Cardiology最新文献

{"title":"Does Height Influence the Effectiveness of Beta-Blocker Therapy after Myocardial Infarction?","authors":"Konstantinos Dean Boudoulas, Konstantinos Marmagkiolis, Cezar Iliescu, Konstantinos Charitakis, Mehmet Cilingiroglu, Harisios Boudoulas","doi":"10.1159/000552230","DOIUrl":"https://doi.org/10.1159/000552230","url":null,"abstract":"","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of socioeconomic status on one-year morbidity and readmission in patients with Takotsubo Syndrome: A Danish cohort study.","authors":"Pernille Palm, Line Ryberg Rasmussen, Anne Vinggaard Christensen, Lia E Bang, Helle Wallach-Kildemoes, Selina Kikkenborg Berg","doi":"10.1159/000551671","DOIUrl":"https://doi.org/10.1159/000551671","url":null,"abstract":"<p><strong>Introduction: </strong>Takotsubo Syndrome (TS) is a cardiac condition that mimics myocardial infarction (MI). Long-term readmission data remain limited. Previous studies in other conditions suggest that socioeconomic factors, such as low income and unemployment, may influence readmission rates, but this has not been explored in TS. This study aims to investigate the risk factors of one-year readmissions in TS patients and the impact of socioeconomic factors, comparing results with matched individuals from the general population and those with MI. Methods A nationwide cohort study was conducted using national registers. Patients discharged alive from Danish hospitals with an incident TS diagnosis between 2008 and 2018 were identified through the Danish National Patient Registry. Each TS patient was matched with four individuals from the general population and patients with MI by sex and age. In the analyses of one-year readmission of TS, we included socioeconomic factors such as cohabitation, labor market attachment, education, family income psychological distress, and comorbidities. Results A total of 1022 individuals with TS were identified, with a median age of 70 years (IQR 61-77), and 89% were women. Compared to the general population, TS patients had higher rates of cardiovascular comorbidities, respiratory diseases, and psychotropic medication use, but fewer cardiac conditions except for heart failure in the MI population. TS patients were more likely to receive incapacity pensions, have basic education, and belong to the lowest income percentile compared to the general population. In the first year, (36%) of TS patients were readmitted, compared to 4% in the general population and 44% in the MI group. The most common causes of readmission in the TS cohort were cardiac (27%), 'other' conditions (22%), and respiratory (20%).Readmission rates were higher among TS patients in vulnerable socioeconomic groups compared to the general population: 37% vs 6% for those in the lowest income percentile, 42% vs 6 % for those with basic education, and 37% vs 4% for those on incapacity pension, but overall lower compared to the MI population. Most readmissions occurred within the first two months. The two lowest income quintiles, vocational/high school and below and living alone all predicted readmission. The lowest income had a Hazard Ratio of 1.64 and 95% confidence intervals of 1.01-2.69. Conclusion Although TS patients exhibit a disadvantaged socioeconomic profile and a substantial comorbidity burden, our analyses suggest that socioeconomic factors are associated with readmission risk, with part of this association potentially mediated through comorbidity burden. These findings indicate that, even in healthcare systems with free access such as Denmark's, socioeconomic inequalities may remain relevant for readmission risk in TS patients.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-21"},"PeriodicalIF":1.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the Disease Burden of Endocarditis Across Asia.","authors":"Huange Cai, Kaibin Fang, Yingbin Lin","doi":"10.1159/000552117","DOIUrl":"https://doi.org/10.1159/000552117","url":null,"abstract":"<p><p>Background This study provides the first comprehensive assessment of the disease burden of endocarditis in Asia, presenting epidemiological trends from 1990 to 2023. Methods Data on endocarditis for Asian countries and territories were obtained from the Global Burden of Disease Study 2023, covering incidence, prevalence, YLDs (Years Lived with Disability), YLLs (Years of Life Lost), DALYs (Disability-Adjusted