Cardiology journal最新文献

{"title":"Diuretic treatment using the RenalGuard® system in patients hospitalized due to acute decompensated heart failure and characterization of the profile of patients with good and poor response to treatment - preliminary study.","authors":"Paweł Siwołowski, Piotr Gajewski, Mateusz Sokolski, Robert Zymliński, Mateusz Guzik, Joanna Szachniewicz, Piotr Ponikowski","doi":"10.5603/cj.102386","DOIUrl":"10.5603/cj.102386","url":null,"abstract":"<p><strong>Background: </strong>The aim of the study was to analyze the potential relationship between the diuretic response, the clinical profile and the concentrations of selected biochemical markers and to identify a group of patients who will benefit from a new form of therapy combining standard diuretic therapy with the use of a RenalGuard® system.</p><p><strong>Methods: </strong>This is a retrospective study of 19 patients (mean age 67 ± 10 years, 95% men) hospitalized due to acute decompensated heart failure (ADHF, NYHA class III-IV, BP 125 ± 14/73 ± 16 mmHg, eGFR 58 ± 24) with persistent overhydration despite standard therapy. A targeted comparative analysis of selected clinical and biochemical parameters was performed to determine the parameters associated with a better diuretic response [good diuretic responders (GDR) group].</p><p><strong>Results: </strong>The good diuretic responders group had significantly lower levels of creatinine (1.23 ± 0.4 vs. 1.69 ± 0.35, p = 0.025) magnesium 0.70 ± 0.14 vs. 0.83 ± 0.09, p = 0.030) and blood urea nitrogen (BUN, 28 ± 11 vs. 39 ± 10, p = 0.045). Additionally, in GDR group a statistically significant greater ability to dilute urine in the 12th and 24th hour of therapy was found.</p><p><strong>Conclusions: </strong>The results of the study indicate the potential use of the RenalGuard® system in combination with standard intravenous diuretic therapy for controlled dehydration in the treatment of a selected group of patients with ADHF. It is advisable to identify the detailed mechanisms of GDR and characterize this group of patients more precisely.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"43-52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing Systemic Coronary Risk Estimation 2 (SCORE2).","authors":"Katarzyna Gryglewska-Wawrzak, Maciej Banach, Agata Sakowicz, Bozena Sosnowska, Weronika Adach, Agata Bielecka-Dabrowa","doi":"10.5603/cj.95922","DOIUrl":"10.5603/cj.95922","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to identify factors associated with the 10-year risk of fatal and non-fatal cardiovascular disease (CVD) events in apparently healthy individuals aged 40-69 years.</p><p><strong>Methods: </strong>148 patients without established CVD were divided into low-risk (70 patients) and high-risk (78 patients) groups based on their CVD risk in SCORE2.</p><p><strong>Results: </strong>High-risk patients presented with higher left atrial volume index (LAVI) (p = 0.003), left ventricular mass index (LVMI) (p < 0.001), and ratio of peak velocity of early diastolic transmitral flow to peak velocity of early diastolic mitral annular motion (E/E') (p < 0.001) but lower oxygen uptake at anaerobic threshold (VO₂AT) (p = 0.02) and maximal oxygen uptake (VO2max) (p = 0.008), compared to their counterparts. High-risk patients also had higher values of high-sensitivity cardiac troponin T (hs-cTnT) (p < 0.001) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) (p<0.001), and lower level of glomerular filtration rate (GFR) (p < 0.001). In a multiple logistic regression model, E/E' > 6.75 cm/s (OR 3.9, 95% CI: 1.5-10.3; p = 0.004) andhs-cTnT > 4.8 pg/ml (OR 6.02, 95% CI: 2.3-15.8; p < 0.001) were independently associated with high and very high CVD risk. SCORE2 (%) correlated positively with metabolic age (R Spearman = 0.79; p < 0.001), hs-cTnT (R = 0.6; p < 0.001), and NT-proBNP (R = 0.5; p < 0.001) and negatively with GFR (R = -0.5; p < 0.001) and VO2max (ml/min/kg) (R = -0.3; p < 0.001).</p><p><strong>Conclusions: </strong>Elevated E/E' and higher hs-cTnT level independently predict high and very high risk in SCORE2. The increasing 10-year cardiovascular disease risk correlates with higher metabolic age, higher levels of NT-proBNP and hs-cTnT, and lower level of GFR.