Cardiology journal最新文献_第3页

Evaluating the effect of the antiPCSK9 vaccine on systemic inflammation and oxidative stress in an experimental mouse model. 评估抗pcsk9疫苗对cfa挑战的白化小鼠全身炎症和氧化应激的影响。

Cardiology journal Pub Date : 2025-01-01 Epub Date: 2025-01-08 DOI: 10.5603/cj.100585

Amir Abbas Momtazi-Borojeni, Maciej Banach, Amirhossein Sahebkar

{"title":"Evaluating the effect of the antiPCSK9 vaccine on systemic inflammation and oxidative stress in an experimental mouse model.","authors":"Amir Abbas Momtazi-Borojeni, Maciej Banach, Amirhossein Sahebkar","doi":"10.5603/cj.100585","DOIUrl":"10.5603/cj.100585","url":null,"abstract":"Background: To investigate whether the antiPCSK9 vaccine can affect the CRP and oxidative stress (OS) during acute systemic inflammation.Methods: Male albino mice were randomly divided into three groups: non-treated mice (the sham group), treated with a nonspecific stimulator of the immune response - Freund's complete adjuvant (CFA; the CFA group), and vaccinated mice treated with CFA (the vaccine group). The vaccine group was subcutaneously immunized with the antiPCSK9 formulation, 4 × in bi-weekly intervals. To induce inflammation, all mice were subjected to the CFA challenge after the vaccination plan. The hsCRP level and OS status were evaluated by a mouse CRP ELISA kit and the pro-oxidant antioxidant balance (PAB) assay, respectively.Results: The vaccine induced a high-titter IgG antiPCSK9 antibody, which was accompanied with a significant PCSK9 reduction (-24.7% and -28.5% compared with the sham and CFA group, respectively), and the inhibition of PCSK9/LDLR interaction (-27.8% and -29.4%, respectively). hsCRP was significantly increased in the vaccine and CFA groups by 225% and 274% respectively, when compared with the sham group; however, it was non-significantly decreased (-18%; p = 0.520) in the vaccine group in comparison with the CFA group. The PAB values indicated that OS was significantly increased in the CFA group (by 72.7%) and the vaccine group (by 76%) when compared to the sham group; however, there was no significant difference in the PAB values between the vaccine and CFA groups.Conclusion: The antiPCSK9 vaccine failed to significantly reduce the serum hs-CRP and OS induced in the CFA-challenged albino mice.","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"73-82"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multivessel disease treated with a double-kiss culotte and chronic total occlusion with support of quantative flow ratio, intravascular ultrasound and shockwave intravascular lithotripsy.

Cardiology journal Pub Date : 2025-01-01 DOI: 10.5603/cj.95950

Mateusz Barycki, Piotr Rola, Adrian Włodarczak, Szymon Włodarczak, Yoshinobu Onuma, Patrick W Serruys, Maciej Lesiak

引用次数: 0

Rationale and design of the MICE study: Exploration of the temporal relation between electrical and mechanical events during myocardial ischemia. 小鼠研究的基本原理和设计：探索心肌缺血时电和机械事件的时间关系。

Cardiology journal Pub Date : 2025-01-01 Epub Date: 2024-12-03 DOI: 10.5603/cj.98481

Niya Mileva, Teodora Yaneva-Sirakova, Irina Hristova, Despina Georgieva, Greta Koleva, Dimitra Psalla, Ranko Georgiev, Dobrin Vassilev

引用次数: 0

IVUS-guided cap puncture of a stumpless chronic total occlusion with sliptream technique.

Cardiology journal Pub Date : 2025-01-01 DOI: 10.5603/cj.99193

Mohsen Mohandes, Cristina Moreno, Luis Mauricio Torres, Humberto Coimbra, José Luis Ferreiro

引用次数: 0

Differences in coronary microcirculation measurements during regadenoson vs. adenosine - induced hyperemia. regadenoson与adenoine诱导的充血期间冠状动脉微循环测量的差异。

Cardiology journal Pub Date : 2025-01-01 Epub Date: 2024-12-20 DOI: 10.5603/cj.97857

Rafał Januszek, Wojciech Siłka, Natalia Bukała, Michał Chyrchel, Wojciech Wańha, Andrzej Surdacki, Stanisław Bartuś