Life Years), and deaths from 1990 to 2023. A secondary analysis of these data yielded the overall disease burden of endocarditis in Asia. Building on this information, we report the epidemiological trends of endocarditis across Asian countries and territories and project the disease burden for the next 17 years. Result In 2023, the total number of incident endocarditis cases in Asia was 675,481, with an ASIR of 14.57 per 100,000 population. The overall prevalence was 150,339, yielding an ASPR of 3.28 per 100,000. A total of 30,594 deaths occurred, corresponding to an ASDR of 0.67 per 100,000. DALYs amounted to 887,280, giving an age-standardized DALY rate of 18.96 per 100,000. YLLs totaled 875,657, resulting in an age-standardized YLL rate of 18.71 per 100,000. YLDs summed to 11,623, equivalent to an age-standardized YLD rate of 0.25 per 100,000. Joinpoint regression analysis revealed that from 1990 to 2023, the AAPC values for ASIR, ASPR, ASDR, and the age‑standardized YLDs rate of endocarditis in Asia were positive, whereas the AAPC values for the age‑standardized DALYs rate and the age‑standardized YLLs rate were negative. It is projected that by 2040, endocarditis will continue to impose a substantial disease burden in Asia. Conclusion In Asia, endocarditis imposes a substantial disease burden and its epidemiological trend is on the rise.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-20"},"PeriodicalIF":1.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between P-wave parameters and atrioventricular synchrony in patients with leadless pacemakers.","authors":"Zhongxin Qin, Qiao Yu, Yutong Liu, Haiwei Li, Zefeng Wang, Fei Hang, Weiping Sun, Yongquan Wu","doi":"10.1159/000551832","DOIUrl":"https://doi.org/10.1159/000551832","url":null,"abstract":"<p><strong>Background: </strong>Correlation between P-wave parameters and atrioventricular synchrony (AVS) in patients with leadless pacemakers (LPs) remains controversial. The purpose of this study was to identify the correlation between P-wave parameters and AVS in patients with leadless pacemakers.</p><p><strong>Method: </strong>Patients undergoing VDD LP implantation at Beijing Anzhen Hospital between August 2022 to August 2024 were followed up at 1 month and 3 months after implantation, respectively. Demographic data, comorbidities, electrocardiogram parameters, echocardiography parameters, and programmable parameters were compared to those with Atrial-synchronized Ventricular Pacing (AsVP) ≥ 80% and those with AsVP < 80%. Logistic regression models were used to investigate the correlation between P-wave characteristics and AsVP. The AsVP and programmable parameters at 1 and 3 months were compared.</p><p><strong>Results: </strong>85 patients (average age 69.1 ± 14.1 years; 68.2% male) undergoing VDD LP implantation were divided into two groups based on AsVP (high AsVP ≥80% and low AsVP <80%). The high AsVP group exhibited significantly greater P-wave area as well as smaller P-wave dispersion (PD) on preoperative electrocardiogram (all P <0.05). Multivariate logistic analysis demonstrated that higher P-wave area and lower PD and E/A were independent predictor of high AsVP. Additionally, a greater AsVP was observed at 3 months compared to 1 month (80.9 ± 13.9% VS 74.6 ± 23.6%, P =0.035) after implantation.</p><p><strong>Conclusion: </strong>Preoperative electrocardiogram P-wave parameters may predict AVS after LP implantation. This finding helps us identify more suitable patients for receiving VDD LP.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-25"},"PeriodicalIF":1.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Janus Kinase Inhibitors and Cardiovascular Safety: Interpreting Signals from the Korea Adverse Event Reporting System.","authors":"Bahar Mikaeili, Ana L Hincapie","doi":"10.1159/000551318","DOIUrl":"https://doi.org/10.1159/000551318","url":null,"abstract":"","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-3"},"PeriodicalIF":1.7,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of right ventricular myocardial features derived from echocardiography using a deep learning framework in pulmonary arterial hypertension.","authors":"Dongwei Xie, Jie Hu, Guizi Liang, Rentao Zhi, Yan Deng","doi":"10.1159/000552266","DOIUrl":"https://doi.org/10.1159/000552266","url":null,"abstract":"<p><strong>Background: </strong>The function and myocardial characteristics of the right ventricle (RV) are linked to RV dysfunction and prognosis in pulmonary arterial hypertension (PAH). The prognostic value of RV myocardial features derived from echocardiography remains unclear.