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"153-163"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A real-life clinical application of cardiac magnetic resonance imaging in patients with acute myocarditis - one-center observational retrospective study.","authors":"Bartosz Gruchlik, Agnieszka Nowotarska, Sylwia Ścibisz-Brenkus, Martyna Nowak, Wiktor Werenkowicz, Małgorzata Niemiec, Andrzej Swinarew, Barbara Mika, Wojciech Wróbel, Maciej Haberka, Bartłomiej Stasiów, Katarzyna Mizia-Stec","doi":"10.5603/cj.97866","DOIUrl":"10.5603/cj.97866","url":null,"abstract":"<p><strong>Background: </strong>The diagnosis of acute myocarditis is complex, with cardiac magnetic resonance (CMR) being a recommended diagnostic method. This study aimed to evaluate the real-life use of CMR in the diagnosis of acute myocarditis and to correlate CMR results with the degree of myocardial damage.</p><p><strong>Methods: </strong>This is a retrospective, observational tertiary single-center study of 90 consecutive patients (F/M:18/72, mean age:39 ± 14 years) hospitalized between 2015-2022 with a clinical diagnosis of acute myocarditis. The study population was divided into two groups: patients who underwent CMR+ and those who did not undergo CMR - In the CMR+ group, various sequences, including T1/T2-weighted imaging, late gadolinium enhancement (LGE), and mapping techniques, were used to assess myocardial inflammation and damage.</p><p><strong>Results: </strong>CMR was performed in 39 patients (43.3%, F/M:10/29, mean age:41 ± 16 years). In this group, myocardial edema (increased T2 signal intensity) was detected in 29 patients, and LGE (signal intensity 2 standard deviations cabove normal on T1 images) was found in 39 patients. Diagnosis based on Lake Louise Criteria was possible in 29 cases. Edema negatively correlated with TnT levels (r = -0.412, p < 0.05) and positively with the number of LGE segments (r = 0.372, p < 0.05). Significant correlations were found between LVEF and LGE mass (r = -0.360, p < 0.05), and maximal TnT levels (r = -0.38, p < 0.05). CMR+ patients had lower myocardial damage markers and CRP concentrations compared to CMR- patients.</p><p><strong>Conclusions: </strong>CMR is underused in diagnosing acute myocarditis. Myocardial damage markers correlate with CMR-detected edema and volumetric measures, but not LGE extent. More research is needed to enhance risk assessment and treatment.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"53-61"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short- and long-term outcomes of Impella-protected, high-risk, elective PCI in patients with multivessel coronary disease and low ejection fraction - Polish Impella Registry.","authors":"Wojciech J Skorupski, Arkadiusz Pietrasik, Aleksandra Gąsecka, Jerzy Sacha, Tomasz Pawłowski, Gabriel Bielawski, Wojciech Balak, Adam Sukiennik, Paulina Burzyńska, Adam Witkowski, Mateusz Warniełło, Łukasz Rzeszutko, Stanisław Bartuś, Artur Pawlik, Mateusz Kaczyński, Robert Gil, Wiktor Kuliczkowski, Krzysztof Reczuch, Marcin Protasiewicz, Jacek Legutko, Paweł Kleczyński, Piotr Wańczura, Sebastian Gurba, Anna Kochanowska, Michał Łomiak, Maciej Krajsman, Włodzimierz Skorupski, Maciej Zarębiński, Piotr Pawluczuk, Szymon Włodarczak, Adrian Włodarczak, Krzysztof Ściborski, Artur Telichowski, Mieszko Pluciński, Jarosław Hiczkiewicz, Karolina Konsek, Michał Hawranek, Mariusz Gąsior, Jan Peruga, Marcin Fiutowski, Robert Romanek, Piotr Kasprzyk, Dariusz Ciećwierz, Andrzej Ochała, Wojciech Wojakowski, Janusz Kochman, Maciej Lesiak, Marek Grygier","doi":"10.5603/cj.103336","DOIUrl":"10.5603/cj.103336","url":null,"abstract":"<p><strong>Background: </strong>The Impella percutaneous mechanical circulatory support device provides improved support in treating patients with high-risk percutaneous coronary interventions (HR-PCI) or in cardiogenic shock. IMPELLA-PL is a multicenter registry developed to share clinical data and experiences using Impella technology in Poland. The retrospective analysis conducted in this study aims to fill the knowledge gap of Impella performance in patients with multivessel coronary artery disease (CAD) and depressed left ventricular ejection fraction (EF) (≤30%) treated with HR-PCI.</p><p><strong>Methods: </strong>Retrospective data were analyzed from patients presenting with multivessel coronary disease and low EF treated with Impella CP collected from 20 Polish interventional cardiology centers registered with IMPELLA-PL to assess the safety and efficacy in short- and long-term clinical outcomes.