic protocol, comprising an exercise treadmill test and transthoracic echocardiography is useful in identifying patients who may benefit from regular, structured cardiovascular medical care.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maintenance therapy with a P2Y12 receptor inhibitor after cangrelor in patients with acute coronary syndrome. The ELECTRA-SIRIO 2 investigators' viewpoint. 急性冠脉综合征患者在康格瑞洛后使用P2Y12受体抑制剂进行维持治疗。ELECTRA-SIRIO 2调查人员的观点。
Cardiology journal Pub Date : 2025-01-01 Epub Date: 2025-01-08 DOI: 10.5603/cj.98323
Jacek Kubica, Piotr Adamski, Robert Gajda, Aldona Kubica, Małgorzata Ostrowska, Gavino Casu, Diana A Gorog, Paul A Gurbel, Tomasz Hajdukiewicz, Miłosz Jaguszewski, Young-Hoon Jeong, Agata Kosobucka-Ozdoba, Zuzana Motovska, Piotr Niezgoda, Maciej Piasecki, Przemysław Podhajski, Paolo Raggi, Uzeyir Rahimov, Jolanta M Siller-Matula, Grzegorz Skonieczny, Łukasz Szarpak, Paweł Szymański, Udaya Tantry, Eliano P Navarese
{"title":"Maintenance therapy with a P2Y12 receptor inhibitor after cangrelor in patients with acute coronary syndrome. The ELECTRA-SIRIO 2 investigators' viewpoint.","authors":"Jacek Kubica, Piotr Adamski, Robert Gajda, Aldona Kubica, Małgorzata Ostrowska, Gavino Casu, Diana A Gorog, Paul A Gurbel, Tomasz Hajdukiewicz, Miłosz Jaguszewski, Young-Hoon Jeong, Agata Kosobucka-Ozdoba, Zuzana Motovska, Piotr Niezgoda, Maciej Piasecki, Przemysław Podhajski, Paolo Raggi, Uzeyir Rahimov, Jolanta M Siller-Matula, Grzegorz Skonieczny, Łukasz Szarpak, Paweł Szymański, Udaya Tantry, Eliano P Navarese","doi":"10.5603/cj.98323","DOIUrl":"10.5603/cj.98323","url":null,"abstract":"<p><p>According to the ESC guidelines, cangrelor may be considered in P2Y12-inhibitor-naïve acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). The aim of this review is to summarize available evidence on the optimal maintenance therapy with P2Y12 receptor inhibitor after cangrelor. Transitioning from cangrelor to a thienopyridine, but not ticagrelor, can be associated with a drug-drug interaction (DDI); therefore, a ticagrelor loading dose (LD) can be given any time before, during, or at the end of a cangrelor infusion, while a LD of clopidogrel or prasugrel should be administered at the time the infusion of cangrelor ends or within 30 minutes before the end of infusion in the case of a LD of prasugrel. Administration of any oral antiplatelet agent at the end of a cangrelor infusion will also result in a transient period of increased platelet reactivity. The inter-individual variability of this period is difficult to predict because it depends on many factors related to the patient and the treatment. In addition, experimental studies indicate that cangrelor may exert a cardioprotective effect beyond the blockade of platelet aggregation. Considering the available data, the potential use of cangrelor in ACS patients goes well beyond the current indications. Furthermore, we believe that it might be prudent to avoid use of thienopyridines during and soon after a cangrelor infusion until conclusive data on the effect of the DDI on the clinical outcome are available. On the other hand, ticagrelor seems to be an optimal oral agent for continuation of P2Y12 inhibition in patients receiving cangrelor infusion.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"83-89"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of COVID-19 on the prevalence of bystanders performing cardiopulmonary resuscitation: A systematic review and meta-analysis. COVID-19 对旁观者实施心肺复苏率的影响:系统回顾和荟萃分析。
Cardiology journal Pub Date : 2025-01-01 Epub Date: 2024-01-22 DOI: 10.5603/cj.98616
Artur Krawczyk, Krzysztof Kurek, Gabriella Nucera, Michal Pruc, Damian Swieczkowski, Dawid Kacprzyk, Ewa Skrzypek, Nicola Luigi Bragazzi, Kamil Safiejko, Lukasz Szarpak
{"title":"Effect of COVID-19 on the prevalence of bystanders performing cardiopulmonary resuscitation: A systematic review and meta-analysis.","authors":"Artur Krawczyk, Krzysztof Kurek, Gabriella Nucera, Michal Pruc, Damian Swieczkowski, Dawid Kacprzyk, Ewa Skrzypek, Nicola Luigi Bragazzi, Kamil Safiejko, Lukasz Szarpak","doi":"10.5603/cj.98616","DOIUrl":"10.5603/cj.98616","url":null,"abstract":"<p><strong>Background: </strong>The importance of bystander cardiopulmonary resuscitation (CPR) during out-of-hospital cardiac arrests is especially important in the context of coronavirus disease 2029 (COVID-19) because it can significantly influence survival outcomes. The objective of this meta-analysis was to examine the primary outcomes of bystander CPR during the pandemic and pre-pandemic periods.