Cardiology journal最新文献

{"title":"Identification of completed coronary stent healing by optical coherence tomography - validation study with histopathology in porcine model of coronary restenosis.","authors":"Maciej Pruski, Mateusz Kachel, Carlos Fernandez, Adam Janas, Aleksandra Błachut, Magdalena Michalak, Paweł Kaźmierczak, Paweł E Buszman, Krzysztof Milewski, Piotr P Buszman","doi":"10.5603/cj.91814","DOIUrl":"https://doi.org/10.5603/cj.91814","url":null,"abstract":"<p><strong>Background: </strong>The potential of optical coherence tomography (OCT) is limited by incomplete validation with histopathology. The study aimed to assess whether OCT can identify a completely healed coronary stent.</p><p><strong>Material and methods: </strong>The study included 40 swine and total of 106 stents (82 DES, 24 BMS). Follow-up OCT and histopathology examination was done after 28 days (n = 53) and 90-days (n = 53). 273 frames were matched between histopathology and OCT. Histopathologic criteria for completed healing: high endothelialization score (2-3), low inflammation score (0-1), low fibrin score (0-1), high neointimal smooth muscle score (2-3) and lack of binary restenosis.</p><p><strong>Results: </strong>Predictors of a well healed stent were presence of homogenous neointima (OR: 2.53) and the total number of struts per section (OR: 1.11). The presence of microvessels (OR: 0.28) and increasing neointimal area (OR: 0.65) predicted incomplete healing. Cutoff values were identified: inflammation score was the highest in segments with neointima thickness over 0.35 mm. Persistent fibrin deposits were found at 28-day follow-up in DES with less than 13 embedded struts per section and neointima area less than 2.234 mm². The number of embedded struts per section showed a positive correlation with the healing score, while both protruding covered and protruding uncovered struts showed a negative correlation.</p><p><strong>Conclusions: </strong>OCT demonstrated moderate ability to predict completed stent healing.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical presentation and outcomes of acute myocardial infarction with vs. without st elevation in octogenarians.","authors":"Wojciech Picheta, Bartłomiej Góra, Mateusz Kachel, Matylda Forszpaniak, Aleksandra Kolarczyk-Haczyk, Michał Dudek, Filip Sawicki, Piotr Buszman, Marek Gierlotka, Mariusz Gąsior, Krzysztof Milewski","doi":"10.5603/cj.103397","DOIUrl":"https://doi.org/10.5603/cj.103397","url":null,"abstract":"<p><strong>Background: </strong>As a result of increased life expectancy, the number of octa- and nonagenarians presenting with myocardial infarction is on the rise. These patients are often underrepresented in clinical trials. The aim of this study was to compare the presentation and outcomes of ST-elevation (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) in patients older than 80 years.</p><p><strong>Methods: </strong>This retrospective study included 14758 patients above 80 years of age hospitalized with STEMI or NSTEMI who were selected from the Polish Registry of Acute Coronary Syndromes using propensity score matching (two equal size groups).</p><p><strong>Results: </strong>Patients with STEMI were more likely to undergo coronary angiography (87.80% vs. 77,03%) and revascularization (80.50% vs. 54.26%); in STEMI the culprit lesion was more likely to be located in left anterior descending artery (LAD) (31.76% vs. 44.43%) or right coronary artery (RCA) (18.41% vs. 35.29%), and NSTEMI more likely to be located in left main (4.59% vs. 1.76%) or other native artery (23.3% vs. 6.02%). Elderly patients with STEMI had higher all-cause mortality at 30-days (19.62% vs. 14.51%) and 1-year (32.00% vs. 29.54%). The difference was highly influenced by initial in-hospital mortality (17.96% vs. 12.48%). Among hospital survivors there was no difference in 30-days mortality and 1-year mortality was higher for NSTEMI hospital survivors (17.06% vs. 14.04%).</p><p><strong>Conclusions: </strong>In patients older than 80 years of age with similar baseline characteristics, STEMI and NSTEMI had different presentation, outcomes and required different treatment strategy. ST-elevation patients had higher in-hospital mortality and NSTEMI patients had higher post-hospital mortality after 1 year.