</p><p><strong>Methods: </strong>A total of 166 patients (mean age, 35.6±11.7 years; 133 females) were included. The primary endpoint was a composite of cardiovascular hospitalization and all-cause mortality. RV myocardium was manually segmented using ITK-SNAP. DenseNet161 was employed to build the deep transfer learning (DTL) model. Seven machine learning algorithms were used to construct radiomics (Rad) and deep learning-based radiomics (DLR) models. A combined nomogram was developed, with its predictive performance assessed using time-dependent ROC analysis and Kaplan-Meier estimates.</p><p><strong>Results: </strong>The three myocardial models were constructed, and their performance was evaluated using ROC, calibration curves, decision curve analysis (DCA), and other relevant metrics. The DLR model outperformed the others, demonstrating superior AUCs in both the training and test cohorts (AUC = 0.977, 0.875). The combined nomogram demonstrated excellent performance in survival ROC analysis, with AUCs of 0.763, 0.824, and 0.935 for 1-, 3-, and 5-year predictions, respectively. Furthermore, the DLR score added prognostic value to the COMPERA 2.0, as demonstrated by a global chi-square and C-statistic comparison (P < 0.001 for both).</p><p><strong>Conclusion: </strong>Echocardiographic RV myocardial features, analyzed using DLR model, were strongly correlated with RV dysfunction and prognosis in PAH. The combined nomogram demonstrated superior predictive value. These results highlight the potential of myocardial features for improved risk stratification and prognosis in PAH.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-23"},"PeriodicalIF":1.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patent Ductus Arteriosus Stenting in Infants with Duct-Dependent Pulmonary Circulation: An Indian Experience.","authors":"Deepali Bangalia, Hemanta Nayak, Sudipta Bhattacharjya, Somrita Laha, Siddhartha Joshi, Santanu Roy","doi":"10.1159/000552118","DOIUrl":"https://doi.org/10.1159/000552118","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to evaluate outcomes of patent ductus arteriosus (PDA) stenting using the latest generation drug-eluting coronary stents in neonates with duct-dependent pulmonary circulation.</p><p><strong>Methods: </strong>This was a retrospective, observational study which included infants who were diagnosed with duct-dependent pulmonary circulation and underwent PDA stenting at a tertiary care center in India. All pre- and post-procedural details of each patient were retrospectively collected from the medical records of the hospital. All the patients were regularly followed up for up to 12 months in the outpatient clinic until the subsequent surgical procedure following the PDA-stenting.</p><p><strong>Results: </strong>A total of 58 patients who underwent PDA stenting were included in the study. The mean age was 50.22±67.69 days and mean weight was 3.18±1.15 kg. Among all, 24 (41.4%) patients were prematurely born (<37 gestational weeks). A total of 35 (60.3%) patients required prostaglandins before PDA stenting to maintain patency of the duct until the procedure. The mean PDA diameter at pulmonary artery end was 2.75±0.63 mm, and the mean PDA length was 17.19±4.68 mm. A total of 60 drug-eluting coronary stents were implanted across 58 PDAs with Tetrilimus everolimus-eluting stents being the most implanted (35%). The mean implanted stent length and diameter were 19.50±5.61 mm and 4.06±2.39 mm. Successful stent deployment at the intended position across the PDA was achieved in all 58 (100%) patients. During hospital-stay, four (6.9%) cases of in-hospital mortality were reported. Post discharge, three deaths were reported up to 12-month follow-up. During 12-month follow-up, 19 (32.8%) patients underwent univentricular surgical repair, while four (6.9%) underwent biventricular surgical pair. Two (3.4%) patients required stent retrieval and subsequently underwent palliative shunting.</p><p><strong>Conclusion: </strong>The PDA stenting with the latest-generation drug-eluting coronary stents is found safe and clinically better palliative care strategy for patients with duct-dependent pulmonary circulation, resulting in improved procedural and follow-up outcomes.