</p><p><strong>Methods: </strong>A search was conducted in the PubMed Central, Scopus, and EMBASE databases, as well as the Cochrane Central Register of Controlled Trials database, up to December 10, 2023. In cases where the value of I² was greater than or equal to 50% or the Q-test indicated that the p-value was less than or equal to 0.05, the studies were considered to be heterogeneous. Sensitivity assessment was performed using the leave-one-out methodology. The study protocol was registered in PROSPERO with the ID number CRD42023494912.</p><p><strong>Results: </strong>Twenty-five articles were included in this meta-analysis. Pooled analysis showed that bystander CPR frequency during the COVID-19 pandemic was 38.8%, compared to 44.8% for the pre-pandemic period (odds ratio: 1.04; 95% confidence interval: 0.93-1.16; p = 0.48).</p><p><strong>Conclusions: </strong>The article's conclusions indicate that the COVID-19 pandemic influenced a reduction in bystander CPR compared to the pre-pandemic period, but this difference was not statistically significant. Further research is recommended to understand attitudes, including the fears of witnesses, before performing CPR on patients with suspected or confirmed infectious diseases. The study highlights the importance of bystander intervention in emergency situations and the impact of a pandemic on public health response behaviors.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"9-18"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139514390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diuretic treatment using the RenalGuard® system in patients hospitalized due to acute decompensated heart failure and characterization of the profile of patients with good and poor response to treatment - preliminary study. 使用 RenalGuard® 系统对急性失代偿性心力衰竭住院患者进行利尿治疗,并对治疗效果好和不好的患者进行特征分析--初步研究。
Cardiology journal Pub Date : 2025-01-01 Epub Date: 2024-11-21 DOI: 10.5603/cj.102386
Paweł Siwołowski, Piotr Gajewski, Mateusz Sokolski, Robert Zymliński, Mateusz Guzik, Joanna Szachniewicz, Piotr Ponikowski
{"title":"Diuretic treatment using the RenalGuard® system in patients hospitalized due to acute decompensated heart failure and characterization of the profile of patients with good and poor response to treatment - preliminary study.","authors":"Paweł Siwołowski, Piotr Gajewski, Mateusz Sokolski, Robert Zymliński, Mateusz Guzik, Joanna Szachniewicz, Piotr Ponikowski","doi":"10.5603/cj.102386","DOIUrl":"10.5603/cj.102386","url":null,"abstract":"<p><strong>Background: </strong>The aim of the study was to analyze the potential relationship between the diuretic response, the clinical profile and the concentrations of selected biochemical markers and to identify a group of patients who will benefit from a new form of therapy combining standard diuretic therapy with the use of a RenalGuard® system.</p><p><strong>Methods: </strong>This is a retrospective study of 19 patients (mean age 67 ± 10 years, 95% men) hospitalized due to acute decompensated heart failure (ADHF, NYHA class III-IV, BP 125 ± 14/73 ± 16 mmHg, eGFR 58 ± 24) with persistent overhydration despite standard therapy. A targeted comparative analysis of selected clinical and biochemical parameters was performed to determine the parameters associated with a better diuretic response [good diuretic responders (GDR) group].</p><p><strong>Results: </strong>The good diuretic responders group had significantly lower levels of creatinine (1.23 ± 0.4 vs. 1.69 ± 0.35, p = 0.025) magnesium 0.70 ± 0.14 vs. 0.83 ± 0.09, p = 0.030) and blood urea nitrogen (BUN, 28 ± 11 vs. 39 ± 10, p = 0.045). Additionally, in GDR group a statistically significant greater ability to dilute urine in the 12th and 24th hour of therapy was found.</p><p><strong>Conclusions: </strong>The results of the study indicate the potential use of the RenalGuard® system in combination with standard intravenous diuretic therapy for controlled dehydration in the treatment of a selected group of patients with ADHF. It is advisable to identify the detailed mechanisms of GDR and characterize this group of patients more precisely.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"43-52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A real-life clinical application of cardiac magnetic resonance imaging in patients with acute myocarditis - one-center observational retrospective study. 心脏磁共振成像在急性心肌炎患者中的实际临床应用--一项中心观察性回顾研究。
Cardiology journal Pub Date : 2025-01-01 Epub Date: 2024-11-13 DOI: 10.5603/cj.97866
Bartosz Gruchlik, Agnieszka Nowotarska, Sylwia Ścibisz-Brenkus, Martyna Nowak, Wiktor Werenkowicz, Małgorzata Niemiec, Andrzej Swinarew, Barbara Mika, Wojciech Wróbel, Maciej Haberka, Bartłomiej Stasiów, Katarzyna Mizia-Stec