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the guidelines. Advanced endovascular therapies in a most challenging aortic coarctation case.","authors":"Wojciech Stecko, Piotr Wańczura, Andrzej Nowak, Robert Sabiniewicz","doi":"10.5603/cj.102385","DOIUrl":"https://doi.org/10.5603/cj.102385","url":null,"abstract":"","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction of inverted compression T-stenting for coronary bifurcation lesion: Double kissing inverted compression T-stenting.","authors":"Fumiaki Nakao","doi":"10.5603/cj.105901","DOIUrl":"https://doi.org/10.5603/cj.105901","url":null,"abstract":"","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conventional versus hands-only cardiopulmonary resuscitation by bystanders for pediatrics with out-of-hospital cardiac arrest: A systematic review and meta-analysis.","authors":"Małgorzata Kietlińska, Artur Krawczyk, Grzegorz Witkowski, Michał Pruc, Monika Tomaszewska, Krzysztof Kurek, Murat Yildirim, Gabriella Nucera, Marek Solecki, Julia M Umińska, Alla Navolokina, Łukasz Szarpak, Basar Cander","doi":"10.5603/cj.104135","DOIUrl":"https://doi.org/10.5603/cj.104135","url":null,"abstract":"<p><strong>Background: </strong>Sudden cardiac arrest (SCA) in pediatric populations is a rare yet critical medical emergency characterized by high mortality and significant neurological impairment among survivors. This systematic review and meta-analysis aim to synthesize existing evidence on pediatric resuscitation techniques, focusing on survival rates, neurological outcomes, and the effectiveness of chest compression-only resuscitation (HCPR) versus standard resuscitation (CCPR), thereby addressing current gaps in clinical understanding and informing future guidelines.</p><p><strong>Methods: </strong>Following PRISMA guidelines, we systematically searched the PubMed, Cochrane Library, and Embase databases for trials comparing HCPR versus CCPR during pediatric resuscitation. We used a comparative meta-analysis to estimate the odds ratio of prehospital return of spontaneous circulation (ROSC), 1-month survival rate, and survival with favorable neurological outcome. Study level odds ratios (ORs) and their 95% confidence intervals (CI) were pooled using random effects.</p><p><strong>Results: </strong>Prehospital ROSC incidence did not significantly differ between HCPR and CCPR, including subgroup analysis based on cause of cardiac arrest. One-month survival rate was 12.3% in HCPR and 18.0% in CCPR (p = 0.04). Additionally, HCPR was less effective in non-cardiac arrest cases and in children over one year of age. Favorable neurological outcomes at one month were also lower for HCPR (6.3%) compared to CCPR (9.0%; p < 0.001), with similar trends observed across subgroups of non-cardiac arrest origin and varying age groups.</p><p><strong>Conclusions: </strong>A pediatric resuscitation technique based solely on chest compressions shows lower efficacy in terms of survival at one month and quality of return of neurological function compared to standard resuscitation.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145017001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic role of the serum uric acid-to-serum creatinine ratio in patients with st-elevation myocardial infarction and multivessel coronary artery disease.","authors":"Ayca Gumusdag, Muhsin Kalyoncuoglu, Huseyin Oguz, Ziya Apaydin, Ali Yasar Kilinc, Mehmet Karaca, Osman Uzman, Ozlem Yildirimturk","doi":"10.5603/cj.103072","DOIUrl":"https://doi.org/10.5603/cj.103072","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to investigate whether serum uric acid to serum creatinine ratio (SUA/SCr) predicts the early major adverse cardiovascular and cerebrovascular events (MACCEs) in patients with ST elevation myocardial infarction (STEMI) and multivessel coronary artery disease (MVCAD).</p><p><strong>Methods: </strong>This study was designed retrospectively and included 572 patients with a mean age of 61.9 ± 12.3 years who presented with STEMI and had MVCAD. The patients were divided into 2 groups as those with and without MACCEs, taking into account the 30-day follow-up period. Serum uric acid, and serum creatinine were obtained at admission. The SUA/SCr of all patients were calculated and evaluated the relationship of SUA/SCr with the 30-day MACCEs.</p><p><strong>Results: </strong>During the mean 27.0 ± 7.7 day follow-up period, 58 (10.1%) patients died, and 84 patients (14.7%) suffered MACCEs. According to multivariable cox regression analysis, advanced age (HR: 1.020, p = 0.028), smoking (HR: 2.513, p = 0.001), lower left ventricular ejection fraction (HR: 0.962, p = 0.001), TIMI < 3 flow (HR: 0.425, p < 0.001), higher syntax score (HR: 1.067, p < 0.001), and higher SUA/SCr (HR: 1.1029, p = 0.011) independently predicted the 30-day MACCEs. The area under the curve for SUA/SCr was 0.606 with a p value of 0.002. The Kaplan Meier curves represented that high-risk patients with SUA/SCr greater than 4.58 had significantly higher MACCEs than low-risk group during the follow up period after index hospitalization (p = 0.001).