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-19"},"PeriodicalIF":1.7,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Episodic Testing: Toward Ambient Monitoring in Heart Failure.","authors":"Hiroaki Hiraiwa, Takahiro Okumura, Toyoaki Murohara","doi":"10.1159/000551719","DOIUrl":"https://doi.org/10.1159/000551719","url":null,"abstract":"","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-3"},"PeriodicalIF":1.7,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13105463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Perfusion in Heart Failure: The Invisible Half of Hemodynamics at Discharge.","authors":"Takahiro Okumura, Hiroaki Hiraiwa, Satoshi Yanagisawa, Toyoaki Murohara","doi":"10.1159/000551157","DOIUrl":"https://doi.org/10.1159/000551157","url":null,"abstract":"","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-4"},"PeriodicalIF":1.7,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Outcomes in Diabetic Patients Treated with SGLT2i and GLP1-RA: A Systematic Review and Meta-Analysis.","authors":"Gaetano Marino, Stefania Angela Di Fusco, Alessandro Alonzo, Vito Altamura, Furio Colivicchi","doi":"10.1159/000551686","DOIUrl":"https://doi.org/10.1159/000551686","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Introduction Type 2 diabetes mellitus (T2DM) represents a significant public health issue due to its high prevalence and associated complications, particularly the cardiovascular and renal impairments that characterize its natural history. Glucagon-like peptide receptor agonists (GLP1-RA) and sodium-glucose cotransporter-2 inhibitors (SGLT2i) are two new classes of glucose-lowering agents. Large-scale international randomized controlled trials (RCTs) have demonstrated that both GLP1-RA and SGLT2i significantly reduce cardiovascular events in patients with T2DM. This study aims to conduct a systematic review and meta-analysis to evaluate cardiovascular outcomes in diabetic patients treated with GLP1-RA, SGLT2i or their combination. Subgroup analysis were performed for specific populations including older adults and patients with chronic kidney disease (CKD). Methods This meta-analysis was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A systematic search was performed across MEDLINE, WOS (Web of Science), SCOPUS, Embase, PubMed, CENTRAL and clinicaltrials.gov to identify multinational RCTs. The primary cardiovascular outcome was 3P-MACE (3 Point-Major Adverse Cardiovascular Events; nonfatal stroke, nonfatal myocardial infarction and cardiovascular death). Safety outcomes included hypoglycemia, pancreatitis, gastrointestinal disorders and cancer for GLP1-RA; hypoglycemia, ketoacidosis, fractures and genitourinary infections for SGLT2i. Risk of bias was assessed using the Cochrane Risk of Bias tool. Hazard ratio (HR), risk difference (RD) and relative risk (RR) were calculated with a 95% confidence interval using inverse variance-weighted method. A random-effects model was applied to synthesize the effect sizes of the studies assuming inter-study heterogeneity. The protocol was registered on the International Prospective Register of Systematic Reviews (PROSPERO; CRD420261306111) Results Seventeen clinical trials met the inclusion criteria; 11 compared GLP1-RA vs placebo and 6 compared SGLT2i vs placebo. Based on the random-effect model, GLP1-RA and SGLT2i significantly reduced 3P-MACE risk with HR of 0.85 (95% CI: [0.80 - 0.90]) and HR 0.87 (95% CI: [0.82 - 0.93]) respectively. No statistically significant differences were observed between combination therapy (GLP1-RA + SGLT2i) vs GLP1-RA monotherapy regarding 3P-MACE (HR 0.76 [0.54 - 1.08] vs HR 0.78 [0.70 - 0.87]; p interaction=0.89) or hospitalization for heart failure (HR 0.58 [0.36 - 0.92] vs HR 0.73 [0.63 - 0.85]; p interaction=0.89). Similarly, combination therapy showed no significant difference compared to SGLT2i monotherapy for 3P-MACE (HR 0.87 [0.66 - 1.15] vs HR 0.89 [0.84 - 0.94]; p interaction=0.87) and heart failure hospitalization (HR 0.82 [0.53 - 1.27] vs HR 0.77 (95% CI: [0.71 - 0.85]; p interaction=0.87). Subgroup analysis revealed that SGLT2i therapy was more effective in reducing 3P-MACE in patient w","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-31"},"PeriodicalIF":1.7,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}