{"title":"A real-life clinical application of cardiac magnetic resonance imaging in patients with acute myocarditis - one-center observational retrospective study.","authors":"Bartosz Gruchlik, Agnieszka Nowotarska, Sylwia Ścibisz-Brenkus, Martyna Nowak, Wiktor Werenkowicz, Małgorzata Niemiec, Andrzej Swinarew, Barbara Mika, Wojciech Wróbel, Maciej Haberka, Bartłomiej Stasiów, Katarzyna Mizia-Stec","doi":"10.5603/cj.97866","DOIUrl":"10.5603/cj.97866","url":null,"abstract":"<p><strong>Background: </strong>The diagnosis of acute myocarditis is complex, with cardiac magnetic resonance (CMR) being a recommended diagnostic method. This study aimed to evaluate the real-life use of CMR in the diagnosis of acute myocarditis and to correlate CMR results with the degree of myocardial damage.</p><p><strong>Methods: </strong>This is a retrospective, observational tertiary single-center study of 90 consecutive patients (F/M:18/72, mean age:39 ± 14 years) hospitalized between 2015-2022 with a clinical diagnosis of acute myocarditis. The study population was divided into two groups: patients who underwent CMR+ and those who did not undergo CMR - In the CMR+ group, various sequences, including T1/T2-weighted imaging, late gadolinium enhancement (LGE), and mapping techniques, were used to assess myocardial inflammation and damage.</p><p><strong>Results: </strong>CMR was performed in 39 patients (43.3%, F/M:10/29, mean age:41 ± 16 years). In this group, myocardial edema (increased T2 signal intensity) was detected in 29 patients, and LGE (signal intensity 2 standard deviations cabove normal on T1 images) was found in 39 patients. Diagnosis based on Lake Louise Criteria was possible in 29 cases. Edema negatively correlated with TnT levels (r = -0.412, p < 0.05) and positively with the number of LGE segments (r = 0.372, p < 0.05). Significant correlations were found between LVEF and LGE mass (r = -0.360, p < 0.05), and maximal TnT levels (r = -0.38, p < 0.05). CMR+ patients had lower myocardial damage markers and CRP concentrations compared to CMR- patients.</p><p><strong>Conclusions: </strong>CMR is underused in diagnosing acute myocarditis. Myocardial damage markers correlate with CMR-detected edema and volumetric measures, but not LGE extent. More research is needed to enhance risk assessment and treatment.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"53-61"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of shock therapy on depression development and remote prognosis in cardiac resynchronization therapy recipients. 休克治疗对心脏再同步化治疗受者抑郁发展及远期预后的影响。
Cardiology journal Pub Date : 2025-01-01 Epub Date: 2024-12-20 DOI: 10.5603/cj.101837
Tomasz Podolecki, Robert Pudlo, Michał Mazurek, Monika Kozieł-Siołkowska, Joanna Boidol, Oskar Kowalski, Radosław Lenarczyk, Zbigniew Kalarus
{"title":"The impact of shock therapy on depression development and remote prognosis in cardiac resynchronization therapy recipients.","authors":"Tomasz Podolecki, Robert Pudlo, Michał Mazurek, Monika Kozieł-Siołkowska, Joanna Boidol, Oskar Kowalski, Radosław Lenarczyk, Zbigniew Kalarus","doi":"10.5603/cj.101837","DOIUrl":"10.5603/cj.101837","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to assess the incidence and clinical significance of depression in patients with cardiac resynchronization therapy with an implantable cardioverter-defibrillator (CRT-D). The study was also to evaluate the impact of shock therapy on depression development and long-term prognosis.</p><p><strong>Methods: </strong>The prospective study encompassed 396 consecutive heart failure (HF) patients implanted with CRT-D. All patients completed the Beck Depression Inventory (BDI-II) and underwent a psychiatric examination at baseline. 221 patients free of depressive symptoms at baseline were included into the final analysis. The assessment of psychiatric status was routinely repeated every 6 months as well as after the shock delivery. The primary outcome was a composite endpoint of death or hospitalization for HF.</p><p><strong>Results: </strong>During long-term observation (median 37.1 months) 52 (23.5%) patients suffered from an implantable cardioverter-defibrillator (ICD) shock, whereas 48 (21.8%) subjects developed depression. The incidence of new-onset depression was significantly higher in patients after shock delivery (Shock Group), CRT non-responders and subjects with atrial fibrillation. The risk for a composite endpoint was higher in the Shock Group than subjects without an ICD intervention: 57.7% vs. 25.4% and in patients with new-onset depression compared to the population free of this disorder: 62.5% vs. 24.9% (all p < 0.001). New-onset depression (HR 1.7) and an ICD shock (HR 2.1) were strong independent predictors of poor prognosis.</p><p><strong>Conclusions: </strong>Depression is a common mental disorder in CRT-D recipients, that adversely affects long-term prognosis. Subjects suffering from ICD shocks and those with HF progression are at higher risk of experiencing depressive symptoms.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"26-34"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shaping cardiac diagnostics: The role of myocardial tissue mapping in unraveling ring-like fibrosis.