</p><p><strong>Conclusions: </strong>Newly defined promising oxidative and inflammatory biomarker, SUA/SCr can be a potential predictor of MACCEs within 30 days and decision-making treatment in STEMI and MVCAD patients.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of angiographically derived coronary radial wall strain and superficial wall stress for the characterization of plaque vulnerability.","authors":"Zhiqing Wang, Jiayue Huang, Chunming Li, Tianxiao Xu, Huihong Hong, Xinkai Qu, Lianglong Chen, Shengxian Tu","doi":"10.5603/cj.101778","DOIUrl":"https://doi.org/10.5603/cj.101778","url":null,"abstract":"<p><strong>Background: </strong>Angiography-derived radial wall strain (RWS) estimates the radial coronary wall deformation caused by pulsatile blood pressure, whereas superficial wall stress (SWS) summarizes the comprehensive wall deformation caused by both blood pressure and cardiac motion. This study sought to investigate the difference between RWS and SWS for the association with plaque vulnerability and the impact of cardiac motion on RWS.</p><p><strong>Methods: </strong>Concurrent RWS, cardiac motion-induced bending angle change (ΔCBA), SWS, and optical coherence tomography image analyses were retrospectively performed in 49 eligible intermediate coronary lesions. Correlation and multivariate linear regression analyses were applied to investigate the difference in the correlations of RWS and SWS with plaque characteristics and the impact of ΔCBA on RWS assessment.</p><p><strong>Results: </strong>Lipid-to-cap ratio (LCR), a novel vulnerable plaque indicator, was found to be correlated with both maximum RWS (RWSmax) (r = 0.58, p < 0.001) and peak SWS (r = 0.29, p = 0.041). RWSmax tended to be more relevant to LCR in comparison with peak SWS, albeit statistically nonsignificant (z = 1.75, p = 0.080). With multivariate linear regression, LCR was independently associated with both RWSmax (normalized β = 0.49, p = 0.001) and peak SWS (normalized β = 0.34, p = 0.012), whereas ΔCBA could only affect peak SWS (normalized β = 0.29, p = 0.035). Peak time-averaged SWS showed similar results to peak SWS.</p><p><strong>Conclusions: </strong>RWS tended to be more relevant to plaque vulnerability and less affected by cyclic bending as compared with SWS.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolution of concomitant mitral regurgitation in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement: a prospective multi-center China-DVD2 cohort study.","authors":"Xiao-Han Zhao, Rui-Sheng Zhang, Peng Li, Ying Guo, Xu-Yang Meng, Xiang Wang, You Zhong, Wen-Duo Zhang, Hui Li, Chen-Guang Yang, Yan-Qing Wu, Jian-Fang Luo, Xian-Bao Liu, Fang Wang, Hui-Ping Zhang","doi":"10.5603/cj.103051","DOIUrl":"https://doi.org/10.5603/cj.103051","url":null,"abstract":"<p><strong>Background: </strong>Severe aortic stenosis (AS) often coexists with mitral regurgitation (MR). This study evaluated the significant evolution of MR in patients undergoing transcatheter aortic valve replacement (TAVR) for AS.</p><p><strong>Methods: </strong>This multi-center China Degenerative Valve Disease II Cohort (China-DVD2) Study enrolled patients undergoing TAVR for AS from January 2020 to October 2023. MR severity was assessed at baseline and 12 months post-TAVR. Composite endpoints included all-cause death, heart failure rehospitalization, myocardial infarction, and angina.</p><p><strong>Results: </strong>Among 424 enrolled patients, 130 (31%) had significant MR at baseline. At 12 months, MR improved in 56 (70%) of 80 patients with follow-up, and greater improvement in left ventricular ejection fraction (LVEF)was associated with MR improvement [odds ratios (OR): 0.97, 95% 95% confidence interval (CI): 0.95-1.00, p = 0.04)]. Patients with MR improvement showed significant New York Heart Association (NYHA) functional class improvement at 12-month follow-up. No survival benefit disparity was observed between patients with and without significant baseline MR, but a trend toward lower composite endpoint rate (12.5% vs. 20.8%, log-rank p = 0.49) was observed in patients with MR improvement. Older age [hazard ratios (HR): 1.12, 95% CI: 1.01-1.24, p = 0.04)] and higher systolic pulmonary arterial pressure (SPAP) (HR: 1.05, 95% CI: 1.00-1.09, p = 0.04) were linked to worse outcomes.