Cardiology最新文献

{"title":"Efficacy and Safety of No-Touch versus Conventional Saphenous Vein Harvesting in Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Xiaomei Chen, Xuge Zhang, Xiang Xiang, Xiang Fang, Fei Wei, Ying Liu, Shenghong Feng","doi":"10.1159/000551298","DOIUrl":"10.1159/000551298","url":null,"abstract":"<p><strong>Introduction: </strong>Saphenous vein graft (SVG) failure is a key determinant of long-term outcomes after coronary artery bypass grafting (CABG), particularly in individuals with multivessel disease or diabetes. This meta-analysis aimed to evaluate whether the no-touch SVG harvesting technique reduces graft occlusion and improves cardiovascular outcomes compared with the conventional approach.</p><p><strong>Methods: </strong>A comprehensive literature search of PubMed, Embase, Web of Science, and the Cochrane Library was conducted up to May 2025 to identify randomized controlled trials (RCTs) comparing the no-touch and conventional saphenous vein harvesting techniques in CABG. A random-effects model was used for meta-analysis, and the certainty of evidence was evaluated using the GRADE framework.</p><p><strong>Results: </strong>Eight RCTs involving 4,258 CABG patients (no-touch: 2,144; conventional: 2,114) were included. The no-touch technique significantly reduced the risk of vein graft occlusion (risk ratio, 0.59; 95% CI: 0.47-0.73; p < 0.00001; I2 = 31%). Subgroup analyses confirmed the consistency of this effect across regions and follow-up durations. Although differences in secondary outcomes - including all-cause and cardiovascular mortality, myocardial infarction, stroke, and repeat revascularization - were not statistically significant, most effect estimates favored the no-touch approach. The certainty of evidence was rated as moderate for the primary and several secondary outcomes according to the GRADE assessment.</p><p><strong>Conclusion: </strong>This meta-analysis shows that no-touch saphenous vein harvesting is associated with a lower risk of graft occlusion compared with conventional harvesting in CABG. However, current randomized evidence does not demonstrate a definitive improvement in major cardiovascular outcomes. These findings highlight the need to balance angiographic benefits against potential trade-offs and underscore the need for large-scale, event-driven randomized trials to clarify the net clinical benefit of this technique.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-15"},"PeriodicalIF":1.7,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase Difference between End-Tidal CO₂ and Ventilation in Heart Failure with Oscillatory Breathing.","authors":"Takako Ichinohe, Naoto Kawamatsu, Isao Nishi, Akira Koike, Tomoko Ishizu","doi":"10.1159/000550762","DOIUrl":"10.1159/000550762","url":null,"abstract":"<p><strong>Introduction: </strong>Oscillatory breathing (OB) observed during cardiopulmonary exercise testing (CPX) is a critical phenomenon, especially in patients with heart failure. Patients with cardiovascular diseases with OB usually present with cyclic changes not only in ventilation (VE) but also in oxygen uptake (VO₂), carbon dioxide output (VCO₂), end-tidal partial pressure of carbon dioxide (P_ETCO₂, reflecting dynamic changes in arterial PCO₂), and other respiratory gas variables. We aimed to evaluate whether the phase difference between the respiratory gas variables obtained from CPX is correlated with cardiopulmonary function.</p><p><strong>Methods: </strong>From a retrospective analysis of 1,740 patients with cardiovascular diseases who underwent CPX, 42 patients (65 ± 13 years) with clear OB were selected. Oscillatory changes were observed in VE, VO₂, VCO₂, P_ETCO₂, and end-tidal oxygen tension (P_ETO₂) in all patients. P_ETCO₂ and P_ETO₂ oscillated almost simultaneously, although their peak and nadir were reversed. Oscillatory changes in P_ETCO₂ and P_ETO₂ preceded those in the other cardiopulmonary variables. After the peak of oscillating P_ETCO₂, the oscillations of VO₂, VCO₂, and VE followed this order.</p><p><strong>Results: </strong>The phase difference between P_ETCO₂ and VE was significantly and positively correlated with the VE-VCO₂ slope, P_ETCO₂ at rest, and P_ETCO₂ at peak (r = 0.414, p = 0.006; r = -0.453, p = 0.003; and r = -0.424, p = 0.005, respectively).</p><p><strong>Conclusion: </strong>The phase difference between P_ETCO₂ and VE is associated with the severity of heart failure and suggests that OB may be partly related to impaired PaCO₂ regulation in patients with cardiovascular diseases.