</p><p><strong>Results: </strong>A total of 115 patients with low EF received Impella CP support during HR-PCI. The success rate of Impella supported HR-PCI was high (99.1%) with an average hospital stay of 15.6 ± 10.7 days. The right femoral artery was the most common access (55.7%) followed by the left femoral artery (37.4%). The in-hospital mortality rate was 6.1%, and the all-cause mortality rate at one year was 13.9%.</p><p><strong>Conclusions: </strong>High-risk PCI with Impella CP periprocedural support was safe and effective in patients with low EF (≤30%). The all-cause mortality rate (6.1% and 13.9%, respectively, for in-hospital and at 12-months) was comparable with other Impella registries.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"248-257"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fractured wire migrated from left clavicle into the heart.","authors":"Tong Zhao, Zhenyan Zhao, Yongjian Wu, Hongliang Zhang","doi":"10.5603/cj.104065","DOIUrl":"10.5603/cj.104065","url":null,"abstract":"","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":"32 3","pages":"338-339"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'Hourglass'-shaped heart: midventricular phenotype of hypertrophic cardiomyopathy.","authors":"Sebastian Graeger, Bishwas Chamling, Robin Bülow, Christian Templin, Klaus Empen","doi":"10.5603/cj.103917","DOIUrl":"10.5603/cj.103917","url":null,"abstract":"","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":"32 3","pages":"344-345"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of intraprocedural stent thrombosis with intracoronary argatroban injection in ST-segment elevation myocardial infarction.","authors":"Hiroshi Abe, Tadao Aikawa, Tomohi Ajima, Ken Yokoyama, Tohru Minamino","doi":"10.5603/cj.103430","DOIUrl":"10.5603/cj.103430","url":null,"abstract":"","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":"32 3","pages":"336-337"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shaping cardiac diagnostics: The role of myocardial tissue mapping in unraveling ring-like fibrosis.","authors":"Katarzyna E Gil, Vien T Truong, Saurabh Rajpal, Karolina M Zareba","doi":"10.5603/cj.101260","DOIUrl":"10.5603/cj.101260","url":null,"abstract":"<p><strong>Background: </strong>Patients with non-ischemic cardiomyopathy exhibit a range of myocardial fibrosis (MF) patterns on cardiovascular magnetic resonance (CMR) late gadolinium enhancement (LGE) imaging. Data suggests that ring-like MF is associated with worse prognosis. In the present study it was sought to analyze the prevalence of parametric mapping abnormalities in ring-like MF and their prognostic value for arrhythmic events.</p><p><strong>Methods: </strong>Patients undergoing clinical CMR at 1.5T/3T were evaluated for ring-like MF defined as midwall/subepicardial fibrosis involving ≥ 3 contiguous left ventricular segments. CMR protocol included cine imaging, T1 and T2 mapping, and LGE. Mean native T1, ECV, and T2 values and a number of mid short axis segments with elevated values were calculated. LGE extent was assessed segmentally. Arrhythmic outcomes were defined as appropriate device shock, premature ventricular contractions ≥ 10%, non-sustained/sustained ventricular tachycardia, or ventricular fibrillation.</p><p><strong>Results: </strong>In total 49 patients (53 ± 17 years, 26.5% female) were analyzed. Many patients had elevated global/segmental mapping values: 45%/76% in native T1, 57%/57% in T2, and 57%/78% in ECV. During median follow-up of 12 months, arrhythmic events occurred in 65% of patients. There was no association between native T1/T2 elevation or number of LGE segments and arrhythmic outcomes. There was a significant association between ECV and arrhythmic outcomes, both septal ECV (p = 0.036) and any segmental ECV elevation (p = 0.03).</p><p><strong>Conclusion: </strong>T1 and T2 myocardial tissue abnormalities are common in patients with ring-like MF. ECV elevation was associated with arrhythmic events in this cohort. Further studies are needed to establish the diagnostic and prognostic value of parametric mapping in patients with ring-like MF.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"62-72"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of pre-existing comorbidities and complications with inpatient COVID-19 mortality - a single-center retrospective study.","authors":"Damian Palus, Martyna Gołębiewska, Olga Piątek-Dalewska, Krzysztof Grudziński, Krzysztof Kuziemski, Radosław Owczuk, Michał Hoffmann, Dariusz Kozłowski, Tomasz Stefaniak","doi":"10.5603/cj.103122","DOIUrl":"10.5603/cj.103122","url":null,"abstract":"<p><strong>Background: </strong>This study evaluates the impact of pre-existing comorbidities and in-hospital complications on COVID-19 mortality rates.