</p><p><strong>Conclusions: </strong>Most patients with significant MR experienced improvement of NYHA class and MR post TAVR. Baseline significant MR was not linked to worse outcomes, but MR improvement showed a trend toward better prognosis. Older age and higher SPAP predicted worse outcomes.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eustachian valve endocarditis in the context of right atrial embryonic remnants: A systematic review and meta-analysis.","authors":"Luiza Nawrot, Marcin Szczepanik, Marcin Kuniewicz, Daniel Rams, Marta Baran, Grzegorz Karkowski, Maciej Stąpór, Barbara Gach-Kuniewicz","doi":"10.5603/cj.105139","DOIUrl":"https://doi.org/10.5603/cj.105139","url":null,"abstract":"<p><strong>Background: </strong>Eustachian valve endocarditis (EVE) is a rare right-sided infective endocarditis (RSIE) manifestation. This condition has scattered and limited clinical characteristics that require collection and systematization. This meta-analysis evaluates the predisposing factors, pathogens, and associated risk profiles in EVE cases.</p><p><strong>Methods: </strong>The meta-analysis included 68 cases of EVE from 57 reports published between 1986 and 2024 from PubMed, Embase, Scopus, Cochrane, and Web of Science. Data on demographics, clinical characteristics, risk factors, and microbiological findings were extracted and analyzed using descriptive and univariate statistical methods. Pooled prevalence rates from observational studies were calculated using a fixed effects model.</p><p><strong>Results: </strong>The pooled prevalence of EVE in RSIE among the analyzed cases was 2.54%. Single-valve infections accounted for 70.6% of cases, with the Eustachian valve as the sole affected structure. The most common pathogen was Staphylococcus aureus (60%), predominantly affecting younger intravenous drug users (IVDU) with an odds ratio [OR (odds ratio), 6.27; 95% CI (confidence interval), 1.62-24.31] in univariate logistic regression analysis. Other predisposing factors, including central venous catheters (CVCs) and cardiac implantable electronic devices (CIED), were not significantly associated with Staphylococcus aureus or other bacterial non-Staphylococcus aureus or fungal infections.</p><p><strong>Conclusions: </strong>EVE is relatively rare and primarily associated with IVDU and younger age, whereas CVCs and CIEDs are insignificant predictors. Identifying embryonic remnants like the Eustachian valve or Chiari network using echocardiography may facilitate early diagnosis in at-risk populations.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of intravascular lithotripsy according to the timing of stent failure: Insights from the COIL registry.","authors":"Michał Kuzemczak, Janusz Lipiecki, Jacek Legutko, Johan Bennett, Joseph Dens, Mohammad Alkhalil","doi":"10.5603/cj.103163","DOIUrl":"https://doi.org/10.5603/cj.103163","url":null,"abstract":"<p><strong>Background: </strong>Cumulative data has highlighted the efficacy of intra-vascular lithotripsy (IVL) in patients with stent failure (SF). However, it remains unclear whether the effectiveness of IVL, and subsequent clinical outcomes, are influenced by the timing of SF. We aimed to evaluate the outcomes of patients with SF undergoing IVL according to the age of index stent implantation.</p><p><strong>Methods: </strong>This is a pre-specified subgroup analysis of the COIL registry (coronary intravascular lithotripsy in patients with stent failure), which included patients who underwent IVL treatment for SF, divided according to the timing of SF, i.e., early (≤12 months), mid-term (12-36 months), and late SF (>36 months). Procedural and clinical outcomes up to 12 months following IVL treatment were recorded. The primary endpoint was defined as the composite of cardiovascular death, spontaneous myocardial infarction, or target vessel revascularization (TVR).</p><p><strong>Results: </strong>There were 88 patients included in this sub-study, of whom 40 (45%), 17 (19%), and 31 (35%) had early, mid-term, and late SF, respectively. Final procedural results were better in those with early compared to mid-term or late SF. At one-year follow-up, the incidence of the primary endpoint was associated with the timing of SF (8% vs. 12% vs. 29%, p = 0.042). The difference among the subgroups was driven by TVR (3% vs. 12% vs. 29%, p = 0.005).</p><p><strong>Conclusions: </strong>Procedural and clinical outcomes following IVL treatment for patients with SF were influenced by the timing of index stent implantation. Further studies are needed to better understand the mechanisms behind recurrent SF.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}