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience on Genetic Testing for Primary Dilated Cardiomyopathy in a Single Austrian Genetic Center and the Role of Myocardial Inflammation.","authors":"Héctor Hugo Manzanilla Romero, Anja Savina Steil, Viktoria Santner, Andreas Von der Heidt, Nicolas Verheyen, Gerhard Pölzl, Martina Witsch-Baumgartner, Sabine Rudnik-Schöneborn","doi":"10.1159/000550976","DOIUrl":"10.1159/000550976","url":null,"abstract":"<p><strong>Introduction: </strong>Molecular genetic testing is increasingly offered to patients with dilated cardiomyopathy (DCM). The diagnosis of an inherited cardiomyopathy has major implications for medical care of patients and relatives. We report the results of a genotype-phenotype analysis of DCM investigated in Austria.</p><p><strong>Methods: </strong>Overall, 194 patients with DCM underwent genetic testing over a period of 6 years. We analyzed the clinical and genetic characteristics of 105 DCM patients who showed a genetic variant and compared the genetic findings and outcome measures of patients with myocardial inflammation on endomyocardial biopsy and those without.</p><p><strong>Results: </strong>In 51.4% (54/105) patients, at least one likely pathogenic or pathogenic genetic variant (LP/P) was detected. Fifty one of 105 patients (48.6%) showed only variants of unknown significance (VUSs). Most LP/P variants (34.3%) were detected in the TTN gene. Clinical characteristics of the most prevalent genetic subgroups (TTN, LMNA, MYH7, MYH6, DMD, SCN5A) were not significantly different. DCM patients with inflammation had significantly higher frequency of memory of infection, left bundle branch block, mitral valve insufficiency but normal CK-MB levels. We added a case report where two family members initially were considered to have an inflammatory cardiomyopathy before a pathogenic variant in LMNA was found.</p><p><strong>Conclusion: </strong>Cardiac features of DCM were not predictive of a specific genetic subgroup. We recommend applying multigene panels extensively since a large proportion of patients without a family history or with evidence of myocardial inflammation showed a genetic predisposition for DCM. However, the large number of VUS remains a challenge.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetocardiography for Phenotyping Ischaemic Heart Disease beyond Epicardial Stenosis.","authors":"Janek Salatzki, Nicolas Hein, Florian André","doi":"10.1159/000551188","DOIUrl":"10.1159/000551188","url":null,"abstract":"","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-3"},"PeriodicalIF":1.7,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Main Lessons of the Recent Andexanet Withdrawal.","authors":"Pierre Sabouret, Dan Atar, Marco Bernardi, Domenico Mario Giamundo","doi":"10.1159/000551185","DOIUrl":"https://doi.org/10.1159/000551185","url":null,"abstract":"","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-3"},"PeriodicalIF":1.7,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Rationale of the EARMI Trial: A Randomized Controlled Trial on Early-Phase Cardiac Rehabilitation Post-Percutaneous Coronary Intervention in Acute Myocardial Infarction Patients.","authors":"Kaiyuan Cen, Fatimah Ahmedy, Mexmollen Marcus, Mohd Fadzli Shukor, Sukhbeer Kaur Darsin Singh","doi":"10.1159/000551060","DOIUrl":"10.1159/000551060","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiac rehabilitation (CR) is a key component of secondary prevention in patients with coronary artery disease. However, the optimal timing, structure, and feasibility of exercise-based cardiac rehabilitation initiated during hospitalization following acute myocardial infarction (AMI) treated with percutaneous coronary intervention (PCI) remain underexplored.</p><p><strong>Methods: </strong>The EARMI trial is a multicenter, randomized, parallel-group controlled trial designed to assess the efficacy and safety of a structured, phase-specific CR program initiated within 24 h post-PCI. This intervention will be implemented across three distinct recovery phases: intensive care unit, hospital ward, and home-based rehabilitation. Eighty AMI patients will be randomized (1:1) to receive exercise-based CR or usual care. The intervention consists of progressive aerobic and resistance training, with individualized progression tailored to each patient's clinical status. The primary outcomes include left ventricular function (measured by left ventricular ejection fraction, LVEDD, LVESD), exercise capacity (assessed by VO₂ peak, 6MWT, and METs), and autonomic function (evaluated by heart rate variability [HRV]). Secondary outcomes include health-related quality of life (assessed by SF-36), metabolic markers, and major adverse cardiovascular events. Over the 12 weeks intervention period, the study is powered to detect clinically significant improvements in myocardial function, exercise tolerance, and autonomic regulation. Safety and feasibility will be assessed through continuous surveillance of adverse events and quantification of adherence rates.</p><p><strong>Conclusion: </strong>The EARMI trial is one of the first studies to evaluate the impact of initiating a structured early-phase CR model during the acute phase of AMI. The findings may provide crucial insights into scalable, time-sensitive rehabilitation strategies for post-AMI recovery and contribute to the integration of CR into modern cardiovascular care pathways.