</p><p><strong>Methods: </strong>A retrospective single-center study was conducted using electronic health records from 640 COVID-19 patients hospitalized at the University Clinical Centre in Gdansk, Poland, between November 2020 and May 2021. Patients were categorized based on disease severity into stable or ICU wards based on the disease severity. Data on demographics, comorbidities, complications, and treatments were collected and verified. Statistical analyses, including odds ratios (ORs) and confidence intervals (CIs), assessed mortality risk factors supported by python-based processing.</p><p><strong>Results: </strong>The mean patient age was 67 years (SD ± 15.89), comprising 39% females (n = 250) and 60.94% males (n = 390). Mortality risk was highest in patients aged 65 years and older (OR 3.00; 95% CI, 1.97-4.60). Among the pre-existing comorbidities, chronic kidney disease (OR 3.28; 95% CI, 2.12-5.09), atrial fibrillation (OR 2.43; CI 95%, 1.63-3.61), and heart failure (OR 2.89; 95% CI, 1.91-4.37) were significant predictors of mortality. In hospital complications, such as severe respiratory failure requiring ICU ventilation (OR 23.59; 95% CI, 2.81-197.87), myocardial infarction (OR 25.43; 95% CI, 3.16-204.97), acute kidney injury requiring renal replacement therapy (OR 19.15; 95% CI, 6.49-56.51), sepsis (OR 7.22, 95% CI, 3.77-13.84), stroke, further increased mortality risk.</p><p><strong>Conclusions: </strong>COVID-19 patients with pre-existing renal and cardiovascular conditions face a higher risk of fatal outcomes. Early diagnosis and intervention targeting these complications are vital to in reducing mortality. Further research is needed to reconcile disparities with existing literature.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"120-129"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of shock therapy on depression development and remote prognosis in cardiac resynchronization therapy recipients.","authors":"Tomasz Podolecki, Robert Pudlo, Michał Mazurek, Monika Kozieł-Siołkowska, Joanna Boidol, Oskar Kowalski, Radosław Lenarczyk, Zbigniew Kalarus","doi":"10.5603/cj.101837","DOIUrl":"10.5603/cj.101837","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to assess the incidence and clinical significance of depression in patients with cardiac resynchronization therapy with an implantable cardioverter-defibrillator (CRT-D). The study was also to evaluate the impact of shock therapy on depression development and long-term prognosis.</p><p><strong>Methods: </strong>The prospective study encompassed 396 consecutive heart failure (HF) patients implanted with CRT-D. All patients completed the Beck Depression Inventory (BDI-II) and underwent a psychiatric examination at baseline. 221 patients free of depressive symptoms at baseline were included into the final analysis. The assessment of psychiatric status was routinely repeated every 6 months as well as after the shock delivery. The primary outcome was a composite endpoint of death or hospitalization for HF.</p><p><strong>Results: </strong>During long-term observation (median 37.1 months) 52 (23.5%) patients suffered from an implantable cardioverter-defibrillator (ICD) shock, whereas 48 (21.8%) subjects developed depression. The incidence of new-onset depression was significantly higher in patients after shock delivery (Shock Group), CRT non-responders and subjects with atrial fibrillation. The risk for a composite endpoint was higher in the Shock Group than subjects without an ICD intervention: 57.7% vs. 25.4% and in patients with new-onset depression compared to the population free of this disorder: 62.5% vs. 24.9% (all p < 0.001). New-onset depression (HR 1.7) and an ICD shock (HR 2.1) were strong independent predictors of poor prognosis.</p><p><strong>Conclusions: </strong>Depression is a common mental disorder in CRT-D recipients, that adversely affects long-term prognosis. Subjects suffering from ICD shocks and those with HF progression are at higher risk of experiencing depressive symptoms.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"26-34"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}