Cardiology journal Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI: 10.5603/cj.101260
Katarzyna E Gil, Vien T Truong, Saurabh Rajpal, Karolina M Zareba
{"title":"Shaping cardiac diagnostics: The role of myocardial tissue mapping in unraveling ring-like fibrosis.","authors":"Katarzyna E Gil, Vien T Truong, Saurabh Rajpal, Karolina M Zareba","doi":"10.5603/cj.101260","DOIUrl":"10.5603/cj.101260","url":null,"abstract":"<p><strong>Background: </strong>Patients with non-ischemic cardiomyopathy exhibit a range of myocardial fibrosis (MF) patterns on cardiovascular magnetic resonance (CMR) late gadolinium enhancement (LGE) imaging. Data suggests that ring-like MF is associated with worse prognosis. In the present study it was sought to analyze the prevalence of parametric mapping abnormalities in ring-like MF and their prognostic value for arrhythmic events.</p><p><strong>Methods: </strong>Patients undergoing clinical CMR at 1.5T/3T were evaluated for ring-like MF defined as midwall/subepicardial fibrosis involving ≥ 3 contiguous left ventricular segments. CMR protocol included cine imaging, T1 and T2 mapping, and LGE. Mean native T1, ECV, and T2 values and a number of mid short axis segments with elevated values were calculated. LGE extent was assessed segmentally. Arrhythmic outcomes were defined as appropriate device shock, premature ventricular contractions ≥ 10%, non-sustained/sustained ventricular tachycardia, or ventricular fibrillation.</p><p><strong>Results: </strong>In total 49 patients (53 ± 17 years, 26.5% female) were analyzed. Many patients had elevated global/segmental mapping values: 45%/76% in native T1, 57%/57% in T2, and 57%/78% in ECV. During median follow-up of 12 months, arrhythmic events occurred in 65% of patients. There was no association between native T1/T2 elevation or number of LGE segments and arrhythmic outcomes. There was a significant association between ECV and arrhythmic outcomes, both septal ECV (p = 0.036) and any segmental ECV elevation (p = 0.03).</p><p><strong>Conclusion: </strong>T1 and T2 myocardial tissue abnormalities are common in patients with ring-like MF. ECV elevation was associated with arrhythmic events in this cohort. Further studies are needed to establish the diagnostic and prognostic value of parametric mapping in patients with ring-like MF.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"62-72"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complete intramyocardial course of dominant left anterior descending coronary artery and its branches: "Myocardial bridging of the whole ventricular coronary tree".
Cardiology journal Pub Date : 2025-01-01 DOI: 10.5603/cj.98620
Paolo Ciliberti, Davide Curione, Luca Borro, Teresa Santangelo, Alessio Perazzolo, Aurelio Secinaro
{"title":"Complete intramyocardial course of dominant left anterior descending coronary artery and its branches: \"Myocardial bridging of the whole ventricular coronary tree\".","authors":"Paolo Ciliberti, Davide Curione, Luca Borro, Teresa Santangelo, Alessio Perazzolo, Aurelio Secinaro","doi":"10.5603/cj.98620","DOIUrl":"https://doi.org/10.5603/cj.98620","url":null,"abstract":"","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":"32 1","pages":"102-103"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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