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetocardiography for Distinguishing Obstructive Coronary Heart Disease and Coronary Microvascular Dysfunction: A Feasibility Study.","authors":"Nandi Bao, Tianwen Han, Dongkai Shan, Yuhao Miao, Jianguo Cui, Liangliang Liu, Xi Wang, Cui Tian, Feng Tian","doi":"10.1159/000550445","DOIUrl":"https://doi.org/10.1159/000550445","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The objective of the study was to evaluate the capability of magnetocardiography (MCG) in distinguishing obstructive coronary heart disease (OCHD) from coronary microvascular dysfunction (CMVD).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Patients with chest pain suspected of having CAD were consecutively enrolled in according to the inclusion and exclusion criteria. All patients underwent coronary angiography and coronary blood flow analysis, and were divided into OCHD group (n = 447) and CMVD group (n = 332) based on the results of imaging analysis. All patients also underwent MCG examination before or after coronary angiology in 48 h, the MCG parameters were analyzed by an independent third party. Univariate and multivariate logistic regression analyses were performed to identify significant clinical and MCG parameters between groups. Diagnostic models were constructed using selected MCG parameters alone or in combination with clinical indicators. Performance was assessed using receiver operating characteristic curves, accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Clinical utility and model performance were further validated via calibration curves and decision curve analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In OCHD group, the prevalence of type 2 diabetes mellitus (35.79% vs. 25.30%, p = 0.022) and interventricular septal thickness (mm) (11.00 [10.25-12.00] vs. 11.00 [10.00-11.00], p &lt; 0.001) was significantly higher than those in the CMVD group, while high-density lipoprotein cholesterol (mmol/L) was significantly lower (1.01 [0.85-1.16] vs. 1.06 [0.93-1.22], p &lt; 0.001). Seven MCG parameters showed significant intergroup differences: QR-enav (10.08 [9.02-11.22] vs. 9.36 [8.38-10.41], p &lt; 0.001), RS-enav (10.29 [9.32-11.33] vs. 9.66 [8.71-10.73], p &lt; 0.001), TT-dicar (0.04 [0.02-0.14] vs. 0.02 [0.01-0.09], p &lt; 0.001), TT-dicd (41.40 [25.75-77.55] vs. 34.40 [20.83-62.90], p &lt; 0.001), TT-didav (60.70 [55.50-66.40] vs. 63.80 [58.02-67.80], p &lt; 0.001), TT-didmse (3.70 [2.10-6.35] vs. 2.90 [1.70-4.77], p &lt; 0.001), and TT-enav (10.44 [9.20-11.57] vs. 9.96 [8.79-11.01], p &lt; 0.001). RS-enav achieved the highest AUC (0.615), with sensitivity, specificity, PPV, and NPV of 48.77%, 69.21%, 70.10%, and 47.72%, respectively. TT-didmse exhibited specificity of 73.51% and PPV of 69.41%, while TT-enav showed specificity of 60.26% and PPV of 67.21%. TT-dicd demonstrated the highest diagnostic sensitivity (78.30%) in distinguishing OCHD patients from CMVD. The integrated model combining seven MCG parameters yielded an AUC of 0.681 (95% CI: 0.642-0.720), which improved to 0.713 (95% CI: 0.674-0.751) in the combined model. Calibration curves confirmed high agreement between nomogram predictions and observed outcomes, and decision curve analysis indicated better net benefit for the combined model.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;MCG parameters, either alone or in combination with c","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-15"},"PeriodicalIF":1.7,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Perfusion Index as a Marker of Hypoperfusion in Heart Failure.","authors":"Kenichi Kasai, Tatsuya Kawasaki","doi":"10.1159/000550873","DOIUrl":"10.1159/000550873","url":null,"abstract":"<p><strong>Introduction: </strong>Current heart failure (HF) guidelines recommend hemodynamic assessment based on four clinical profiles: dry warm, wet warm, dry cold, and wet cold. While physical examination for signs of congestion, e.g., jugular venous distention, is commonly performed, evaluation of perfusion status is often neglected due to the lack of simple and reliable physical indicators. This study aims to evaluate the perfusion index (PI), a noninvasive parameter derived from the ratio of pulsatile to non-pulsatile blood flow components, as a useful tool for assessing perfusion status in patients with HF.</p><p><strong>Methods: </strong>This prospective study included 257 patients hospitalized for the management of acute HF. Peripheral PI was measured on the index finger before discharge. The presence or absence of a cold perfusion profile was determined using standard clinical criteria. All patients were followed after discharge. The primary outcome was a composite of all-cause mortality and hospitalization for worsening HF.