{"title":"Differences in coronary microcirculation measurements during regadenoson vs. adenosine - induced hyperemia.","authors":"Rafał Januszek, Wojciech Siłka, Natalia Bukała, Michał Chyrchel, Wojciech Wańha, Andrzej Surdacki, Stanisław Bartuś","doi":"10.5603/cj.97857","DOIUrl":"10.5603/cj.97857","url":null,"abstract":"Background: Little is known about the similarity of microcirculation assessment outcomes performed with regadenoson and adenosine. The aim of the current study was to compare coronary flow reserve (CFR) and index of microcirculatory resistance (IMR) assessment using adenosine and regadenoson, and to evaluate predictors regarding the size of differences.Methods: 44 patients were enrolled and diagnosed between 2021 and 2023. Fractional flow reserve (FFR), CFR and IMR were measured twice in the circumflex (Cx) (n = 8) or left anterior descending (LAD) (n = 36) artery: once with continuous infusion of adenosine (Adenocor 140 µg/kg/min) and 10 minutes later with regadenoson (Rapiscan 400 µg i.v.).Results: Averaged results were quantified with adenosine and regadenoson for FFR (0.81 [0.75 ÷ 0.89] vs. 0.80 [0.73 ÷ 0.88]), CFR (3.84 [1.67 ÷ 4.08] vs. 3.97 [1.78 ÷ 4.32]) and IMR (20.01 [11 ÷ 24.5] vs. 20.25 [10.75 ÷ 23]), respectively. None of the differences were statistically significant. Among the significant (p < 0.05) predictors of greater ΔCFR, the following can be noted: prior percutaneous transluminal angioplasty/carotid artery stenting (β = 2.35), oral anticoagulant usage (β = 0.89), and prior stroke/transient ischaemic attack (TIA) (β = 1.09), with the latter being also confirmed for greater ΔIMR (β = 8.89). Moreover, patients with New York Heart Association (NYHA) class II/III, as compared to those with NYHA class I, were more likely to have greater ΔIMR (β = 11.89).Conclusions: Regadenoson may be a feasible alternative to adenosine in coronary microcirculation assessment, as it produces similar outcomes. Selected factors were found to be predictors of greater differences in IMR, CFR and FFR values according to the agent used for coronary hyperemia.","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"19-25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Air embolism resulting from atrioesophageal fistula following thoracoscopic atrial fibrillation ablation.

Cardiology journal Pub Date : 2025-01-01 DOI: 10.5603/cj.98108

Fangxiao Gong, Sen Ye

引用次数: 0

Murray law-based quantitative flow ratio for assessment of nonculprit lesions in patients with ST-segment elevation myocardial infarction. 基于默里定律的定量血流比率用于评估 ST 段抬高型心肌梗死患者的非病灶。

Cardiology journal Pub Date : 2024-01-01 Epub Date: 2024-07-08 DOI: 10.5603/cj.93499

Xinjian Li, Lin Mi, Juntao Duan, Liyuan Tao, Xinye Xu, Guisong Wang

{"title":"Murray law-based quantitative flow ratio for assessment of nonculprit lesions in patients with ST-segment elevation myocardial infarction.","authors":"Xinjian Li, Lin Mi, Juntao Duan, Liyuan Tao, Xinye Xu, Guisong Wang","doi":"10.5603/cj.93499","DOIUrl":"10.5603/cj.93499","url":null,"abstract":"Introduction: Revascularization of nonculprit arteries in patients with ST-Segment Elevation Myocardial Infarction (STEMI) is now recommended based on several trials. However, the optimal therapeutic strategy of nonculprit lesions remains unknown. Murray law-based Quantitative Flow Ratio (μQFR) is a novel, non-invasive, vasodilator-free method for evaluating the functional severity of coronary artery stenosis, which has potential applications for nonculprit lesion assessment in STEMI patients.Material and methods: Patients with STEMI who received staged PCI before hospital discharge were enrolled retrospectively. μQFR analyses of nonculprit vessels were performed based on both acute and staged angiography.Results: Eighty-four patients with 110 nonculprit arteries were included. The mean acute μQFR was 0.76 ± 0.18, and the mean staged μQFR was 0.75 ± 0.19. The average period between acute and staged evaluation was 8 days. There was a good correlation (r = 0.719, P < 0.001) between acute μQFR and staged μQFR. The classification agreement was 89.09%. The area under the receiver operator characteristic (ROC) curve for detecting staged μQFR ≤ 0.80 was 0.931.Conclusions: It is feasible to calculate the μQFR during the acute phase of STEMI patients. Acute μQFR and staged μQFR have a good correlation and agreement. The μQFR could be a valuable method for assessing functional significance of nonculprit arteries in STEMI patients.","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"522-527"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SELECT semaglutide to improve outcomes in patients with obesity and cardiovascular disease, also without diabetes. SELECT semaglutide 可改善肥胖和心血管疾病患者（也包括非糖尿病患者）的治疗效果。

Cardiology journal Pub Date : 2024-01-01 Epub Date: 2024-09-17 DOI: 10.5603/cj.102158

Grzegorz Gajos

引用次数: 0

Veno-arterial extracorporeal membrane oxygenation circuit as second vascular access for transcatheter aortic valve replacement. 静脉-动脉体外膜氧合回路作为经导管主动脉瓣置换术的第二血管通路。

Cardiology journal Pub Date : 2024-01-01 DOI: 10.5603/cj.97144

Raphaël Giraud, Benjamin Assouline, Nils Perrin, Karim Bendjelid, Stéphane Noble

引用次数: 0

Electrocardiogram recording vest: A useful tool in explaining recurrent syncope. 心电图记录背心：解释反复晕厥的有用工具。

Cardiology journal Pub Date : 2024-01-01 Epub Date: 2023-12-28 DOI: 10.5603/cj.87231

Justyna Suchecka, Michał Świątczak, Mikołaj Młyński, Ludmiła Daniłowicz-Szymanowicz, Dariusz Kozłowski

引用次数: 0