</p><p><strong>Results: </strong>During a mean follow-up of 446 ± 280 days, 109 patients experienced a primary outcome event. Patients with a cold perfusion profile, as defined by standard criteria, had a higher incidence of the primary outcome (hazard ratio 1.98, 95% confidence interval 1.28-2.91, p < 0.01), as did those with a peripheral PI <1.1 (hazard ratio 2.27, 95% confidence interval 1.55-3.32, p < 0.01). These associations remained consistent across subgroup analyses.</p><p><strong>Conclusion: </strong>Assessing perfusion status using peripheral PI before discharge may provide a simple and practical method for risk stratification in patients with HF, offering prognostic value comparable to that of a cold perfusion profile determined by standard clinical criteria.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Disease and Cancer: Two Sides of the Same Coin.","authors":"Stefania Angela Di Fusco, Maria Laura Canale, Stefano Oliva, Irma Bisceglia, Giuseppina Gallucci, Antonella Spinelli, Alessandro Alonzo, Antonio Concistrè, Iacopo Fabiani, Maria Grazia Delle Donne, Stefano Aquilani, Andrea Matteucci, Silvio Fedele, Giuseppe Imperoli, Federico Nardi, Furio Colivicchi","doi":"10.1159/000550818","DOIUrl":"10.1159/000550818","url":null,"abstract":"<p><strong>Background: </strong>Growing evidence shows that the relationship between cancer and cardiovascular disease is not unidirectional. The recognized impact of cardiovascular risk factors and cardiovascular disease on cancer risk has led to the coining of the term \"reverse cardio-oncology.\"</p><p><strong>Summary: </strong>Cardiovascular risk factors such as smoking, hypertension, diabetes, dyslipidemia, and obesity are involved in several pathophysiologic mechanisms that also underlie cancer development and progression. These mechanisms include inflammation, oxidative stress, and DNA damage. In addition, cardiovascular diseases such as atrial fibrillation, atherosclerotic cardiovascular disease, and heart failure by causing an imbalance in the autonomic nervous system and neurohormonal system function through the activation of tumorigenesis processes may facilitate cancer development. Epidemiological studies, which show an increased incidence and a faster progression of cancer in patients with concurrent cardiovascular disease, support the existence of an association between these two sets of diseases.</p><p><strong>Key messages: </strong>Several biological pathways underlying cardiovascular risk factors and cardiovascular diseases are also involved in cancer development and progression. Reverse cardio-oncology has the potential to become the foundation for integrated healthcare strategies aimed at reducing global disease burden.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic Valve Calcification Scores versus CT-FFR: Prediction of Major Adverse Cardiovascular Events after Transcatheter Aortic Valve Replacement.","authors":"Shuangxin Li, Xugang Wang, Wenxuan Yang, Jiali Liu, Ruoshui Zheng, Jun Shu, Yongkang Bai, Jian Yang, Minwen Zheng, Didi Wen","doi":"10.1159/000550738","DOIUrl":"10.1159/000550738","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to assess the prognostic value of aortic valve calcification (AVC) score and CT angiography-derived fractional flow reserve (CT-FFR) for major adverse cardiovascular events (MACEs) after transcatheter aortic valve replacement (TAVR).</p><p><strong>Methods: </strong>In this retrospective observational cohort study, we included patients with severe aortic valve diseases undergoing TAVR between February 2016 and April 2022. Patients were followed, and univariable and multivariate Cox regression were applied for outcome analysis using a composite endpoint including all-cause mortality, nonfatal myocardial infarction, unstable angina, heart failure rehospitalization. The incremental prognostic value of CT-FFR was also analyzed.</p><p><strong>Results: </strong>A total of 251 patients were enrolled (mean age, 67 ± 10 years; 176 men). During a mean follow-up period of 36 months, 60 (23.9%) patients experienced MACE. AVC score ≥2,000 (hazard ratio [HR] = 1.714, 95% confidence intervals [CI]: 1.020, 2.882, p = 0.042) and CT-FFR ≤0.8 (HR = 3.248, 95% CI: 1.760, 5.996, p < 0.001) were independent predictors of MACE. The C statistics revealed that adding CT-FFR to the clinical risk factors alone or combined with AVC score provided incremental prognostic value for MACE after TAVR (C-index: 0.697 vs. 0.645 [p = 0.012]; and 0.710 vs. 0.672 [p = 0.030]).</p><p><strong>Conclusion: </strong>AVC score and CT-FFR were associated with MACE in patients after TAVR, and CT-FFR presented incremental prognostic value for MACE beyond clinical risk factors alone or combined with AVC score. Therefore, CT-FFR may provide incremental prognostic information and requires prospective validation prior to routine implementation.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13030899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}